MycoData

Liver supportSkin & hydration

Niu-Chang-Chih · 2006 · Research Support, Non U.S. Gov'T · World journal of gastroenterology

Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats.

AIM: To investigate the effects of filtrate of fermented mycelia from Antrodia camphorata (FMAC) on liver fibrosis induced by carbon tetrachloride (CCl(4)) in rats. METHODS: Forty Wistar rats were divided randomly into control group and model group..

Immune supportLiver supportRespiratory

Maitake · 2006 · Research Support, Non U.S. Gov'T · Antiviral research

Inhibition of hepatitis B virus by D-fraction from Grifola frondosa: synergistic effect of combination with interferon-alpha in HepG2 2.2.15.

In this study, D-fraction extracted from Grifola frondosa (GF-D) and its combination with human interferon alpha-2b (IFN) were investigated for the inhibitory effect on hepatitis B virus (HBV) in HepG2 2.2.15 cells (2.2.15 cells)..

Immune supportLiver support

Niu-Chang-Chih · 2006 · Patent · journal metadata

Polysaccharide and composition from Antrodia camphorata and use thereof

The invention relates to polysaccharide extracted from Antrodia camphorata and the method for preparing the polysaccharide. The invention also relates to compositions and methods for hepatoprotective effect..

Immune supportGut & microbiomeLiver supportSkin & hydration

Reishi · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Safety Considerations for Natural Products with Adaptogenic and Immunomodulating Activities.

Background/Objectives: Natural products with claimed adaptogenic and/or immunomodulatory effects are widely used in traditional medicine systems across Eurasia. These include herbal remedies (e.g., Panax ginseng), fungi (e.g., Ganoderma lucidum), and animal-derived substances (e.g., propolis from Apis mellifera)..

Energy & fatigueGut & microbiomeLiver supportSkin & hydration

Shiitake · 2024 · Research Article · American journal of physiology. Gastrointestinal and liver physiology

AHCC inhibited hepatic stellate cells activation by regulation of cytoglobin induction via TLR2-SAPK/JNK pathway and collagen production via TLR4-NF-κβ pathway.

Cirrhosis, which represents the end stage of liver fibrosis, remains a life-threatening condition without effective treatment. Therefore, prevention of the progression of liver fibrosis through lifestyle habits such as diet and exercise is crucial..

Immune supportEnergy & fatigueLiver supportRespiratory

Reishi · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Immuno-physiological effects of dietary reishi mushroom powder as a source of beta-glucan on Rohu, Labeo rohita challenged with Aeromonas veronii.

Beta-glucans have immense potential to stimulate immune modulation in fish by being injected intramuscularly, supplemented with feed or immersion routes of administration. We studied how supplementing Labeo rohita's diet with reishi mushroom powder containing beta-glucan influenced immunological function..

Cordyceps · 2023 · Case Reports · ACG case reports journal

Traditional Chinese Medicine, Cordyceps, Related to Hepatoportal Sclerosis.

We describe a case of hepatoportal sclerosis (HPS) identified in an 81-year-old woman taking a traditional Chinese herbal supplementation, Cordyceps. The patient presented with splenomegaly and weight loss..

Energy & fatigueMetabolic healthGut & microbiomeLiver support

Cordyceps · 2022 · Research Support, Non U.S. Gov'T · Scientific reports

Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis.

Ectopic ceramide accumulation in insulin-responsive tissues contributes to the development of obesity and impairs insulin sensitivity. Moreover, pharmacological inhibition of serine palmitoyl transferase (SPT), the first enzyme essential for ceramide biosynthesis using myriocin in rodents reduces body weight and….

Cognition & nervesLiver support

Almond Mushroom · 2021 · Clinical Trial Protocol · Trials

Protocol for the methamphetamine approach-avoidance training (MAAT) trial, a randomised controlled trial of personalised approach bias modification for methamphetamine use disorder.

BACKGROUND: Globally, methamphetamine use has increased in prevalence in recent years. In Australia, there has been a dramatic increase in numbers of people seeking treatment, including residential rehabilitation, for methamphetamine use disorder (MUD)..

Immune supportLiver supportRespiratory

Shiitake · 2020 · Journal Article · Minerva gastroenterologica e dietologica

Possible therapeutic role of a highly standardized mixture of active compounds derived from cultured Lentinula edodes mycelia (AHCC) in patients infected with 2019 novel coronavirus.

The outbreak of SARS-CoV-2 disease (COVID-19) is currently, March 2020, affecting more than 100,000 people worldwide and, according to the WHO (World Health Organization), a pandemic is shortly expected..

Immune supportLiver support

Lion's Mane · 2020 · Journal Article · International journal of biological macromolecules

Preparation, characterization and controlled-release property of CS crosslinked MWCNT based on Hericium erinaceus polysaccharides.

In present study, the optimal condition of prepared drug was determined by response surface methodology. In addition, their physicochemical properties, drug release and uptake ability of CS-MWCNT-HEP were studied, and the distribution of the drug in ICR mice and the sites of action were further evaluated..

Metabolic healthLiver support

Mesima · 2019 · Research Article · Nutrients

Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes.

Hypoglycemic and hypolipidemic effects of P. linteus have been observed in numerous studies, but the underlying molecular mechanisms are unclear.

Maitake · 2019 · Research Article · RSC advances

The polysaccharides from Grifola frondosa attenuate CCl4-induced hepatic fibrosis in rats via the TGF-β/Smad signaling pathway.

The TGF-β1/Smad signaling pathway has been linked to hepatic fibrosis. Previous studies have shown that yellow polysaccharide can prevent the development of hepatic fibrosis.

Metabolic healthGut & microbiomeLiver support

Maitake · 2018 · Journal Article · Food & function

Effect of Grifola frondosa 95% ethanol extract on lipid metabolism and gut microbiota composition in high-fat diet-fed rats.

This study aimed to investigate the effects of 95% ethanol extract of G. frondosa (GF95) on lipid metabolism and gut microbiota composition in high-fat diet (HFD) fed rats.

Enoki · 2018 · Journal Article · International journal of biological macromolecules

Metabonomic profiling in study hepatoprotective effect of polysaccharides from Flammulina velutipes on carbon tetrachloride-induced acute liver injury rats using GC-MS.

This study was performed to evaluate the hepatoprotective effect of FVP on carbon tetrachloride induced acute liver injury rats. Transaminase levels, antioxidant effect and histopathology were used to assess the recovery of FVP treated acute liver injury rats..

Maitake · 2018 · Journal Article · International journal of biological macromolecules

The synergism and attenuation effect of Selenium (Se)-enriched Grifola frondosa (Se)-polysaccharide on 5-Fluorouracil (5-Fu) in Heps-bearing mice.

Previous study revealed that Se-GP11 could exhibited its antitumor activity by improving the immune functions. 5-Fu, as a chemotherapeutic drugs, can kill many immune cells in addition to tumor cells.

OncologyImmune supportMetabolic healthLiver support

Reishi · 2016 · Journal Article · Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan

Gene mutations in Ganoderma lucidum during continuous subculturing

Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan in 2016. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..

Gut & microbiomeLiver support

Shiitake · 2020 · Research Article · Nutrients

Suppressive Effect of Shiitake Extract on Plasma Ethanol Elevation.

Alcohol is usually consumed with meals, but chronic consumption is a leading cause of alcoholic liver diseases. We investigated if shiitake extracts with a high lentinic acid content (Shiitake-H) and without lentinic acid (Shiitake-N) could suppress the elevation in plasma ethanol concentrations by accelerating….

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2019 · Journal Article · Journal of microbiology and biotechnology

Secondary Fermented Extract of Chaga-Cheonggukjang Attenuates the Effects of Obesity and Suppresses Inflammatory Response in the Liver and Spleen of High-Fat Diet-Induced Obese Mice.

Cheonggukjang and chaga mushrooms have numerous health benefits, and have been used in alternative medicine. Therefore, a powder mixture of 98: Cheonggukjang and 2: Chaga extracts was fermented with Lactobacillus acidophilus KCTC3925 (FCC) and its anti-obesity effects in high-fat diet (HFD)-induced obese mice were….

OncologyImmune supportCognition & nervesLiver support

Niu-Chang-Chih · 2005 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Antrodia camphorata prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis.

Antrodia camphorata (A. camphorata) is a rare medicinal fungus with antioxidative, vasorelaxtative, anti-inflammatory and anti-hepatitive effects.

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2005 · Research Support, Non U.S. Gov'T · Cancer letters

Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines.

The fruiting body of Antrodia camphorata is well known in Taiwan as a traditional medicine for treating cancer and inflammation. The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A.

Niu-Chang-Chih · 2005 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture.

The effect of methanolic extracts of mycelia (MEM) from Antrodia camphorata (Polyporaceac, Aphyllophorales) of submerged culture (ACSC) on the inhibition of cell viability and the mechanism of MEM-induced cytotoxic in hepatoma cells were investigated..

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2004 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species.

We have previously reported that polysaccharides extracted from fruiting bodies or cultured mycelia of Antrodia camphorata exhibit an anti-hepatitis B virus effect..

Cognition & nervesLiver support

Niu-Chang-Chih · 2003 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Antioxidative and hepatoprotective effects of Antrodia camphorata extract.

Antrodia camphorata (A. camphorata) is well-known in Taiwan as a traditional Chinese medicine.

Mesima · 2003 · Comparative Study · Biotechnology letters

Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats.

Extracts of Phellinus linteus (EPB), grown on germinated brown rice, protected rats from liver injury induced by carbon tetrachloride (CCl4). Peroxidation products in the liver were decreased to 10% by EPB..

Metabolic healthLiver support

Lion's Mane · 2003 · Research Support, Non U.S. Gov'T · Bioscience, biotechnology, and biochemistry

Hypolipidemic Effect of an Exo-biopolymer Produced from a Submerged Mycelial Culture of Hericium erinaceus

The hypolipidemic effect of an exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus was investigated in dietary-induced hyperlipidemic rats. Hypolipidemic effects were proportionally increased with the increasing concentration of the exo-biopolymer for oral administration..

Niu-Chang-Chih · 2003 · Patent · journal metadata

Liver-caring medicine containing antrodia camphorata

The present invention relates to a liver-caring medicine that cures alcohol-induced liver cancer and contains active ingredients from the fruiting body and the mycelium of Antrodia Camphorata or Antrodia Cinnamomea, which is a kind of mushroom that only grows inside a unique plant in Taiwan, a Cinnamomum kanehirae….

OncologyMetabolic healthLiver support

Niu-Chang-Chih · 2003 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats.

The protective effects and the possible mechanisms of dry matter of fermented filtrate (DMF) from Antrodia camphorata in submerged culture (ACSC) on H(2)O(2)-induced cytotoxicity in HepG2 and carbon tetrachloride (CCl(4))-induced hepatotoxicity in Sprague-Dawley rats were investigated..

Mesima · 2002 · Research Support, Non U.S. Gov'T · Carcinogenesis

The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide.

Modulation of gap junctional intercellular communication (GJIC) is a known cellular event associated with tumor promotion. The present study was undertaken to test the potential preventive effect of mushroom Phellinus linteus extract (PL) on the inhibition of GJIC, induced by hydrogen peroxide (H(2)O(2)), in WB-F344….

Snow Fungus · 1994 · English Abstract · Yakugaku zasshi: Journal of the Pharmaceutical Society of Japan

[Polysaccharides in fungi. XXXIII. Hypoglycemic activity of an acidic polysaccharide (AC) from Tremella fuciformis].

Glucuronoxylomannan (AC) from the fruiting bodies of Tremella fuciformis exhibited a significant dose-dependent hypoglycemic activity in normal mice and also showed a significant activity in streptozotocin-induced diabetic mice, by intraperitoneal (i.p.) administration..

Snow Fungus · 1992 · English Abstract · Yakugaku zasshi: Journal of the Pharmaceutical Society of Japan

[Synthesis and antitumor activities of conjugates of mitomycin C-polysaccharide from Tremella fuciformis].

The conjugates of mitomycin C (MMC) with glucuronoxylomannan (AC) from Tremella fuciformis were synthesized by the use of spacers (glycine, glycylglycine, glycylglycylglycine). In i.p.-i.p..

Almond Mushroom · 2026 · Review · Journal of advanced nursing

A Comparative Evaluation of Conceptual Frameworks for Examining Neighbourhood Socioeconomic Deprivation and Cancer Care Accessibility.

AIM (S): To identify and evaluate conceptual frameworks for studying neighbourhood deprivation and access to cancer services in nursing research. DESIGN: Discussion paper..

Immune supportLiver supportRespiratory

Almond Mushroom · 2024 · Scoping Review · BMC infectious diseases

Agent based modelling of blood borne viruses: a scoping review.

BACKGROUND: The models that historically have been used to model infectious disease outbreaks are equation-based and statistical models. However, these models do not capture the impact of individual and social factors that affect the spread of common blood-borne viruses (BBVs) such as human immunodeficiency virus….

Immune supportLiver support

Almond Mushroom · 2024 · Review · Advances in immunology

Post-transcriptional (re)programming of B lymphocyte development: From bench to bedside?

Hematopoiesis, a process which generates blood and immune cells, changes significantly during mammalian development. Definitive hematopoiesis is marked by the emergence of long-term hematopoietic stem cells (HSCs)..

Cordyceps · 2023 · Journal Article · International journal of medicinal mushrooms

Antihyperuricemic and Renal Protective Effect of Cordyceps chanhua (Ascomycetes) Fruiting Bodies in Acute Hyperuricemia and Chronic Gout Rodent Models.

Cordyceps chanhua has been widely used in traditional Chinese medicine. The uric acid-lowering effect of artificially cultivated fruiting bodies of C.

Cordyceps · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Post-Application Field Persistence and Efficacy of Cordyceps javanica against Bemisia tabaci.

Previously, Cordyceps javanica Wf GA17, a causing agent of whitefly epizootics in southern Georgia, demonstrated superior temperature tolerance and higher virulence against the whitefly Bemisia tabaci than commercial strains in the laboratory. The post-application persistence and efficacy of this fungus against B..

OncologyImmune supportEnergy & fatigueLiver support

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

The cellular uptake of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles and their induced apoptosis of HepG2 cells via mitochondria- and death receptor-mediated pathways.

This wok investigated the effects of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles (EPS-SeNPs), EPS-Se-1, EPS-Se-2, EPS-Se-3, and EPS-Se-4) with particle sizes (79-124 nm) and Se contents (20.11-40.80 μg/mg) on endocytosis and antitumor activity against human hepatocellular carcinoma (HepG2) cells and….

Metabolic healthGut & microbiomeLiver support

Cordyceps · 2022 · Research Article · Frontiers in nutrition

Cordyceps guangdongensis lipid-lowering formula alleviates fat and lipid accumulation by modulating gut microbiota and short-chain fatty acids in high-fat diet mice.

Obesity has caused serious health and economic problems in the world. Cordyceps guangdongensis is a high-value macrofungus with broad application potential in the food and bio-medicine industry.

Cognition & nervesLiver support

Cordyceps · 2022 · Journal Article · International journal of clinical pharmacology and therapeutics

Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis.

The use of herbal and dietary supplements is increasing worldwide. Consumers consider it as a natural, and therefore safe and healthy alternative to conventional synthetic drugs and do not expect adverse effects..

Immune supportEnergy & fatigueLiver support

Cordyceps · 2022 · Journal Article · International journal of biological macromolecules

Protective effects of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles on H2O2-induced oxidative stress in HepG2 cells.

This work investigated the protective effects of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles (EPS-SeNPs) at different Se/EPS ratios (1/20, 1/3, 1/1, and 4/3) against 0.4 mM H2O2-induced oxidative stress in human hepatoma (HepG2) cells..

Cordyceps · 2021 · Journal Article · Chemistry & biodiversity

Alleviation of Liver Dysfunction, Oxidative Stress, and Inflammation Underlines the Protective Effects of Polysaccharides from Cordyceps cicadae on High Sugar/High Fat Diet-Induced Metabolic Syndrome in Rats.

This study investigated the protective effects of two polysaccharides (CPA-1 and CPB-2) from Cordyceps cicadae against high fructose/high fat diet (HF/HFD) induced obesity and metabolic disorders in rats. Rats were either fed with normal diet or HF/HFD and treated with CPA-1 and CPB-2 (100 and 300 mg/kg) for 11 weeks..

Immune supportGut & microbiomeLiver support

Oyster Mushroom · 2021 · Journal Article · Journal of agricultural and food chemistry

Influence of a Biotechnologically Produced Oyster Mushroom (Pleurotus sajor-caju) on the Gut Microbiota and Microbial Metabolites in Obese Zucker Rats.

Mushrooms are a rich source of dietary fiber. This study aimed to characterize the modulation of colonic microbiota in Zucker rats after supplementing their diet with a biotechnologically produced oyster mushroom (Pleurotus sajor-caju)..

Immune supportEnergy & fatigueMetabolic healthLiver support

Oyster Mushroom · 2021 · Journal Article · Journal of proteomics

Tandem mass tag-based proteomics for studying the effects of a biotechnologically produced oyster mushroom against hepatic steatosis in obese Zucker rats.

Hepatic steatosis is a very common response to liver injury and often attributed to metabolic disorders. Prior studies have demonstrated the efficacy of a biotechnologically produced oyster mushroom (Pleurotus sajor-caju, PSC) in alleviating hepatic steatosis in obese Zucker rats..

Metabolic healthLiver support

Oyster Mushroom · 2021 · Journal Article · International journal of medicinal mushrooms

The Pink Oyster Mushroom, Pleurotus djamor (Agaricomycetes): A Potent Antioxidant and Hypoglycemic Agent.

The present investigation aimed to study the physicochemical properties, nutritional indices, antioxidant properties, and hypoglycemic effects of dried pink oyster mushroom (Pleurotus djamor) powder..

Immune supportEnergy & fatigueMetabolic healthLiver support

King Oyster · 2026 · Journal Article · International journal of biological macromolecules

Antidiabetic effects of Agaricus bisporus polysaccharide in HFD/STZ-induced mice.

Fungal polysaccharides have garnered attention for their antidiabetic potential. Here, we evaluated five edible fungal polysaccharides-Agaricus bisporus (ABP), Pleurotus eryngii (PEP), Boletus spp.

Cordyceps · 2026 · Journal Article · Journal of clinical laboratory analysis

Edible Fungus Compound Cordycepin Protects Against Acetaminophen-Induced Liver Injury.

BACKGROUND: Medicinal-edible natural products like Cordyceps militaris (C.militaris), a functional food rich in cordycepin (COR), are promising for health maintenance..

Immune supportEnergy & fatigueLiver supportSkin & hydration

Cordyceps · 2026 · Journal Article · Journal of ethnopharmacology

Paecilomyces hepiali Chen (Cs-4) polysaccharides ameliorate chronic liver fibrosis via inhibiting TGF-β1/Smad and NLRP3/Caspase-1-mediated hepatic stellate cells activation in vivo and in vitro.

ETHNOPHARMACOLOGICAL RELEVANCE: Paecilomyces hepiali Chen (Cs-4), recognized as the classic deficiency-tonifiying medicine of traditional Chinese medicine (TCM), is the principal and most valuable medicinal species of Ophiocordyceps sinensis (known as Cordyceps sinensis (Berk.) Sacc., or 'Dong-Chong-Xia-Cao' in….

Immune supportCognition & nervesEnergy & fatigueLiver support

Cordyceps · 2025 · Research Article · Scientific reports

Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.

Excessive exercise can lead to physical fatigue and disruption of the antioxidant system, resulting in neurological damage and cognitive decline. Cordycepin, the main component of Cordyceps militaris, has anti-inflammatory, antioxidant and neuroprotective effects..

King Oyster · 2025 · Research Article · Foods (Basel, Switzerland)

Identification and Nutrient Composition of a Wild Pleurotus pulmonarius Strain from Tibet, and the Antioxidant and Cytotoxic Activities of Polysaccharides from This Fungus.

The selection and breeding of high-quality wild edible fungal strains can bring significant economic and social benefits. A wild fungal strain (X21185) from the Tibetan Plateau was isolated and identified as a novel Pleurotus pulmonarius (P.