MycoData

BACKGROUND: Despite claims as key enzymes in enzymatic delignification, very scarce information on the reaction rates between the ligninolytic versatile peroxidase (VP) and lignin peroxidase (LiP) and the lignin polymer is available, due to methodological difficulties related to lignin heterogeneity and low….

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · Nanoscale

Easy conversion of protein-rich enoki mushroom biomass to a nitrogen-doped carbon nanomaterial as a promising metal-free catalyst for oxygen reduction reaction.

The search for low-cost, highly active, and stable catalysts to replace the Pt-based catalysts for oxygen reduction reaction (ORR) has recently become a topic of interest..

Energy & fatigue

Medium relevance

Maitake · 2015 · Research Support, Non U.S. Gov'T · Journal of chromatography. A

pH recycling aqueous two-phase systems applied in extraction of Maitake β-Glucan and mechanism analysis using low-field nuclear magnetic resonance.

In this paper, a recycling aqueous two-phase systems (ATPS) based on two pH-response copolymers PADB and PMDM were used in purification of β-Glucan from Grifola frondosa..

Medium relevance

Cordyceps · 2013 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

DNA barcoding the commercial Chinese caterpillar fungus.

Chinese caterpillar fungus (Ophiocordyceps sinensis) has been widely used as tonic in Asian medicine. Considering its curative effect and high cost, various counterfeit versions of O.

Medium relevance

King Oyster · 2012 · Research Support, Non U.S. Gov'T · Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine

Influence of alkali and alkaline earth elements on the uptake of radionuclides by Pleurototus eryngii fruit bodies.

In the literature, there are many data available on radionuclide contents and their transfer to different species of mushrooms. There are some variables, however, which affect the transfer but are very difficult to observe in collected wild mushrooms..

Medium relevance

King Oyster · 2011 · Research Support, Non U.S. Gov'T · Physical chemistry chemical physics: PCCP

EPR parameters of amino acid radicals in P. eryngii versatile peroxidase and its W164Y variant computed at the QM/MM level.

Quantum mechanics/molecular mechanics (QM/MM) methods, employing density functional theory (DFT), have been used to compute the electron paramagnetic resonance (EPR) parameters of tryptophan and tyrosyl radical intermediates involved in the catalytic cycle of Pleurotus eryngii versatile peroxidase (VP) and its W164Y….

Medium relevance

Maitake · 2010 · Research Support, Non U.S. Gov'T · Cancer immunology, immunotherapy: CII

Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity.

Bone marrow myelotoxicity is a major limitation of chemotherapy. While granulocyte colony stimulating factor (G-CSF) treatment is effective, alternative approaches to support hematopoietic recovery are sought..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Enoki · 2010 · Research Support, Non U.S. Gov'T · International immunopharmacology

Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma.

FVE is a documented immunomodulatory protein purified from Enoki mushroom (Flammulina velutipes) and known as an activator for human T lymphocytes. This present study was aimed to investigate the anti-tumor effect and the related mechanisms of oral administration of FVE using a murine hepatoma model..

OncologyImmune supportLiver support

Medium relevance

Maitake · 2009 · Review Article · International journal of general medicine

Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy.

Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as beta-glucan..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Maitake · 2007 · Research Support, Non U.S. Gov'T · Clinical and vaccine immunology: CVI

Enhancement of umbilical cord blood cell hematopoiesis by maitake beta-glucan is mediated by granulocyte colony-stimulating factor production.

Maitake beta-glucan (MBG) is an extract from the fruit body of the Grifola frondosa mushroom that is being widely used to treat cancer in Asia. We have previously reported that MBG enhances mouse bone marrow cell (BMC) hematopoiesis in vitro and protects BMC from doxorubicin (DOX) toxicity..

OncologyImmune supportGut & microbiome

Medium relevance

Turkey Tail · 2007 · Patent · journal metadata

STRAIN OF TURKEY TAIL MUSHROOM, EXTRACT FROM THE SAME, AND USE OF THE SAME

Disclosed is a strain of turkey tail mushroom (Trametes versicolor) having excellent biological activities (Accession number: FERM BP-10633). The strain is excellent in platelet aggregation inhibitory effect, chemokine gene expression inhibitory effect, anti-mutagenic effect, anti-tumor effect, anti-hypertensive….

OncologyImmune supportMetabolic healthSkin & hydration

Medium relevance

King Oyster · 2026 · Evaluation Study · Food chemistry

A simple and cost-effective method for quantifying cyanide in the fruiting bodies and cultured mycelia of mushrooms using alkaline-SDS extraction and Conway diffusion.

This study describes a simple, cost-effective method for cyanide quantification in mushrooms. This involves an alkaline/SDS extraction producer to disrupt the cell wall while stabilizing volatile hydrogen cyanide as the cyanide ion (CN-) under alkaline conditions, which is subsequently recovered using Conway diffusion….

Metabolic health

Medium relevance

Cordyceps · 2025 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications.

This systematic review examines the antidepressant potential of edible medicinal fungi (EMFs), focusing on their bioactive compounds and mechanisms of action. EMFs modulate neurotransmitter systems, including serotonin (5-HT) and dopamine (DA), alleviating depressive symptoms..

Immune supportCognition & nervesGut & microbiome

Medium relevance

King Oyster · 2025 · Evaluation Study · Food chemistry

Effects of three edible mushroom polysaccharides on the freeze-thaw stability of silver carp (Hypophthalmichthys molitrix) surimi gels: Water retention, gel quality, and structural properties.

In this study, the effects of three edible mushroom crude polysaccharides, including Tremella polysaccharide (TP), Flammulina velutipes polysaccharide (FVP), and Pleurotus eryngii polysaccharide (PEP) on the freeze-thaw stability of silver surimi were investigated..

Immune support

Medium relevance

Shiitake · 2025 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

Nearly telomere-to-telomere genome assembly of the L. edodes diploid genome.

Lentinula edodes (shiitake mushroom) possesses substantial nutritional and medicinal value. Even though the genomes of several strains have been reported, some essential observations, including the exact chromosome number, still need validation..

Medium relevance

King Oyster · 2025 · Evaluation Study · Food chemistry

Successive fungal solid-state fermentation and UV-B irradiation: A novel strategy to boost bioactive potential and vitamin D2 levels of corn flour.

This study introduces a novel biofortification strategy that combines solid-state fermentation (SSF) using edible fungi Pleurotus eryngii and Hericium erinaceus, followed by UV-B irradiation of colonized corn flour, to enhance its vitamin D₂ content and functional properties..

Gut & microbiome

Medium relevance

Cordyceps · 2025 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Synergistic Effect of HAD-B1 and Osimertinib Against Gefitinib Resistant HCC827 Non-Small Cell Lung Cancer Cells.

In this study, we investigated the synergistic effect of co-administration of osimertinib and HAD-B1 using gefitinib-resistant non-small cell lung cancer cells, HCC827-GR. HAD-B1 is composed of 4 natural drugs, Panax Notoginseng Radix, Panax ginseng C.

OncologyRespiratory

Medium relevance

Chaga · 2025 · Research Support, Non U.S. Gov'T · Apoptosis: an international journal on programmed cell death

β-glucan nanoparticles alleviate acute asthma by suppressing ferroptosis and DNA damage in mice.

Asthma is a severe respiratory disease marked by airway inflammation, remodeling, and oxidative stress. β-Glucan (BG), a polysaccharide constituent of fungal cellular structures, exhibits potent immunomodulatory activities..

OncologyImmune supportRespiratory

Medium relevance

King Oyster · 2024 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Bioremediation of petroleum hydrocarbons polluted soil by spent mushroom substrates: Microbiological structure and functionality.

Spent mushroom substrate (SMS) holds valuable microbiota that can be useful in remediating polluted soils with hydrocarbons. However, the microorganisms behind the bioremediation process remain uncertain..

Gut & microbiome

Medium relevance

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Cordycepin alleviates diabetes mellitus-associated hepatic fibrosis by inhibiting SOX9-mediated Wnt/β-catenin signal axis.

Diabetes mellitus can induce liver injury and easily progress to liver fibrosis. However, there is still a lack of effective treatments for diabetes-induced hepatic fibrosis..

Metabolic healthLiver support

Medium relevance

King Oyster · 2024 · Brief Report · Food science and biotechnology

Microbiological quality and safety of fresh mushroom products at retail level in Korea.

Several investigations and recalls have demonstrated that Listeria monocytogenes can occur on mushrooms. This study aimed to assess the microbiological quality and safety of four types of edible mushrooms (Flammulina velutipes, Pleurotus ostreatus, Pleurotus eryngii, and Agaricus bisporus) available in the Korean….

Medium relevance

Shiitake · 2024 · Research Support, Non U.S. Gov'T · Brain research

Potential role of ergothioneine rich mushroom as anti-aging candidate through elimination of neuronal senescent cells.

Oxidative stress can upset the antioxidant balance and cause accelerated aging including neurodegenerative diseases and decline in physiological function. Therefore, an antioxidant-rich diet plays a crucial role in healthy aging..

Cognition & nervesEnergy & fatigueSkin & hydration

Medium relevance

Chaga · 2023 · Journal Article · Biological & pharmaceutical bulletin

3,4-Dihydroxybenzalacetone Inhibits the Propagation of Hydrogen Peroxide-Induced Oxidative Effect via Secretory Components from SH-SY5Y Cells

The polyphenol derivative 3,4-dihydroxybenzalacetone (DBL) is the primary antioxidative component of the medicinal folk mushroom Chaga (Inonotus obliquus (persoon) Pilat)..

Immune supportCognition & nerves

Medium relevance

Reishi · 2023 · Journal Article · Food Research International

3D printable vegan plant-based meat analogue: fortification with three different mushrooms, investigation of printability, and characterization

In this study, a meat analogue formulation prepared using different protein sources as a printable ink for 3D printers and fortified with three different mushroom cultivars (reishi, Ganoderma lucidum (GL); saffron milk-cap, Lactarius deliciosus (LD); and oyster, Pleurotus ostreatus (PO))..

Energy & fatigueSkin & hydration

Medium relevance

Oyster Mushroom · 2023 · Research Article · Science advances

A carnivorous mushroom paralyzes and kills nematodes via a volatile ketone.

The carnivorous mushroom Pleurotus ostreatus uses an unknown toxin to rapidly paralyze and kill nematode prey upon contact. We report that small lollipop-shaped structures (toxocysts) on fungal hyphae are nematicidal and that a volatile ketone, 3-octanone, is detected in these fragile toxocysts..

Cognition & nervesEnergy & fatigue

Medium relevance

King Oyster · 2023 · Journal Article · Preparative biochemistry & biotechnology

Agro-industrial wastes revalorization as feedstock: production of lignin-modifying enzymes extracts by solid-state fermentation using white rot fungi.

The purpose of the study was to evaluate the production of lignin-modifying enzyme extracts and delignified biomass from agro-industrial wastes using white rot fungi (Inonotus sp. Sp2, Stereum hirsutum Ru-104, Bjerkandera sp.

Gut & microbiome

Medium relevance

King Oyster · 2023 · Research Article · ACS omega

Cellulose Fiber Rejects as Raw Material for Integrated Production of Pleurotus spp. Mushrooms and Activated Biochar for Removal of Emerging Pollutants from Aqueous Media.

Cellulose fiber rejects from industrial-scale recycling of waste papers were dried and de-ashed using a combined cyclone-drying and sieving process. The upgraded fiber reject was used as a component of substrates for the cultivation of Pleurotus ostreatus and Pleurotus eryngii mushrooms..

Gut & microbiome

Medium relevance

Cordyceps · 2023 · Research Article · In vivo (Athens, Greece)

Cordycepin Enhances SIRT1 Expression and Maintains Stemness of Human Mesenchymal Stem Cells.

BACKGROUND/AIM: Mesenchymal stem cells (MSCs) have been employed for therapeutic applications of various degenerative diseases. However, the major concern is MSC aging during the in vitro cultivation..

Skin & hydration

Medium relevance

Cordyceps · 2023 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Cordycepin improved neuronal synaptic plasticity through CREB-induced NGF upregulation driven by MG-M2 polarization: a microglia-neuron symphony in AD.

PURPOSE: Microglia-neuron crosstalk is critically involved in synaptic plasticity and degeneration by releasing diverse mediators in Alzheimer's disease (AD). Therefore, determining contributors that modulate the systemic microenvironment is essential..

OncologyCognition & nerves

Medium relevance

Cordyceps · 2023 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Cordycepin inhibits myogenesis via activating the ERK1/2 MAPK signalling pathway in C2C12 cells.

Cordycepin (with a molecular formula of C10H13N5O3), a natural adenosine isolated from Cordyceps militaris, has an important regulatory effect on skeletal muscle remodelling and quality maintenance..

Energy & fatigue

Medium relevance

Cordyceps · 2023 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway.

Type 2 diabetes mellitus (T2DM) is a common and multiple endocrine metabolic disease. When pancreatic β cell in case of dysfunction, the synthesis and secretion of insulin are reduced..

OncologyEnergy & fatigueMetabolic health

Medium relevance

Cordyceps · 2023 · Research Article · Journal of cancer research and clinical oncology

Cordycepin remodels the tumor microenvironment of colorectal cancer by down-regulating the expression of PD-L1.

PURPOSE: Colorectal cancer, as a common malignant tumor, poses a serious threat to human life. Cordycepin, derived from Cordyceps militaris extract, which was established as a capable inhibitor of tumor growth.

OncologyGut & microbiome

Medium relevance

Cordyceps · 2023 · Journal Article · International immunopharmacology

Cordycepin suppresses vascular inflammation, apoptosis and oxidative stress of arterial smooth muscle cell in thoracic aortic aneurysm with VEGF inhibition.

BACKGROUND: Thoracic aortic aneurysm (TAA) is a type of common and serious vascular disease, in which inflammation, apoptosis and oxidative stress are strongly involved in the progression. Cordycepin, a bioactive compound from Cordyceps militaris, exhibits anti-inflammatory and anti-oxidative activities..

OncologyImmune supportEnergy & fatigue

Medium relevance

King Oyster · 2023 · Journal Article · Journal of colloid and interface science

Core-shell FeCo@carbon nanocages encapsulated in biomass-derived carbon aerogel: Architecture design and interface engineering of lightweight, anti-corrosion and superior microwave absorption.

The development of multifunctional microwave absorbing materials for practical applications in complex environments is a challenging research hotspot. Herein, the core-shell structure FeCo@C nanocages were successfully anchored on the surface of biomass-derived carbon (BDC) from pleurotus eryngii (PE) via….

Energy & fatigue

Medium relevance

Lion's Mane · 2023 · Research Article · Molecules (Basel, Switzerland)

Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound.

Hericium erinaceus, a mushroom species commonly known as Yamabushitake in Japan, is known to have a stimulatory effect on neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)..

Cognition & nervesMetabolic healthGut & microbiome

Medium relevance

Oyster Mushroom · 2023 · Journal Article · Trees

Diagnosis and recommendations for management of trees and shrubs in green squares in Warsaw based on research on fungal diseases

KEY MESSAGE: Comprehensive management of urban greenery is a key approach to control fungal diseases of trees and shrubs to avoid the deterioration in their health status..

Medium relevance

Lion's Mane · 2023 · Journal Article · International journal of medicinal mushrooms

Effects of Dietary Supplementation with In Vitro-Cultivated Arboreal Medicinal Mushrooms on Long-Term Memory and Anxiety-Like Behavior of Male Mice.

Health-promoting effects of medicinal mushrooms have been postulated for centuries in folk medicine in Asia and Europe and are currently being verified by scientific research..

Cognition & nerves

Medium relevance

Cordyceps · 2023 · Research Article · Synthetic and systems biotechnology

Engineering Komagataella phaffii to biosynthesize cordycepin from methanol which drives global metabolic alterations at the transcription level.

Cordycepin has the potential to be an alternative to the disputed herbicide glyphosate. However, current laborious and time-consuming production strategies at low yields based on Cordyceps militaris lead to extremely high cost and restrict its application in the field of agriculture..

Metabolic health

Medium relevance

King Oyster · 2023 · Research Article · Animals: an open access journal from MDPI

Fermentation Quality, In Vitro Digestibility, and Aerobic Stability of Ensiling Spent Mushroom Substrate with Microbial Additives.

This experiment investigated the effects of lactic acid bacteria and cellulase on the fermentation quality, in vitro digestibility, and aerobic stability of Flammulina velutipes spent mushroom substrate silage (F-silage) and Pleurotus eryngii spent mushroom substrate silage (P-silage)..

Gut & microbiome

Medium relevance

King Oyster · 2023 · Journal Article · Bulletin of entomological research

Growth, development, and host preference of Histiostoma feroniarum (Acaridida: Histiostomatidae): effects of temperature and types of mushroom cultivar.

One of the most common harmful mites in edible fungi is Histiostoma feroniarum Dufour (Acaridida: Histiostomatidae), a fungivorous astigmatid mite that feeds on hyphae and fruiting bodies, thereby transmitting pathogens..

Medium relevance

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

Horizontal gene transfer of Cccyt contributes to virulence of mycoparasite Calcarisporium cordycipiticola by interacting with a host heat shock protein.

Horizontal gene transfer (HGT) is an important driving force for virulence evolution of pathogens, however, functions of these transferred genes are still not fully investigated..

Immune support

Medium relevance

King Oyster · 2023 · Journal Article · The Science of the total environment

Increasing the value of Phragmites australis straw in a sustainable integrated agriculture model (SIAM) comprising edible mushroom cultivation and spent mushroom substrate compost.

Because of the regular annual harvest, Phragmites australis used in wetland protection produces an abundance of straw, resulting in a large amount of straw waste. As a result, the extra straw should be used in a convenient and efficient manner.

Medium relevance

King Oyster · 2023 · Research Article · Foods (Basel, Switzerland)

Microbiological Assessment of White Button Mushrooms with an Edible Film Coating.

The development of edible coatings incorporating bioextracts from mushrooms native to Portuguese forests aims to enhance the value of the endogenous forest and mycological resources by harnessing their potential as a source of antimicrobial and antioxidant compounds..

Medium relevance

Cordyceps · 2023 · Journal Article · Microorganisms

Natural Product Cordycepin (CD) Inhibition for NRP1/CD304 Expression and Possibly SARS-CoV-2 Susceptibility Prevention on Cancers.

NRP1/CD304 is a typical membrane-bound co-receptor for the vascular endothelial cell growth factor (VEGF), semaphorin family members, and viral SARS-CoV-2. Cordycepin (CD) is a natural product or active gradient from traditional Chinese medicine (TCM) from Cordyceps militaris Link and Ophiocordyceps sinensis (Berk.)..

OncologyImmune supportRespiratory

Medium relevance

King Oyster · 2023 · Research Article · Microorganisms

New Potential Biological Limiters of the Main Esca-Associated Fungi in Grapevine.

The strains Trichoderma harzianum TH07.1-NC (TH), Aphanocladium album MX95 (AA), Pleurotus eryngii AL142PE (PE) and Pleurotus ostreatus ALPO (PO) were tested as biological limiters against Fomitiporia mediterranea Fme22.12 (FM), Phaeoacremonium minimum Pm22.53 (PM) and Phaeomoniella chlamydospora Pc22.65 (PC)..

Medium relevance

Chaga · 2023 · Research Article · Heliyon

Preventive effects of inotodiol on polyinosinic-polycytidylic acid-induced inflammation in human dermal fibroblasts.

Double-strand RNA(dsRNA), which can induce inflammation, can be generated by necrotic keratinocytes in the skin environment. As an analog of dsRNA, polyinosinic-polycytidylic acid (poly(I:C)) is used to induce inflammation via the Toll-like Receptor 3 (TLR3) signaling pathway..

Immune supportSkin & hydration

Medium relevance

Chaga · 2023 · Journal Article · Heliyon

Preventive effects of inotodiol on polyinosinic–polycytidylic acid-induced inflammation in human dermal fibroblasts

Double-strand RNA(dsRNA), which can induce inflammation, can be generated by necrotic keratinocytes in the skin environment. As an analog of dsRNA, polyinosinic–polycytidylic acid (poly(I:C)) is used to induce inflammation via the Toll-like Receptor 3 (TLR3) signaling pathway..

Immune supportSkin & hydration

Medium relevance

King Oyster · 2023 · Research Article · Molecules (Basel, Switzerland)

Protection and Disinfection Activities of Oregano and Thyme Essential Oils Encapsulated in Poly(ε-caprolactone) Nanocapsules.

The biocolonization of building materials by microorganisms is one of the main causes of their degradation. Fungi and bacteria products can have an undesirable impact on human health.

Gut & microbiome

Medium relevance

King Oyster · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Solid-State Fermentation with White Rot Fungi (Pleurotus Species) Improves the Chemical Composition of Highland Barley Straw as a Ruminant Feed and Enhances In Vitro Rumen Digestibility.

Lignin degradation is important for enhancing the digestibility and improving the nutritive quality of ruminant feeds. White rot fungi are well known for their bioconversion of lignocellulosic biomass..

Metabolic healthGut & microbiome

Medium relevance

Oyster Mushroom · 2023 · Research Article · Heliyon

Zinc bioaccessibility in finger millet porridge blended with zinc-dense mushroom.

INTRODUCTION: Zinc deficiency is a common health problem among people who rely heavily on cereal-based foods. Consequently, most people from low-income families, particularly young children in Sub-Saharan Africa, who rely mainly on cereal-based meals, have suffered from Zinc deficiency-related health issues..

Cognition & nervesGut & microbiome