MycoData

A preliminary biological investigation of the dry basidiomata of strain C-142-c of Pleurotus eryngii has shown significant antioxidant activity. Two different polysaccharides (PEPS-A1 and PEPS-A2) were isolated from the cultivated edible mushroom, P.

OncologyImmune support

High relevance

Cordyceps · 2018 · Journal Article · Food & function

Structural elucidation and immunostimulatory activity of a new polysaccharide from Cordyceps militaris.

A new polysaccharide (CMPB90-1) was isolated from cultured Cordyceps militaris by alkaline extraction. The chemical structure of CMPB90-1 was determined by analysis of physicochemical and spectral data..

OncologyImmune support

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Lion's Mane · 2017 · Journal Article · International journal of medicinal mushrooms

A Polysaccharide Isolated from Mycelia of the Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Induced Apoptosis in Precancerous Human Gastric Cells.

Hericium erinaceus is typically used in traditional Chinese medicine for mucosal protection, healing of gastric ulcers, and treatment of gastritis. We purified from the cultured mycelia of H..

OncologyImmune support

High relevance

King Oyster · 2017 · Journal Article · International immunopharmacology

Activity-guided isolation and structural identification of immunomodulating substances from Pleurotus eryngii byproducts.

A two-step extraction process was used to investigate the bioactive substances from the byproducts of the fungus Pleurotus eryngii. Methanol extraction followed by extraction using different polar solvents coupled with silica column chromatography was carried out to separate the bioactive components..

OncologyImmune support

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Shiitake · 2017 · Journal Article · Journal of food processing and preservation

Anti‐Inflammatory and Antioxidant Properties of Pulsed Light Irradiated Lentinula edodes

Intense pulsed light irradiation is used in food decontamination and in production of mushrooms with high level of ergocalciferol. Lentinula edodes (Berk.) Pegler, shiitake, was freeze‐dried and milled into powder and irradiated with 20, 40 and 60 pulses of pulsed light at a distance of 6 cm and the irradiation energy….

OncologyImmune supportEnergy & fatigue

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Cordyceps · 2017 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Anticancer Efficacy of Cordyceps militaris Ethanol Extract in a Xenografted Leukemia Model.

Cordyceps militaris is used widely as a traditional medicine in East Asia. Although a few studies have attempted to elucidate the anticancer activities of C.

OncologyImmune support

High relevance

Niu-Chang-Chih · 2017 · Research Article · PloS one

Antimelanogenic, Antioxidant and Antiproliferative Effects of Antrodia camphorata Fruiting Bodies on B16-F0 Melanoma Cells.

Antrodia camphorata is a fungus that is endemic to Taiwan, and its fruiting body has been used as a folk medicine for the prevention or treatment of diverse diseases..

OncologySkin & hydration

High relevance

King Oyster · 2017 · Journal Article · International journal of biological macromolecules

Antioxidant, antitumor and immunostimulatory activities of the polypeptide from Pleurotus eryngii mycelium.

The objective of this study was to investigate the antioxidant, antitumor and immunological activities of the polypeptide from Pleurotus eryngii mycelium (PEMP). The ability of the polypeptide to stimulate Ana-1 macrophages to englobe neutral red, secrete NO, H2O2, TNF-α, and IL-6, increase TLR2 and TLR4 expression….

OncologyImmune supportSkin & hydrationRespiratory

High relevance

Maitake · 2017 · Journal Article · Nutrition and cancer

Antitumoral Effects of D-Fraction from Grifola Frondosa (Maitake) Mushroom in Breast Cancer.

D-Fraction is protein-bound β-1,6 and β-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity..

OncologyImmune supportRespiratory

High relevance

Niu-Chang-Chih · 2017 · Journal Article · Environmental toxicology

Antrodia camphorata attenuates cigarette smoke-induced ROS production, DNA damage, apoptosis, and inflammation in vascular smooth muscle cells, and atherosclerosis in ApoE-deficient mice.

Cigarette smoke exposure activates several cellular mechanisms predisposing to atherosclerosis, including oxidative stress, dyslipidemia, and vascular inflammation..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2017 · Research Article · Oncotarget

Cordycepin and a preparation from Cordyceps militaris inhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signaling in a murine oral cancer model.

Cordyceps militaris (CM) and its active ingredient cordycepin have been reported to inhibit tumor growth, but the mechanisms are not fully understood. This study used a mouse model for oral cancer and a cell line, 4NAOC-1 derived from the model to study the mechanisms..

OncologyImmune support

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Cordyceps · 2017 · Journal Article · Journal of ethnopharmacology

Cordycepin-enriched WIB-801C from Cordyceps militaris improves functional recovery by attenuating blood-spinal cord barrier disruption after spinal cord injury.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps militaris is an ingredient of traditional Chinese medicine and have been widely used for inflammatory diseases and cancer. Cordycepin is one of the major bioactive components of Cordyceps militaris, and has been known to have anti-inflammatory and anti-oxidant effects..

OncologyImmune supportCognition & nerves

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Cordyceps · 2017 · Journal Article · Bioscience, biotechnology, and biochemistry

Cytotoxic compounds against cancer cells from Bombyx mori inoculated with Cordyceps militaris.

Two compounds, 3'-deoxyinosine and cordycepin, were isolated from Bombyx mori inoculated with Cordyceps militaris. In the bioassay examining cytotoxicity against cancer cells, both compounds showed toxicity against A549, PANC-1, and MCF-7 cancer cells..

Oncology

High relevance

Almond Mushroom · 2017 · Research Article · BioMed research international

Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™.

Agaricus blazei Murill is an edible mushroom of the Basidiomycetes family, which has been found to contain a number of compounds with antitumor properties, such as proteoglycans and ergosterol..

Oncology

High relevance

Cordyceps · 2017 · Journal Article · Applied biochemistry and biotechnology

Functional Analysis of Ribonucleotide Reductase from Cordyceps militaris Expressed in Escherichia coli.

Cordyceps militaris produces cordycepin (3'-deoxyadenosine), which has various activities, including anti-oxidant, anti-tumoral, anti-viral, and anti-inflammatory. Ribonucleotide reductase (RNR) seems to be a candidate to produce cordycepin in C..

OncologyImmune supportMetabolic healthRespiratory

High relevance

Reishi · 2017 · Journal Article · Biochemical and biophysical research communications

Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/β-catenin signaling.

The medical mushroom Ganoderma lucidum (Reishi), a traditional Chinese medicine, has exhibited a promising anti-cancer effect. However, the molecular mechanism of its action on cancer cells remains unclear..

Oncology

High relevance

Maitake · 2017 · Research Article · International journal of molecular medicine

Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway.

Grifola frondosa, a type of food and medical fungus, has been shown to exhibit various pharmacological activities, including anticancer effects. As the most typical cancer diagnosed among female patients, breast cancer remains a huge concern threatening human health globally..

OncologyImmune supportEnergy & fatigue

High relevance

Cordyceps · 2017 · Journal Article · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Identification of a novel component leading to anti-tumor activity besides the major ingredient cordycepin in Cordyceps militaris extract.

In accordance with our previous study that was carried out to identify novel anti-tumor ingredients, chromatographic separation in combination with an anti-tumor activity assay was used for analysis of Cordyceps militaris extract in this study..

Oncology

High relevance

King Oyster · 2017 · Journal Article · International journal of medicinal mushrooms

Immunomodulatory Effects of Extracellular β-Glucan Isolated from the King Oyster Mushroom Pleurotus eryngii (Agaricomycetes) and Its Sulfated Form on Signaling Molecules Involved in Innate Immunity.

The aim of this study was to determine, using murine RAW 264.7 macrophages, the immunomodulatory effect of extracellular β-glucan isolated from Pleurotus eryngii (PEBG) and its sulfated derivative (PEBG-S) on signaling molecules implicated in host innate immunity..

OncologyImmune supportEnergy & fatigue

High relevance

King Oyster · 2017 · Journal Article · Food & function

In vitro and in vivo inhibitory effects of a Pleurotus eryngii protein on colon cancer cells.

Edible mushrooms have been considered as a good source of bioactive components with various health benefits. Our previous study demonstrated the identity of a novel protein from Pleurotus eryngii, namely PEP, and its anti-inflammatory activities..

OncologyImmune supportGut & microbiome

High relevance

King Oyster · 2017 · Journal Article · The Journal of organic chemistry

Pleurocins A and B: Unusual 11(9 → 7)-abeo-Ergostanes and Eringiacetal B: A 13,14-seco-13,14-Epoxyergostane from Fruiting Bodies of Pleurotus eryngii and Their Inhibitory Effects on Nitric Oxide Production.

Two novel 11(9 → 7)-abeo-ergostane-type steroids, named pleurocins A (1) and B (2), a 13,14-seco-13,14-epoxy ergostane, named eringiacetal B (3), and an ergostane steroid (4) were isolated from the fruiting bodies of Pleurotus eryngii (Pleurotaceae)..

Oncology

High relevance

Almond Mushroom · 2017 · Journal Article · Food & function

Regulation of RAW 264.7 cell-mediated immunity by polysaccharides from Agaricus blazei Murill via the MAPK signal transduction pathway.

Agaricus blazei Murill (ABM) is a common anticancer folk remedy. Its active ingredients, i.e., polysaccharides, have been isolated and exhibit indirect tumor-suppressing activity via immunological activation.

OncologyImmune support

High relevance

King Oyster · 2017 · Journal Article · Carbohydrate polymers

Safe therapeutics of murine melanoma model using a novel antineoplasic, the partially methylated mannogalactan from Pleurotus eryngii.

A heteropolysaccharide was isolated by cold aqueous extraction from edible mushroom Pleurotus eryngii ("King Oyster") basidiocarps and its biological properties were evaluated. Structural assignments were carried out using mono- and bidimensional NMR spectroscopy, monosaccharide composition, and methylation analyses..

OncologyImmune supportMetabolic health

High relevance

Maitake · 2017 · Research Article · Integrative cancer therapies

Synergistic Apoptotic Effect of D-Fraction From Grifola frondosa and Vitamin C on Hepatocellular Carcinoma SMMC-7721 Cells.

The aim of this study was to investigate the anticancer effect of a combination of D-fraction polysaccharide from Grifola frondosa (DFP) and vitamin C (VC) on hepatocellular carcinoma in vitro. DFP is a bioactive extract from the maitake mushroom..

OncologyImmune supportLiver support

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Cordyceps · 2017 · Journal Article · International journal of biological macromolecules

The preparation of three selenium-containing Cordyceps militaris polysaccharides: Characterization and anti-tumor activities.

In the present work, three fractions of selenized Cordyceps militaris polysaccharides (SeCPS) named SeCPS- I, SeCPS- II and SeCPS- III were isolated and purified by ultra-filtration. Their selenium content were measured as 541.3, 863.7 and 623.3μg/g respectively by a graphite furnace atomic absorption spectroscopy..

OncologyImmune supportMetabolic healthLiver support

High relevance

Turkey Tail · 2017 · Research Article · PloS one

Tramesan, a novel polysaccharide from Trametes versicolor. Structural characterization and biological effects.

Mushrooms represent a formidable source of bioactive compounds. Some of these may be considered as biological response modifiers; these include compounds with a specific biological function: antibiotics (e.g.

OncologyImmune supportEnergy & fatigue

High relevance

Snow Fungus · 2017 · Research Article · Molecular medicine reports

Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1.

Tremella fuciformis polysaccharide (TFPS), which is the extract of Tremella fuciformis Berk, has previously been demonstrated to exhibit potent anti‑oxidative, anti‑inflammatory and anti‑aging effects. However, the mechanisms underlying these protective and therapeutic effects remain to be elucidated..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2017 · Journal Article · The American journal of Chinese medicine

Uncovering the Molecular Mechanism of Anti-Allergic Activity of Silkworm Pupa-Grown Cordyceps militaris Fruit Body.

Cordyceps militaris has been widely used as an herbal drug and tonic food in East Asia and has also been recently studied in the West because of its various pharmacological activities such as antitumoral, anti-inflammatory and immunomodulatory effects..

OncologyImmune support

High relevance

Lion's Mane · 2016 · Journal Article · International journal of medicinal mushrooms

Anti-Inflammatory Effects of Ethanol Extract of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis.

This study investigated the anti-inflammatory activity of ethanol extracts of Hericium erinaceus in the inflammatory bowel disease (IBD) model. Twenty C57BL/6 mice were exposed to 2% (w/v) dextran sulfate sodium (DSS) in their drinking water for 7 d to induce acute intestinal inflammation..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2016 · Research Article · Food science and biotechnology

Antioxidant and anticancer effects of extracts from fermented Haliotis discus hannai with Cordyceps militaris mycelia.

In this study, Haliotis discus hannai (H. discus hannai) was fermented using Cordyceps militaris (C.

Oncology

High relevance

King Oyster · 2016 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Antioxidant and cytotoxicites of Pleurotus eryngii residue polysaccharides obtained by ultrafiltration

Response surface methodology was used to optimize the extraction of polysaccharides Pleurotus eryngii residue (CPPS). The yield of CPPS was 10.69 ± 0.31% under the modified condition (leaching temperature of 70 °C, leaching time of 140 min and ratio of water to raw material of 25 mL/g)..

OncologyImmune supportEnergy & fatigue

High relevance

Yellow Morel · 2016 · Research Article · International journal of molecular sciences

Characteristics and Antitumor Activity of Morchella esculenta Polysaccharide Extracted by Pulsed Electric Field.

Polysaccharides from Morchella esculenta have been proven to be functional and helpful for humans. The purpose of this study was to investigate the chemical structure and anti-proliferating and antitumor activities of a Morchella esculenta polysaccharide (MEP) extracted by pulsed electric field (PEF) in submerged….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2016 · Journal Article · Carbohydrate polymers

Chemical characterization of Pleurotus eryngii polysaccharide and its tumor-inhibitory effects against human hepatoblastoma HepG-2 cells

This study was designed to investigate the chemical characterization and antitumor effects of Pleurotus eryngii polysaccharides (PEP). The crude PEP was fractionated into two fractions, namely PEP-1 and PEP-2..

OncologyImmune supportMetabolic healthLiver support

High relevance

Chaga · 2016 · Research Article · Heliyon

Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice.

AIMS: Cancer is a leading cause of morbidity and mortality worldwide; therefore, effective measures for cancer prevention and treatment are in constant demand. The extracts of Inonotus obliquus (Chaga mushroom) demonstrate potent anti-tumor activities and have been used to treat cancer in several countries; however,….

OncologyEnergy & fatigueMetabolic healthRespiratory

High relevance

Cordyceps · 2016 · Research Article · Molecular medicine reports

Cordyceps militaris induces tumor cell death via the caspase‑dependent mitochondrial pathway in HepG2 and MCF‑7 cells.

Cordyceps militaris (CM), an entomopathogenic fungus belonging to the class ascomycetes, possesses various pharmacological activities, including cytotoxic effects, on various types of human tumor cells..

OncologyEnergy & fatigueLiver support

High relevance

Maitake · 2016 · Journal Article · International journal of medicinal mushrooms

High-Level Production of Exopolysaccharides by a Cosmic Radiation-Induced Mutant M270 of the Maitake Medicinal Mushroom, Grifola frondosa (Agaricomycetes).

A new Grifola frondosa mutant, M270, was successfully isolated for high production of exopolysaccharides (EPSs) using cosmic radiation-induced mutagenesis. We found that the mutant M270 had a clearer and thicker EPS layer (~10 µm) adhering to mycelia than those of its parent strain 265 after Congo red staining..

OncologyImmune supportMetabolic health

High relevance

Lion's Mane · 2016 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Improvement of erinacine A productivity in Hericium erinaceus mycelia and its neuroprotective bioactivity against the glutamate-insulted apoptosis

Hericium erinaceus (Bulliard: Fries) Persoon (HE), synonymously called Monkey Head mushroom or Yamabushitake, contains a huge amount of nutrients, in particular, the erinacines..

OncologyCognition & nervesEnergy & fatigue

High relevance

Niu-Chang-Chih · 2016 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Osteoporosis Recovery by Antrodia camphorata Alcohol Extracts through Bone Regeneration in SAMP8 Mice.

Antrodia camphorata has previously demonstrated the efficacy in treating cancer and anti-inflammation. In this study, we are the first to evaluate Antrodia camphorata alcohol extract (ACAE) for osteoporosis recovery in vitro with preosteoblast cells (MC3T3-E1) and in vivo with an osteoporosis mouse model established….

OncologyImmune support

High relevance

Zhu Ling · 2016 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Polyporus umbellatus inhibited tumor cell proliferation and promoted tumor cell apoptosis by down-regulating AKT in breast cancer.

Breast cancer (BC) is the foremost cause of cancer-related mortality in women worldwide. Polyporus umbellatus is a polysaccharide preparation of the Chinese traditional herb medicine, which has been explored as an inhibitory compounds in suppressing many cancers..

OncologyImmune support

High relevance

Chaga · 2016 · Research Article · International journal of molecular sciences

Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice.

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in diabetes mellitus. Oxidative stress, insulin resistance and pro-inflammatory cytokines have been shown to play an important role in pathogeneses of renal damage on type 2 diabetes mellitus (DM)..

OncologyImmune supportMetabolic health

High relevance

Snow Fungus · 2016 · Journal Article · Molecular medicine reports

Studies on the purification of polysaccharides separated from Tremella fuciformis and their neuroprotective effect.

The present study aimed to investigate the protective effect of purified polysaccharides from Tremella fuciformis against glutamate-induced cytotoxicity in differentiated PC12 (DPC12) cells..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Oyster Mushroom · 2016 · Journal Article · International journal of medicinal mushrooms

Study of Antimicrobial and Cytotoxic Potential of the Oyster Mushroom Pleurotus ostreatus cv. Florida (Agaricomycetes).

This work was undertaken to evaluate in vitro antimicrobial and cytotoxic potential of Pleurotus ostreatus cv. Florida.

Oncology

High relevance

Almond Mushroom · 2016 · Research Article · PloS one

The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse.

BACKGROUND: The novel A/J Min/+ mouse, which is a model for human Familial Adenomatous Polyposis (FAP), develops spontaneously multiple adenocarcinomas in the colon as well as in the small intestine..

OncologyImmune supportGut & microbiome

High relevance

King Oyster · 2016 · Journal Article · Journal of microbiology and biotechnology

The Anti-Adipogenic Activity of a New Cultivar, Pleurotus eryngii var. ferulae 'Beesan No. 2', through Down-Regulation of PPAR γ and C/EBP α in 3T3-L1 Cells.

Adipogenesis is one of the cellular processes and a highly controlled program. Nowadays, inhibition of adipogenesis has received attention as an effective way to regulate obesity.

OncologyImmune support

High relevance

Lion's Mane · 2014 · Review · Food & function

Hericium erinaceus (Yamabushitake): a unique resource for developing functional foods and medicines.

Hericium erinaceus (HE) is a fungus inhabiting the mountainous areas of the northeast territories in Asia. HE has been used in traditional folk medicine and medicinal cuisine in China, Korea and Japan..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2013 · Review · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Advances on Cordyceps militaris constituents and pharmacological effect].

Cordyceps militaris is a parasitic fungus in a variety of lepidopteran pupae and larvae. It was reported that Cordyceps militaris has strong activity on the immuregulation, tumor, virus, infecction.

OncologyRespiratory

High relevance

Cordyceps · 2013 · Review Article · Journal of traditional and complementary medicine

A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in Dong-ChongXiaCao ( Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients.

The caterpillar fungus Ophiocordyceps sinensis (syn.Cordyceps sinensis), which was originally used in traditional Tibetan and Chinese medicine, is called either "yartsa gunbu" or "DongChongXiaCao ( Dōng Chóng Xià Cǎo)" ("winter worm-summer grass"), respectively..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2013 · Review · Journal of complementary & integrative medicine

Hericium erinaceus: an edible mushroom with medicinal values.

Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion's Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Zhu Ling · 2013 · Review · Journal of ethnopharmacology

Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) Fries: a review.

ETHNOPHARMACOLOGICAL RELEVANCE: Polyporus umbellatus (Pers.) Fries (Polyporaceae, Zhuling ) has been commonly used in medicine for a wide range of ailments related to the edema, scanty urine, vaginal discharge, urinary dysfunction, as well as jaundice and diarrhea..

OncologyImmune supportLiver support

High relevance

Chaga · 2010 · Review · Applied microbiology and biotechnology

Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production.

Inonotus obliquus (Fr.) Pilat is a white rot fungus belonging to the family Hymenochaetaceae in the Basidiomycota. In nature, this fungus rarely forms a fruiting body but usually an irregular shape of sclerotial conk called 'Chaga'.

OncologyImmune supportSkin & hydrationRespiratory