MycoData

Immune supportCognition & nervesEnergy & fatigue

Reishi · 2025 · Research Article · Frontiers in chemistry

Non-destructive analysis of Ganoderma lucidum composition using hyperspectral imaging and machine learning.

BACKGROUND: Ganoderma lucidum is a widely used medicinal fungus whose quality is influenced by various factors, making traditional chemical detection methods complex and economically challenging..

Cognition & nervesEnergy & fatigueMetabolic healthGut & microbiome

King Oyster · 2025 · Research Article · Foods (Basel, Switzerland)

Production and Optimization of Anti-Aging Peptides from Pleurotus eryngii Mushroom Feet: Mechanistic Insights via Integrated Transcriptomics and Metabolomics.

This study established an optimized process for obtaining anti-aging peptides from Pleurotus eryngii mushroom feet (PEMFPeps). Using response surface methodology, high yields of protein (51.31 ± 3.00%) and peptides (48.71 ± 0.17% hydrolysis degree) were achieved..

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2025 · Review · Natural product research

Reishi Mushroom (Ganoderma lucidum): pharmacology of a potent healer in traditional Chinese medicine.

Reishi mushroom, also known as Lingzhi or Ganoderma lucidum, is a widely studied macrofungus in Traditional Chinese Medicine, revered for over two millennia in Asia..

Reishi · 2025 · Research Article · Frontiers in pharmacology

Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation.

INTRODUCTION: Sporoderm-Removed Ganoderma lucidum Spore Powder (S-GLSP), derived from the spores of the medically valued fungus Ganoderma lucidum, exhibits diverse pharmacological activities and shows considerable potential in the treatment of Alzheimer's disease (AD)..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Structural characteristics of a heteropolysaccharide from Ganoderma lucidum and its protective effect against Alzheimer's disease via modulating the microbiota-gut-metabolomics.

Ganoderma lucidum is a traditional Chinese medicine used to treat Alzheimer's disease (AD), whose main active ingredient is polysaccharides. A heteropolysaccharide named GLPZ-1 was isolated from Ganoderma lucidum.

OncologyCognition & nervesGut & microbiomeSkin & hydration

Reishi · 2025 · Research Article · Discover oncology

Systematic network pharmacology and experimental validation reveal anti-glioma mechanisms of ganoderma lucidum via multi-target regulation.

BACKGROUND: Glioma is the most common and lethal primary brain tumor with limited therapeutic options and poor prognosis. Traditional Chinese medicine (TCM) offers a promising avenue for discovering multi-target agents against complex diseases..

Reishi · 2025 · Research Article · Scientific reports

The protecting role of Ganoderma lucidum polysaccharides on the retinal neurovascular units in rats with retinal ischemia-reperfusion injury.

This study investigates the protective mechanisms of Ganoderma lucidum polysaccharides (GLP) on retinal neurovascular units (NVUs) in a rat model of retinal ischemia-reperfusion injury (RIR), focusing on oxidative stress, glial activation, vascular dysfunction, and functional recovery..

OncologyImmune supportCognition & nervesSkin & hydration

Reishi · 2025 · Review · 3 Biotech

Unlocking the therapeutic potential of bioactive compounds in Ganoderma lucidum: a new frontier in natural medicine.

Ganoderma lucidum (Reishi), a valued medicinal fungus used in traditional medicine for over 2000 years, has sparked widespread scientific attention due to its extensive range of bioactive ingredients and therapeutic promise in modern medicine. This study presents a detailed and up-to-date examination of G..

Lion's Mane · 2025 · Review · Frontiers in pharmacology

Unveiling the role of erinacines in the neuroprotective effects of Hericium erinaceus: a systematic review in preclinical models.

The medicinal mushroom lion's mane (Hericium erinaceus) is suggested to have therapeutic potential for neurological disorders due to its neuroprotective and neurotrophic properties. Mycelia of H..

Lion's Mane · 2025 · Research Article · International journal of molecular sciences

Yamabushitake Mushroom (Hericium erinaceus (Bull.) Pers. 1797) Mycelium Improves Reproductive System Dysfunction in Male Rats Induced by Polystyrene Microplastics.

The use of plastic products has increased, leading to higher levels of plastic pollution, and it is becoming a major public health concern. Health risks-especially those related to reproductive system dysfunction caused by polystyrene microplastics (PS-MPs)-are emerging issues that require urgent attention..

Immune supportCognition & nervesMetabolic healthRespiratory

Cordyceps · 2024 · Research Article · Heliyon

Adjuvant activity of cordycepin, a natural derivative of adenosine from Cordyceps militaris, on an inactivated rabies vaccine in an animal model.

Vaccination is the most feasible way of preventing rabies, an ancient zoonosis that remains a major public health concern globally. However, administration of inactivated rabies vaccination without adjuvants is always inefficient and necessitates four to five injections..

Immune supportCognition & nervesLiver supportSkin & hydration

King Oyster · 2024 · Journal Article · International journal of biological macromolecules

Antibacterial and hemostatic chitin sponge directly constructed from Pleurotus Eryngii via top-down approach.

Chitin, the second most abundant polysaccharide on earth, possesses unique characteristics, including biosafety, biodegradability, and procoagulant activity, making it an attractive material for hemostasis. However, the conventional bottom-up construction of chitin-based materials is intricate and time-consuming..

Cordyceps · 2024 · Research Article · Pharmaceuticals (Basel, Switzerland)

Coffee with Cordyceps militaris and Hericium erinaceus Fruiting Bodies as a Source of Essential Bioactive Substances.

Drinking coffee is a daily routine for many people. Supplement manufacturers have proposed adding powdered Cordyceps militaris, known for its ergogenic and immunostimulating properties, and Hericium erinaceus, known for its nerve growth factor (NGF)-stimulating properties, to coffee..

Lion's Mane · 2024 · Research Article · ACS omega

Combining Deep Learning and Structural Modeling to Identify Potential Acetylcholinesterase Inhibitors from Hericium erinaceus.

Alzheimer's disease (AD) is the most common type of dementia, affecting over 50 million people worldwide. Currently, most approved medications for AD inhibit the activity of acetylcholinesterase (AChE), but these treatments often come with harmful side effects..

Cognition & nervesGut & microbiome

Niu-Chang-Chih · 2024 · Review · Frontiers in pharmacology

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders.

Prevalent neurological disorders such as Alzheimer's disease, Parkinson's disease, and stroke are increasingly becoming a global burden as society ages. It is well-known that degeneration and loss of neurons are the fundamental underlying processes, but there are still no effective therapies for these neurological….

Cordyceps · 2024 · Research Article · Metabolites

Effects of Different Drying Methods on Amino Acid Metabolite Content and Quality of Ophiocordyceps sinensis by LC-MS/MS Combined with Multivariate Statistical Methods.

Ophiocordyceps sinensis, a medicinal fungus utilized in traditional Chinese medicine, exhibits a range of biological activities and pharmacological functions. In this study, we determined the amino acid composition of 94 amino acids in Ophiocordyceps sinensis using liquid chromatography-tandem mass spectrometry….

Reishi · 2024 · Randomized Controlled Trial · International journal of medicinal mushrooms

Efficacy of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Supplementation on Psychological Stress and Selective Fitness Profile Parameters in Female College Students in West Bengal, India.

Psychological disparities impact physical activity and fitness in sedentary female college students by affecting cardiovascular efficiency. Ganoderma lucidum, vitality-enhancing herb alleviates health and rejuvenates the mind-body to improve endurance fitness..

Oyster Mushroom · 2024 · Research Article · Current issues in molecular biology

Evaluation of the Influence of Varied Juncao Grass Substrates on Physiological and Enzymatic Reactions of Pleurotus ostreatus.

Pleurotus ostreutus is one of the world's most commonly consumed mushrooms. The cultivation of mushrooms using wood resources usually results in environmental issues such as deforestation..

Cordyceps · 2024 · Research Article · International journal of molecular sciences

Expanded Gene Regulatory Network Reveals Potential Light-Responsive Transcription Factors and Target Genes in Cordyceps militaris.

Cordyceps militaris, a fungus widely used in traditional Chinese medicine and pharmacology, is recognized for its abundant bioactive compounds, including cordycepin and carotenoids..

Reishi · 2024 · Research Article · Frontiers in pharmacology

Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease.

Introduction: Ganoderma lucidum (G. lucidum, Lingzhi) has long been listed as a premium tonic that can be used to improve restlessness, insomnia, and forgetfulness..

Lion's Mane · 2024 · Research Article · Molecules (Basel, Switzerland)

Identification and Reconstitution of the First Two Enzymatic Steps for the Biosynthesis of Bioactive Meroterpenoids from Hericium erinaceus (Lion's Mane Mushroom).

Hericium erinaceus (Lion's Mane mushroom) is widely consumed for its numerous reported benefits for brain health. A growing body of evidence suggests that these benefits are likely attributable to aromatic compounds contained in its fruiting bodies, including the meroterpenoids hericenones..

Cognition & nervesEnergy & fatigueSkin & hydration

Reishi · 2024 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Integrating convolutional neural networks with UV–Vis spectroscopy for monitoring the extraction procedure of Ganoderma lucidum spore powder

The rise of Ganoderma lucidum spores as a nutraceutical is gaining sharp acceptance and popularity. Aqueous extraction is the primary means of obtaining phytochemicals from the spores..

Shiitake · 2024 · Research Article · Foods (Basel, Switzerland)

Machine Learning Models to Classify Shiitake Mushrooms (Lentinula edodes) According to Their Geographical Origin Labeling.

The shiitake mushroom has gained popularity in the last decade, ranking second in the world for mushrooms consumed, providing consumers with a wide variety of nutritional and healthy benefits. It is often not clear the origin of these mushrooms, so it becomes of great importance to the consumers..

Reishi · 2024 · Research Article · Frontiers in pharmacology

Sporoderm-removed Ganoderma lucidum spores ameliorated early depression-like behavior in a rat model of sporadic Alzheimer's disease.

Introduction: Ganoderma lucidum: (G. lucidum, Lingzhi) is a medicinal and edible homologous traditional Chinese medicine that is used to treat various diseases, including Alzheimer's disease and mood disorders.

Cognition & nervesEnergy & fatigueLiver support

Reishi · 2024 · Research Article · Heliyon

The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts.

AIMS: This study aims to delve into the anti-fatigue and sleep-aiding effects of various formulations containing Ganoderma lucidum extracts. MATERIALS AND METHODS: PGB [incorporating Ganoderma lucidum extract (GE), broken Ganoderma lucidum spore powder (GB) and Paecilomyces hepiali mycelium (PH)] and GBS [composed of….

Reishi · 2024 · Review · Molecules (Basel, Switzerland)

The Biological Activity of Ganoderma lucidum on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks.

Neurodegenerative diseases represent a cluster of conditions characterized by the progressive degeneration of the structure and function of the nervous system. Despite significant advancements in understanding these diseases, therapeutic options remain limited..

OncologyImmune supportCognition & nervesLiver support

Reishi · 2023 · Review · International journal of biological macromolecules

A novel promising neuroprotective agent: Ganoderma lucidum polysaccharide.

Nervous system diseases (NSDs) are characterized by a wide range of symptoms, a complex pathophysiology, an unclear etiology, a great deal of variation in treatment response, and lengthy therapy cycles, all of which pose considerable hurdles to clinical treatment..

Maitake · 2023 · Review · International journal of medicinal mushrooms

Maitake Medicinal Mushroom, Grifola frondosa (Agaricomycetes), and Its Neurotrophic Properties: A Mini-Review.

Neurodegeneration is one of the most common manifestations in an aging population. The occurrence of oxidative stress and neuroinflammation are the main contributors to the phenomenon..

Reishi · 2023 · Review · Medicinal research reviews

Neuroprotective, neurogenic, and anticholinergic evidence of Ganoderma lucidum cognitive effects: Crucial knowledge is still lacking.

Ganoderma lucidum is a mushroom that has been widely used for centuries in Asian countries for its antiaging properties. It is popularly known as "Ling Zhi," "Reishi," and "Youngzhi," and because of its benefits, it is known as the "immortality mushroom." Pharmacological assays have revealed that G..

Lion's Mane · 2023 · Randomized Controlled Trial · Nutrients

The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study.

BACKGROUND: Given the bioactive properties and limited work to date, Hericium erinaceus (Lion's mane) shows promise in improving cognitive function and mood. However, much of the human research has concentrated on chronic supplementation in cognitively compromised cohorts..

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2022 · Review · Frontiers in pharmacology

Ganoderma lucidum: Unutilized natural medicine and promising future solution to emerging diseases in Africa.

Ganoderma lucidum is a well-known medicinal mushroom that has been used for the prevention and treatment of different ailments to enhance longevity and health specifically in China, Japan, and Korea..

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2022 · Review · The American journal of Chinese medicine

The Pharmacological Rationales and Molecular Mechanisms of Ganoderma lucidum Polysaccharides for the Therapeutic Applications of Multiple Diseases.

As a versatile Chinese herb, Ganoderma lucidum (Leyss. ex Fr.) Karst (G.

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2021 · Review · Phytotherapy research: PTR

Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties.

Reishi owes an exceptional value in nutritional, cosmeceutical, and medical treatments; however, none of the studies has provided its future-driven critical assessment..

Immune supportCognition & nervesMetabolic health

Reishi · 2021 · Review Article · Nutrients

Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum.

Medicinal mushrooms are rich sources of pharmacologically active compounds. One of the mushrooms commonly used in traditional Chinese medicine is Ganoderma lucidum (Leyss.

Cordyceps · 2017 · Randomized Controlled Trial · International journal of medicinal mushrooms

Clinical Effects of a Commercial Supplement of Ophiocordyceps sinensis and Ganoderma lucidum on Cognitive Function of Healthy Young Volunteers.

Ophiocordyceps sinensis (= Cordyceps sinensis) and Ganoderma lucidum are medicinal mushrooms used in traditional Chinese medicine. The effects of O.

Maitake · 2009 · Randomized Controlled Trial · Journal of cancer research and clinical oncology

A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects.

BACKGROUND: Cancer patients commonly use dietary supplements to "boost immune function". A polysaccharide extract from Grifola frondosa (Maitake extract) showed immunomodulatory effects in preclinical studies and therefore the potential for clinical use..

Lion's Mane · 2009 · Randomized Controlled Trial · Phytotherapy research: PTR

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.

A double-blind, parallel-group, placebo-controlled trial was performed on 50- to 80-year-old Japanese men and women diagnosed with mild cognitive impairment in order to examine the efficacy of oral administration of Yamabushitake (Hericium erinaceus), an edible mushroom, for improving cognitive impairment, using a….

Lion's Mane · 2026 · Review · International journal of molecular sciences

Beyond Neurotrophins: A Proposed Neurotrophic-Epigenetic Axis Mediated by Non-Coding RNA Networks for Hericium erinaceus Bioactives-A Hypothesis-Driven Review.

Hericium erinaceus (H. erinaceus), a medicinal mushroom, is a source of bioactive compounds with demonstrated neuroprotective potential.

Reishi · 2026 · Review · Frontiers in microbiology

Biocontrol strategies for fungal diseases of Ganoderma lucidum: from antagonistic microbes and synthetic communities to intelligent technologies.

Ganoderma lucidum, a rare macrofungus renowned for its substantial medicinal and economic significance, is increasingly at risk from various pathogenic fungi, such as Neurospora sitophila, Trichoderma spp., and Fusarium graminearum, particularly during extensive cultivation processes..

Immune supportCognition & nervesGut & microbiome

Reishi · 2026 · Review · International journal of biological macromolecules

Ganoderma lucidum polysaccharides target the gut-brain axis: Unveiling a novel mechanism for ameliorating aging-induced cognitive impairment and oxidative stress.

With the rapid progression of global population aging, the incidence of cognitive dysfunction-related disorders is steadily increasing. In recent years, growing attention has been directed toward the interaction between the gut microbiota and the central nervous system (CNS)..

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2026 · Scoping Review · Chemistry & biodiversity

Hericenones From Hericium erinaceus (Bull.) Pers.: A Scoping Review of Structural Diversity and Health Benefits.

Hericium erinaceus (Bull.) Pers., an edible and medicinal mushroom, has garnered significant scientific interest due to its rich array of bioactive compounds. Extensive research has highlighted the pharmacological properties of its constituents, including neuroprotective, neurotrophic, immunomodulatory, and anticancer….

OncologyImmune supportCognition & nervesGut & microbiome

Lion's Mane · 2025 · Review · International journal of biological macromolecules

Extraction, purification, structural characteristics, biological activities, modifications, and applications from Hericium erinaceus polysaccharides: A review.

Hericium erinaceus (Bull.) Pers. is a respected medicinal and edible fungus known for its outstanding nutritional profile.

Lion's Mane · 2025 · Review · Nutrition research reviews

Hericium erinaceus: A possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease? - A narrative review.

At present, the treatment of Alzheimer's disease involves only symptomatic medications which have continually demonstrated little efficacy, primarily due to the presence of biological barriers..

Immune supportCognition & nervesGut & microbiomeLiver support

Lion's Mane · 2025 · Review · International journal of biological macromolecules

Recent insights into Hericium erinaceus polysaccharides: Gastrointestinal, gut microbiota, microbial metabolites, overall health and structure-function correlation.

Hericium erinaceus polysaccharides (HEPs) have attracted significant interest due to their potential to support gastrointestinal health and modulate gut microbiota..

OncologyImmune supportCognition & nervesMetabolic health

Snow Fungus · 2025 · Review · Journal of food science

Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review.

Tremella fuciformis (TF) is a valuable edible fungus rich in various nutrients, with TF polysaccharide (TFP) as its primary bioactive component. Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory-enhancing, anti-inflammatory,….

Immune supportCognition & nervesGut & microbiome

Lion's Mane · 2025 · Review · Psychopharmacology bulletin

Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant Schizophrenia.

Schizophrenia is a serious mental illness that is a leading cause of disability worldwide. While antipsychotic agents are the most effective medications, up to one-third of patients experience treatment resistance, and approximately one-sixth of patients experience ultra-resistant illness..

Reishi · 2025 · Review · Chinese herbal medicines

Unraveling bioactive potential and production in Ganoderma lucidum through omics and machine learning modeling.

Ganoderma lucidum, a medicinal mushroom renowned for its production of a diverse array of compounds, accounts for the pharmacological effects including anti-inflammatory, antioxidant, immunomodulatory, and anticancer characteristics..

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2024 · Review · Chinese herbal medicines

Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review.

Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. G.