MycoData

Reishi · 2023 · Review · Chinese herbal medicines

Germplasm resources and secondary metabolism regulation in Reishi mushroom (Ganoderma lucidum).

Ganoderma lucidum is a valuable medical macrofungus with a myriad of diverse secondary metabolites, in which triterpenoids are the major constituents. This paper introduced the germplasm resources of genus Ganoderma from textual research, its distribution and identification at the molecular level..

Immune supportCognition & nerves

Maitake · 2023 · Review · International journal of medicinal mushrooms

Maitake Medicinal Mushroom, Grifola frondosa (Agaricomycetes), and Its Neurotrophic Properties: A Mini-Review.

Neurodegeneration is one of the most common manifestations in an aging population. The occurrence of oxidative stress and neuroinflammation are the main contributors to the phenomenon..

OncologyImmune supportCognition & nerves

Reishi · 2023 · Review · Medicinal research reviews

Neuroprotective, neurogenic, and anticholinergic evidence of Ganoderma lucidum cognitive effects: Crucial knowledge is still lacking.

Ganoderma lucidum is a mushroom that has been widely used for centuries in Asian countries for its antiaging properties. It is popularly known as "Ling Zhi," "Reishi," and "Youngzhi," and because of its benefits, it is known as the "immortality mushroom." Pharmacological assays have revealed that G..

Chaga · 2023 · Review · Journal of inflammation research

Research Progress on Application of Inonotus obliquus in Diabetic Kidney Disease.

Diabetic kidney disease (DKD) is one of the prime causes of end-stage renal disease. At present, the treatment of DKD is mainly confined to inhibiting the renin-angiotensin-aldosterone system, but the therapeutic effects is not satisfactory..

Cognition & nervesEnergy & fatigue

Lion's Mane · 2023 · Randomized Controlled Trial · Nutrients

The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study.

BACKGROUND: Given the bioactive properties and limited work to date, Hericium erinaceus (Lion's mane) shows promise in improving cognitive function and mood. However, much of the human research has concentrated on chronic supplementation in cognitively compromised cohorts..

Cordyceps · 2023 · Meta-Analysis · Phytomedicine: international journal of phytotherapy and phytopharmacology

The effects of Ophiocordyceps sinensis combined with ACEI/ARB on diabetic kidney disease: A systematic review and meta-analysis.

BACKGROUND: Ophiocordyceps sinensis (OS), a medicinal fungus, has been made into OS preparations, which are frequently used as adjunctive therapy for patients with Diabetic Kidney Disease (DKD) in China..

Immune supportRespiratory

Reishi · 2023 · Review · International journal of medicinal mushrooms

The Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Can Combat Cytokine Storm and Other COVID-19 Related Pathologies: A Review.

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is characterized by acute respiratory distress syndrome (ARDS) facilitated by cytokine storm and other risk factors that increase susceptibility and complications leading to death..

Reishi · 2022 · Review · International journal of medicinal mushrooms

A Review of Substrates for Solid-State Fermentation of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), for Basidiome Production and Effect on Bioactive Compounds.

Mushrooms in the genus Ganoderma have been collected and used as medicine since ancient times. However, commercial basidiome production has only recently been achieved..

Cordyceps · 2022 · Review · Mycobiology

Comprehensive Transcriptomic Analysis of Cordyceps militaris Cultivated on Germinated Soybeans.

The ascomycete fungus Cordyceps militaris infects lepidopteran larvae and pupae and forms characteristic fruiting bodies. Owing to its immune-enhancing effects, the fungus has been used as a medicine.

OncologyImmune supportGut & microbiome

Cordyceps · 2022 · Review · Microorganisms

Cordyceps militaris as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms.

Cordyceps militaris (C. militaris) is a medicinal mushroom possessing a variety of biofunctionalities.

OncologyImmune supportMetabolic healthLiver support

Almond Mushroom · 2022 · Review · Current research in food science

Critical review on chemical compositions and health-promoting effects of mushroom Agaricus blazei Murill.

Agaricus blazei Murrill (AbM) is a medical mushroom which has huge potential commercial value with various health-promoting functions. However, the chemical composition and therapeutic mechanisms of AbM have not been concluded systematically yet..

Energy & fatigueMetabolic health

Oyster Mushroom · 2022 · Randomized Controlled Trial · International journal of medicinal mushrooms

Dietary Supplementation with Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), Reduces Visceral Fat and Hyperlipidemia in Inhabitants of a Rural Community in Mexico.

The abandonment of traditional foods in the Mexican diet is one of the causes for the increase in diseases associated with obesity. Edible mushrooms have been a part of the Mexican diet since pre-Hispanic times..

OncologyImmune supportLiver support

Mesima · 2022 · Randomized Controlled Trial · Medicine

Effects of Phellinus linteus extract on immunity improvement: A CONSORT-randomized, double-blinded, placebo-controlled trial.

BACKGROUND: Immunity protects the body from external threats and prevents the development of cancer. Biological response modifiers extracted from natural sources are being actively studied, and the immunostimulatory and anticancer effects of various types of fungi have been reported..

Mesima · 2022 · Randomized Controlled Trial · Medicine

Efficacy of Phellinus linteus extract on immunity enhancement: A CONSORT-randomized, double-blind, placebo-controlled pilot trial.

BACKGROUND: Immunity is a major system that defends the human body from the outside. Recently, interest in foods related to immunity has been increasing.

Immune support

OncologyImmune supportLiver supportSkin & hydration

Reishi · 2022 · Review · Frontiers in pharmacology

Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis.

Ganoderma lucidum (G. lucidum, Lingzhi) is a well-known herbal medicine with a variety of pharmacological effects.

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2022 · Review · Frontiers in pharmacology

Ganoderma lucidum: Unutilized natural medicine and promising future solution to emerging diseases in Africa.

Ganoderma lucidum is a well-known medicinal mushroom that has been used for the prevention and treatment of different ailments to enhance longevity and health specifically in China, Japan, and Korea..

Shiitake · 2022 · Review · International journal of molecular sciences

Immunomodulatory Properties of Polysaccharides from Lentinula edodes.

Lentinula edodes (Berk.) Pegler, also known as shiitake mushroom, is a popular edible macrofungus and a source of numerous bioactive substances with multiple beneficial health effects. L..

Skin & hydrationRespiratory

Reishi · 2022 · Review · Foods (Basel, Switzerland)

Nutritional Profile and Health Benefits of Ganoderma lucidum "Lingzhi, Reishi, or Mannentake" as Functional Foods: Current Scenario and Future Perspectives.

Ganoderma lucidum has a long history of medicinal uses in the Far East countries of more than 2000 years due to its healing properties. Recently, G.

King Oyster · 2022 · Randomized Controlled Trial · Pharmacological research

Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity.

The aim of this study was to examine potential postprandial benefits of Pleurotus eryngii in nineteen volunteers with metabolically unhealthy obesity. An acute, randomized, crossover-designed trial comparing a meal with Pleurotus eryngii and a control meal was performed..

Turkey Tail · 2022 · Review · Biomedicines

Polysaccharide-Peptide from Trametes versicolor: The Potential Medicine for Colorectal Cancer Treatment.

The incidence and mortality of colorectal cancer have shown an upward trend in the past decade. Therefore, the prevention, diagnosis, and treatment of colorectal cancer still need our continuous attention..

OncologyImmune supportLiver support

Shiitake · 2022 · Clinical Trial · Integrative cancer therapies

Preventing Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy With Active Hexose-correlated Compound Derived From Lentinula edodes Mycelia.

PURPOSE: Active hexose-correlated compound (AHCC), a standardized extract of cultured Lentinula edodes mycelia, exerts antitumor effects through anti-inflammatory and immune-modulatory functions..

Cordyceps · 2022 · Review · Bioengineering (Basel, Switzerland)

Research Progress on Cordycepin Synthesis and Methods for Enhancement of Cordycepin Production in Cordyceps militaris.

C. militaris is an insect-born fungus that belongs to Ascomycota and Cordyceps.

OncologyImmune supportMetabolic health

Cordyceps · 2022 · Review · Frontiers in nutrition

Structural Elucidation and Activities of Cordyceps militaris-Derived Polysaccharides: A Review.

Cordyceps militaris is a parasitic edible fungus and has been used as tonics for centuries. Polysaccharides are a major water-soluble component of C.

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2022 · Review · The American journal of Chinese medicine

The Pharmacological Rationales and Molecular Mechanisms of Ganoderma lucidum Polysaccharides for the Therapeutic Applications of Multiple Diseases.

As a versatile Chinese herb, Ganoderma lucidum (Leyss. ex Fr.) Karst (G.

Maitake · 2021 · Meta-Analysis · Journal of ethnopharmacology

Antitumor activities of Grifola frondosa (Maitake) polysaccharide: A meta-analysis based on preclinical evidence and quality assessment.

ETHNOPHARMACOLOGICAL RELEVANCE: The antitumor effects of Grifola frondosa/maitake polysaccharide (GFP) have been reported in many preclinical studies, especially in vivo experiments..

Maitake · 2021 · Review · Foods (Basel, Switzerland)

Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake).

Grifola frondosa (G. frondosa), generally known as hen-of-the-woods or maitake in Japanese and hui-shu-hua in Chinese, is an edible mushroom with both nutritional and medicinal properties..

Cordyceps · 2021 · Review · Journal of fungi (Basel, Switzerland)

Biomass and Cordycepin Production by the Medicinal Mushroom Cordyceps militaris-A Review of Various Aspects and Recent Trends towards the Exploitation of a Valuable Fungus.

Cordyceps militaris is an entomopathogenic ascomycete with similar pharmacological importance to that of the wild caterpillar fungus Ophiocordyceps sinensis. C.

Mesima · 2021 · Clinical Trial Protocol · Trials

Clinical trial to analyze the effects of oral intake of Phellinus linteus (sanghuang) extract on immune function: a study protocol for a randomized, double-blind controlled trial.

BACKGROUND: As the population of Korea ages, interest in healthcare has increased. In particular, there is an increasing demand for immune-function improvement to prevent infectious diseases.

Immune supportEnergy & fatigueRespiratory

Cordyceps · 2021 · Review · Foods (Basel, Switzerland)

Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity.

Cordyceps spp. mushrooms have a long tradition of use as a natural raw material in Asian ethnomedicine because of their adaptogenic, tonic effects and their ability to reduce fatigue and stimulate the immune system in humans..

Energy & fatigueGut & microbiome

Oyster Mushroom · 2021 · Randomized Controlled Trial, Veterinary · Journal of dairy science

Enzymatic effects of Pleurotus ostreatus spent substrate on whole-plant corn silage and performance of lactating goats.

Pleurotus ostreatus (oyster mushroom) synthesizes enzymes that degrade lignin, cellulose, and hemicellulose. The objectives of this study were to evaluate the effect of Pleurotus ostreatus spent substrate (POSS) on whole-plant corn silage (WPCS) chemical composition, antioxidant capacity, lignin monomers, and in vitro….

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2021 · Review · Phytotherapy research: PTR

Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties.

Reishi owes an exceptional value in nutritional, cosmeceutical, and medical treatments; however, none of the studies has provided its future-driven critical assessment..

Immune supportCognition & nervesMetabolic health

Reishi · 2021 · Review Article · Nutrients

Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum.

Medicinal mushrooms are rich sources of pharmacologically active compounds. One of the mushrooms commonly used in traditional Chinese medicine is Ganoderma lucidum (Leyss.

Immune supportMetabolic healthGut & microbiome

Shiitake · 2021 · Randomized Controlled Trial · European journal of nutrition

Modulation of human intestinal microbiota in a clinical trial by consumption of a β-D-glucan-enriched extract obtained from Lentinula edodes.

PURPOSE: The aim of this study was to evaluate the hypocholesterolemic, immune- and microbiota-modulatory effect of a mushroom extract in hypercholesterolemic subjects..

OncologyImmune supportMetabolic healthRespiratory

Cordyceps · 2021 · Review · Frontiers in bioengineering and biotechnology

New Insights Into the Biosynthesis of Typical Bioactive Components in the Traditional Chinese Medicinal Fungus Cordyceps militaris.

Cordyceps militaris, a traditional medicinal ingredient with a long history of application in China, is regarded as a high-value fungus due to its production of various bioactive ingredients with a wide range of pharmacological effects in clinical treatment..

OncologyImmune supportMetabolic healthRespiratory

Chaga · 2021 · Review · Polymers

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application.

Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, and some occidental countries. Among the extracts from Inonotus obliquus, Inonotus obliquus polysaccharide (IOPS) is supposed to be one of the major bioactive components in Inonotus obliquus, which….

Reishi · 2021 · Review Article · Pharmaceutical biology

The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk.

CONTEXT: Various herbal medicines are thought to be useful in the management of cardiometabolic disease and its risk factors. Ganoderma lucidum (Curtis) P.

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2019 · Clinical Trial · Oxidative medicine and cellular longevity

Cordyceps militaris Improves Chronic Kidney Disease by Affecting TLR4/NF-κB Redox Signaling Pathway.

Cordyceps militaris may show good promise in protecting against chronic kidney disease (CKD) but the molecular mechanism remains unclear. CKD risk is associated with the Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) signaling pathway..

Cordyceps · 2017 · Randomized Controlled Trial · International journal of medicinal mushrooms

Clinical Effects of a Commercial Supplement of Ophiocordyceps sinensis and Ganoderma lucidum on Cognitive Function of Healthy Young Volunteers.

Ophiocordyceps sinensis (= Cordyceps sinensis) and Ganoderma lucidum are medicinal mushrooms used in traditional Chinese medicine. The effects of O.

Cognition & nerves

OncologyImmune supportGut & microbiome

Shiitake · 2015 · Randomized Controlled Trial · Journal of the American College of Nutrition

Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults.

BACKGROUND: Mushrooms are widely cited for their medicinal qualities, yet very few human intervention studies have been done using contemporary guidelines. OBJECTIVE: The aim of this study was to determine whether consumption of whole, dried Lentinula edodes (shiitake) mushrooms could improve human immune function..

OncologyImmune supportMetabolic health

Almond Mushroom · 2012 · Randomized Controlled Trial · Scandinavian journal of immunology

Agaricus blazei Murrill and inflammatory mediators in elderly women: a randomized clinical trial.

There is scientific evidence to suggest that the medicinal mushroom Agaricus blazei Murrill (AbM) has immunomodulatory effects on cytokine synthesis, both in vitro and in vivo. This study was the first randomized, double-blind, placebo-controlled trial designed to investigate these purported actions in elderly women..

Maitake · 2010 · Randomized Controlled Trial · Journal of alternative and complementary medicine (New York, N.Y.)

Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate.

BACKGROUND: Insulin resistance is a prominent feature of polycystic ovary syndrome (PCOS), and insulin-sensitizing drugs are used to induce ovulation. Recently, it was reported that an extract from Maitake mushroom (Grifola frondosa) improves insulin resistance..

Metabolic health

OncologyImmune supportCognition & nerves

Maitake · 2009 · Randomized Controlled Trial · Journal of cancer research and clinical oncology

A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects.

BACKGROUND: Cancer patients commonly use dietary supplements to "boost immune function". A polysaccharide extract from Grifola frondosa (Maitake extract) showed immunomodulatory effects in preclinical studies and therefore the potential for clinical use..

Lion's Mane · 2009 · Randomized Controlled Trial · Phytotherapy research: PTR

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.

A double-blind, parallel-group, placebo-controlled trial was performed on 50- to 80-year-old Japanese men and women diagnosed with mild cognitive impairment in order to examine the efficacy of oral administration of Yamabushitake (Hericium erinaceus), an edible mushroom, for improving cognitive impairment, using a….

Cognition & nerves

Oyster Mushroom · 2025 · Preprint · journal metadata

Precision Microclimate Control Using IoT for Enhanced Production of Pleurotus ostreatus (Oyster Mushroom)

Environmental factors are essential to effective mushroom cultivation, as controlled moisture, humidity, and temperature directly affect yield, quality, and growth..

Oyster Mushroom · 2020 · Systematic Review · Nutrients

Effect of the Intake of Oyster Mushrooms (Pleurotus ostreatus) on Cardiometabolic Parameters-A Systematic Review of Clinical Trials.

Cardiometabolic diseases are a leading global health challenge. Their incidence as well as progression is strongly affected by diet.

Metabolic health

Reishi · 2020 · Meta Analysis · Nutrients

Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as Radioprotector.

For millennia, naturopaths and physicians have used Ganoderma lucidum (reishi mushroom) for its diverse therapeutic properties, as recorded in the oldest Chinese herbal encyclopedia. Indeed, a radioprotective effect has been reported in the isolated components of its extracts..

Immune support

Reishi · 2017 · Systematic Review · International journal of medicinal mushrooms

The Efficacy and Toxicity of Using the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Its Products in Chemotherapy (Review).

Around the world, cancer patients often combine conventional anticancer treatment with complementary alternative medicines derived from natural sources such as fungi and mushrooms, including the popular lingzhi or reishi medicinal mushroom Ganoderma lucidum..

Immune supportGut & microbiome

Cordyceps · 2026 · Journal Article · Probiotics and antimicrobial proteins

Cordyceps Militaris Exopolysaccharides and Lactiplantibacillus Plantarum H8 Synergistically Improve Immune Function Damage in Cyclophosphamide-Induced Immunosuppressed Mice.

Metadata-grounded summary: This journal article indexes research on Cordyceps militaris in Probiotics and antimicrobial proteins in 2026. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..