MycoData

Grifola frondosa (GF) is an edible mushroom with hypoglycemic and hypolipidemic effects. In this study, the specific pathogen-free male mice were randomized into the normal (NM), low-dose GF (LGF), medium-dose GF (MGF), and high-dose GF (HGF) groups..

Immune supportMetabolic healthGut & microbiome

High relevance

Turkey Tail · 2023 · Journal Article · Heliyon

Mathematical modeling for operative improvement of the decoloration of Acid Red 27 by a novel microbial consortium of Trametes versicolor and Pseudomonas putida: A multivariate sensitivity analysis

In this work, it is presented a first approach of a mathematical and kinetic analysis for improving the decoloration and further degradation process of an azo dye named acid red 27 (AR27), by means of a novel microbial consortium formed by the fungus Trametes versicolor and the bacterium Pseudomonas putida..

Metabolic health

High relevance

Turkey Tail · 2023 · Research Article · Heliyon

Mathematical modeling for operative improvement of the decoloration of Acid Red 27 by a novel microbial consortium of Trametes versicolor and Pseudomonas putida: A multivariate sensitivity analysis.

Metabolic health

High relevance

Oyster Mushroom · 2023 · Journal Article · Chemistry & biodiversity

Metabolite Profiling of Pleurotus ostreatus Grown on Sisal Agro-Industrial Waste Supplemented with Cocoa Almond Tegument and Wheat Bran.

Pleurotus ostreatus is an edible fungus with high nutritional value that uses industrial and agricultural lignocellulosic residues as substrates for growth and reproduction..

Metabolic health

High relevance

Reishi · 2023 · Journal Article · Applied microbiology and biotechnology

Mitochondrial pyruvate carrier influences ganoderic acid biosynthesis in Ganoderma lucidum.

Mitochondrial pyruvate carriers (MPCs), located in the inner membrane of mitochondria, are essential carriers for pyruvate to enter mitochondria. MPCs regulate a wide range of intracellular metabolic processes, such as glycolysis, the tricarboxylic acid cycle (TCA cycle), fatty acid metabolism, and amino acid….

Energy & fatigueMetabolic health

High relevance

Reishi · 2023 · Research Article · Current research in food science

Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids.

Ganoderma lucidum triterpenoids (GP) have been reported to help prevent and improve hyperlipidemia. Modulation of the gut microbiota was proposed as underlying factor as well as a novel measure to prevent and treat hyperlipidemia..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Shiitake · 2023 · Journal Article · Journal of basic microbiology

Morphological and transcriptomic analysis revealing morphological variations and genetic clues in one Lentinula edodes abnormal browning strain.

Strain abnormal browning is a common problem during cultivation of Lentinula edodes. In this study, the L.

Immune supportMetabolic health

High relevance

Shiitake · 2023 · Journal Article · Applied microbiology and biotechnology

Multi-stage nuclear transcriptomic insights of morphogenesis and biparental role changes in Lentinula edodes.

Based on six offspring with different mitochondrial (M) and parental nuclear (N) genotypes, the multi-stage morphological characteristics and nuclear transcriptomes of Lentinula edodes were compared to investigate morphogenesis mechanisms during cultivation, the key reason for cultivar resistance to genotype changes,….

Energy & fatigueMetabolic health

High relevance

Maitake · 2023 · Research Article · Frontiers in pharmacology

Mushroom polysaccharides from Grifola frondosa (Dicks.) Gray and Inonotus obliquus (Fr.) Pilat ameliorated dextran sulfate sodium-induced colitis in mice by global modulation of systemic metabolism and the gut microbiota.

Introduction: Polysaccharides from Grifola frondosa (Dicks.) Gray (HSH) and Inonotus obliquus (Fr.) Pilat (BHR) showed noticeable effects on dextran sulfate sodium (DSS)-induced colitis, but their systemic modulation effects have not been fully revealed..

Immune supportMetabolic healthGut & microbiome

High relevance

Wood Ear · 2023 · Journal Article · International journal of biological macromolecules

Mycelial biomass and intracellular polysaccharides production, characterization, and activities in Auricularia auricula-judae cultured with different carbon sources.

The carbon source, an essential factor for submerged culture, affects fungal polysaccharides production, structures, and activities. This study investigated the impact of carbon sources, including glucose, fructose, sucrose, and mannose, on mycelial biomass and the production, structural characterization, and….

Immune supportMetabolic health

High relevance

Oyster Mushroom · 2023 · Research Article · Foods (Basel, Switzerland)

Mycoprotein Production by Submerged Fermentation of the Edible Mushroom Pleurotus ostreatus in a Batch Stirred Tank Bioreactor Using Agro-Industrial Hydrolysate.

The demand for cheap, healthy, and sustainable alternative protein sources has turned research interest into microbial proteins. Mycoproteins prevail due to their quite balanced amino acid profile, low carbon footprint and high sustainability potential..

Metabolic health

High relevance

Reishi · 2023 · Research Article · Frontiers in microbiology

Optimization of chemical conditions for metabolites production by Ganoderma lucidum using response surface methodology and investigation of antimicrobial as well as anticancer activities.

Ganoderma lucidum (G. lucidum) is a medicinal mushroom that is known for its ability to produce compounds with physiological effects on human health.

OncologyImmune supportMetabolic health

High relevance

Snow Fungus · 2023 · Research Article · International journal of oncology

Overcharged lipid metabolism in mechanisms of antitumor by Tremella fuciformis‑derived polysaccharide.

Tremella fuciformis‑derived polysaccharide (TFP) is a natural macromolecular compound that is well known for whitening skin, as well as for its ability to regulate lipids and immunity. However, its mechanism of action is not clear..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Chaga · 2023 · Journal Article · Microbial pathogenesis

Polysaccharide from fermented mycelium of Inonotus obliquus attenuates the ulcerative colitis and adjusts the gut microbiota in mice.

Ulcerative colitis (UC) is a disease characterized by chronic inflammation of the colon. Polysaccharides not only have biological activities but also can regulate gut microbiota to alleviate the symptoms of UC..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2023 · Journal Article · Brazilian journal of biology = Revista brasleira de biologia

Production of mycelial biomass, proteases and protease inhibitors by Ganoderma lucidum under different submerged fermentation conditions.

Ganoderma lucidum is a medicinal mushroom widely recognized as a source of biomolecules with pharmacological properties, however, little is known about the factors that influence the synthesis of bioactive proteins by this fungus when cultivated under submerged fermentation..

Metabolic health

High relevance

Reishi · 2023 · Research Article · ACS omega

Proteoglycan Extracted from Ganoderma lucidum Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro.

Muscle atrophy often occurs in type 2 diabetes (T2D) and leads to an increase in physical disability and insulin resistance. However, there are very few studies that have investigated potential natural products used for this condition.

Immune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2023 · Journal Article · International journal of biological macromolecules

Significance of culture period on the physiochemistry and anti-cancer potentials of polysaccharides from mycelia of Ganoderma lucidum.

Ganoderma lucidum polysaccharides (GPS) have many functions. Polysaccharides are abundant in G.

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Snow Fungus · 2023 · Research Article · Foods (Basel, Switzerland)

Structural Characterization and Anti-Inflammatory Activity of Polysaccharides from Tremella fuciformis on Monosodium Urate-Stimulated RAW264.7 Macrophages.

The structural characteristics and anti-inflammatory activity of Tremella fuciformis polysaccharides (TFPs) were investigated. The study showed that TFPs were mainly composed of mannose, rhamnose, glucuronic acid, glucose, galactose, xylose, and fucose..

Immune supportEnergy & fatigueMetabolic health

High relevance

Lion's Mane · 2023 · Journal Article · International journal of biological macromolecules

Structural characterization of Hericium erinaceus polysaccharides and the mechanism of anti-T2DM by modulating the gut microbiota and metabolites.

A low molecular weight polysaccharides of HEP-1, with molecular weights of 1.67 × 104 Da and composition of →6)-β-D-Glcp-(1→, →3)-β-D-Glcp-(1→, β-D-Glcp-(1→ and →3,6)-β-D-Glcp-(1→, was isolated and characterized from the fruiting body of Hericium erinaceus..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Shiitake · 2023 · Journal Article · International journal of biological macromolecules

Structural elucidation and anti-inflammatory activity of a proteoglycan from spent substrate of Lentinula edodes.

A proteoglycan LEPS1 was firstly isolated and purified from the spent substrate of Lentinula edodes, an agricultural waste that may cause environmental pollution..

Immune supportMetabolic health

High relevance

Mesima · 2023 · Research Article · Molecules (Basel, Switzerland)

Study on Extraction, Physicochemical Properties, and Bacterio-Static Activity of Polysaccharides from Phellinus linteus.

We optimized an ultrasound-assisted extraction process of Phellinus linteus mycelium polysaccharides (PLPs) and studied their monosaccharide composition and bacteriostatic properties..

Immune supportMetabolic health

High relevance

Chaga · 2023 · Research Article · Food science & nutrition

Study on the hypolipidemic effect of Inonotus obliquus polysaccharide in hyperlipidemia rats based on the regulation of intestinal flora.

The purpose of this study was to observe the effect of Inonotus obliquus polysaccharide (IOP) on blood lipids and its regulation on the intestinal flora in hyperlipidemia rats, and explore the modern biological connotation of IOP in reducing blood lipids..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Shiitake · 2023 · Research Article · Molecules (Basel, Switzerland)

Synthesis, Characterization and Biological Activities of Zinc Oxide Nanoparticles Derived from Secondary Metabolites of Lentinula edodes.

Zinc oxide nanoparticles (ZnO NPs) are the second most prevalent metal oxide, owing to their characteristics of low cost, safe, and easily prepared. ZnO NPs have been found to exhibit unique properties which show their potential to be used in various therapies..

Immune supportMetabolic health

High relevance

Reishi · 2023 · Journal Article · World J Microbiol Biotechnol

The key technologies of Ganoderma lucidum liquid spawn preparation and scale expansion

Ganoderma lucidum possesses a variety of valuable pharmacological activities, and it has long been used to prevent and treat various human diseases. Up to now, far too little attention has been paid to the liquid spawn of G.

Metabolic health

High relevance

Reishi · 2023 · Journal Article · World journal of microbiology & biotechnology

The key technologies of Ganoderma lucidum liquid spawn preparation and scale expansion.

Metabolic health

High relevance

Shiitake · 2023 · Research Article · Food science and biotechnology

The physicochemical, antioxidant, hypoglycemic and prebiotic properties of γ-irradiated polysaccharides extracted from Lentinula edodes.

UNLABELLED: In this study, the influence of γ-irradiation with different dose (0, 4, 8, and 16 kGy) on chemical composition, physicochemical features and bioactivities of polysaccharides extracted from Lentinula edodes (LEP) were investigated..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2023 · Journal Article · Journal of ethnopharmacology

Toxicogenic effects of the mushroom Ganoderma lucidum on human liver and kidney tumor cells and peripheral blood lymphocytes.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Curtis) P. Karst., a bioactive mushroom with medicinal properties, is known to exert immunomodulatory, anti-inflammatory, hypocholesterolemic, hypoglycemic, and hepatoprotective effects.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Oyster Mushroom · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Transcriptome Analysis Revealed That Hydrogen Peroxide-Regulated Oxidative Phosphorylation Plays an Important Role in the Formation of Pleurotus ostreatus Cap Color.

Pleurotus ostreatus is widely cultivated in China. H2O2, as a signaling molecule, can regulate the formation of cap color, but its regulatory pathway is still unclear, severely inhibiting the breeding of dark-colored strains.

Metabolic healthRespiratory

High relevance

Shiitake · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Two Strains of Lentinula edodes Differ in Their Transcriptional and Metabolic Patterns and Respond Differently to Thermostress.

Temperature type is one of the key traits determining the cultivation regime of Lentinula edodes. However, the molecular and metabolic basis underling temperature type remain unclear.

Metabolic health

High relevance

Cordyceps · 2023 · Research Article · Medicine

Uncovering anti-influenza mechanism of Ophiocordyceps sinensis using network pharmacology, molecular pharmacology, and metabolomics.

Ophiocordyceps sinensis is a precious Chinese traditional herb with a long medicinal history. This study used UPLC-MS metabolomics to explore and compare the metabolic profiles of the stroma (OSBSz), sclerotium (OSBSh), and mycelium (OSBS) of O sinensis to analyze their differential metabolites and identified….

Metabolic healthRespiratory

High relevance

Oyster Mushroom · 2023 · Journal Article · Journal of environmental management

Use of oyster mushrooms (Pleurotus ostreatus) for increased circularity and valorization of rapeseed residues.

In Europe, rapeseed is a common oilseed crop, resulting in the production of 20 million tons of rapeseed press cake yearly. This press cake can be further upcycled and a protein fraction can be extracted for food purposes, leaving de-proteinized fiber-rich residues..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Turkey Tail · 2023 · Journal Article · Journal of biotechnology

Yellow laccase produced by Trametes versicolor K1 on tomato waste: A comparative study with the blue one produced on semi-synthetic medium.

Laccase production by fungal growth on agrifood waste is still poorly studied. Trametes versicolor K1 isolated from palm bark produced a yellow non glycosylated laccase from tomato waste based medium (TMT) and a blue glycosylated laccase on glucose medium (GLU)..

Metabolic health

High relevance

Maitake · 2022 · Journal Article · International journal of biological macromolecules

A cold-water polysaccharide-protein complex from Grifola frondosa exhibited antiproliferative activity via mitochondrial apoptotic and Fas/FasL pathways in HepG2 cells.

Grifola frondosa (G. frondosa) is widely known for its anti-tumor potential, which has been demonstrated by numerous scientific researches.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Niu-Chang-Chih · 2022 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

A network pharmacology-based strategy to explore the pharmacological mechanisms of Antrodia camphorata and antcin K for treating type II diabetes mellitus.

BACKGROUND: Diabetes mellitus is a chronic carbohydrate metabolism disorder, which could develop a series of complications and thus lead to poor quality of life or even mortality. Antrodia camphorata is a rare parasitic fungus and has been proven to be effective for treating type II diabetes..

Immune supportMetabolic health

High relevance

Chaga · 2022 · Journal Article · International journal of biological macromolecules

A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus.

Type 2 diabetes mellitus is a global disease that endangers human health, and the need for the development of nontoxic treatment candidates is urgent. In the present work, one homogeneous polysaccharide from Inonotus obliquus (IN) was isolated, and the protective effect and mechanism of IN on type 2 diabetes mellitus….

Immune supportMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2022 · Research Article · Polymers

Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid-Rich Polysaccharides Derived from Tremella fuciformis.

Obesity is rapidly becoming an emerging disease in developing countries due to the Westernization of societies and lifestyle changes. This study evaluated the ameliorative effect of acidic heteropolysaccharides derived from Tremella fuciformis (TFPS) on high-fat diet (HFD; 34.9% fat)-induced obesity in mice..

Immune supportMetabolic healthGut & microbiome

High relevance

Chaga · 2022 · Journal Article · Nutricion hospitalaria

Anti-diabetic eﬀects of Inonotus obliquus extract in high fat diet combined streptozotocin-induced type 2 diabetic mice.

Introduction: type 2 diabetes (T2DM) is a complex disease affected by lifestyle and genetic factors. Although the drugs currently used to treat T2DM have certain curative effects, they still have some adverse side effects.

Metabolic healthLiver support

High relevance

Reishi · 2022 · Research Article · Molecules (Basel, Switzerland)

Autotoxicity of Endogenous Organic Acid Stress in Two Ganoderma lucidum Cultivars.

Ganoderma lucidum has been used as a rare medical mushroom for centuries in China, due to its health-promoting properties. Successive cropping obstacles are common in the cultivation of G.

Energy & fatigueMetabolic health

High relevance

Turkey Tail · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

Bioactivity of Biomass and Crude Exopolysaccharides Obtained by Controlled Submerged Cultivation of Medicinal Mushroom Trametes versicolor.

The aim of this study is to characterize the bioactivity of mycelial biomass and crude exopolysaccharides (EPS) produced by Trametes versicolor NBIMCC 8939 and to reveal its nutraceutical potential. The EPS (1.58 g/L) were isolated from a culture broth..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2022 · Journal Article · Frontiers in bioengineering and biotechnology

Bioreactor-grown exo- and endo-β-glucan from Malaysian Ganoderma lucidum: An in vitro and in vivo study for potential antidiabetic treatment.

This study aims to identify the roles of exo-β-glucan (EPS-BG) and endo-β-glucan (ENS-BG) extracted from Ganoderma lucidum (GL) in inhibiting the alpha-glucosidase enzyme, a target mechanism for postprandial hyperglycaemia regulation. Upscale production of GL was carried out using a 10 L bioreactor..

Metabolic health

High relevance

Turkey Tail · 2022 · Journal Article · Water environment research: a research publication of the Water Environment Federation

Bioremediation of bisphenol A found in industrial wastewater using Trametes versicolor (TV) laccase nanoemulsion-based bead organogel in packed bed reactor.

Bisphenol A (BPA) is one of the toxic chemicals, which is widely used for manufacturing epoxy, polyester resin, and polycarbonates. These materials are extensively used in manufacturing of reusable bottles, baby bottles, dental sealants, various medical devices, and so forth..

Immune supportEnergy & fatigueMetabolic health

High relevance

Yellow Morel · 2022 · Journal Article · Carbohydrate polymers

Characterization and immunomodulatory effect of an alkali-extracted galactomannan from Morchella esculenta

In our continuous exploration for bioactive polysaccharides, a novel polysaccharide FMP-2 was isolated and purified from the fruiting bodies of Morchella esculenta by alkali-assisted extraction..

Immune supportMetabolic health

High relevance

Yellow Morel · 2022 · Journal Article · Carbohydrate polymers

Characterization and immunomodulatory effect of an alkali-extracted galactomannan from Morchella esculenta.

In our continuous exploration for bioactive polysaccharides, a novel polysaccharide FMP-2 was isolated and purified from the fruiting bodies of Morchella esculenta by alkali-assisted extraction..

Immune supportMetabolic health

High relevance

Reishi · 2022 · Journal Article · ACS omega

Characterization of γ-Cadinene Enzymes in Ganoderma lucidum and Ganoderma sinensis from Basidiomycetes Provides Insight into the Identification of Terpenoid Synthases.

Enzymes boost protein engineering, directed evolution, and the biochemical industry and are also the cornerstone of metabolic engineering. Basidiomycetes are known to produce a large variety of terpenoids with unique structures.

Metabolic health

High relevance

Shiitake · 2022 · Journal Article · Journal of basic microbiology

Cloning and characterization of phosphoglucose isomerase in Lentinula edodes.

Phosphoglucose isomerase (PGI) is a key enzyme that participates in polysaccharide synthesis, which is responsible for the interconversion of glucose-6-phosphate (G-6-P) and fructose-6-phosphate (F-6-P), but there is little research focusing on its role in fungi, especially in higher basidiomycetes..

Immune supportMetabolic health

High relevance

Cordyceps · 2022 · Research Article · Molecules (Basel, Switzerland)

Comparison of Widely Targeted Metabolomics and Untargeted Metabolomics of Wild Ophiocordyceps sinensis.

The authors of this paper conducted a comparative metabolomic analysis of Ophiocordyceps sinensis (OS), providing the metabolic profiles of the stroma (OSBSz) and sclerotia (OSBSh) of OS by widely targeted metabolomics and untargeted metabolomics..

Metabolic health

High relevance

Chaga · 2022 · Research Article · Nutrients

Effect of Inonotus obliquus Extract Supplementation on Endurance Exercise and Energy-Consuming Processes through Lipid Transport in Mice.

Inonotus obliquus (IO) is used as functional food to treat diabetes. This study investigated the effect of IO supplementation on body composition in relation to changes in energy expenditure and exercise performance..

OncologyEnergy & fatigueMetabolic health

High relevance

Snow Fungus · 2022 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Effect of surfactants on the production and biofunction of Tremella fuciformis polysaccharide through submerged fermentation

Tremella fuciformis polysaccharide (TFPS) have been widely used in the fields of food and medicine due to their multiple functions. submerged cultivation of mushroom is viewed as a promising alternative for efficient production of TFPS..

Immune supportMetabolic health

High relevance

Reishi · 2022 · Journal Article · BioMed research international

Effects and Mechanism of Ganoderma lucidum Polysaccharides in the Treatment of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats.

Ganoderma lucidum polysaccharides (GLP) have renal protection effect but there was no study on the diabetic nephropathy. This study was designed to investigate its effect and mechanism using a diabetic rat model induced by streptozotocin (50 mg/kg, i.p.)..

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2022 · Journal Article · International journal of medicinal mushrooms

Efficacy of Aqueous Extract of Chinese Caterpillar Mushroom Ophiocordyceps sinensis (Ascomycota) Against Simulated Altitude Stress and Subacute Toxicity Studies.

Exposure to high altitude severely impacts performance of unacclimatized individuals and contraindications associated with synthetic drugs ascertain the need for development of herbal drugs..

Immune supportEnergy & fatigueMetabolic health