MycoData

Immune supportGut & microbiome

Wood Ear · 2025 · Research Article · Ultrasonics sonochemistry

Anti-inflammatory and gut microbiota regulatory effects of ultrasonic degraded polysaccharides from Auricularia auricula-judae in DSS-induced colitis mice.

Auricularia auricula-judae is a widely cultivated mushroom species known for its edible and medicinal properties. Polysaccharides have been the focus of research because of their potential bioactivities; nonetheless, the structural complexity and molecular weight have hindered a complete understanding of their….

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Lion's Mane · 2025 · Research Article · BMB reports

Anti-inflammatory effects of Hericium erinaceus hot water extract via the JAK1/STAT3 pathway in LPS-stimulated RAW 264.7 macrophages.

Several individual bioactive compounds isolated from Hericium erinaceus exhibit various physiological and biochemical activities, including neuroprotective, neurotrophic, gastrointestinal protective, immunoregulatory, and anti-inflammatory effects. However, the specific anti-inflammatory effects of H..

OncologyImmune supportCognition & nervesLiver support

Zhu Ling · 2025 · Research Article · Computational and structural biotechnology journal

Anticancer effects and mechanisms of Pulsatilla chinensis, Bupleurum chinense and Polyporus umbellatus on human lung carcinoma and hepatoma cells.

Herbs are extensively utilized in Traditional Chinese Medicine (TCM) for lung and liver cancer treatment, but the mechanisms behind these herbs remain largely unknown. Here, high-throughput transcriptomic analysis technology was used to uncover molecular mechanisms of herbal treatment..

Immune supportGut & microbiome

Yellow Morel · 2025 · Journal Article · Bioorganic chemistry

Antioxidant and immunomodulatory effects of acetylated Morchella esculenta polysaccharide in DSS-induced ulcerative colitis mice.

This study follows the current attempt to discover and develop natural therapeutic substances for counteracting ulcerative colitis. Commercial Morchella esculenta polysaccharide after deproteinization (yielding MP) was hydrolyzed with commercial snailase (yielding EMP) then acetylated (yielding AEMP)..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Journal of medicinal food

Antioxidant Properties of Mexican Ganoderma lucidum Extracts in Obese C57BL/6 Mice Fed with a High-Fat and Sugar Diet.

Oxidative stress is a key factor of comorbidities in obesity. A Mexican genotype of the medicinal mushroom Ganoderma lucidum (Gl) contains bioactive compounds showing antioxidant, hypocholesterolemic, anti-inflammatory, anticancer, and prebiotic properties..

Reishi · 2025 · Research Article · Foods (Basel, Switzerland)

AOX Affects the Synthesis of Polysaccharides by Regulating the Reactive Oxygen Species in Ganoderma lucidum.

Alternative oxidase (AOX) is a terminal oxidase in the mitochondrial electron transport chain that does not contribute to the generation of ATP. It plays a critical role in maintaining the balance between reactive oxygen species (ROS) production and intracellular redox homeostasis within the mitochondria..

Immune supportEnergy & fatigueGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Association of α-Klotho with anti-aging effects of Ganoderma lucidum in animal models.

ETHNOPHARMACOLOGICAL RELEVANCE: Aging is a complex, universal process characterized by structural and functional decline across multiple organs. Ganoderma lucidum (G.

OncologyImmune supportEnergy & fatigueSkin & hydration

Reishi · 2025 · Research Article · Microbial cell factories

ATP deficiency triggers ganoderic acids accumulation via fatty acid β-oxidation pathway in Ganoderma lucidum.

BACKGROUND: Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a broad spectrum of pharmacological activities, including immunomodulation, anti-cancer, and anti-aging properties..

OncologyImmune supportMetabolic healthRespiratory

Oyster Mushroom · 2025 · Research Article · Current research in food science

Bioactive properties of selenium-enriched polysaccharides extracted from Pleurotus ostreatus using ultrasonic-assisted extraction.

Mushrooms are well recognized as functional foods owing to their rich nutritional and medicinal properties, particularly polysaccharides with notable therapeutic potential..

Mesima · 2025 · Research Article · Current issues in molecular biology

Bioconversion of Chamaecyparis obtusa Leaves with Phellinus linteus Mycelium Modulates Antioxidant and Anti-Inflammatory Activities.

Chamaecyparis obtusa (Hinoki cypress) has been extensively studied for its leaves and bark, which are known to contain high levels of polyphenols and flavonoids with potent bioactivities. In this study, the phytochemical transformation and changes in bioactivity of C..

OncologyImmune support

Immune supportEnergy & fatigueGut & microbiomeLiver support

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Biomacromolecular composite microspheres based on sodium alginate and tremella fuciformis polysaccharide for enhanced protection and delivery of camellia oil: A comprehensive study in simulated digestion.

This study presents the development of a novel polysaccharide biomolecule composite microsphere system based on sodium alginate (SA) and tremella fuciformis polysaccharide (TFP) for the encapsulation and controlled release of camellia oil (CO)..

Immune supportEnergy & fatigueLiver support

Turkey Tail · 2025 · Research Article · International journal of molecular sciences

Biopolymers of Polycaprolactone Loaded with Caffeic Acid and Trametes versicolor Extract Induced Proliferation in Human Coronary Artery Endothelial Cells and Inhibited Platelet Activity.

In atherosclerosis, the proliferation and migration of endothelial and smooth muscle cells (SMCs) and platelet activation alter endothelial function. Naturally occurring substances, such as caffeic acid (CA) and Trametes versicolor extract (TvE), have medicinal properties and are traditionally used for their….

Turkey Tail · 2025 · Journal Article · Journal of food composition and analysis

Chemical composition of Trametes versicolor, Hericium erinaceus, and Pleurotus ostreatus mushroom biomass: Deciphering their rich α-glucan composition and nutritional value

This study provides the first comprehensive characterization of the Trametes versicolor (TV), Hericium erinaceus (HE), and Pleurotus ostreatus (PO) biomasses, emphasizing their abundant α-glucan content and the presence of (1→4)-β-glucans..

Immune supportEnergy & fatigueSkin & hydration

Oyster Mushroom · 2025 · Journal Article · International journal of biological macromolecules

Chitosan/collagen films loaded with Pleurotus ostreatus polysaccharide-epigallocatechin gallate conjugates with excellent antioxidant and antibacterial activities for pork preservation.

The purpose of this study was to develop a multifunctional active food packaging composite films to solve the environmental and health problems of traditional petroleum-based plastic packaging and for food preservation..

Turkey Tail · 2025 · Research Article · Biomacromolecules

Chitosan/Trametes versicolor Laccase Nanostructures with Modulated Catalytic Activity.

Polymer/enzyme nanoassemblies are a class of nanomaterials of increasing interest for the medical, industrial, or environmental fields. This study comprises a thorough scrutiny of the formation of nanoassemblies between Trametes versicolor laccase and a polysaccharide, chitosan, employing various experimental and….

OncologyImmune supportCognition & nerves

Reishi · 2025 · Journal Article · Organic letters

Chizhiaroterpenoids A-C: Benzofused Rearranged Lanostane-Type Triterpenoids from Ganoderma lucidum.

Chizhiaroterpenoids A-C (1-3), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 (1), 6/6/6/6/7 (2), and 6/6/6/5/6 (3) ring systems, were isolated from Ganoderma lucidum. Their biosynthetic pathways were proposed..

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · Food Hydrocolloids

Co-microencapsulation of Lactobacillus paracasei and Inonotus obliquus polysaccharide in alginate system: Physicochemical and functional properties

In this study, sodium alginate (SA) was used as shell material, and Lactobacillus paracasei JY062/Inonotus obliquus polysaccharide (IOP) were used as core material (JY062-IOP/SA). The microcapsules were prepared by polymer gel technology and analyzed by SEM, FTIR, TGA and XRD..

Shiitake · 2025 · Research Article · Foods (Basel, Switzerland)

Comparison of the Conventional, Chemical, and Ultrasound Extraction of Crude Polysaccharides and Their Properties from Lentinula edodes (Berk.) Pegler.

This study aimed to compare the efficiency of four extraction methods, hot water (HW), hot alkaline (HA), ultrasound-assisted water (UW), and ultrasound-assisted alkaline (UA), for extracting crude β-glucan from Lentinula edodes, focusing on yield, functionality, and antidiabetic potential..

Immune supportEnergy & fatigueMetabolic health

Shiitake · 2025 · Journal Article · Industrial crops and products

Cytology, transcriptomics, and proteomics analyses revealed selenium accumulation mechanisms and nutritional quality changes at sodium selenite in Lentinula edodes

Lentinula edodes is one of the most popular edible mushrooms worldwide, with remarkable potential for selenium (Se) biofortification. However, little is known about the mechanisms underlying Se stress in L.

Reishi · 2025 · Journal Article · Journal of food composition and analysis

Data fusion strategy for rapid prediction of glyceryl trioleate and polysaccharide content in Ganoderma lucidum spore powder based on near-infrared spectroscopy and hyperspectral imaging

Glyceryl trioleate and polysaccharide are key components in Ganoderma lucidum spore powder (GLSP), which is highly valued for its nutritional value. Traditional methods for assessing these contents are often destructive and time-consuming, while non-destructive techniques like near-infrared spectroscopy (NIRS) and….

Zhu Ling · 2025 · Research Article · Microorganisms

Different Symbiotic Species of Armillaria Affect the Yield and Active Compound Contents of Polyporus umbellatus.

Polyporus umbellatus is a medicinal fungus primarily used for diuresis, with its sclerotium serving as the medicinal component. The growth and development of sclerotia are reliant on a symbiotic relationship with Armillaria..

Immune supportCognition & nerves

Lion's Mane · 2025 · Journal Article · Food Bioscience

Dynamic analysis of terpenoids in Hericium erinaceus liquid-fermented mycelium by non-targeted metabolomics and their mechanisms against Helicobacter pylori-associated gastritis

Biosynthetic functional food ingredients represent an innovative strategy within the food industry. The fruiting bodies of Hericium erinaceus have traditionally been utilized as an adjunctive treatment for gastric ulcers.

Immune supportMetabolic healthGut & microbiomeSkin & hydration

Enoki · 2025 · Journal Article · Food chemistry

Effect of Flammulina velutipes polysaccharidees on the quality and digestibility of fresh wet rice noodles: A study perspective from physicochemical and postprandial glucose homeostasis in vivo.

This study investigated the effects of alkali-extracted Flammulina velutipes polysaccharides (AEFP) on the physicochemical properties, starch digestibility, and glycemic response of fresh wet rice noodles (WRN)..

Lion's Mane · 2025 · Journal Article · Cryo letters

Effect of Hericium erinaceus polysaccharides on the cryopreservation of bull semen.

BACKGROUND: The field of sperm cryopreservation requires the search for and development of new effective cryopreservatives with low toxicity. OBJECTIVE: The purpose of this study was to evaluate the characteristics of bull spermatozoa subjected to freezing and storage at -80 degree C for 28 days in a diluent with the….

Immune supportSkin & hydration

Snow Fungus · 2025 · Research Article · Ultrasonics sonochemistry

Effect of ultrasound pretreatment on the drying characteristics and quality of Tremella fuciformis under heat pump drying.

To enhance the heat pump drying (HPD) efficiency and quality of Tremella fuciformis (T. fuciformis), this study employed ultrasound pretreatment and evaluated its effects on drying behavior and product attributes at various ultrasound intensities [0.00 (the control group, CK), 0.20, 0.34, 0.54, and 0.74 W/g]..

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Effect of water-soluble antimicrobial films of carboxymethyl chitosan containing pearl powder and Tremella fuciformis polysaccharides on strawberry fresh-keeping.

Tremella fuciformis polysaccharides (TFPS) extracted from an edible fungus, with abundant hydrophilic groups, possess biological activities such as antioxidant, moisturizing, and immune-enhancing effects..

Immune supportEnergy & fatigueGut & microbiome

Enoki · 2025 · Research Article · BMC veterinary research

Effects of flammulina velutipes stipe wastes on egg performance, cecum microbiota, intestinal barrier and serum immune response of laying hens.

BACKGROUND: Improving production performance and health is the key goal of laying hens farming. This experiment was conducted to examine the effects of Flammulina velutipes stipe wastes (FVW) on the performance of laying hens by regulating cecum microbiota, intestinal barrier and immune response..

Immune supportCognition & nervesGut & microbiomeSkin & hydration

Reishi · 2025 · Journal Article · Die Naturwissenschaften

Effects of Ganoderma lucidum polysaccharide on learning and memory impairment and intestinal flora in mice with D-galactose-induced aging.

Learning and memory impairment is one of the main manifestations of cognitive impairment. Gut flora can affect cognitive function and behavior through the gut-brain axis.

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2025 · Research Article · Animals: an open access journal from MDPI

Effects of Ganoderma lucidum Polysaccharides on Dexameth-Asone-Induced Immune Injury in Goslings.

This study aimed to investigate the role of ganoderma lucidum polysaccharides (GLP) in mitigating dexamethasone (DEX)-induced immune injury in goslings. Dexamethasone (DEX) is commonly used to establish an animal model of immune suppression, which mimics the immune injury caused by stress or certain pathological….

Maitake · 2025 · Journal Article · Journal of food science

Effects of Simulated Digestion on the Structure and Macrophages and Dendritic Cells Activation of Grifola frondosa Polysaccharides.

The present work was analyzed the effects of simulated digestion on the structure of a multibranched polysaccharide (PM) from Grifola frondosa. Additionally, the activation effect of PM on macrophages and dendritic cells was compared before and after simulated digestion..

Maitake · 2025 · Journal Article · International journal of biological macromolecules

Efficient production, structural characterization and bioactivity of an extracellular polysaccharide from Grifola frondosa endophytic Burkholderia sp.

Endophytic bacteria Burkholderia sp. (GFB) was firstly identified and isolated from Grifola frondosa.

OncologyImmune supportEnergy & fatigue

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells

Phellinus linteus (PL) is a medicinal fungus known for producing hispolon, a bioactive compound with antioxidant, anti-inflammatory, and anticancer properties. However, the natural scarcity of PL and the unsuccessful cultivation of its fruiting bodies have led to the exploration of alternative methods for enhancing….

OncologyImmune supportEnergy & fatigue

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells

OncologyImmune supportEnergy & fatigue

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells.

Immune supportCognition & nervesEnergy & fatigue

Shiitake · 2025 · Journal Article · Neuroscience

Ergothioneine-rich Lentinula edodes mushroom extract restores mitochondrial functions in senescent HT22 cells.

A decline in mitochondrial functions associated with ageing is the key factor of free radical generation which contributes to age-related pathologies. Protecting healthy functional mitochondrial networks with antioxidants is critical in promoting healthy ageing..

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Evaluation of Anticancer Potential of Ganoderma lucidum on MCF-7 Breast Cancer Cells Through Genetic Transcription of Energy Metabolism.

Ganoderma lucidum has long been recognized for its medicinal properties, particularly due to its antioxidant, anti-inflammatory, and pro-apoptotic components such as polysaccharides and triterpenoids. This study aimed to evaluate the cytotoxic and molecular effects of ethanol and methanol extracts of G..

Immune supportEnergy & fatigueMetabolic healthRespiratory

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Evidence to support cultivated fruiting body of Ophiocordyceps sinensis (Ascomycota)'s role in relaxing airway smooth muscle.

ETHNOPHARMACOLOGICAL RELEVANCE: Ophiocordyceps sinensis (O. sinensis) is a genus of Ascomycete fungus that is endemic to the alpine meadows of the Tibetan Plateau and adjoining Himalayas..

Oyster Mushroom · 2025 · Journal Article · Letters in applied microbiology

Exo and endopolysaccharides production from Pleurotus ostreatus cultivated in medium containing fruit wastes.

Studies have demonstrated the potential for utilizing agro-industrial byproducts for Pleurotus spp. Extracts containing polysaccharides from mushrooms obtained through solid culture, as well as from mycelial biomass obtained through liquid culture (endopolysaccharides), can regulate the immune response and increase….

Shiitake · 2025 · Journal Article · International journal of biological macromolecules

Exogenous trehalose increased polysaccharide content and altered their properties and metabolism in Lentinula edodes mycelium.

Trehalose promotes polysaccharide synthesis in edible mushrooms, yet its effect on the antioxidant activity and structure of Lentinula edodes mycelium polysaccharides is still unknown. We investigated the effect of trehalose on the antioxidant activity of L.

Immune supportCognition & nervesEnergy & fatigue

Reishi · 2025 · Journal Article · Mycopathologia

Exopolysaccharides of Ganoderma lucidum Activate the NLRP3 Inflammasome, Modulating Phagocytes and the Response of Mice to Infection with Cryptococcus neoformans.

Interleucin-1β (IL-1β) is a pivotal cytokine in pro-inflammatory response induction, and it is regarded as protective in various diseases. IL-1β secretion is mainly associated with activation of the inflammasome complex, which normally is tightly regulated, depending on two signals for significant activity..

OncologyImmune supportCognition & nervesRespiratory

Agarikon · 2025 · Research Article · Frontiers in pharmacology

Exploration of the role of Fomitopsis officinalis Ames in the treatment of gastric cancer using network pharmacology, molecular docking, and in vitro experiments.

BACKGROUND: Gastric cancer (GC) is one of the most common malignant tumors worldwide, with approximately one million people diagnosed with gastric cancer each year..

Oyster Mushroom · 2025 · Journal Article · Applied biochemistry and biotechnology

Exploring Botryosphaeran, a (1 → 3)(1 → 6)-β-D-Glucan, as a Matrix for the Stabilization of Laccase from Pleurotus ostreatus Florida onto a Zinc Oxide Quantum Dots Platform for the Electrochemical Determination of 2,6-Dimethoxyphenol.

This work describes the development of a novel biosensor obtained by immobilizing laccase from Pleurotus ostreatus Florida onto a glassy carbon electrode platform modified with zinc oxide quantum dots. For enzyme immobilization, the exopolysaccharide botryosphaeran from Botryosphaeria rhodina MAMB-05 was used..

Yellow Morel · 2025 · Journal Article · International Journal of Biological Macromolecules

Exploring Morchella esculenta polysaccharide extracts: In vitro digestion, fermentation characteristics, and prebiotic potential for modulating gut microbiota and function

Morchella esculenta, a nutritious and medicinal edible mushroom, has gained an increasing attention due to the bioactive properties of its polysaccharides. This study employed in vitro simulated human digestion and fecal fermentation models to evaluate the effects of M..

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Exploring Morchella esculenta polysaccharide extracts: In vitro digestion, fermentation characteristics, and prebiotic potential for modulating gut microbiota and function.

Immune supportMetabolic healthLiver support

Yellow Morel · 2025 · Journal Article · International Journal of Biological Macromolecules

Exploring the mechanism of Morchella esculenta polysaccharides ameliorating liver lipid metabolism in high-fat diet mice by transcriptomics

This study isolated a high-molecular-weight Morchella esculenta polysaccharide (MEP-1), mainly composed of glucose with a triple-helix structure. MEP-1 alleviated high-fat diet (HFD)-induced hepatic lipid metabolic disorders and inflammation by significantly reducing the levels of TC, TG, LDL-C, TNF-α, IL-6, and….

Immune supportMetabolic healthLiver support

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Exploring the mechanism of Morchella esculenta polysaccharides ameliorating liver lipid metabolism in high-fat diet mice by transcriptomics.

Enoki · 2025 · Journal Article · International journal of biological macromolecules

Flammulina velutipes polysaccharide exerts immunomodulatory function involving RSAD2 to regulate the NF-κB/MAPK signaling pathway in RAW264.7 macrophage cells and in mouse spleen cells.

There are ongoing efforts to explore the potential of natural bioactive substances including polysaccharides in immunological regulation and understand the mechanisms under their immune-regulating function..

Enoki · 2025 · Journal Article · International journal of biological macromolecules

Flammulina Velutipes polysaccharides ameliorate cisplatin-induced acute kidney injury in mice via regulation of gut microbiota and Ferroptosis pathway.

Acute kidney injury (AKI) is a common and serious clinical complication with high incidence. Polysaccharides extracted from Flammulina velutipes (FVPs) have been proven to possess anti-inflammatory and antioxidant properties..

Enoki · 2025 · Journal Article · Journal of food engineering

Flammulina velutipes polysaccharides as an alternative cryoprotectant for frozen shrimp

Flammulina velutipes polysaccharides (FVPs) have shown promise as cryoprotectants in food preservation. This study investigates the specific role of FVP in inhibiting ice recrystallization and preserving the quality of Pacific white peeled shrimp during freeze-thaw cycles..