MycoData

Ascomycete lectins may play an important role in their life cycle. In this report, we mined a ricin B-type lectin, named CmRlec, from the Cordyceps militaris genome by homology search..

High relevance

Cordyceps · 2023 · Journal Article · Enzyme and microbial technology

Heterologous expression, purification, and characterization of a recombinant Cordyceps militaris lipase from Candida rugosa-like family in Pichia pastoris.

Multiple sequence alignments of three lipase isoforms from the filamentous fungus, Cordyceps militaris, have revealed that the deduced protein from their common sequence belongs to the Candida rugosa lipase-like group. To express the protein in its active form, recombinant lipase from C..

High relevance

Cordyceps · 2023 · Journal Article · Bioresource technology

High-level production of cordycepin by the xylose-utilising Cordyceps militaris strain 147 in an optimised medium.

Cordycepin is an important active metabolite of Cordyceps militaris. Xylose, an attractive feedstock for producing chemicals through microbial fermentation, cannot be effectively utilised by many reported C.

Energy & fatigue

High relevance

Cordyceps · 2023 · Research Article · International journal of molecular sciences

Hydrophobin Gene Cmhyd4 Negatively Regulates Fruiting Body Development in Edible Fungi Cordyceps militaris.

A deep understanding of the mechanism of fruiting body development is important for mushroom breeding and cultivation. Hydrophobins, small proteins exclusively secreted by fungi, have been proven to regulate the fruiting body development in many macro fungi..

High relevance

King Oyster · 2023 · Research Article · Frontiers in nutrition

Hypolipidemic mechanism of Pleurotus eryngii polysaccharides in high-fat diet-induced obese mice based on metabolomics.

OBJECTIVE: In this study, the structure of Pleurotus eryngii polysaccharides (PEPs) was characterized, and the mechanism of PEP on obesity and hyperlipidemia induced by high-fat diet was evaluated by metabonomic analysis..

Immune supportEnergy & fatigueMetabolic health

High relevance

Yellow Morel · 2023 · Journal Article · Journal of agricultural and food chemistry

Identification and Characterization of Novel Umami Peptides from Protein Hydrolysates of Morchella esculenta and Their Interaction with T1R1/T1R3 Receptor.

The study aimed to explore umami peptides derived from protein hydrolysates of Morchella esculenta. According to the electronic tongue and sensory evaluation, the ultrafiltration fractions (<3 kDa) of the protein hydrolysates exhibited the strongest umami taste..

Cognition & nerves

High relevance

King Oyster · 2023 · Journal Article · Journal of the science of food and agriculture

Identification and preparation of selenium-containing peptides from selenium-enriched Pleurotus eryngii and their protective effect on lead-induced oxidative damage in NCTC1469 hepatocytes.

BACKGROUND: Lead (Pb) is a highly toxic and persistent substance that easily accumulates in living organisms, eliciting cellular toxicity and oxidative stress. Some selenium-containing proteins and peptides prepared from plant extracts are beneficial for protecting the body's health and resisting external….

OncologyEnergy & fatigueGut & microbiomeLiver support

High relevance

King Oyster · 2023 · Journal Article · Journal of the science of food and agriculture

Identification and preparation of selenium‐containing peptides from selenium‐enriched Pleurotus eryngii and their protective effect on lead‐induced oxidative damage in NCTC1469 hepatocytes

BACKGROUND: Lead (Pb) is a highly toxic and persistent substance that easily accumulates in living organisms, eliciting cellular toxicity and oxidative stress. Some selenium‐containing proteins and peptides prepared from plant extracts are beneficial for protecting the body's health and resisting external….

OncologyEnergy & fatigueGut & microbiomeLiver support

High relevance

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

Identification of a type II LacNAc specific binding lectin CMRBL from Cordyceps militaris.

The Cordyceps militaris gene CCM_03832 encodes a ricin-B like lectin. The gene was cloned and expressed in Escherichia coli, and its protein product, named CMRBL (C.

High relevance

Cordyceps · 2023 · Research Article · 3 Biotech

Identification of potential inhibitors against Alzheimer-related proteins in Cordyceps militaris ethanol extract: experimental evidence and computational analyses.

UNLABELLED: Laboratory experiments were carried out to identify the chemical composition of Cordyceps militaris and reveal the first evidence of their Alzheimer-related potential. Liquid chromatography-mass spectrometry analysis identified 21 bioactive compounds in the ethanol extract (1-21)..

Cognition & nervesEnergy & fatigue

High relevance

Reishi · 2023 · Research Article · Aging medicine (Milton (N.S.W))

Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA.

OBJECTIVE: Alzheimer's disease (AD) is one of the most prevalent neurological ailments, affecting around 50 million individuals globally. The condition is characterized by nerve cell damage due to the formation of amyloid-beta plaques and neurofibrillary tangles..

Cognition & nervesEnergy & fatigue

High relevance

King Oyster · 2023 · Journal Article · Molecular biology reports

Identification of s9ap used as an endogenous reference gene in qualitative and real-time quantitative PCR detection of Pleurotus eryngii.

BACKGROUND: Pleurotus eryngii is a kind of edible fungi with good quality, and it is popular among consumers. At present, some adulterated edible fungi are available in the market.

High relevance

Cordyceps · 2023 · Research Article · Food chemistry: X

Impacts of selenium enrichment on nutritive value and obesity prevention of Cordyceps militaris: A nutritional, secondary metabolite, and network pharmacological analysis.

This study aimed to compare the nutritive value and obesity prevention of ordinary Cordyceps militaris (CM) and selenium-enriched CM (SeCM). The results indicated that Se enrichment significantly increased the total carbohydrate and soluble dietary fiber content, while the protein and insoluble dietary fiber content….

Metabolic health

High relevance

Cordyceps · 2023 · Journal Article · Food chemistry

Improving flavor of summer Keemun black tea by solid-state fermentation using Cordyceps militaris revealed by LC/MS-based metabolomics and GC/MS analysis.

Cordyceps militaris (C. militaris) has been approved and widely used in healthy food.

High relevance

Shiitake · 2023 · Journal Article · Journal of the science of food and agriculture

In silico tools to assess the potential allergenicity of shiitake mushrooms (Lentinula edodes).

BACKGROUND: Computational tools may have an edge over conventional methods for the preliminary evaluation of food allergenicity. In this study, the allergenic potential of Lentinula edodes was evaluated and validated using in silico tools..

Immune support

High relevance

Reishi · 2023 · Research Article · BMC research notes

In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts.

OBJECTIVE: Ganoderma extracts have the potential to be used as anti-cancer, anti-inflammatory, immunomodulator, and antimicrobial agents, as evaluated in numerous studies..

OncologyImmune support

High relevance

King Oyster · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

In Vitro Fermentation of Pleurotus eryngii Mushrooms by Human Fecal Microbiota: Metataxonomic Analysis and Metabolomic Profiling of Fermentation Products.

Edible mushrooms contain biologically active compounds with antioxidant, antimicrobial, immunomodulatory and anticancer properties. The link between their anticancer and immunomodulatory properties with their possible prebiotic activity on gut micro-organisms has been the subject of intense research over the last….

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2023 · Journal Article · Food Chemistry

In-situ and real-time monitoring of two-stage enzymatic preparation of ACE inhibitory peptides from Cordyceps militaris medium residues by ultrasonic-assisted pretreatment

A protocol for the preparation of angiotensin-Ⅰ-converting enzyme (ACE) inhibitory peptides from Cordyceps militaris medium residues (CMMR) was established by two-stage enzymatic hydrolysis (amylase and protease)..

Energy & fatigue

High relevance

Cordyceps · 2023 · Journal Article · Food chemistry

In-situ and real-time monitoring of two-stage enzymatic preparation of ACE inhibitory peptides from Cordyceps militaris medium residues by ultrasonic-assisted pretreatment.

Energy & fatigue

High relevance

Cordyceps · 2023 · Journal Article · Heliyon

Influence of Cordyceps militaris-fermented grain substrate extracts on alleviating food allergy in mice

Cordyceps militaris is recognized as a tonic in traditional Chinese medicine, and there have been documented findings on the anti-allergic properties of its extract derived from the fruiting body. Due to the limited availability of wild C..

Immune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2023 · Research Article · Heliyon

Influence of Cordyceps militaris-fermented grain substrate extracts on alleviating food allergy in mice.

BACKGROUND: Cordyceps militaris is recognized as a tonic in traditional Chinese medicine, and there have been documented findings on the anti-allergic properties of its extract derived from the fruiting body. Due to the limited availability of wild C..

Immune supportMetabolic healthGut & microbiome

High relevance

Shiitake · 2023 · Research Article · Mycobiology

Influence of Storage Temperature on Levels of Bioactive Compounds in Shiitake Mushrooms (Lentinula edodes).

Shiitake mushroom (Lentinula edodes) hold high nutritional and medicinal value as they contain an abundance of health-promoting compounds. However, the effect of long-term postharvest storage on the variation in the levels of health-promoting compounds has not been extensively studied..

High relevance

Oyster Mushroom · 2023 · Research Article · PloS one

Influence of the chemical content of sawdust on the levels of important macronutrients and ash composition in Pearl oyster mushroom (Pleurotus ostreatus).

Influence of chemical composition of sawdust on the nutritional profile of oyster mushrooms (Pleurotus ostreatus) has yet to receive significant research attention. This information will help mushroom growers to select specific sawdust for the production of mushroom with desired dietary preferences..

High relevance

Reishi · 2023 · Journal Article · International journal of biological macromolecules

Inhibition of intrarenal PRR-RAS pathway by Ganoderma lucidum polysaccharide peptides in proteinuric nephropathy.

Excessive proteinuria leads to renal dysfunction and damage. Ganoderma lucidum polysaccharide peptide (GL-PP) and Ganoderma lucidum polysaccharide peptide 2 (GL-PP2) are biologically active compounds extracted from Ganoderma lucidum..

Immune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2023 · Journal Article · Heliyon

Inhibitory effect of polysaccharides extracted from Changbai Mountain Ganoderma lucidum on periodontal inflammation

As the main bioactive substance of Ganoderma lucidum, Ganoderma lucidum polysaccharide (GLP) has anti-inflammatory, antibacterial, and other biological activities..

Immune support

High relevance

Reishi · 2023 · Research Article · Heliyon

Inhibitory effect of polysaccharides extracted from Changbai Mountain Ganoderma lucidum on periodontal inflammation.

As the main bioactive substance of Ganoderma lucidum, Ganoderma lucidum polysaccharide (GLP) has anti-inflammatory, antibacterial, and other biological activities..

Immune support

High relevance

Cordyceps · 2023 · Research Article · Frontiers in microbiology

Integrated enzymes activity and transcriptome reveal the effect of exogenous melatonin on the strain degeneration of Cordyceps militaris.

As a valuable medicinal and edible fungus, Cordyceps militaris has been industrialized with broad development prospects. It contains a lot of bioactive compounds that are beneficial to our health..

Energy & fatigueGut & microbiome

High relevance

Chaga · 2023 · Research Article · BMC genomics

Integrated omic profiling of the medicinal mushroom Inonotus obliquus under submerged conditions.

BACKGROUND: The Inonotus obliquus mushroom, a wondrous fungus boasting edible and medicinal qualities, has been widely used as a folk medicine and shown to have many potential pharmacological secondary metabolites..

Immune supportMetabolic health

High relevance

Enoki · 2023 · Journal Article · International journal of medicinal mushrooms

Interactive Effects of Selenium, Zinc, and Iron on the Uptake of Selenium in Mycelia of the Culinary-Medicinal Winter Mushroom Flammulina velutipes (Agaricomycetes).

The present study for the first time addressed whether the simultaneous presence of selenium, zinc and iron may have effects on the selenium uptake in the mycelia of the winter mushroom (also known as enoki), Flammulina velutipes..

High relevance

King Oyster · 2023 · Research Article · Foods (Basel, Switzerland)

Investigation of Consequences of High-Voltage Pulsed Electric Field and TGase Cross-Linking on the Physicochemical and Rheological Properties of Pleurotus eryngii Protein.

This study aimed to evaluate the effects of high-voltage pulsed electric fields (HPEF) and transglutaminase (TGase) cross-clinking on the physicochemical and rheological properties of Pleurotus eryngii protein (PEP). The results showed that HPEF increased α-helixes and β-turns but decreased β-folds..

High relevance

King Oyster · 2023 · Journal Article · Carbohydrate polymers

Investigation of the structural and immunomodulatory properties of alkali-soluble β-glucans from Pleurotus eryngii fruiting bodies.

Fungal β-glucans have received a lot of interest due to their proinflammatory activity towards cells of the innate immune system. Although commonly described as (1➔3)-β-glucans with varying degree of (1➔6)-branching, the fungal β-glucans constitute a diverse polysaccharide class..

Immune supportMetabolic health

High relevance

King Oyster · 2023 · Journal Article · International journal of medicinal mushrooms

King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes), Extract Can Attenuate Doxorubicin-Induced Lung Damage by Inhibiting Oxidative Stress in Rats.

Doxorubicin (DOX), a broad spectrum chemotherapeutic, has toxic effects on healthy tissues. Mitochondrial processes and oxidative stress act in the DOX-induced toxicity, therefore antioxidant therapies are widely used..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Shiitake · 2023 · Research Article · Iranian journal of basic medical sciences

Lentinan and β-glucan extract from shiitake mushroom, Lentinula edodes, alleviate acute LPS-induced hematological changes in mice.

OBJECTIVES: Immunomodulatory activity of β-glucans of shiitake mushroom (Lentinula edodes) has been known. We investigated whether β-glucans from L.

Immune supportRespiratory

High relevance

Shiitake · 2023 · Journal Article · Trends in food science & technology

Lentinan, β-glucan from Shiitake (Lentinula edodes): A review on structure, conformational transition, and gastro-intestinal interaction contributing towards its anti-diabetic potential

Lentinan (LNT), a β-glucan in Shiitake mushroom (Lentinula edodes) has attracted attention for its potent biofunctionalities and immune-boosting properties. Despite comprehensive research into its chemical structure and conformation transitions, the exact mechanism of digestion and absorption remains a subject of….

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Shiitake · 2023 · Research Article · Foods (Basel, Switzerland)

Lentinula edodes Sing Polysaccharide: Extraction, Characterization, Bioactivities, and Emulsifying Applications.

In the present work, the optimization of extraction, emulsifying properties, and biological activities of polysaccharides from Lentinula edodes Sing (LES) were studied. The results showed LES polysaccharides extracted by hot water or ultrasonication are a group of β-glucan..

Immune support

High relevance

Reishi · 2023 · Journal Article · Food & function

Mapping the metabolic characteristics of probiotic-fermented Ganoderma lucidum and its protective mechanism against Cd-induced nephrotoxicity.

An animal model of Cd-induced kidney damage was designed to investigate the nephroprotective potential of the probiotic-fermented Ganoderma lucidum (FGL) via metabonomic analysis. The results showed that FGL enhanced sugar and amino acid metabolism..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2023 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Metabolites profiling of protein enriched oyster mushroom (Pleurotus ostreatus (Jacq.) P. Kumm.) grown on oil palm empty fruit bunch substrate

This study aimed to compare the nutritional composition and metabolites profiles of the Pleurotus ostreatus oyster mushroom grown on oil palm empty fruit bunch (EFB) and rubber wood sawdust (RWS) substrates..

Immune supportEnergy & fatigue

High relevance

Shiitake · 2023 · Journal Article · Journal of food composition and analysis

Model optimization for geographical discrimination of Lentinula edodes based stable isotopes and multi-elements in China

Geographical origin discrimination of agricultural products is essential to guarantee food safety and fair trade. Lentinula edodes (Shiitake mushroom) samples cultivated in three major production regions in China were characterized using stable isotopes (δ¹³C, δ²H, δ¹⁸O, δ¹⁵N, and δ³⁴S) and elemental contents (%C, %N,….

Energy & fatigue

High relevance

Reishi · 2023 · Journal Article · Phytochemical analysis: PCA

Modeling and optimization of the protocol of complex chromatography separation of cyclooxygenase-2 inhibitors from Ganoderma lucidum spore.

INTRODUCTION: The spores of the medicinal fungus Ganoderma lucidum possess hepatoprotective properties. The main components, triterpenes, are particularly beneficial, making the screening and preparation of active triterpenes from Ganoderma lucidum significant..

Energy & fatigueLiver support

High relevance

Turkey Tail · 2023 · Research Article · Frontiers in microbiology

Modeling the microbial pretreatment of camelina straw and switchgrass by Trametes versicolor and Phanerochaete chrysosporium via solid-state fermentation process: A growth kinetic sub-model in the context of biomass-based biorefineries.

Advancing microbial pretreatment of lignocellulose has the potential not only to reduce the carbon footprint and environmental impacts of the pretreatment processes from cradle-to-grave, but also increase biomass valorization, support agricultural growers, and boost the bioeconomy..

Energy & fatigueMetabolic health

High relevance

Lion's Mane · 2023 · Journal Article · Journal of the science of food and agriculture

Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice.

BACKGROUND: The gut microbiota (GM) is recognized as a significant contributor to the immune system. In the present study, the effects of Hericium erinaceus polysaccharides (HEP) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate the attenuate of immunosuppression by….

Immune supportMetabolic healthGut & microbiome

High relevance

Lion's Mane · 2023 · Journal Article · Journal of the science of food and agriculture

Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide‐treated mice

BACKGROUND: The gut microbiota (GM) is recognized as a significant contributor to the immune system. In the present study, the effects of Hericium erinaceus polysaccharides (HEP) on immunoregulation and GM in cyclophosphamide (CTX)‐treated mice were investigated to elucidate the attenuate of immunosuppression by….

Immune supportMetabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2023 · Journal Article · Archives of virology

Molecular characterization of a novel deltaflexivirus infecting the edible fungus Pleurotus ostreatus.

A novel positive single-stranded RNA virus, Pleurotus ostreatus deltaflexivirus 1 (PoDFV1), was isolated from the edible fungus Pleurotus ostreatus strain ZP6. The complete genome of PoDFV1 is 7706 nucleotides (nt) long and contains a short poly(A) tail..

Respiratory

High relevance

Cordyceps · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Molecular Phylogeny and Morphology Reveal Cryptic Species in the Cordyceps militaris Complex from Vietnam.

The Cordyceps militaris complex, which is a special group in the genus Cordyceps, is rich in species diversity and is widely distributed in nature. Throughout the investigations of arthropod-pathogenic fungi in the national reserves and in Vietnam parks, collections of C..

High relevance

Cordyceps · 2023 · Journal Article · Bioresource technology

Multi-omics analysis unravels positive effect of rotenone on the cordycepin biosynthesis in submerged fermentation of Cordyceps militaris.

Cordycepin is the key pharmacologically active compound of Cordyceps militaris, and various fermentation strategies have been developed to increase cordycepin production. This study aimed to investigate the effect of rotenone on cordycepin biosynthesis in submerged fermentation of C..

Energy & fatigue

High relevance

Cordyceps · 2023 · Journal Article · Applied microbiology and biotechnology

Multifactorial interaction of selenium, iron, xylose, and glycine on cordycepin metabolism in Cordyceps militaris.

Cordycepin, a nucleoside analog, is the main antioxidative and antimicrobial substance in Cordyceps militaris. To improve the metabolism of cordycepin, carbon sources, nitrogen sources, trace elements, and precursors were studied by single factor, Plackett-Burman, and central composite designs in C..

Metabolic health

High relevance

Reishi · 2023 · Research Article · Molecules (Basel, Switzerland)

Multiple Fingerprint-Activity Relationship Assessment of Immunomodulatory Polysaccharides from Ganoderma lucidum Based on Chemometric Methods.

Polysaccharides with molecular weights ranging from 1.75 × 103 to 1.14 × 104 g/mol were obtained from the fruit bodies of Ganoderma lucidum. The multiple fingerprints and macrophage immunostimulatory activity of these fractions were analyzed as well as the fingerprint-activity relationship..

Immune support

High relevance

Shiitake · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Multivariate Statistical Techniques: A New Approach to Identify the Commercial Properties of Mixtures of Flours of Lentinula edodes and Cocoa Pod Husk.

Lentinula edodes is known to show high nutritional and organoleptic properties and can be mixed with different by-products in the production of new foods with important functional characteristics. Cocoa pod husk (CPH) is the main by-product in the cocoa industry and presents important bioactivities..

High relevance

King Oyster · 2023 · Research Article · AMB Express

Mycoremediation of lead and cadmium by lignocellulosic enzymes of Pleurotus eryngii.

This study aimed to investigate the ability of Pleurotus eryngii fungus to absorb lead and cadmium from industrial wastewater. After culturing the fungus on a potato dextrose agar (PDA) medium containing 0 (control), 150 mg L-1, 250 mg L-1, and 350 mg L-1 concentrations of lead and cademium for 30 days, the mycelia….

High relevance

Shiitake · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Nutraceutical Potential of Lentinula edodes' Spent Mushroom Substrate: A Comprehensive Study on Phenolic Composition, Antioxidant Activity, and Antibacterial Effects.

Lentinula edodes, commonly known as shiitake mushroom, is renowned for its potential health advantages. This research delves into the often-overlooked by-product of shiitake cultivation, namely spent mushroom substrate (SMS), to explore its nutraceutical properties..

Gut & microbiome