MycoData

Oyster Mushroom · 2024 · Research Article · Food science and biotechnology

Effect of steam cooking and particle size on the nutritional composition, phytochemicals and antioxidant activities of oyster mushroom (Pleurotus ostreatus) powder.

In this study raw and steamed Pleurotus ostreatus were dried and ground and fractionated by sieving into four granulometric classes ( 355 µm) and unsieved powders..

Gut & microbiomeLiver support

Oyster Mushroom · 2024 · Research Article · Animals: an open access journal from MDPI

Effects of Spent Substrate of Oyster Mushroom (Pleurotus ostreatus) on Feed Utilization and Liver Serum Indices of Hu Sheep from the Perspective of Duodenal Microorganisms.

This study aimed to evaluate the effects of Pleurotus ostreatus spent mushroom substrate (P.SMS), which is characterized by high production but low utilization, on feed utilization and liver serum indices from the perspective of duodenal microorganisms..

Cordyceps · 2024 · Research Article · Scientific reports

Enhancing cancer immunotherapy using cordycepin and Cordyceps militaris extract to sensitize cancer cells and modulate immune responses.

Integrating immunotherapy with natural compounds holds promise in enhancing the immune system's ability to eliminate cancer cells. Cordyceps militaris, a traditional Chinese medicine, emerges as a promising candidate in this regard.

Metabolic healthGut & microbiomeLiver support

Enoki · 2024 · Research Article · Foods (Basel, Switzerland)

Enhancing the Hypolipidemic and Functional Properties of Flammulina velutipes Root Dietary Fiber via Steam Explosion.

Flammulina velutipes is an edible mushroom widely cultivated in China. As a by-product of Flammulina velutipes, the roots are rich in high-quality dietary fiber (DF)..

Oyster Mushroom · 2024 · Research Article · Foods (Basel, Switzerland)

Exploring Therapeutic Potential of Pleurotus ostreatus and Agaricus bisporus Mushrooms against Hyperlipidemia and Oxidative Stress Using Animal Model.

The mushrooms oyster (Pleurotus ostreatus) and white button (Agaricus bisporus) contain bioactive compounds that have potential beneficial effects on hypercholesterolemia and cardiovascular diseases..

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2024 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum ethanol extracts ameliorate hepatic fibrosis and promote the communication between metabolites and gut microbiota g_Ruminococcus through the NF-κB and TGF-β1/Smads pathways.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum, a traditional edible medicinal mushroom, has been widely reported to improve liver diseases as a dietary intervention for people..

Reishi · 2024 · Research Article · Heliyon

Ganoderma lucidum polysaccharides reduce the severity of acute liver injury by improving the diversity and function of the gut microbiota.

Acute liver injury (ALI) is an abnormal liver function caused by oxidative stress, inflammation and other mechanisms.The interaction between intestine and liver plays an important role in ALI, and natural polysaccharides can participate in the regulation of ALI by regulating the composition of intestinal flora..

Oyster Mushroom · 2024 · Randomized Controlled Trial, Veterinary · Tropical animal health and production

Low dietary oyster mushroom spent substrate limitedly ameliorates detrimental effects of feeding combined marula seed cake and mucuna seed meal as soya bean replacements in broiler chickens.

This study investigated ameliorative effects of dietary oyster mushroom (Pleurotus ostreatus) spent substrate (OMSS) in broiler chickens fed diets supplemented with combined marula seed cake (MSC) and mucuna seed meal (MSM) replacing soya bean meal (SBM)..

OncologyImmune supportMetabolic healthLiver support

Turkey Tail · 2024 · Journal Article · South African journal of botany

Medicinal potential of Turkey tail mushroom (Trametes versicolor): A comprehensive review

Medicinal mushroom are known for their therapeutic capabilities and one such notable example is the Turkey tail mushroom (Trametes versicolor). This fascinating medicinal fungus, belonging to the genusTrametes that has been in used for centuries in traditional medicine systems, particularly in Asia..

Immune supportMetabolic healthGut & microbiomeLiver support

King Oyster · 2024 · Journal Article · International journal of biological macromolecules

Pleurotus eryngii polysaccharides alleviate aflatoxin B1-induced liver inflammation in ducks involving in remodeling gut microbiota and regulating SCFAs transport via the gut-liver axis.

Aflatoxin B1 (AFB1) is one of the most widespread contaminants in agricultural commodities. Pleurotus eryngii (PE) is widely used as a feed additive for its anti-inflammatory properties, and its major active substance is believed to be polysaccharides..

OncologyImmune supportGut & microbiomeLiver support

Reishi · 2024 · Research Article · Molecules (Basel, Switzerland)

Structure Identification of Ganoderma lucidum Spore Polysaccharides and Their Antitumor Activity In Vivo.

Ganoderma lucidum spore powder, valued for its nutritional and medicinal properties, contains polysaccharides crucial for its efficacy. However, the complex structural nature of these polysaccharides necessitates further investigation to fully realize their potential..

Cognition & nervesEnergy & fatigueLiver support

Reishi · 2024 · Research Article · Heliyon

The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts.

AIMS: This study aims to delve into the anti-fatigue and sleep-aiding effects of various formulations containing Ganoderma lucidum extracts. MATERIALS AND METHODS: PGB [incorporating Ganoderma lucidum extract (GE), broken Ganoderma lucidum spore powder (GB) and Paecilomyces hepiali mycelium (PH)] and GBS [composed of….

Immune supportLiver supportRespiratory

Reishi · 2024 · Research Article · Toxics

The Protective Effects of Ganoderma lucidum Active Peptide GLP4 on Lung Injury Induced by Cadmium Poisoning in Mice.

Ganoderma triterpenes and spore powder have shown promising results in mitigating cadmium-induced renal and hepatic injuries. Ganoderma lucidum active peptide GLP4 is a natural protein with dual antioxidant activities derived from the mycelium of Ganoderma lucidum..

OncologyImmune supportMetabolic healthLiver support

Shiitake · 2024 · Journal Article · Trends in food science & technology

Therapeutic values and nutraceutical properties of shiitake mushroom (Lentinula edodes): A review

Mushrooms are generally regarded as useful products with multiple applications in the food and health industry. Shiitake (Lentinula edodes) is one of the most cultured and consumed mushrooms around the world..

Snow Fungus · 2024 · Journal Article · Advances in clinical and experimental medicine: official organ Wroclaw Medical University

Transcriptome analysis of immune-inflammatory regulation in Tremella fuciformis-derived polysaccharide reeducated B16 cells: A subcutaneous model.

BACKGROUND: Circulating cancer cells have characteristics of tumor self-targeting. Modified circulating tumor cells may serve as tumor-targeted cellular drugs.

Immune supportLiver support

Cordyceps · 2024 · Research Article · Animals: an open access journal from MDPI

Transcriptomic and Metabolomic Analyses Reveal the Attenuating Role of Cordycepin and Cordyceps militaris Extract on Acute Liver Injury Induced by LPS in Piglets.

Cordyceps militaris extract (CME) contains many bioactive compounds, mainly cordycepin (CPN). This study aimed to investigate the possible mechanisms underlying the amelioration of LPS-induced acute liver injury in piglets by CME or CPN supplementation using multi-omics analysis..

OncologyImmune supportCognition & nervesLiver support

Reishi · 2023 · Review · International journal of biological macromolecules

A novel promising neuroprotective agent: Ganoderma lucidum polysaccharide.

Nervous system diseases (NSDs) are characterized by a wide range of symptoms, a complex pathophysiology, an unclear etiology, a great deal of variation in treatment response, and lengthy therapy cycles, all of which pose considerable hurdles to clinical treatment..

OncologyImmune supportMetabolic healthLiver support

Almond Mushroom · 2022 · Review · Current research in food science

Critical review on chemical compositions and health-promoting effects of mushroom Agaricus blazei Murill.

Agaricus blazei Murrill (AbM) is a medical mushroom which has huge potential commercial value with various health-promoting functions. However, the chemical composition and therapeutic mechanisms of AbM have not been concluded systematically yet..

Mesima · 2022 · Randomized Controlled Trial · Medicine

Effects of Phellinus linteus extract on immunity improvement: A CONSORT-randomized, double-blinded, placebo-controlled trial.

BACKGROUND: Immunity protects the body from external threats and prevents the development of cancer. Biological response modifiers extracted from natural sources are being actively studied, and the immunostimulatory and anticancer effects of various types of fungi have been reported..

OncologyImmune supportLiver supportSkin & hydration

Reishi · 2022 · Review · Frontiers in pharmacology

Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis.

Ganoderma lucidum (G. lucidum, Lingzhi) is a well-known herbal medicine with a variety of pharmacological effects.

Shiitake · 2022 · Clinical Trial · Integrative cancer therapies

Preventing Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy With Active Hexose-correlated Compound Derived From Lentinula edodes Mycelia.

PURPOSE: Active hexose-correlated compound (AHCC), a standardized extract of cultured Lentinula edodes mycelia, exerts antitumor effects through anti-inflammatory and immune-modulatory functions..

OncologyImmune supportMetabolic healthLiver support

Reishi · 2025 · Journal Article · JPMA. The Journal of the Pakistan Medical Association

Therapeutic potential of Ganoderma lucidum/ Reishi mushroom.

Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in JPMA. The Journal of the Pakistan Medical Association in 2025.

OncologyImmune supportMetabolic healthLiver support

Mesima · 2023 · Systematic Review · International journal of biological macromolecules

Polysaccharides from Phellinus linteus: A systematic review of their extractions, purifications, structures and functions.

Phellinus linteus (P. linteus) is a famous Chinese medicine and has a long history in China.

Reishi · 2026 · Review · Pharmaceuticals (Basel, Switzerland)

Anti-Inflammatory Potential of Ganoderma lucidum Triterpenes: A Systematic Review and Meta-Analysis of Preclinical Evidence.

Background: Ganoderma lucidum triterpenes are bioactive compounds with recognized anti-inflammatory, antitumor, and immunomodulatory properties. This systematic review synthesizes evidence regarding the anti-inflammatory activity of these triterpenes based on studies from the last two decades..

OncologyImmune supportLiver supportSkin & hydration

Reishi · 2026 · Review · Phytotherapy research: PTR

Unlocking the Therapeutic Potential of Ganoderma lucidum: From Bioactive Compounds to Clinical Translation.

Ganoderma lucidum, a revered medicinal mushroom with a rich history in traditional East Asian medicine, has garnered significant scientific attention for its diverse pharmacological properties..

Immune supportCognition & nervesGut & microbiomeLiver support

Lion's Mane · 2025 · Review · International journal of biological macromolecules

Recent insights into Hericium erinaceus polysaccharides: Gastrointestinal, gut microbiota, microbial metabolites, overall health and structure-function correlation.

Hericium erinaceus polysaccharides (HEPs) have attracted significant interest due to their potential to support gastrointestinal health and modulate gut microbiota..

Immune supportLiver supportSkin & hydration

Oyster Mushroom · 2025 · Review · Molecules (Basel, Switzerland)

Structure-Forming Properties of Pleurotus ostreatus: A Promising Resource for Edible 3D Printing Applications.

Approximately 20-30% of cultivated oyster mushrooms (Pleurotus ostreatus) are classified as low grade due to morphological and visual imperfections or mechanical damage, representing significant waste in mushroom production systems. This review examines the structural and biochemical properties of P..

OncologyImmune supportCognition & nervesLiver support

Reishi · 2024 · Review · Life (Basel, Switzerland)

Research Progress on the Biological Activity of Ganoderic Acids in Ganoderma lucidum over the Last Five Years.

Ganoderma lucidum (G. lucidum) is a traditional edible and medicinal mushroom in China.

Reishi · 2023 · Preprint · journal metadata

A Review of the Application of Ganoderma lucidum (Curtis) P. Karst. In Nanotechnology for the Treatment of Cancer

Ganoderma lucidum, commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for its potential health benefits, and medicinal properties in traditional Chinese medicine..

Energy & fatigueMetabolic healthLiver support

Shiitake · 2022 · Preprint · journal metadata

Effects of supplementation with Shiitake powder, Lentinula edodes, on anti-oxidative activities and energy/ lipid metabolism in healthy dogs

Abstract Obesity is the number one health problem pets face. Effective food and supplement should be developed to improve anti-oxidative activities and energy /lipid metabolism in obese animals..

Chaga · 2021 · Preprint · journal metadata

Characterization and Anticancer Effects of Folate Targeted Inotodiol Liposome From Inonotus Obliquus (Chaga Mushroom)

Abstract Inotodiol, one tetracyclic triterpenoid isolated from inonotus obliquus (Chaga mushroom) possess excellent anticancer, antioxidant and anti-inflammatory activities, however it has not been applied to medical use due to its low solubility and low bioavailability..

Metabolic healthGut & microbiomeLiver support

Cordyceps · 2026 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Biotransformation-derived metabolites from Astragalus membranaceus and Cordyceps militaris alleviate hyperuricemia via multi-target regulation.

Hyperuricemia is a common metabolic disorder, and current pharmacological treatments are often associated with adverse effects. This study evaluated the anti-hyperuricemic activity of an ethanol extract obtained from bidirectional solid-state fermentation of Astragalus membranaceus and Cordyceps militaris (AMC-BFE) in….

Energy & fatigueGut & microbiomeLiver supportRespiratory

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Toxins

Functional Characterization and Toxicological Study of Cordyceps militaris in Weaned Pigs.

Cordyceps militaris (CM), a well-known parasitic fungus that grows on the larvae of Lepidoptera, has a variety of pharmacological activities. However, little is known about its safe dosage for animals, including pigs..

Lion's Mane · 2023 · Journal Article · Food & function

Ameliorating effects of Hericium erinaceus polysaccharides on intestinal barrier injury in immunocompromised mice induced by cyclophosphamide.

Hericium erinaceus is a kind of large fungus with rich nutrition and its polysaccharides exhibit various biological activities. In recent years, widespread interest has been focused on maintaining or improving intestinal health through the consumption of edible fungi..

OncologyMetabolic healthLiver supportSkin & hydration

Cordyceps · 2023 · Research Article · Pharmaceutics

CD44-Targeted Lipid Polymer Hybrid Nanoparticles Enhance Anti-Breast Cancer Effect of Cordyceps militaris Extracts.

This study aimed to improve the anticancer effect of Cordyceps militaris herbal extract (CME) on breast cancer cells with hyaluronic acid (HYA) surface-decorated lipid polymer hybrid nanoparticles (LPNPs) and evaluate the applicability of a synthesized poly(glycerol adipate) (PGA) polymer for LPNP preparation..

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

CM3-SII polysaccharide obtained from Cordyceps militaris ameliorates hyperlipidemia in heterozygous LDLR-deficient hamsters by modulating gut microbiota and NPC1L1 and PPARα levels.

Accumulating evidence has demonstrated that polysaccharides derived from edible fungi have lipid-lowering effects in mice. However, the lipid metabolism mechanisms in mice and humans are different..

Immune supportEnergy & fatigueMetabolic healthLiver support

Mesima · 2023 · Journal Article · Journal of trace elements in medicine and biology: organ of the Society for Minerals and Trace Elements (GMS)

Dietary supplementation with selenium polysaccharide from selenium-enriched Phellinus linteus improves antioxidant capacity, immunity and production performance of laying hens.

BACKGROUND: Selenium (Se) plays a beneficial role in the physiological function of humans and animals. Selenium polysaccharide, improving enzyme activity and regulating immunity, is the extraction from selenium-rich plants or mushrooms..

Energy & fatigueMetabolic healthLiver support

Reishi · 2023 · Journal Article · Applied microbiology and biotechnology

Effects of glutamate oxaloacetate transaminase on reactive oxygen species in Ganoderma lucidum.

Nitrogen metabolism can regulate mycelial growth and secondary metabolism in Ganoderma lucidum. As an important enzyme in intracellular amino acid metabolism, glutamate oxaloacetate transaminase (GOT) has many physiological functions in animals and plants, but its function in fungi has been less studied..

Reishi · 2023 · Research Article · Foods (Basel, Switzerland)

Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial.

Fungi-derived β-glucan, a type of glucopolysaccharide, has been shown to possess immune-modulatory properties in clinical settings. Studies have indicated that β-glucan derived from Ganoderma lucidum (commonly known as Reishi) holds particular promise in this regard, both in laboratory and in vivo settings..

OncologyEnergy & fatigueGut & microbiomeLiver support

King Oyster · 2023 · Journal Article · Journal of the science of food and agriculture

Identification and preparation of selenium-containing peptides from selenium-enriched Pleurotus eryngii and their protective effect on lead-induced oxidative damage in NCTC1469 hepatocytes.

BACKGROUND: Lead (Pb) is a highly toxic and persistent substance that easily accumulates in living organisms, eliciting cellular toxicity and oxidative stress. Some selenium-containing proteins and peptides prepared from plant extracts are beneficial for protecting the body's health and resisting external….

OncologyEnergy & fatigueGut & microbiomeLiver support

King Oyster · 2023 · Journal Article · Journal of the science of food and agriculture

Identification and preparation of selenium‐containing peptides from selenium‐enriched Pleurotus eryngii and their protective effect on lead‐induced oxidative damage in NCTC1469 hepatocytes

BACKGROUND: Lead (Pb) is a highly toxic and persistent substance that easily accumulates in living organisms, eliciting cellular toxicity and oxidative stress. Some selenium‐containing proteins and peptides prepared from plant extracts are beneficial for protecting the body's health and resisting external….

Energy & fatigueLiver support

Reishi · 2023 · Journal Article · Phytochemical analysis: PCA

Modeling and optimization of the protocol of complex chromatography separation of cyclooxygenase-2 inhibitors from Ganoderma lucidum spore.

INTRODUCTION: The spores of the medicinal fungus Ganoderma lucidum possess hepatoprotective properties. The main components, triterpenes, are particularly beneficial, making the screening and preparation of active triterpenes from Ganoderma lucidum significant..

Cordyceps · 2023 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Preparation and evaluation of Cordyceps militaris polysaccharide- and sesame oil-loaded nanoemulsion for the treatment of candidal vaginitis in mice.

BACKGROUND: Candida albicans is the most prevalent fungal pathogen, affecting over 75% of women who have experienced candidal vaginitis. Given the identification of drug-resistant C.

Yellow Morel · 2023 · Journal Article · Carbohydrate polymers

Structure and hepatoprotective activity of Usp10/NF-κB/Nrf2 pathway-related Morchella esculenta polysaccharide

The water-soluble Morchella esculenta polysaccharide 2 (MEP2) was purified and isolated from an aqueous extract of the Morchella esculenta fruiting bodies. MEP2, having a molecular weight of 959 kDa, has a →4)-α-D-Glcp-(1→ glucan backbone, and this branch was substituted at the H-6 position by an α-D-Glcp-(1 →….

Yellow Morel · 2023 · Journal Article · Carbohydrate polymers

Structure and hepatoprotective activity of Usp10/NF-κB/Nrf2 pathway-related Morchella esculenta polysaccharide.

Reishi · 2023 · Journal Article · Food & function

The anti-hepatocellular carcinoma effects of polysaccharides from Ganoderma lucidum by regulating macrophage polarization via the MAPK/NF-κB signaling pathway.

The response of macrophages to environmental signals demonstrates its heterogeneity and plasticity. After different forms of polarized activation, macrophages reach the M1 or M2 activation state according to their respective environment..

Reishi · 2022 · Research Article · iScience

Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.

Ganoderma lucidum is a traditional Chinese medicine with a variety of active compounds and possesses adequate lipid-lowering and anti-atherosclerotic effects. However, its main active components and potential mechanisms still remain unclear..

Cognition & nervesEnergy & fatigueLiver supportSkin & hydration

King Oyster · 2022 · Journal Article · Carbohydrate polymers

Chitin-glucan composite sponge hemostat with rapid shape-memory from Pleurotus eryngii for puncture wound

Efficient hemostasis is a great challenge for treating the inaccessible hemorrhage wounds. A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca²⁺ crosslinking..