MycoData

Immune supportCognition & nerves

Lion's Mane · 2025 · Preprint · journal metadata

Calm Under Challenge: Immune Balancing and Stress Quenching Effects of Hericium erinaceus Mycelium in Human Immune Cells

Hericium erinaceus is a medicinal mushroom valued for its neuroprotective, immunomodulatory, and antioxidant activities. While many extracts and bioactive compounds from both mycelium and fruit bodies have been characterized, the mechanisms driving their effects are not fully understood..

Chaga · 2025 · Published Erratum · Frontiers in pharmacology

Corrigendum: Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing.

[This corrects the article DOI: 10.3389/fphar.2025.1556739.]..

OncologyImmune supportMetabolic healthRespiratory

Cordyceps · 2025 · Comparative Study · Applied biochemistry and biotechnology

GC-MS Analysis of Polysaccharides from an Intergeneric Hybrid of Pleurotus florida and Cordyceps militaris: A Comparative Study.

Edible and medicinal mushrooms are valuable sources of polysaccharides, known for their dual roles as immunostimulants and immunosuppressants. This study aimed to enhance polysaccharide content by fusing two mushroom species, P.

Immune supportMetabolic health

Reishi · 2025 · Preprint · journal metadata

Identification of a Ganoderma lucidum Endogenous Reference Gene and Its Validation for Quantitative Analysis of Spore Powders and Fruiting Bodies from Different Land Sources

Background: Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) are believed to be one of the major bioactive components to promote health benefits.

Oyster Mushroom · 2025 · Preprint · journal metadata

Improving Nutrition Facts of Cassava and Soybean Residue through Solid-State Fermentation by Pleurotus ostreatus Mycelium: A Pathway to Safety Animal Feed Production

The overwhelming amount of cassava residues and okara is a foremost challenge for the food processing industry environmental loading. The purpose of this article is to utilize Pleurotus ostreatus mycelium to ferment solid cassava and soybean residue, resulting in mycelial biomass with nutritional values and promising….

OncologyImmune supportLiver support

Yellow Morel · 2025 · Preprint · journal metadata

Morchella esculenta Intensifies Testosterone Production and Spermatogenesis in Male Mice with High-Fat Diet-Induced Obesity by Enhancing Antioxidant Capacity

Obesity has become a major health concern worldwide and is strongly correlated with various comorbidities including reproductive dysfunction. Therefore, this study aimed to explore the ef-fects of Morchella esculenta (ME) in improving reproductive dysfunction caused by high-fat di-et-induced obesity..

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · Preprint · journal metadata

Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid Metabolism

Abstract Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action..

OncologyImmune supportCognition & nervesGut & microbiome

Shiitake · 2025 · Preprint · journal metadata

Oral Lentinula edodes mycelia extract enhances the antitumor effect of radiotherapy via gut-associated activation of dendritic and cytotoxic T cells

Abstract Oral administration of Lentinula edodes mycelia extract (L.E.M.) has been shown to stimulate systemic T cell–mediated antitumor immunity and inhibit tumor growth in mice, suggesting its potential to modulate host immune responses. However, the route of this systemic antitumor effect remains unclear..

Reishi · 2025 · Preprint · journal metadata

Overexpression of GlATIC gene enhances adenosine production in Ganoderma lucidum

Adenosine recognized for its immunomodulatory, anti-inflammatory, and anti-cancer properties, has limited clinical and commercial applications due to low production levels in Ganoderma lucidum..

OncologyImmune support

OncologyImmune supportMetabolic health

Shiitake · 2025 · Preprint · journal metadata

Screening of Lentinula edodes Strains for High Polysaccharide Productions and In Vitro Antioxidant Activities

Lentinan is one of the main metabolites of Lentinula edodes, and exhibits numerous biological activities such as anti-tumor and antioxidant. Despite recent advancements, its commercialization remains constrained by a lengthy cultivation cycle, low yield, and high cost..

Shiitake · 2025 · Preprint · journal metadata

Sequential Enzymatic and Ultrasonic Extraction of Lentinula edodes Mushroom Proteins Leading to Enhanced Yield and Significant Immunoactivity

Abstract Lentinula edodes is a widely consumed edible fungus and a rich source of proteins with both nutritional and medicinal value. This study discovered an effective process to extract proteins from L..

OncologyImmune supportGut & microbiomeSkin & hydration

Reishi · 2025 · Preprint · journal metadata

Study on the anti-tumor effect of Wall-broken Ganoderma lucidum spore powder on papillary thyroid cancer

Abstract Ganoderma lucidum wall-broken spores (BGLSP), traditionally used in Traditional Chinese Medicine for immunity and chronic diseases, contain bioactive triterpenoids with anti-tumor potential, but their mechanisms against papillary thyroid cancer (PTC) remain unclear..

OncologyImmune supportEnergy & fatigueRespiratory

Reishi · 2025 · Preprint · journal metadata

Synergistic Anti-Tumor and Immunomodulatory Effects of Sporoderm-Removed Ganoderma Lucidum Spore Powder and Anti-PD-L1 Antibody in Lung Cancer Mice

Abstract Background The therapeutic efficacy of PD-1/PD-L1 inhibitors in lung cancer management remains suboptimal. Sporoderm-removed Ganoderma Lucidum Spore Powder (RGLS), an immunostimulant, has been shown to amplify the anti-tumor effects of anti-PD-L1 antibodies (αPD-L1)..

OncologyImmune supportCognition & nervesGut & microbiome

Reishi · 2024 · Preprint · journal metadata

Bioactive compounds and nanoparticles in Ganoderma lucidum: New perspectives on health benefits

The unique medicinal properties of Ganoderma lucidum have led to a growing demand for it as an essential source of dietary supplements in the food sector. The wide array of therapeutic and pharmacological effects of G.

Oyster Mushroom · 2024 · Preprint · journal metadata

Evaluation of Physiological and Biochemical Reactions of Pleurotus ostreatus Cultivated in Varied Juncao Grass Substrates

Background: Pleurotus ostreutus is one of the world’s most commonly consumed mushrooms. Cultivation of mushrooms using wood resources usually results in environmental issues of deforestation..

Immune supportMetabolic healthLiver support

Maitake · 2024 · Preprint · journal metadata

Grifola frondosa polysaccharide Ameliorates Inflammation and Insulin Resistance by Regulating Macrophage Polarization of liver in Type 2 diabetes mellitus Rats

Type 2 diabetes mellitus (T2DM) is a common metabolic disease characterized by a lack of insulin secretion, insulin resistance (IR), and hyperglycemia. Given its high prevalence and multifarious complications, diabetes is globally ranked as the third leading cause of mortality..

Immune supportCognition & nerves

Reishi · 2024 · Preprint · journal metadata

Investigating the neuroprotective mechanism of Ganoderma lucidum in glaucoma treatment through network pharmacology and molecular docking analysis

Abstract Ganoderma lucidum(GL), a medicinal fungus belonging to the polyporaceae family, has been extensively utilized in the treatment of glaucoma. To elucidate the underlying mechanisms of GL in glaucoma therapy, network pharmacology methods were employed for screening its active compounds, potential targets, and….

Cordyceps · 2024 · Preprint · journal metadata

Ophiocordyceps sinensis infection alters the immune system of the host Thitarodes xiaojinensis investigated by the interaction between immunity and gut microbiota escaping to hemolymph

Abstract Background Ophiocordyceps sinensis as one typical entomopathogenic fungus (EPF) has the long-term symbiosis process with its host Thitarodes xiaojinensis. O.

OncologyImmune supportMetabolic healthSkin & hydration

Snow Fungus · 2024 · Preprint · journal metadata

Overcharged lipid metabolism in mechanisms of antitumor by Tremella Fuciformis Polysaccharide

Tremella Fuciformis polysaccharides (TFP) is a natural macromolecular compound well-known for whitening, lipid and immunity regulation. To evaluate the effect of TFP on melanogenesis, lipid metabolism programmes and immune system of B16 cells in vitro and in vivo, the cell proliferation, cell cycle and apoptosis were….

Immune supportCognition & nervesRespiratory

Cordyceps · 2024 · Preprint · journal metadata

The Preventive Potential of the Mycelial Submerged Culture of Ophiocordyceps sinensis against Neurodegenerative Diseases and Its Possible Active Compounds

The pharmacological effects of the fruiting body of Ophiocordyceps sinensis (Os) exerted antioxidant, anti-virus, and immunomodulatory, whereas the anti-inflammatory effects and active components of Os mycelial submerged culture (OMSC) are not known..

OncologyImmune supportCognition & nerves

Snow Fungus · 2024 · Preprint · journal metadata

Tremella fuciformis polysaccharides alleviate early brain injury in experimental subarachnoid hemorrhage by inhibiting the KDR-mediated P38 MAPK/NF-κB pathway

Abstract Background Subarachnoid hemorrhage is associated with high mortality and morbidity rates. In its early stages, the substantial influx of blood into the subarachnoid space triggers excessive activation of microglial cells, which markedly contributes to early brain injury, a pivotal determinant of poor….

Shiitake · 2023 · Journal Article · Mushroom Science and Biotechnology

Effects of 137Cs concentration in mushroom logs and yield on 137Cs transfer from logs to shiitake (Lentinula edodes) fruiting bodies

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2023. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Cordyceps · 2023 · Journal Article · Journal of biochemical and molecular toxicology

Network pharmacology and molecular docking analysis on the mechanism of Cordyceps militaris polysaccharide regulating immunity through TLR4/TNF-α pathwayss.

The role of polysaccharide components in the immune system, especially immunomodulatory effects, has received increasing attention. In this context, in this study, network pharmacology was adopted to explore the hypothesis of a multitarget mechanism for immune modulation by Chrysalis polysaccharides..

Shiitake · 2022 · Journal Article · Journal of The National Institute of Technology, Asahikawa College

Attempt of the Cryopreservation of Shiitake (Lentinula edodes) Mycelia at a Temperature Zone around -18°C using a Domestic Freezer

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Journal of The National Institute of Technology, Asahikawa College in 2022. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Maitake · 2022 · Journal Article · Mushroom Science and Biotechnology

Determination of the mating system of Grifola frondosa (maitake) IM-BM21

Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Mushroom Science and Biotechnology in 2022. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Immune supportRespiratory

Cordyceps · 2022 · Research Article · Microorganisms

Immunostimulatory Activity of Cordyceps militaris Fermented with Pediococcus pentosaceus SC11 Isolated from a Salted Small Octopus in Cyclophosphamide-Induced Immunocompromised Mice and Its Inhibitory Activity against SARS-CoV 3CL Protease.

In this study, we investigated the immune-enhancing and anti-viral effects of germinated Rhynchosia nulubilis (GRC) fermented with Pediococcus pentosaceus SC11 (GRC-SC11) isolated from a salted small octopus. The cordycepin, β-glucan, and total flavonoid contents increased in GRC after SC11 fermentation..

Shiitake · 2022 · Journal Article · The Japanese Forest Society Congress

Relationship between Cs concentration of shiitake(Lentinula edodes)fruiting body and Cs distribution in oak log

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in The Japanese Forest Society Congress in 2022. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Shiitake · 2022 · Journal Article · Mokuzai Gakkaishi

The Antioxidant Activity of the Extracts from Disposition of the Waste Sawdust Substrate from Shiitake Mushroom (Lentinula edodes) Cultivation by the Two-step Hot/hot-compressed Water Percolation

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mokuzai Gakkaishi in 2022. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportMetabolic health

Cordyceps · 2022 · Journal Article · Food & function

The polysaccharide-peptide complex from mushroom Cordyceps militaris ameliorates atherosclerosis by modulating the lncRNA-miRNA-mRNA axis.

An N-glycosidic polysaccharide-peptide complex CMPS-80 was obtained from the fruiting body of C. militaris.

Shiitake · 2021 · Journal Article · Mushroom Science and Biotechnology

Content of several ingredients in log-cultivated shiitake (Lentinula edodes) dried under different conditions

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2021. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Shiitake · 2021 · Journal Article · Mushroom Science and Biotechnology

Influence of water-permeable weed control sheets on additional radioactive cesium contamination of Shiitake (Lentinula edodes) bed logs in open-field cultivation

Immune supportMetabolic health

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris.

Hyperlipidemia is one major cause of atherosclerosis, which is a basic pathological change of cardiovascular diseases. Polysaccharide is a water-soluble component with lipid-lowering effects.

Immune supportLiver support

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris.

One novel alkali-extracted polysaccharide, CM3-SII, was obtained from the fruiting body of C. militaris via column chromatography.

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2021 · Research Article · Frontiers in molecular biosciences

The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR(-/-) Mice by Improving Hyperlipidemia.

Atherosclerotic cardiovascular disease has a high mortality worldwide. Our lab previously purified a polysaccharide designated as CM1 with (1→4)-β-D-Glcp and (1→2)-α-D-Manp glycosyls as the backbone..

OncologyImmune supportCognition & nervesGut & microbiome

Almond Mushroom · 2020 · Review · Nutrients

Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies.

Since the 1980s, medicinal effects have been documented in scientific studies with the related Basidiomycota mushrooms Agaricus blazei Murill (AbM), Hericium erinaceus (HE) and Grifola frondosa (GF) from Brazilian and Eastern traditional medicine..

OncologyImmune supportMetabolic health

King Oyster · 2020 · Review · International journal of biological macromolecules

Extraction, structure and bioactivities of the polysaccharides from Pleurotus eryngii: A review.

Pleurotus eryngii (also known as king trumpet mushroom or king oyster mushroom) is an edible mushroom cultivated widely in many regions of the world. Polysaccharides from P.

OncologyImmune supportMetabolic healthRespiratory

Reishi · 2020 · Review · International journal of biological macromolecules

Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review.

Ganoderma lucidum, commonly known as "Lingzhi" in Chinese, are well-known medicinal mushrooms. Lingzhi has been used in traditional Chinese herbal medicines for more than two thousand years.

Cordyceps · 2020 · Review · Frontiers in pharmacology

Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin.

Cordyceps militaris (C. militaris) is a fungus with a long history of widespread use in folk medicine, and its biological and medicinal functions are well studied.

OncologyImmune supportSkin & hydration

Cordyceps · 2019 · Review · International journal of biological macromolecules

Advance in Cordyceps militaris (Linn) Link polysaccharides: Isolation, structure, and bioactivities: A review.

Cordyceps militaris is a unique and precious medical fungus in Chinese Cordyceps, which has been widely used as the traditional medicines or as biocontrol agents against pests in China for centuries..

OncologyImmune supportGut & microbiomeRespiratory

Agarikon · 2019 · Review · Mycology

Antimicrobial properties of Fomitopsis officinalis in the light of its bioactive metabolites: a review.

Fomitopsis officinalis, also known as Laricifomes officinalis, is a medicinal polypore used for millennia (Agarikon) to contrast several diseases, particularly the pulmonary ones..

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2019 · Review · Critical reviews in food science and nutrition

Recent developments in Hericium erinaceus polysaccharides: extraction, purification, structural characteristics and biological activities.

Hericium erinaceus (H. erinaceus), an edible mushroom with medicinal value, has a long history of usage in China and other oriental countries.

OncologyImmune supportMetabolic healthRespiratory

Maitake · 2019 · Review · Progress in molecular biology and translational science

The biological activities of the antitumor drug Grifola frondosa polysaccharide.

Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps..

OncologyImmune supportLiver supportRespiratory

Zhu Ling · 2019 · Review · Progress in molecular biology and translational science

The efficacy of Polyporus Umbellatus polysaccharide in treating hepatitis B in China.

Polyporus umbellatus polysaccharide (PUPS) has been identified as the major bioactive component in the mushroom Polyporus umbellatus that has immuno-enhancing, anti-tumor, anti-inflammatory, and hepatoprotective activities..

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2019 · Review · International journal of molecular sciences

Therapeutic Potential of Hericium erinaceus for Depressive Disorder.

Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects..

Immune supportSkin & hydration

Reishi · 2017 · Review Article · Aging and disease

Emerging Roles of Ganoderma Lucidum in Anti-Aging.

Ganoderma lucidum is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity. It has been revealed that several extractions from Ganoderma lucidum, such as Ethanol extract, aqueous extract, mycelia extract, water soluble extract of the culture medium of Ganoderma….

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2017 · Review · International journal of biological macromolecules

Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review.

Hericium erinaceus (Bull.) Pers., also known as Yamabushitake, Houtou and Lion's Mane, is capable of fortifying the spleen and nourishing the stomach, tranquilizing the mind, and fighting cancer. Over the past decade, it has been demonstrated that H..

OncologyImmune supportMetabolic health

Mesima · 2016 · Review · Fitoterapia

Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus: A review.

Medicinal mushroom Phellinus linteus ("Sanghuang" in Chinese, ) is a famous fungus which is widely used in China, Korea, and other Asian countries. As a traditional Chinese medicine with a 2000-year long history, medicinal applications of Phellinus linteus mainly include treating hemorrhage, hemostasis and diseases….

Reishi · 2026 · Journal Article · Journal of food composition and analysis

A review of Ganoderma lucidum: Cultivation, active ingredients and its application as functional ingredients

Ganoderma lucidum, a medicinal and edible fungus with active components possessing antioxidant, anti-inflammatory, and anti-cancer properties, has attracted global attention and been extensively cultivated since the 1970s..

OncologyImmune support