MycoData

Cordyceps · 2026 · Journal Article · Computational biology and chemistry

Microbial biomolecule-driven identification of next-gen GSK-3β inhibitors for brain disorders.

Health conditions of neurological disorders, including Alzheimer's, schizophrenia, and bipolar disorder, are associated with abnormalities in glycogen synthase kinase-3β (GSK-3β), an essential enzyme that plays a role in neurological growth, neural adaptation, and regulating mood..

Almond Mushroom · 2026 · Journal Article · Cost effectiveness and resource allocation: C/E

Strategic resource allocation: an agent-based model of ambidextrous strategies in the pharmaceutical industry.

In this study, we investigate how pharmaceutical firms manage the allocation of their resources between exploitation and exploration based on their competitive standing for the attainment of strategic ambidexterity..

Almond Mushroom · 2025 · Research Article · Current research in toxicology

A computational dynamic systems model for in silico prediction of neural tube closure defects.

Neural tube closure is a critical morphogenetic event during early vertebrate development. This complex process is susceptible to perturbation by genetic errors and chemical disruption, which can induce severe neural tube defects (NTDs) such as spina bifida..

OncologyCognition & nerves

Almond Mushroom · 2025 · Research Article · Bulletin of mathematical biology

Astrocyte Reprogramming Drives Tumor Progression and Chemotherapy Resistance in Agent-Based Models of Breast Cancer Brain Metastases.

Breast cancer brain metastases (BCBM) affect nearly 90,000 patients annually in the United States and carry a significant risk of mortality. As metastatic lesions develop, the unique milieu of the brain microenvironment shapes disease progression and therapeutic response..

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2025 · Journal Article · International immunopharmacology

Cordycepin alleviates renal ischemia-reperfusion injury by suppressing the p38/JNK signaling pathway.

Renal ischemia-reperfusion injury (IRI) makes a significant contribution to delayed graft function (DGF) and reduced allograft survival time post-transplantation, thereby complicating the prognosis of renal transplant recipients..

Immune supportCognition & nervesRespiratory

Chaga · 2025 · Research Article · Frontiers in digital health

Dissecting the difference between positive and negative brain health sentiment using X data.

INTRODUCTION: Human behavior is significantly influenced by emotions, with negative sentiments such as fear and anxiety driving various coping mechanisms, including cognitive behavioral therapy (CBT), dietary changes, and medication use..

Almond Mushroom · 2025 · Research Article · PloS one

Exploring team dynamics and performance in extended space missions using agent-based modeling.

As humanity prepares for crewed missions to Mars, these will be among the most extended and isolated journeys, presenting challenges in team performance and dynamics..

Shiitake · 2025 · Journal Article · Journal of environmental management

Exploring the impact of innovation on organic farms: a comparative life cycle assessment of seven case studies.

There is widespread recognition of an urgent need for a transition to sustainable food systems; with organic farming methods proposed as a part of the solution. However few studies have compared highly diverse innovative organic farms with more mainstream specialised organic production systems..

OncologyCognition & nervesEnergy & fatigueLiver support

Cordyceps · 2025 · Journal Article · Phytomedicine

Ginsenoside F2-modified liposomes delivering FTY720 enhance glioblastoma targeting and antitumor activity via ferroptosis

Glioblastoma (GBM) is the most malignant primary intracranial tumor. Owing to its unfavorable prognosis and frequent recurrence, patient outcomes are poor even with standard treatment..

OncologyCognition & nervesEnergy & fatigueLiver support

Cordyceps · 2025 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ginsenoside F2-modified liposomes delivering FTY720 enhance glioblastoma targeting and antitumor activity via ferroptosis.

BACKGROUND: Glioblastoma (GBM) is the most malignant primary intracranial tumor. Owing to its unfavorable prognosis and frequent recurrence, patient outcomes are poor even with standard treatment..

Cordyceps · 2025 · Research Article · Scientific reports

In vitro and in silico neuroprotective evaluation of new biotransformation metabolites of (-)-α-bisabolol.

Biotransformation of (-)-α-bisabolol (1) was investigated by screening twenty-two fungal strains in an effort to produce new more polar and potentially bioactive metabolites. Three fungi were selected for scale-up biotransformation: Cordyceps sinensis, Alternaria alternata and Aspergillus flavus..

Lion's Mane · 2025 · Research Article · Frontiers in integrative neuroscience

Kiperin Mind Focus supplement mitigates chronic stress-induced neuroinflammation and molecular dysregulation and improves stress-related affective and exploratory behaviors in rats.

BACKGROUND: Chronic stress is known to impair emotional regulation and adaptive behavioral responses through neuroinflammatory activation, oxidative imbalance, and dysregulation of neuroplasticity-related genes..

Almond Mushroom · 2025 · Journal Article · Journal of Environmental Management

Trace of change: How stigmergy maps social learning loops in Companion Modeling through participatory simulation

This study explored integrating stigmergy in Companion Modeling (ComMod) to enhance social learning loops (SLL) in participatory natural resource management. Taking a case study from the Ferlo region of Senegal, the research focuses on how stigmergy – a concept derived from biology involving indirect coordination….

Almond Mushroom · 2025 · Journal Article · Journal of environmental management

Trace of change: How stigmergy maps social learning loops in Companion Modeling through participatory simulation.

This study explored integrating stigmergy in Companion Modeling (ComMod) to enhance social learning loops (SLL) in participatory natural resource management. Taking a case study from the Ferlo region of Senegal, the research focuses on how stigmergy - a concept derived from biology involving indirect coordination….

Immune supportCognition & nerves

Almond Mushroom · 2024 · Research Article · Antibodies (Basel, Switzerland)

50 Years of Antibody Numbering Schemes: A Statistical and Structural Evaluation Reveals Key Differences and Limitations.

BACKGROUND: The complementarity-determining region (CDR) of antibodies represents the most diverse region both in terms of sequence and structural characteristics, playing the most critical role in antibody recognition and binding for immune responses..

Almond Mushroom · 2024 · Research Article · PeerJ. Computer science

A machine learning based framework for IoT devices identification using web traffic.

Identification of the Internet of Things (IoT) devices has become an essential part of network management to secure the privacy of smart homes and offices. With its wide adoption in the current era, IoT has facilitated the modern age in many ways..

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2024 · Journal Article · Journal of ethnopharmacology

Bioinformatics analyses of infiltrating immune cell participation on pancreatic ductal adenocarcinoma progression and in vivo experiment of the therapeutic effect of Shuangshen granules.

ETHNOPHARMACOLOGICAL RELEVANCE: Shuangshen granules (SSG), a nationally patented Chinese medicinal formula, including Panax quinquefolium L., Panax notoginseng (Burkill) F. H..

OncologyCognition & nervesGut & microbiomeRespiratory

Cordyceps · 2024 · Journal Article · Viruses

Cordycepin Inhibits Enterovirus A71 Replication and Protects Host Cell from Virus-Induced Cytotoxicity through Adenosine Action Pathway.

Enterovirus A71 (EV-A71) infection typically causes mild illnesses, such as hand-foot-and-mouth disease (HFMD), but occasionally leads to severe or fatal neurological complications in infants and young children. Currently, there is no specific antiviral treatment available for EV-A71 infection..

Cognition & nervesRespiratory

Almond Mushroom · 2024 · Journal Article · International journal of women's health

Current Situation and Mental Health of Pregnant Women During the Prevention and Control of Novel Coronavirus Infection: A Cross-Sectional Study on the Investigation of Influencing Factors.

BACKGROUND: COVID-19 is a highly contagious respiratory infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which became a global public health crisis..

Cordyceps · 2024 · Research Article · Nature communications

Early warning of trends in commercial wildlife trade through novel machine-learning analysis of patent filing.

Unsustainable wildlife trade imperils thousands of species, but efforts to identify and reduce these threats are hampered by rapidly evolving commercial markets. Businesses trading wildlife-derived products innovate to remain competitive, and the patents they file to protect their innovations also provide an….

Cordyceps · 2024 · Journal Article · Environmental science and pollution research international

Investigating fungal community characteristics in co-composted cotton stalk and various livestock manure products.

Agricultural wastes, comprising cotton straw and livestock manure, can be effectively managed through aerobic co-composting. Nevertheless, the quality and microbial characteristics of co-composting products from different sources remain unclear..

Almond Mushroom · 2024 · Research Article · Scientific reports

Measuring network dynamics of opioid overdose deaths in the United States.

The US opioid overdose epidemic has been a major public health concern in recent decades. There has been increasing recognition that its etiology is rooted in part in the social contexts that mediate substance use and access; however, reliable statistical measures of social influence are lacking in the literature..

Almond Mushroom · 2024 · Research Article · Scientific reports

Temporal meta-optimiser based sensitivity analysis (TMSA) for agent-based models and applications in children's services.

With current and predicted economic pressures within English Children's Services in the UK, there is a growing discourse around the development of methods of analysis using existing data to make more effective interventions and policy decisions..

Almond Mushroom · 2023 · Review · Heliyon

A systematic review of the evaluation of agricultural policies: Using prisma.

BACKGROUND: The food security of each country depends on agricultural development, which is sensitive to the implementation of agricultural public policies. These must evolve as new ruralities arise, with new phenomena, such as climate change, ecosystem services, changes in consumer preferences, globalization,….

OncologyImmune supportCognition & nervesEnergy & fatigue

Chaga · 2023 · Preprint · journal metadata

Mixed Medicinal Mushroom Mycelia Attenuates Alzheimer's Disease Pathologies In Vitro and In Vivo

Alzheimer's disease (AD) is characterized by memory impairment and existence of amyloid-β (Aβ) plaques and neuroinflammation. Due to the pivotal role of oxidative damage in AD, natural antioxidative agents, such as polyphenol-rich fungi, have garnered scientific scrutiny..

Lion's Mane · 2023 · Review · CNS drugs

Over the Counter Supplements for Memory: A Review of Available Evidence.

In 2021, the Global Brain Health Supplement Industry Market size was valued at US$7.6 billion. It is predicted to increase to US$15.59 billion by 2030.

Almond Mushroom · 2021 · Review · Cognitive neuropsychiatry

Electroconvulsive therapy related autobiographical amnesia: a review and case report.

Introduction: While short-term cognitive impairment following electroconvulsive therapy (ECT) is well described and acknowledged, the relationship between ECT and persistent memory impairment, particularly of autobiographical memory, has been controversial..

Lion's Mane · 2021 · Review · Journal of clinical and translational research

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.

BACKGROUND AND AIM: Brain health is becoming more important to the average person as the number of people with cognitive impairments, such as Alzheimer's disease (AD), is rising significantly..

OncologyImmune supportCognition & nervesSkin & hydration

Cordyceps · 2021 · Review · Molecules (Basel, Switzerland)

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin.

Cordycepin is an adenosine derivative isolated from Cordyceps sinensis, which has been used as an herbal complementary and alternative medicine with various biological activities..

Cognition & nervesEnergy & fatigueMetabolic health

Cordyceps · 2020 · Journal Article · BioMed research international

Effects of Cultured Cordycep militaris on Sexual Performance and Erectile Function in Streptozotocin-Induced Diabetic Male Rats.

Cordyceps militaris (CM), a valuable edible and medicinal fungus, has been used as traditional medicine to treat health conditions, as well as hyposexuality in Asian societies for over a century. Due to the high demand, several artificial cultivation methods have been developed for their biological activities..

Oyster Mushroom · 2024 · Comparative Study · Sensors (Basel, Switzerland)

Deep Learning-Based Classification of Macrofungi: Comparative Analysis of Advanced Models for Accurate Fungi Identification.

This study focuses on the classification of six different macrofungi species using advanced deep learning techniques. Fungi species, such as Amanita pantherina, Boletus edulis, Cantharellus cibarius, Lactarius deliciosus, Pleurotus ostreatus and Tricholoma terreum were chosen based on their ecological importance and….

Cognition & nervesMetabolic health

Lion's Mane · 2024 · Research Support, Non U.S. Gov'T · CNS neuroscience & therapeutics

Exploring the Synergistic Effects of Erinacines on Microglial Regulation and Alzheimer's Pathology Under Metabolic Stress.

BACKGROUND: Hericium erinaceus mycelium and its constituents, erinacines A and S, have shown neuroprotective effects in APP/PS1 transgenic mice; however, the precise mechanisms by which they modulate microglial phenotypes remain unclear..

Immune supportCognition & nervesSkin & hydration

Lion's Mane · 2024 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Hericenone C attenuates the second phase of formalin-induced nociceptive behavior by suppressing the accumulation of CD11c-positive cells in the paw epidermis via phosphorylated P65.

Hericenone C is one of the most abundant secondary metabolites derived from Hericium erinaceus, under investigation for medicinal properties. Here, we report that Hericenone C inhibits the second phase of formalin-induced nociceptive behavior in mice..

Lion's Mane · 2023 · Research Article · Tropical life sciences research

Benefits of Erinacines from Different Cultivate Formulas on Cognitive Deficits and Anxiety-Like Behaviour in Mice with Trimethyltin-Induced Toxicity.

We investigated the neurological effects of the varied erinacine composition of different mycelia cultures in mice with trimethyltin (TMT)-induced neurodegeneration. Forty male ICR mice were randomly divided into five groups of Sham-veh, TMT-veh, TMT-EME, TMT-EMR and TMT-EME/R..

Zhu Ling · 2023 · Research Article · Microorganisms

Hallmarks of Comparative Transcriptome between Rhizomorphs and Hyphae of Armillaria sp. 541 Participating in Fungal Symbiosis with Emphasis on LysM Domains.

Armillaria sp. 541, a genus of root-infecting fungi, forms a symbiosis with traditional Chinese medicine Gastrodia elata (Orchid) and Polyporus umbellatus via extensive networks of durable rhizomorphs.

OncologyImmune supportCognition & nerves

Reishi · 2023 · Journal Article · Journal of visualized experiments: JoVE

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma.

One of the biggest challenges in developing effective therapies against glioblastoma is overcoming the strong immune suppression within the tumor microenvironment. Immunotherapy has emerged as an effective strategy to turn the immune system response against tumor cells..

Shiitake · 2023 · Research Article · Parasites & vectors

Lentinan has a beneficial effect on cognitive deficits induced by chronic Toxoplasma gondii infection in mice.

BACKGROUND: Toxoplasma gondii (T. gondii) is increasingly considered a risk factor for neurodegenerative diseases.

OncologyImmune supportCognition & nervesEnergy & fatigue

Reishi · 2023 · Journal Article · Current issues in molecular biology

Mixed Medicinal Mushroom Mycelia Attenuates Alzheimer's Disease Pathologies In Vitro and In Vivo.

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2023 · Journal Article · Nutrients

Mushroom-Based Supplements in Italy: Let's Open Pandora's Box.

Mushrooms and derivates are well known to the scientific community for having different health benefits and exhibit a wide range of pharmacological activities, including lipid-lowering, antihypertensive, antidiabetic, antimicrobic, antiallergic, anti-inflammatory, anticancer, immunomodulating, neuroprotective and….

Reishi · 2023 · Journal Article · Journal of Alzheimer's disease reports

Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo.

BACKGROUND: Alzheimer's disease (AD) is a multifactorial disorder characterized by cognitive decline. Current available therapeutics for AD have limited clinical benefit.

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2023 · Research Article · International journal of molecular sciences

Neuroprotective Effects of Erinacine A on an Experimental Model of Traumatic Optic Neuropathy.

Erinacine A (EA), a natural neuroprotectant, is isolated from a Chinese herbal medicine, Hericium erinaceus. The aim of this study was to investigate the neuroprotective effects of EA in a rat model of traumatic optic neuropathy..

Turkey Tail · 2023 · Research Article · Molecules (Basel, Switzerland)

Smartphone-Based Electrochemical Biosensor for On-Site Nutritional Quality Assessment of Coffee Blends.

This work aimed to develop an easy-to-use smartphone-based electrochemical biosensor to quickly assess a coffee blend's total polyphenols (Phs) content at the industrial and individual levels..

Immune supportCognition & nerves

Reishi · 2023 · Journal Article · Journal of neuroimmunology

The mechanism of LZ-8-mediated immune response in the mouse model of Parkinson's disease.

Parkinson's disease (PD) is associated with microscopic changes in the brain, particularly substantia nigra (SN). Ganoderma lucidum immunoregulatory protein (rLZ-8) is might confer protective effects against PD..

Immune supportCognition & nerves

Oyster Mushroom · 2023 · Journal Article · Chemosphere

Various species of Basidiomycota fungi reveal different abilities to degrade pharmaceuticals and also different pathways of degradation.

The presence of pharmaceuticals (PhACs) in the aquatic environment is an emerging problem worldwide. PhACs reach surface water via the effluents of wastewater treatment plants (WWTPs).

OncologyImmune supportCognition & nerves

Maitake · 2022 · Research Article · Optoelectronics letters

A label-free lateral offset spliced coreless fiber MZI biosensor based on hydrophobin HGFI for TNF-α detection.

A real-time label-free lateral offset spliced coreless fiber (CF) Mach-Zehnder interferometer (MZI) biosensor functionalized with hydrophobin Grifola frondosa I (HGFI) was proposed for the detection of cytokine tumour necrosis factor alpha (TNF-α)..

Zhu Ling · 2022 · Journal Article · Pediatrics international: official journal of the Japan Pediatric Society

Classification of pediatric headache cases referred to a neurology department.

BACKGROUND: Headaches are very common in children. The patients often have mild symptoms, but on occasion may have severe, secondary headaches.

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Lion's Mane · 2022 · Journal Article · Life sciences

Erinacine A attenuates glutamate transporter 1 downregulation and protects against ischemic brain injury.

Maintaining glutamate homeostasis through astrocyte-enriched glutamate transporter 1 (GLT-1) is critical for neuronal survival, but it is often disrupted after brain injury..

OncologyCognition & nervesEnergy & fatigue

Chaga · 2022 · Journal Article · Food & function

Neuroprotective effects of a new triterpenoid from edible mushroom on oxidative stress and apoptosis through the BDNF/TrkB/ERK/CREB and Nrf2 signaling pathway in vitro and in vivo.

Inonotus obliquus (Fr.) Pilat is an edible mushroom which is used to produce tea and syrup due to its medicinal properties. In this study, 10 secondary metabolites (1-10), including a new lanostane triterpenoid named 2α-hydroxy-inotodiol (2α-HI, 1), were identified from the edible mushroom I..