MycoData

OncologyImmune supportMetabolic healthLiver support

Almond Mushroom · 2008 · Review Article · Evidence-based complementary and alternative medicine: eCAM

The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems.

Agaricus blazei Murrill (ABM) popularly known as 'Cogumelo do Sol' in Brazil, or 'Himematsutake' in Japan, is a mushroom native to Brazil, and widely cultivated in Japan for its medicinal uses, so it is now considered as one of the most important edible and culinary-medicinal biotechnological species..

OncologyImmune supportMetabolic health

Shiitake · 2026 · Research Support, Non U.S. Gov'T · Journal of translational medicine

A novel combination for in vivo breast cancer treatment: TAK1 inhibition combined with metformin and Lentinula edodes compounds synergistically reinvigorates CD8+ T Cells.

BACKGROUND: Breast cancer (BC) is the most prevalent cancer among women, and retrieving the anti-tumor function of the immune system seems a promising treatment approach for its crucial role in combating cancer cells..

Energy & fatigueMetabolic health

Lion's Mane · 2026 · Comparative Study · Food chemistry

Comparative Iron biofortification in Hericium erinaceus: A study of different ionic forms and their uptake efficiency.

Iron biofortification of Hericium erinaceus is a promising strategy for enhancing its nutritional profile. This study examined the effects of supplementing growth substrates with various iron forms (FeCl3·6H2O, FeSO4·7H2O, and FeHBED) on iron uptake, accumulation, and metabolic profiles in H..

OncologyImmune supportCognition & nervesMetabolic health

Shiitake · 2026 · Research Support, Non U.S. Gov'T · The breast journal

Lentinula edodes Cultured Extract Intake at Puberty Mitigates Inflammatory Signals at the Mammary Glands by the Involvement of Epigenetic Mechanisms in BALB/c Mice.

Exposure to immune stress or lipopolysaccharide (LPS) during critical developmental stages like puberty may lead to gut microbiome dysbiosis and epigenetic dysregulation in mammary glands, affecting gene expression and potentially elevating breast cancer susceptibility in adulthood..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2026 · Research Support, Non U.S. Gov'T · Biomolecules

Study on the Mechanism of Ganoderma lucidum Polysaccharides for Ameliorating Dyslipidemia via Regulating Gut Microbiota and Fecal Metabolites.

In today's world, unhealthy living habits have contributed to the rise in metabolic disorders like hyperlipidemia. Recognized as a popular edible and medicinal mushroom in China and various eastern nations, Ganoderma lucidum is a promising high-value functional and medicinal food with multiple biological activities..

Cordyceps · 2026 · Journal Article · Analytical methods: advancing methods and applications

Unraveling the alteration of chemical compositions in Cordyceps and its host larvae using mass spectrometry imaging.

Cordyceps (Chinese caterpillar fungus) is a precious medicinal and edible fungus-larva complex that is naturally formed in a specific environment. However, limited data have been reported on spatial alterations in the lipidome and metabolome of larvae before and after entomopathogenic fungal infection..

Immune supportEnergy & fatigueMetabolic health

Lion's Mane · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Anti-radiation metabolomics of Hericium erinaceus polysaccharides based on gas chromatography-mass spectrometry].

A serum metabolomics analysis method based on gas chromatography-mass spectrometry(GC-MS) was used to investigate the metabolic regulation mechanism of Hericium erinaceus(H. erinaceus) polysaccharides on radiation injury.

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Ganoderma lucidum spore polysaccharides regulate JAK2/STAT3 pathway to alleviate cancer-related fatigue in mouse model of spleen deficiency syndrome].

Ganoderma lucidum spore polysaccharides(GLSP) are the main active ingredients of G. lucidum spores and have pharmacological effects of regulating immunity and inhibiting tumor growth.

Immune supportEnergy & fatigueMetabolic healthLiver support

Snow Fungus · 2025 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

A Novel Polysaccharide From Tremella fuciformis Alleviated High-Fat Diet-Induced Obesity by Promoting AMPK/PINK1/PRKN-Mediated Mitophagy in Mice.

SCOPE: Polysaccharides from Tremella fuciformis have gained significant interest due to their diverse biological activities. This study focuses on characterizing a purified polysaccharide, TPSP2, extracted from T.

OncologyMetabolic healthRespiratory

Cordyceps · 2025 · Comparative Study · Journal of pharmaceutical and biomedical analysis

Integrating 2D NMR-based metabolomics and in vitro assays to explore the potential viability of cultivated Ophiocordyceps sinensis as an alternative to the wild counterpart.

Ophiocordyceps sinensis is widely used to treat various diseases and as a health supplement. The present study comprehensively compared the metabolic differences between wild and cultivated O.

Yellow Morel · 2024 · Comparative Study · International journal of biological macromolecules

Comparative study on physicochemical properties and hypoglycemic activities of intracellular and extracellular polysaccharides from submerged fermentation of Morchella esculenta.

The structural characteristic, physicochemical properties and structure-hypoglycemic activity relationship of intracellular (IPS) and extracellular (EPS) from submerged fermentation of Morchella esculenta were systematically compared and assessed..

Maitake · 2024 · Published Erratum · Food & function

Correction: Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats.

Correction for 'Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats' by Lu Li et al., Food Funct., 2019, 10, 2560-2572, https://doi.org/10.1039/C9FO00075E..

OncologyImmune supportMetabolic healthRespiratory

Reishi · 2024 · Research Support, Non U.S. Gov'T · Journal of the Chinese Medical Association: JCMA

Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis.

BACKGROUND: Ganoderma lucidum ( G. lucidum ) is a traditional Chinese herbal medicine that has shown potential as an alternative adjuvant therapy for cancer patients.

Reishi · 2024 · Research Support, Non U.S. Gov'T · Communications biology

The CBS/H2S signalling pathway regulated by the carbon repressor CreA promotes cellulose utilization in Ganoderma lucidum.

Cellulose is an important abundant renewable resource on Earth, and the microbial cellulose utilization mechanism has attracted extensive attention. Recently, some signalling molecules have been found to regulate cellulose utilization and the discovery of underlying signals has recently attracted extensive attention..

OncologyImmune supportMetabolic healthLiver support

Snow Fungus · 2024 · Research Support, Non U.S. Gov'T · Mycologia

Triple quadrupole liquid chromatography-mass spectrometry-mediated evaluation of vitamin D2 accumulation potential, antioxidant capacities, and total polyphenol content of white jelly mushroom (Tremella fuciformis Berk.).

Tremella fuciformis Berk. (TF), or the white jelly mushroom, is well known for its myriad of pharmacological properties, such as immunomodulatory, anti-inflammatory, antidiabetic, antitumor, and antioxidant activities, and hypocholesterolemic and hepatoprotective effects that boost human health..

Shiitake · 2023 · Research Article · Veterinary sciences

A Supplement with Bromelain, Lentinula edodes, and Quercetin: Antioxidant Capacity and Effects on Morphofunctional and Fecal Parameters (Calprotectin, Cortisol, and Intestinal Fermentation Products) in Kennel Dogs.

Oxidative stress causes several pathological conditions in humans and animals, including gastrointestinal disorders. The aim of this study was to analyze the antioxidant capacity of three natural powdered raw materials containing quercetin, bromelain, and Lentinula edodes and develop a new feed supplement for dogs….

Shiitake · 2023 · Journal Article · International journal of biological macromolecules

Active polysaccharides from Lentinula edodes and Pleurotus ostreatus by addition of corn straw and xylosma sawdust through solid-state fermentation.

In this study, Lentinula edodes and Pleurotus ostreatus were selected as representatives to explore the effects of corn straw and xylosma sawdust on the production and activity of polysaccharides by edible fungi during solid-state fermentation..

Reishi · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

An Efficient CRISPR/Cas9 Genome Editing System for a Ganoderma lucidum Cultivated Strain by Ribonucleoprotein Method.

The CRISPR/Cas9 system has become a popular approach to genome editing. Compared with the plasmid-dependent CRISPR system, the ribonucleoprotein (RNP) complex formed by the in vitro assembly of Cas9 and single-guide RNA (sgRNA) has many advantages..

OncologyMetabolic healthRespiratory

Maitake · 2023 · Journal Article · Plant foods for human nutrition (Dordrecht, Netherlands)

Anti-α-glucosidase, Anti-proliferative and Anti-enterovirus 71 Activity of Secondary Metabolites Identified from Grifola Frondosa.

Grifola frondosa, an edible and medicinal resource, is widely used as functional foods worldwide. To explore bioactive compounds against α-glucosidase, human tumor cells and enterovirus 71 (EV71), eight compounds were isolated from G.

OncologyImmune supportMetabolic health

Maitake · 2023 · Research Article · International journal of food science

Antioxidant and Immunomodulatory Activities of Polysaccharides from Fermented Wheat Products of Grifola frondosa: In Vitro Methods.

Despite the well-known health benefits of Grifola frondosa, there is a lack of understanding regarding the potential antioxidant and immunomodulatory properties of different varieties when fermented with wheat grains. We aimed to explore the potential of G.

Immune supportMetabolic healthGut & microbiomeLiver support

Wood Ear · 2023 · Journal Article · International journal of biological macromolecules

Auricularia auricula-judae (Bull.) polysaccharides improve obesity in mice by regulating gut microbiota and TLR4/JNK signaling pathway.

Obesity has emerged as a crucial factor impacting people's lives, and gut microbiota disorders contribute to its development and progression. Auricularia auricula-judae (Bull.) polysaccharides (AAPs), a traditional functional food in Asia, exhibit potential anti-obesity effects..

Maitake · 2023 · Research Article · Biotechnology for biofuels and bioproducts

Biochemical and structural characterization of a glucan synthase GFGLS2 from edible fungus Grifola frondosa to synthesize β-1, 3-glucan.

BACKGROUND: Grifola frondosa is a Basidiomycete fungus belonging to the family of Grifolaceae and the order of Polyporales. β-Glucans are the main polymers in G.

Energy & fatigueMetabolic healthLiver support

Oyster Mushroom · 2023 · Research Article · Biomimetics (Basel, Switzerland)

Biowelding 3D-Printed Biodigital Brick of Seashell-Based Biocomposite by Pleurotus ostreatus Mycelium.

Mycelium biocomposites are eco-friendly, cheap, easy to produce, and have competitive mechanical properties. However, their integration in the built environment as durable and long-lasting materials is not solved yet..

Turkey Tail · 2023 · Research Article · Pharmaceuticals (Basel, Switzerland)

Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome.

The present study aimed to examine the biological activity and cardioprotective potential of Trametes versicolor heteropolysaccharides (TVH) in a rat model of metabolic syndrome (MetS)..

OncologyEnergy & fatigueMetabolic healthLiver support

Niu-Chang-Chih · 2023 · Journal Article · Natural product research

Chemical investigations and cytotoxic effects of metabolites from Antrodia camphorata against human hepatocellular carcinoma cells.

Antrodia camphorata is used as a medicinal fungus in Taiwan to treat fatigue, food intoxication, and enhance liver function. Here we identified fermented metabolic components from the mycelium of A.

Oyster Mushroom · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Co-Culture of White Rot Fungi Pleurotus ostreatus P5 and Bacillus amyloliquefaciens B2: A Strategy to Enhance Lipopeptide Production and Suppress of Fusarium Wilt of Cucumber.

Fusarium wilt, caused by Fusarium oxysporum f. sp.

Cordyceps · 2023 · Journal Article · International microbiology: the official journal of the Spanish Society for Microbiology

Compositional and functional diversities of core microbial communities in wild and artificial Ophiocordyceps sinensis.

Ophiocordyceps sinensis is an entomogenous fungus, and its wildlife resource is very insufficient, as it is widely traded as a natural health product. The artificial culture of O.

Yellow Morel · 2023 · Journal Article · Journal of the science of food and agriculture

Digestion profile, antioxidant, and antidiabetic capacity of Morchella esculenta exopolysaccharide: in vitro, in vivo and microbiota analysis

BACKGROUND: Novel functional polysaccharides from fungi are important nutraceuticals. An exopolysaccharide, Morchella esculenta exopolysaccharide (MEP 2), was extracted and purified from the fermentation liquor of M.

Yellow Morel · 2023 · Journal Article · Journal of the science of food and agriculture

Digestion profile, antioxidant, and antidiabetic capacity of Morchella esculenta exopolysaccharide: in vitro, in vivo and microbiota analysis.

Immune supportMetabolic healthGut & microbiomeSkin & hydration

Reishi · 2023 · Journal Article · Food & function

Edible and medicinal mushrooms (Pleurotus ostreatus, Ustilago maydis, Ganoderma lucidum) reduce endoplasmic reticulum stress and inflammation in adipose tissue of obese Wistar rats fed with a high fat plus saccharose diet.

Obesity is an increasing global public health problem. A strategy to treat obesity is the use of functional foods.

OncologyImmune supportMetabolic health

Enoki · 2023 · Journal Article · Journal of food science

Effect of Flammulina velutipes polysaccharides on endoplasmic reticulum stress-mediated apoptosis by activating PLC-IP3 pathway in HepG2 cells.

Flammulina velutipes polysaccharides (FVP) have been proven to induce apoptosis in HepG2 cells. It is well known that endoplasmic reticulum stress (ERS) is involved in apoptosis.

Immune supportMetabolic healthGut & microbiomeLiver support

Yellow Morel · 2023 · Journal Article · Food & function

Effect of water-soluble polysaccharides from Morchella esculenta on high-fat diet-induced obese mice: changes in gut microbiota and metabolic functions.

Morchella esculenta polysaccharides exhibit numerous probiotic activities, but their regulatory effects on the gut microbiota are unclear. This study was conducted to explore whether M.

Reishi · 2023 · Research Article · ACS omega

Effects of a Ganoderma lucidum Proteoglycan on Type 2 Diabetic Rats and the Recovery of Rat Pancreatic Islets.

Type 2 diabetes (T2D) results from both insulin resistance and pancreatic β-cell dysfunction. A natural proteoglycan extracted from Ganoderma lucidum, namely, FYGL, has been demonstrated to be capable of ameliorating insulin resistance in previous work..

Enoki · 2023 · Research Article · Food science and biotechnology

Effects of Flammulina velutipes polysaccharides on gut microbiota composition and metabolism in vitro fermentation.

UNLABELLED: Flammulina velutipes polysaccharides (FVP) exhibit many biological activities, but the effects on gut microflora and metabolism were still unclear. Here, we explored the composition of FVP, their influence on human gut microflora composition and metabolites..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2023 · Journal Article · PloS one

Effects of Mexican Ganoderma lucidum extracts on liver, kidney, and the gut microbiota of Wistar rats: A repeated dose oral toxicity study.

Well-characterized and standardized extracts of a Mexican genotype of Ganoderma lucidum (Gl), a medicinal mushroom, cultivated on oak sawdust (Gl-1) or oak sawdust plus acetylsalicylic acid (Gl-2, ASA), have been shown to exert antioxidant, hypocholesterolemic, anti-inflammatory, prebiotic, and anticancer properties..

Immune supportEnergy & fatigueMetabolic health

Snow Fungus · 2023 · Research Article · Ultrasonics sonochemistry

Effects of ultrasonic-enzymatic-assisted ethanol precipitation method on the physicochemical characteristics, antioxidant and hypoglycemic activities of Tremella fuciformis polysaccharides.

This investigation involved the extraction of a novel polysaccharide from the spore fermentation broth of Tremella fuciformis using a method that combined ultrasonic and enzymatic assistance with ethanol precipitation. It was then compared with enzymatic and ultrasonic extraction methods..

Oyster Mushroom · 2023 · Research Article · Open life sciences

Exopolysaccharides from Pseudomonas tolaasii inhibit the growth of Pleurotus ostreatus mycelia.

In the present study, the effect of exopolysaccharides (EPSs) extracted from Pseudomonas tolaasii on the growth of Pleurotus ostreatus mycelia was determined. P.

Immune supportMetabolic healthGut & microbiomeLiver support

Enoki · 2023 · Journal Article · International journal of biological macromolecules

Flammulina velutipes polysaccharides regulate lipid metabolism disorders in HFD-fed mice via bile acids metabolism.

Our recent study demonstrated that the dynamic changes of gut microbiota mediated by Flammulina velutipes polysaccharide (FVP) could effectively regulate the lipid metabolism in high fat diet-fed (HFD-fed) obese mice model..

OncologyImmune supportEnergy & fatigueMetabolic health

Enoki · 2023 · Research Article · Poultry science

Flammulina velutipes stem regulates oxidative damage and synthesis of yolk precursors in aging laying hens by regulating the liver-blood-ovary axis.

Egg production levels in late laying hens are negatively correlated with increasing age. Decreased liver and ovarian function in aging laying hens is accompanied by decreased antioxidant capacity, reproductive hormone levels, and follicular development, resulting in decreased synthesis of yolk precursors..

Agarikon · 2023 · Research Article · Antibiotics (Basel, Switzerland)

Fomitopsis officinalis: Spatial (Pileus and Hymenophore) Metabolomic Variations Affect Functional Components and Biological Activities.

Fomitopsis officinalis is a holartic polyporous mushroom that forms large fruiting bodies on old standing trees, fallen logs, or stumps. F.

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2023 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum polysaccharide peptides GL-PPSQ2 alleviate intestinal ischemia-reperfusion injury via inhibiting cytotoxic neutrophil extracellular traps.

Ganoderma lucidum polysaccharides peptides (GLPP) are the main effective ingredients from G. lucidum (Leyss.

Reishi · 2023 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum polysaccharides improve lipid metabolism against high-fat diet-induced dyslipidemia.

ETHNOPHARMACOLOGICAL RELEVANCE: As a kind of traditional medicinal fungi, Ganoderma lucidum has been employed as folk medicine in China against multiple metabolic diseases on account of its superior bioactivities. Recently, accumulated reports have investigated the protective effects of G..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Lion's Mane · 2023 · Research Article · International journal of molecular sciences

Hericium erinaceus Promotes Anti-Inflammatory Effects and Regulation of Metabolites in an Animal Model of Cerebellar Ataxia.

Cerebellar ataxia is a neurodegenerative disorder with no definitive treatment. Although previous study demonstrated the neuroprotective effects of Hericium erinaceus (H.E.), the mechanisms of H.E.

Metabolic healthGut & microbiome

Enoki · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Heterogeneous Distribution of Phospholipid Molecular Species in the Surface Culture of Flammulina velutipes: New Facts about Lipids Containing α-Linolenic Fatty Acid.

Mycelial fungi grow as colonies consisting of polar growing hyphae, developing radially from spore or inoculum. Over time, the colony develops, hyphae are subject to various exogenous or endogenous stimuli, and mycelium becomes heterogeneous in growth, gene expression, biosynthesis, and secretion of proteins and….

Shiitake · 2023 · Research Article · Frontiers in microbiology

Hydrated lime promoted the polysaccharide content and affected the transcriptomes of Lentinula edodes during brown film formation.

Brown film formation, a unique developmental stage in the life cycle of Lentinula edodes, is essential for the subsequent development of fruiting bodies in L. edodes cultivation.

Oyster Mushroom · 2023 · Research Article · Plants (Basel, Switzerland)

Improving Enzymatic Saccharification of Peach Palm (Bactris gasipaes) Wastes via Biological Pretreatment with Pleurotus ostreatus.

The white-rot fungus Pleurotus ostreatus was used for biological pretreatment of peach palm (Bactris gasipaes) lignocellulosic wastes. Non-treated and treated B.

Immune supportMetabolic healthLiver support

Mesima · 2023 · Research Article · International journal of molecular sciences

Inhibitory Effect of Styrylpyrone Extract of Phellinus linteus on Hepatic Steatosis in HepG2 Cells.

The prevalence of nonalcoholic fatty liver disease (NAFLD) is estimated to be approximately about 25.24% of the population worldwide. NAFLD is a complex syndrome and is characterized by a simple benign hepatocyte steatosis to more severe steatohepatitis in the liver pathology..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Chaga · 2023 · Research Article · Frontiers in nutrition

Inonotus obliquus polysaccharide are linear molecules that alter the abundance and composition of intestinal microbiota in Sprague Dawley rats.

INTRODUCTION: The macromolecular polysaccharide Inonotus obliquus polysaccharide (IOP) is composed of various monosaccharides, and it could modulate the composition and diversity of intestinal flora. However, its impact on the intestinal flora in rats of different genders remains unclear..

Mesima · 2023 · Journal Article · International journal of biological macromolecules

Integrated microbiota and metabolite profiling analysis of prebiotic characteristics of Phellinus linteus polysaccharide in vitro fermentation.

Phellinus linteus polysaccharide (PLP) had received increasing attention due to its multiple biological activities. Herein, the extraction, characterization and in vitro fermentation of PLP were studied to explore its physiochemical properties and the interaction mechanism between the gut microbiota and PLP..