MycoData

Cordyceps militaris polysaccharides, especially β-glucans, have presented significant antitumor, hypoglycemic, and immunomodulatory activities. However, the enzymes involved in the branching formation of C.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · Journal Article · Food Bioscience

Ganoderma lucidum polysaccharides: A comprehensive overview of pharmacological effects and future perspectives

Ganoderma lucidum polysaccharides (GLPs), derived from the medicinal mushroom Ganoderma lucidum, are recognized for their diverse pharmacological properties. This systematic review offers a detailed analysis of how the structure of GLPs influences their biological functions..

OncologyImmune supportLiver support

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum spore oil modulates immunity in hepatoma H22-bearing mice and restricts tumor growth by inhibiting eicosanoid metabolism pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum spore oil (GLSO) is a well-known health product that is beneficial for immuno-enhancement, which stems from a medicine fungus: Ganoderma lucidum (Curtis) P. Karst.

OncologyImmune supportMetabolic healthLiver support

High relevance

Reishi · 2025 · Review · Antioxidants (Basel, Switzerland)

Ganoderma lucidum-From Ancient Remedies to Modern Applications: Chemistry, Benefits, and Safety.

Ganoderma lucidum (G. lucidum), commonly known as Reishi or Lingzhi, is a medicinal mushroom with a rich history in traditional Asian medicine.

OncologyImmune supportMetabolic healthLiver support

High relevance

Cordyceps · 2025 · Journal Article · Cellular and molecular biology (Noisy-le-Grand, France)

GC-MS analysis of volatile components in different populations of Ophiocordyceps sinensis.

Cordyceps, a genus of ascomycete fungi, are renowned for their medicinal and functional food applications, and are attributed to bioactive compounds such as nucleosides, lipids, saccharides, and amino acids..

Oncology

High relevance

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Heat Treatment Abolishes Cytotoxicity of the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycota) Cold-Phosphate-Buffered Saline Extract.

Cordyceps militaris is an entomopathogenic fungus that is traditionally used in East Asian medicine. The fungus contains various bioactive compounds that have potential therapeutic applications.

OncologyImmune support

High relevance

Shiitake · 2025 · Review · Chemistry & biodiversity

Holistic Evaluation of Shiitake mushrooms (Lentinula edodes): Unraveling Its Medicinal and Therapeutic Potentials.

Lentinula edodes (Shiitake mushroom [SM]), a Basidiomycete with extensive ethnomedicinal use, exhibits significant nutraceutical and pharmaceutical potential. This review critically discusses findings from multidisciplinary sources, including ScienceDirect, PubMed, Scopus, Web of Science, Google Scholar, and classical….

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Reishi · 2025 · Review · Current issues in molecular biology

Immunomodulatory Effects of Ganoderma lucidum Bioactive Compounds on Gut-Brain and Gut-Liver Axis Disorders.

Ganoderma lucidum (Lingzhi), a traditional medicinal mushroom, is renowned for its immunomodulatory, anti-inflammatory, and antioxidant properties, primarily attributed to its bioactive components such as polysaccharides and triterpenoids..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Almond Mushroom · 2025 · Research Article · Biomedicines

Immunomodulatory Effects of Multivitamin Complexes Containing Agaricus blazei in Patients Undergoing Curative Resection for Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Multicenter Pilot Trial.

Background/Objectives: Surgical resection of non-small-cell lung cancer (NSCLC) often results in temporary suppression of natural killer cell activity (NKA), potentially increasing the risk of recurrence..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Reishi · 2025 · Journal Article · Heliyon

In vitro evaluation of antioxidant, probiotic, and antiproliferative activity of Ganoderma lucidum-extracted polysaccharides for the prevention of complication associated with gastrointestinal inflammatory diseases

Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, are associated with increased oxidative stress, chronic inflammation, and in some cases, abnormal cell proliferation, which can lead to serious complications such as cancer..

OncologyImmune supportGut & microbiome

High relevance

Almond Mushroom · 2025 · Journal Article · Biometals: an international journal on the role of metal ions in biology, biochemistry, and medicine

Influence of Agaricus blazei Murill polysaccharides on synthesis, stabilization, acute toxicity and antifungal activity of copper (II) oxide nanoparticles.

In general, nanomaterials tend to have better physical, chemical and biological properties than conventional materials. Furthermore, the polysaccharides from Agaricus blazei Murill mushroom have several pharmacological properties, in addition to low cytotoxicity and high biocompatibility..

OncologyImmune support

High relevance

Reishi · 2025 · Journal Article · Phytotherapy research: PTR

Inhibition of Hepatoblastoma by Ganoderma Lucidum Polysaccharide via the Induction of HDAC4-p16-RB Axis-Mediated Cellular Senescence.

Hepatoblastoma (HB), the most common primary malignant liver tumor in children, is characterized by high metastatic potential and poor prognosis. Ganoderma lucidum polysaccharide (GLP), the main bioactive compound of Ganoderma lucidum, has not been fully investigated for its therapeutic effects on HB..

OncologyImmune supportLiver supportSkin & hydration

High relevance

Chaga · 2025 · Research Article · Animal microbiome

Inonotus obliquus fermentation product improves growth performance and meat quality probably through intestine and antioxidant capacity enhanced by gut microbes and metabolites regulation in rabbits.

BACKGROUND: Inonotus obliquus is a medicinal edible fungus that contains a variety of biologically active ingredients and has multiple physiological effects. When supplemented in avian diet, Inonotus obliquus has proved to be beneficial.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2025 · Journal Article · Anticancer research

Integrating Network Pharmacology and Optimization of Preparation Methods to Enhance the Anticancer Effect of Cordyceps militaris on Lung Cancer.

BACKGROUND/AIM: Cordyceps militaris, a medicinal fungus, is renowned for its anticancer properties. To maximize its therapeutic efficacy, this study aimed to optimize the extraction and preparation methods of Cordyceps militaris and evaluate its effects on non-small cell lung cancer (NSCLC)..

OncologyGut & microbiomeRespiratory

High relevance

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Internet of Things (IoT)-Driven Fermentation System for Enhanced Cordycepin Production in Cordyceps militaris (Ascomycetes) under Hypoxic Conditions.

Cordycepin, known for its tumor-suppressive and antiviral properties, has garnered attention due to its therapeutic and biological potential. Current Cordyceps militaris - based cordycepin production methods involve time-consuming and cost-intensive solid-state fermentation..

OncologyMetabolic healthRespiratory

High relevance

Reishi · 2025 · Journal Article · Biochemical and biophysical research communications

Investigating the therapeutic potential of Ganoderma lucidum in treating optic nerve atrophy through network pharmacology and experimental validation.

OBJECTIVE: The aim of this study is to employ network pharmacology to identify potential therapeutic targets for Ganoderma lucidum in the treatment of optic atrophy, and elucidate the underlying pharmacological mechanism. METHODS: This study is mainly divided into two parts..

OncologyImmune supportCognition & nerves

High relevance

Cordyceps · 2025 · Research Article · PloS one

Investigation of biometabolites and novel antimicrobial peptides derived from promising source Cordyceps militaris and effect of non-small cell lung cancer genes computationally.

Mushrooms are considered one of the safe and effective medications because they have great economic importance due to countless biological properties. Cordyceps militaris contains bioactive compounds with antioxidant, antimicrobial and anti-cancerous properties..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2025 · Research Article · BMC complementary medicine and therapies

Laboratory cultivated Cordyceps militaris modulates cockroach allergen-induced inflammation in keratinocytes and macrophages dual cell platforms.

BACKGROUND: Cordyceps militaris (CM) is noted for its anti-inflammatory properties and potential efficacy in treating allergic diseases. This research aimed to investigate the anti-inflammatory effect of ethanolic and aqueous extracts from laboratory-cultivated specific Cordyceps militaris on Per a 2-induced….

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Mesima · 2025 · Journal Article · Microscopy research and technique

Mechanical Analysis of Phellinus Linteus-Induced Apoptosis of Hepatoma Cells.

Liver cancer is prevalent with the third highest mortality rate globally. The biomechanical properties of cancer cells play a crucial role in their proliferation and differentiation.

OncologyLiver support

High relevance

Reishi · 2025 · Research Article · Diabetes, metabolic syndrome and obesity: targets and therapy

Mechanistic Insights Into Ganoderma Lucidum for Diabetes Treatment via Network Pharmacology and Validation.

PURPOSE: There is an urgent need to develop antidiabetic medications with minimal side effects and low toxicity. Ganoderma lucidum, a food-medicine homologous in China, has been used to treat diabetes.

OncologyMetabolic health

High relevance

Chaga · 2025 · Journal Article · International journal of medicinal mushrooms

Mechanistic Study of Chaga Medicinal Mushroom Inonotus obliquus (Agaricomycetes) Phenolic Compounds in the Treatment of Liver Cancer: A Database and Simulation Approach.

Inonotus obliquus is a large fungus with high phenolic content that has demonstrated promising potential for the treatment of liver cancer. However, studies investigating its mechanism of action in the treatment of liver cancer are scarce..

OncologyEnergy & fatigueLiver support

High relevance

Yellow Morel · 2025 · Research Article · Scientific reports

Medicinal potential of Morchella esculenta oil inhibits cancer cell proliferation, metabolite characterization through GCMS, GC×GC-TOF-MS and UHPLC-QTOF-MS.

The current study investigated comprehensive phytochemical profile through high resolution techniques like GCMS, GC×GC-TOF-MS, UHPLC-QTOF-MS, total phenolic content, total flavonoid content, antioxidant, and anticancer activities of Morchella esculenta oil using in vitro approaches..

OncologyGut & microbiome

High relevance

Chaga · 2025 · Journal Article · Environmental toxicology and pharmacology

Mitigation of experimental hepatocellular Carcinoma by Inonotus obliquus Mushroom extract in association with oxidative stress and inflammation signaling.

Chaga mushroom (Inonotus obliquus) has been a component of folk medicine treating several disorders mainly through its anti-inflammatory and antioxidant properties, yet its effects on liver carcinoma needed elucidation..

OncologyImmune supportMetabolic healthLiver support

High relevance

Chaga · 2025 · Research Article · International journal of molecular sciences

Molecular Mechanisms of Phytochemicals from Chaga Mushroom (Inonotus obliquus) Against Colorectal Cancer: Insights from Network Pharmacology, Molecular Docking, and Bioinformatics.

This study aimed to explore the molecular mechanisms of phytochemicals from Chaga mushroom (Inonotus obliquus) against colorectal cancer (CRC) using a combination of network pharmacology, molecular docking, and bioinformatics. Active components and targets of Chaga mushroom and CRC were collected from databases..

OncologyImmune support

High relevance

Lion's Mane · 2025 · Review · Brazilian journal of biology = Revista brasleira de biologia

Morphology, anticancer and neurological activities of Hericium erinaceus.

Hericium erinaceus, commonly known as Lion's Mane, is a species of medicinal mushroom that possesses remarkable therapeutic properties and has been extensively employed in the practice of traditional Chinese medicine. H..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Chaga · 2025 · Review · Current issues in molecular biology

Natural Products and Health Care Functions of Inonotus obliquus.

With the increasing attention of modern medicine to natural medicinal agents, Inonotus obliquus (chaga), a macrofungus with remarkable medicinal value, has gradually garnered widespread academic interest. This paper reviews the primary bioactive components of I..

OncologyImmune support

High relevance

Reishi · 2025 · Journal Article · Journal of Ethnopharmacology

Network pharmacology combined with transcriptomics reveals that Ganoderma lucidum spore and Sanghuangporus vaninii compound extract exerts anti-colorectal cancer effects via CYP24A1-mediated VDR pathway and TERT-mediated Wnt signaling pathway

As traditional medicinal fungi, Ganoderma lucidum and Sanghuangporus vaninii are widely used in the treatment of tumor related diseases and cancer adjuvant therapy with potent anticancer effects. However, the anticancer effect and mechanism of action of their compound extract remain unclear..

OncologyEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Network pharmacology combined with transcriptomics reveals that Ganoderma lucidum spore and Sanghuangporus vaninii compound extract exerts anti-colorectal cancer effects via CYP24A1-mediated VDR pathway and TERT-mediated Wnt signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: As traditional medicinal fungi, Ganoderma lucidum and Sanghuangporus vaninii are widely used in the treatment of tumor related diseases and cancer adjuvant therapy with potent anticancer effects..

OncologyEnergy & fatigue

High relevance

Cordyceps · 2025 · Journal Article · Food and Bioproducts Processing

Novel advanced nanoliposomes incorporating adenosine, cordycepin from riched-Cordyceps militaris extract, and curcumin: Formulation, stability, in vitro digestion, and enhanced biological activities

This study details the development and evaluation of novel nanoliposomes for the co-delivery of adenosine and cordycepin from Cordyceps militaris extract, alongside curcumin..

OncologyGut & microbiomeLiver support

High relevance

Reishi · 2025 · Journal Article · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Pharmacokinetic and tissue distribution analysis of sporoderm-removed Ganoderma lucidum spore powder in rats.

Ganoderma lucidum (Lingzhi), a medicinal mushroom, is recognized for its broad pharmacological activities, including potential health and longevity benefits. Notably, several triterpenoids derived from its spores and fruiting body have demonstrated anti-inflammatory, anti-tumor, and immunomodulatory effects..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · Research Article · Scientific reports

Phytochemical analysis and antimicrobial activity of Ganoderma lucidum against selected bacteria and fungi of medical importance.

Ganoderma lucidum is a rapidly growing mushroom, wood-colonizing fungus belonging to the phylum Basidiomycota. G.

OncologyGut & microbiome

High relevance

Cordyceps · 2025 · Research Article · Journal of cosmetic dermatology

Potential Cosmetic Applications of the Combined Extract of Panax ginseng, Ganoderma lucidum, Cordyceps militaris, and Several Asian Plants.

OBJECTIVE: Although bioactive compounds from single herbs are extensively explored in cosmetics, the synergistic potential of herbal combinations remains understudied..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Reishi · 2025 · Review · Pharmaceutics

Recent Advances in the Use of Ganoderma lucidum and Coriolus versicolor Mushrooms to Enhance the Anticancer Efficacy of EGFR-Targeted Drugs in Lung Cancer.

Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the major subtype, accounting for more than 85% of all lung cancer cases..

OncologyImmune supportSkin & hydrationRespiratory

High relevance

Reishi · 2025 · Review · Natural product research

Reishi Mushroom (Ganoderma lucidum): pharmacology of a potent healer in traditional Chinese medicine.

Reishi mushroom, also known as Lingzhi or Ganoderma lucidum, is a widely studied macrofungus in Traditional Chinese Medicine, revered for over two millennia in Asia..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Shiitake · 2025 · Research Article · Scientific reports

Safety assessment and in vitro cytotoxicity profiling of fruiting bodies from Lentinula edodes (shiitake) strains in HeLa and MCF-7 cell lines.

Medicinal mushrooms offer diverse therapeutic benefits, but proper administration is crucial to avoid long-term health issues linked to fungal toxicity. This study evaluated the safety and in vitro cytotoxic potential of Lentinula edodes (shiitake) mushrooms for broader use in food and health supplements..

OncologyImmune supportMetabolic health

High relevance

King Oyster · 2025 · Journal Article · International journal of biological macromolecules

Structural characteristics of Pleurotus eryngii polysaccharide and its protective mechanisms against mastitis in mice.

Mastitis, a common inflammatory condition in female mammals, increases the risk of breast cancer and causes substantial economic losses. Although antibiotics effectively treat mastitis, their overuse poses a threat to public health and safety..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Recent patents on anti-cancer drug discovery

Survival Benefits of Ganoderma Lucidum in Early-stage Triple-negative Breast Cancer: A Real World Study.

BACKGROUND: Ganoderma lucidum extracts are widely used as adjuvants in the treatment of triple-negative breast cancers (TNBC) in China. However, its clinical value in TNBC remains unclear..

Oncology

High relevance

Reishi · 2025 · Research Article · Discover oncology

Systematic network pharmacology and experimental validation reveal anti-glioma mechanisms of ganoderma lucidum via multi-target regulation.

BACKGROUND: Glioma is the most common and lethal primary brain tumor with limited therapeutic options and poor prognosis. Traditional Chinese medicine (TCM) offers a promising avenue for discovering multi-target agents against complex diseases..

OncologyCognition & nervesGut & microbiomeSkin & hydration

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Telomere-to-Telomere Assembly of the Cordyceps militaris CH1 Genome and Integrated Transcriptomic and Metabolomic Analyses Provide New Insights into Cordycepin Biosynthesis Under Light Stress.

Cordyceps militaris, a model species in the genus Cordyceps, is widely distributed globally and is known for its significant medicinal value. It has been traditionally used in Chinese medicine to enhance immunity, alleviate fatigue, and treat tumors, among other therapeutic purposes..

OncologyImmune supportEnergy & fatigue

High relevance

Chaga · 2025 · Journal Article · Bioscience, biotechnology, and biochemistry

The aqueous extracts of Inonotus obliquus (Chaga) augment host defense against Listeria monocytogenes infection.

Listeria monocytogenes, which grows in host cells intracellularly, is important as an opportunistic pathogen. Extracts of Chaga mushroom, Inonotus obliquus, have been shown to possess various biological activities.

OncologyImmune supportLiver support

High relevance

Oyster Mushroom · 2025 · Journal Article · Bulletin of experimental biology and medicine

The Effect of β-D-Glucans of Pleurotus ostreatus (Oyster Mushroom) on the Development of Myelosuppression and Colitis Induced by 5-Fluorouracil in Mice.

We studied the effect of the water-soluble fraction of the extract containing β-glucans from Pleurotus ostreatus (oyster mushroom) on myelosuppression and colitis induced by 5-fluorouracil (5-FU) in male BALB/c mice..

OncologyMetabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Research Article · Journal of microbiology and biotechnology

The Inhibitory Effects of Cordyceps militaris ARA301 Extract on Lipopolysaccharide-Induced Lung Injury in vivo.

Lung injury is a critical health concern associated with severe inflammatory responses and tissue damage that can weaken respiratory function and potentially become life-threatening in severe cases..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Reishi · 2025 · Research Article · Scientific reports

The protecting role of Ganoderma lucidum polysaccharides on the retinal neurovascular units in rats with retinal ischemia-reperfusion injury.

This study investigates the protective mechanisms of Ganoderma lucidum polysaccharides (GLP) on retinal neurovascular units (NVUs) in a rat model of retinal ischemia-reperfusion injury (RIR), focusing on oxidative stress, glial activation, vascular dysfunction, and functional recovery..

OncologyImmune supportCognition & nerves

High relevance

King Oyster · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Therapeutic Potential of Bioactive Compounds in Edible Mushroom-Derived Extracellular Vesicles: Isolation and Characterization of EVs from Pleurotus eryngii.

Background/Objectives: Over the past twenty years, there has been a rapid increase in studies aimed at comprehending how cells communicate with each other via Extracellular Vesicles (EVs), accompanied by a heightened interest in plant-derived extracellular vesicles due to their potential relevance in dietary….

OncologyImmune supportMetabolic healthRespiratory

High relevance

Reishi · 2025 · Research Article · AMB Express

Unlocking Reishi's secrets: nutritional and medicinal traits of Ganoderma lucidum isolated from tree bark in Egypt.

Ganoderma lucidum is an edible mushroom with high consumption rates in many cultures especially East Asian. This study assessed the in-vitro antimicrobial, antitumor, antiviral as well as antioxidant capacity of Ganoderma lucidum water extract (GLWE)..

OncologyEnergy & fatigueLiver supportRespiratory

High relevance

Reishi · 2025 · Review · Pharmaceutics

Unlocking the Potential of Ganoderma lucidum (Curtis): Botanical Overview, Therapeutic Applications, and Nanotechnological Advances.

Background:Ganoderma lucidum (GL), commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for its potential health benefits and medicinal properties in traditional Chinese medicine..

OncologyImmune support

High relevance

Reishi · 2025 · Review · 3 Biotech

Unlocking the therapeutic potential of bioactive compounds in Ganoderma lucidum: a new frontier in natural medicine.

Ganoderma lucidum (Reishi), a valued medicinal fungus used in traditional medicine for over 2000 years, has sparked widespread scientific attention due to its extensive range of bioactive ingredients and therapeutic promise in modern medicine. This study presents a detailed and up-to-date examination of G..

OncologyImmune supportCognition & nervesSkin & hydration

High relevance

Chaga · 2024 · Review · Heliyon

A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms.

This literature review offers an extensive exploration of Chaga mushrooms (Inonotus obliquus), focusing on their phytochemical composition, health-promoting attributes, and mechanisms of action..

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2024 · Journal Article · Life sciences

A novel exosome-like nanovesicles from Cordyceps militaris potentiate immunomodulatory and anti-tumor effect by reprogramming macrophages.

AIMS: Fungi-derived exosome-like nanovesicles (ENs) are emerging as a highly promising class of nanoparticles, particularly noted for their cost-effective production. However, their impact on immune regulation and their potential as anti-tumor agents need further exploration..

OncologyImmune support

High relevance

Reishi · 2024 · Review · Foods (Basel, Switzerland)

A Review of Ganoderma lucidum Polysaccharide: Preparations, Structures, Physicochemical Properties and Application.

Ganoderma lucidum (GL) is a kind of edible fungus with various functions and a precious medicinal material with a long history. Ganoderma lucidum polysaccharide (GLP) is one of the main bioactive substances in GL, with anti-tumor, anti-oxidation, anti-cancer, and other biological activities..

OncologyImmune support