MycoData

Immune supportMetabolic healthGut & microbiome

Cordyceps · 2024 · Journal Article · Carbohydrate polymers

Metabolic outcomes of Cordyceps fungus and Goji plant polysaccharides during in vitro human fecal fermentation

This study was to assess the digestion and colonic fermentation of two bioactive polysaccharides, EPS-LM and LBPS, and the subsequent influences on human gut microbiota through simulated gastrointestinal systems..

Immune supportSkin & hydration

Cordyceps · 2024 · Journal Article · Journal of pharmaceutical and biomedical analysis

Metabolites analysis and new bioactive compounds from the medicine food homology product of Cordyceps chanhua on artificial media.

Cordyceps chanhua on artificial media has been approved as a medicine food homology product. However, the metabolites have not been extensively studied.

Cordyceps · 2024 · Journal Article · Fungal biology

Metabolome and transcriptome unveil the mechanism of light on regulating beauvericin synthesis in Cordyceps chanhua.

Cordyceps chanhua, an important cordycipitoid medical mushroom with wide use in Asia, has gained attention for its bioactive component beauvericin (BEA), which is of medicinal value as a drug lead, but also of food safety risk. Recent observations by our group revealed a significant decrease of BEA content in C..

Immune supportEnergy & fatigueMetabolic health

Cordyceps · 2024 · Journal Article · Journal of ethnopharmacology

Multi-omics reveals the testosterone promotion effect mechanism of Cordyceps Sobolifera on Leydig cells.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps sobolifera (CS) has been traditionally utilized as an ethnic remedy for various health conditions, including chronic kidney diseases, anti-fatigue interventions, and management of chronic inflammation..

Shiitake · 2024 · Journal Article · Food chemistry

Natural deep eutectic solvents for the extraction of lentinan from shiitake mushroom: COSMO-RS screening and ANN-GA optimizing conditions.

Using natural deep eutectic solvents (NDES) for green extraction of lentinan from shiitake mushroom is a high-efficiency method. However, empirical and trial-and-error methods commonly used to select suitable NDES are unconvincing and time-consuming..

Energy & fatigue

Cordyceps · 2024 · Journal Article · Phytochemical analysis: PCA

Nondestructive rapid identification of wild Cordyceps sinensis with portable instrument.

INTRODUCTION: Cordyceps sinensis (CS) is a precious medicinal fungus. Wild CS (WCS) and artificial CS (ACS) are destroyed for their identification using traditional methods, which are time consuming and labor-intensive.

OncologyMetabolic healthGut & microbiomeLiver support

Oyster Mushroom · 2024 · Journal Article · Food & function

Novel approach for ameliorating high-fat diet-induced syndromes via probiotic-fermented oyster mushroom: from metabolites and microbiota to regulation mechanisms.

The potential effects of probiotics on lowering lipid accumulation and alleviating gut microbiota perturbation have been extensively substantiated, but whether Lactobacillus rhamnoses-fermented oyster mushroom (FOM) could more pronouncedly attenuate obesity remains unclear..

Immune supportEnergy & fatigueMetabolic health

Nameko · 2024 · Journal Article · Journal of environmental management

Performance of co-composting Pholiota nameko spent mushroom substrate and pig manure at different proportions: Chemical properties and humification process.

Co-composting is the controlled aerobic degradation of organics, using more than one feedstock. By combining the spent mushroom substrate of Pholiota nameko (SMS) and pig manure (PM), the benefits of each could be used to optimize the composting process and the final product..

Cordyceps · 2024 · Research Article · Frontiers in microbiology

Potential geographical distribution of Cordyceps cicadae and its two hosts in China under climate change.

INTRODUCTION: The fungus Cordyceps cicadae is both edible and medicinal. METHODS: To acquire a thorough comprehension of its distribution in China, two host insects, Macrosemia pieli and Platypleura kaempferi, were selected as biological factors potentially associated with its distribution, the ENMTools program was….

Cordyceps · 2024 · Journal Article · Biological control

Production of heat-resistant blastospores by Cordyceps javanica IF-1106 through optimizing metal ions composition

Heat tolerance of fungi is critical for field stability and efficacy of fungal insecticides. Components of the medium, such as carbon source, nitrogen source and metal ions, contribute to the thermotolerance of fungi..

Immune supportEnergy & fatigueMetabolic health

Cordyceps · 2024 · Research Article · International journal of molecular sciences

RNA-Seq-Based Transcriptome Analysis of Chinese Cordyceps Aqueous Extracts Protective Effect against Adriamycin-Induced mpc5 Cell Injury.

Pharmacogenomic analysis based on drug transcriptome characteristics is widely used to identify mechanisms of action. The purpose of this study was to elucidate the molecular mechanism of protective effect against adriamycin (ADM)-induced mpc5 cell injury of Chinese cordyceps aqueous extracts (WCCs) by a systematic….

OncologyImmune supportRespiratory

Cordyceps · 2024 · Research Article · Frontiers in microbiology

Roles of CcDFR and CcOMT9 in the cyanidin biosynthesis and development of Cordyceps cicadae.

INTRODUCTION: Cordyceps cicadae is a traditional Chinese medicinal fungus known for its rich production of bioactive substances, particularly cyanidin, an anthocyanin commonly found in plants with notable anti-inflammatory, anti-tumor, antiviral, and antibacterial properties..

Cordyceps · 2024 · Journal Article · Pesticide biochemistry and physiology

Secondary metabolites in Cordyceps javanica with insecticidal potential.

Cordyceps javanica has been registered as a fungal insecticide in several countries. However, little is known about whether metabolic toxins are involved in the insecticidal process.

Oyster Mushroom · 2024 · Journal Article · International journal of medicinal mushrooms

Taxonomic Identification and Nutritional Profiling of Wild Isolates of the Pink Oyster Mushroom Pleurotus djamor (Agaricomycetes) from Northwestern Himalayas (India).

For generations, individuals have been incorporating wild edible fungi into their diets. Precisely identifying mushrooms is essential for harnessing their potential benefits for human use.

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

The "crosstalk" between gut microbiota, metabolites and genes in diet-induced hepatic steatosis mice intervened with Cordyceps guangdongensis polysaccharides.

Cordyceps guangdongensis, a novel edible mushroom in China, has shown many positive health effects. In this study, we extracted the C.

Immune supportCognition & nervesGut & microbiome

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

The effects of Cordyceps polysaccharides on ischemic brain injury in rats via intervening with IL-23/IL-17 axis and the intestinal barrier.

Cordyceps polysaccharide (CSP) has been shown to exhibit anti-inflammatory and antioxidant effects, with potential applications in ischemic stroke. This work is to explore the interventional potential of CSP in MCAO rats and the effects on the intestinal and cerebral IL-23/IL-17 axis..

Immune supportEnergy & fatigue

Cordyceps · 2024 · Journal Article · Journal of ethnopharmacology

The protective role of Cordyceps cicadae and its active ingredient myriocin against sodium iodate-induced age-related macular degeneration via an anti-necroptotic TNF-RIPK1/3 pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps cicadae (C.cicadae), named "Chan Hua", an anamorph of Isaria cicadae Miquel, is an entomogenous complex formed by fungi parasitizing on the larvae of cicadas and belongs to the Claviciptaceae family and the genus Codyceps, which traditionally holds a significant place in….

Immune supportMetabolic health

Cordyceps · 2024 · Journal Article · Analytical and bioanalytical chemistry

Tissue distribution of metabolites in Cordyceps cicadae determined by DESI-MSI analysis.

In this paper, we establish an in situ visualization analysis method to image the spatial distribution of metabolites in different parts (sclerotium, coremium) and different microregions of Cordyceps cicadae (C..

OncologyImmune supportMetabolic healthGut & microbiome

Cordyceps · 2024 · Journal Article · The Journal of pharmacy and pharmacology

Wild Cordyceps proteins reinforce intestinal epithelial barrier through MAPK/NF-κB pathway in MRL/lpr mice.

OBJECTIVES: The effects of wild Cordyceps proteins (WCPs) on the gut microbiota and the immune system of MRL/lpr mice were studied. METHODS: The effects of WCP on serum metabolic indexes (total triglyceride, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol) content was….

Oyster Mushroom · 2023 · Review · International journal of medicinal mushrooms

Examining the Cultivation, Degradation Characteristics and Health Effects of the Golden Oyster Mushroom Pleurotus citrinopileatus (Agaricomycetes): A Review.

Pleurotus citrinopileatus, also known as golden oyster mushroom, is a newly industrialized edible mushroom mainly distributed in East Asia. It is a kind of saprophytic edible fungus with strong degradation characteristics, commonly found on fallen trees and stumps of broad-leaf tree species..

Cordyceps · 2023 · Review · Journal of inflammation research

Research Progress of Cordyceps sinensis and Its Fermented Mycelium Products on Ameliorating Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition.

Renal fibrosis is a hallmark and common outcome of various chronic kidney diseases (CKDs) and manifests pathologically as accumulation and deposition of extracellular matrix (ECM) in the kidney. Epithelial-to-mesenchymal transition (EMT) has been shown to be an important mechanism involved in renal fibrosis..

Cordyceps · 2020 · Journal Article · Gene

Expression profiling of Cordyceps DnaJ protein family in Tolypocladium guangdongense during developmental and temperature stress processes.

DnaJ is an important molecular chaperone, with significant roles in growth, development, and stress resistance. Studies on the DnaJ gene family in macro-fungi such as Cordyceps spp.

Energy & fatigue

Cordyceps · 2020 · Journal Article · International journal of biological macromolecules

Polysaccharides from Cordyceps miltaris cultured at different pH: Sugar composition and antioxidant activity.

In the study, the β-glucan content, the primary structure and the antioxidant capacity of polysaccharides in Cordyceps militaris cultivated with different initial growth pH were evaluated. Meanwhile, the mechanism of β-glucan biosynthesis was investigated by RNA-Seq.

King Oyster · 2020 · Journal Article · Protein and peptide letters

Purification, Biochemical Characterization and Decolorization Efficiency of Laccases from Peach and Cherry Cultures of Pleutorus eryngii: A Comparative Study.

BACKGROUND: Laccases (Lacs) are used potentially in industrial and biotechnological applications such as decolorization of dyes, degradation of industrial effluents, delignification, etc. thanks to their large varieties of substrate specificities and excellent catalytic efficiencies..

Energy & fatigue

Immune supportMetabolic health

Maitake · 2020 · Journal Article · International journal of biological macromolecules

Purification, isolation, and structure characterization of water soluble and insoluble polysaccharides from Maitake fruiting body.

The crude polysaccharides (GFP) were isolated from the Maitake fruiting body (Grifola frondosa) and purified by DEAE Cellulose-52 ionic-exchange chromatography and Sephadex G-25 gel filtration chromatography in that order. Five main fractions, GFP-1 to GFP-5 were obtained through the isolation and purification steps..

Energy & fatigueMetabolic health

Shiitake · 2020 · Journal Article · International journal of medicinal mushrooms

Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): Absence of Changes in Maternal Reproductive Performance and Embryofetal Development In Vivo.

The shiitake culinary-medicinal mushroom Lentinus edodes (=Lentinula edodes) has been used as a nutritional complement. This study evaluated, through reprotox tests, the consumption of L.

Maitake · 2019 · Journal Article · International immunopharmacology

Maturation of dendritic cells by maitake α-glucan enhances anti-cancer effect of dendritic cell vaccination.

Dendritic cells (DCs) play a primary role in antigen presentation to CD4+ and CD8+ T cells and induce acquired immune response against cancer cells. Therefore, determining positive modulators of DC activation to improve therapeutic approaches for cancer immunotherapy is greatly needed..

OncologyImmune support

OncologyImmune supportRespiratory

Maitake · 2018 · Research Article · Oncotarget

Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells.

Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy.

Cordyceps · 2018 · Research Article · Molecules (Basel, Switzerland)

Novel Arsenic Markers for Discriminating Wild and Cultivated Cordyceps.

Ophiocordyceps sinensis has been utilized in China and adjacent countries for thousands of years as a rare functional food to promote health and treat diverse chronic diseases. In recent years, adulterants are usually identified in the processed products of wild O.

OncologyImmune supportGut & microbiomeLiver support

Maitake · 2017 · Research Article · PloS one

Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor.

Maitake α-glucan, YM-2A, isolated from Grifola frondosa, has been characterized as a highly α-1,6-branched α-1,4 glucan. YM-2A has been shown to possess an anti-virus effect in mice; however, it does not directly inhibit growth of the virus in vitro, indicating that the anti-virus effect of YM-2A might be associated….

Immune supportCognition & nervesRespiratory

Shiitake · 2017 · Other · Food & nutrition research

Lentinula edodes β-glucan enriched diet induces pro- and anti-inflammatory macrophages in rabbit.

β-glucans exhibited in cell walls of several pathogens as bacteria or fungi are sensed by pathogen recognition receptors such as scavenger receptors present in antigen presenting cells, i.e., macrophages. β-glucans obtained from Shiitake mushrooms were chemically characterized..

Enoki · 2016 · Research Support, Non U.S. Gov'T · Polish journal of microbiology

Complex Biochemical Analysis of Fruiting Bodies from Newly Isolated Polish Flammulina velutipes Strains.

The present study examined Polish strains of Flamulina velutipes as a potential source of nutraceuticals and found that their nutritional value is dependent on the fruiting bodies gathering time. To prove the above hypothesis protein, carbohydrate and phenolic substances concentration were determined..

Shiitake · 2016 · Journal Article · World journal of microbiology & biotechnology

Selection of strains for shiitake production in axenic substrate.

Shiitake mushroom consumption is increasing in Brazil. In addition to the implementation of new production methods, it is also important to increase productivity, quality and reduce production costs..

Maitake · 2003 · Journal Article · Biosystems engineering

Thin-layer Drying of Maitake Mushroom analysed with a Simplified Model

The drying of Maitake mushroom (Grifola frondosa), which has a high initial moisture content, was analysed using the modified plate drying model. This consists of three parameters; surface mass transfer coefficient H, dynamic equilibrium moisture content Me, and drying constant K..

Maitake · 1987 · Journal Article · Journal of nutritional science and vitaminology

Effect of Shiitake (Lentinus edodes) and Maitake (Grjfola frondosa) Mushrooms on Blood Pressure and Plasma Lipids of Spontaneously Hypertensive Rats

To study the effect of Shiitake (Lentinus edodes) and Maitake (Grifola frondosa) on hypertension, spontaneously hypertensive rats (SHR) were fed a diet containing 5% mushroom powder and 0.5% NaCl solution as drinking water for 9 weeks. The dietary mushrooms decreased the blood pressure..

OncologyImmune supportLiver support

Shiitake · 2026 · Review · Colloids and surfaces. B, Biointerfaces

Comprehensive mechanisms and advanced delivery strategies of lentinan in antitumor therapy: A review.

Lentinan (LNT) is a bioactive polysaccharide derived from shiitake mushrooms (Lentinula edodes). It exhibits a unique triple-helix structure and specific glycosidic bonds, which confer exceptional water solubility and gel-forming properties..

Immune supportCognition & nervesEnergy & fatigueRespiratory

King Oyster · 2026 · Review · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Neuroprotection in the age of emerging infections: The untapped power of medicinal mushrooms.

Infections affecting the nervous system require a rapid expansion of effective therapeutic strategies. The emergence of new viral pathogens continues to pose a substantial threat to brain health worldwide, as evidenced by the recent pandemic..

Cordyceps · 2026 · Review · Functional & integrative genomics

Recent developments in CRISPR/Cas9 genome editing research for edible fungiculture.

Fungiculture refers to the deliberate cultivation or agricultural practice involving the growth and management of fungi. The practice encompasses the intentional culture of diverse species of macrofungi, including mushrooms and truffles, within controlled habitats or under specified conditions, in order to fulfill….

Almond Mushroom · 2026 · Randomized Controlled Trial · Translational psychiatry

The role of the dorsal attention network in attention bias modification for social anxiety disorder.

Identifying reliable biomarkers of treatment response is central to advancing personalized psychiatry. While whole-brain functional connectivity models have shown promise in predicting clinical outcomes, especially for broad-spectrum interventions like cognitive-behavioral therapy, targeted treatments may benefit from….

Cognition & nerves

Metabolic healthGut & microbiome

King Oyster · 2026 · Review · Pharmaceuticals (Basel, Switzerland)

The Significance of a Mushroom Diet in the Prevention of Osteoporosis.

Osteoporosis is a metabolic disease of the skeleton characterized by a low bone mass and deterioration of bone tissue structure, leading to increased fragility and susceptibility to fractures. It is often referred to as the "silent killer of bones" because it progresses without symptoms until a bone fracture occurs..

Chaga · 2025 · Review · Bulletin of experimental biology and medicine

Antiviral Activity of Plant-Based Preparations against SARS-CoV-2 and Herpes Simplex Virus Type 2 In Vitro: A Review of Experimental Findings.

We reviewed published data on the efficacy of plant-derived preparations, including the authors' original in vitro findings on the antiviral activity of aqueous and dry ethanol extracts against the RNA virus SARS-CoV-2 and the DNA virus herpes simplex virus type 2 (HSV-2)..

Respiratory

King Oyster · 2025 · Review · Applied microbiology and biotechnology

Aryl-alcohol oxidases: catalysis, diversity, structure-function and emerging biotechnological applications.

Aryl-alcohol oxidases (AAOs) are flavin-dependent enzymes of the glucose-methanol-choline (GMC) oxidoreductase superfamily that catalyze the oxidation of a broad range of activated primary alcohols into their corresponding aldehydes, generating hydrogen peroxide..

Cordyceps · 2025 · Review · Journal of agricultural and food chemistry

Chemistry and Biology of Ustiloxin Analogs as Mycotoxins.

Ustiloxin analogs, including ustiloxins and phomopsins, are a group of cyclopeptide mycotoxins produced by fungi. They are a 13-membered macrocyclic ring and an ether linkage between tyrosine and isoleucine as the core structure.

Almond Mushroom · 2025 · Randomized Controlled Trial · Scientific reports

Effect of attention bias modification on depressive affect.

Cognitive interventions targeting depressive mood and major depressive disorder have emerged as a critical focus in mental health research. While studies on anxiety disorders, social phobia, eating disorders, and addiction have consistent findings, research on attentional bias modification in depression yields….

Cognition & nerves

Immune supportCognition & nervesMetabolic healthGut & microbiome

Cordyceps · 2025 · Review · Molecules (Basel, Switzerland)

Fungal Polysaccharides as Modulators of Molecular Pathways in Liver Health.

Fungal polysaccharides represent a structurally diverse group of bioactive compounds with increasing recognition for their hepatoprotective potential. This review synthesizes current evidence on their roles in the prevention and treatment of liver diseases, including alcohol-related liver disease (ALD), metabolic….

King Oyster · 2025 · Review · Journal of agricultural and food chemistry

Fungal Pretreatment of Lignocellulosic Feedstocks: Challenges and Opportunities in Lignin Degradation, Structural Polysaccharide Preservation, and Conversion into Ruminant Feed.

This review provides a comprehensive meta-summary of recent literature on fungal pretreatment of lignocellulosic biomass (LCB), emphasizing selective lignin degradation and polysaccharide preservation to improve the nutritive value of treated biomass for ruminant nutrition..

OncologyImmune supportGut & microbiome

King Oyster · 2025 · Review · International journal of molecular sciences

Medicinal Mushrooms in Colon Cancer Therapy: Mechanisms of Action of Bioactive Compounds and Therapeutic Potential.

Colon cancer is the second leading cause of cancer-related deaths in the world. This is commonly observed among older adults, and the occurrence of colon cancer is mainly influenced by unhealthy lifestyle factors..

OncologyImmune supportGut & microbiomeLiver support

Cordyceps · 2025 · Review · International journal of medicinal mushrooms

The Role of Medicinal Mushrooms in Cancer Treatment: Bioactive Compounds and Therapeutic Potential.

In recent years, research on the therapeutic potential of mushroom species has notably expanded, and the effects of these organisms on cancer treatment have come to the forefront..