MycoData

The purpose of this experiment was to investigate the effects of Hot Water Extract of Juncao-substrate Ganoderma lucidum Residue (HWE-JGLR) on the immune function and intestinal health of yellow-feather broilers..

Immune supportEnergy & fatigueGut & microbiome

High relevance

Cordyceps · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

The Anti-Inflammatory Effects and Mechanism of the Submerged Culture of Ophiocordyceps sinensis and Its Possible Active Compounds.

The pharmacological effects of the fruiting body of Ophiocordyceps sinensis (O. sinensis) such as antioxidant, anti-virus, and immunomodulatory activities have already been described, whereas the anti-inflammatory effects and active components of the submerged culture of O..

Immune supportCognition & nervesRespiratory

High relevance

Lion's Mane · 2024 · Research Article · Antioxidants (Basel, Switzerland)

The Cerebral Protective Effect of Novel Erinacines from Hericium erinaceus Mycelium on In Vivo Mild Traumatic Brain Injury Animal Model and Primary Mixed Glial Cells via Nrf2-Dependent Pathways.

Hericium erinaceus, a consumable mushroom, has shown a potential to enhance the production of neuroprotective bioactive metabolites. Traumatic brain injury (TBI) often leads to cognitive, physical, and psychosocial impairments, resulting in neuroinflammation and the loss of cortical neurons..

Immune supportCognition & nerves

High relevance

Reishi · 2024 · Journal Article · Food Research International

The effect of Mesona blume straw fermented by Ganoderma lucidum to improve physicochemical, in vitro digestion and gut bacteria of noodles

Mesona blume straw (MBS) is a class of high-fiber, low-value Mesona blume’s colloid by-products. We investigated the changes in dietary fiber (DF), triterpenoid, and polysaccharide contents of fermented Mesona blume straw (FMBS) by Ganoderma lucidum (GL), we also examined the effect of adding FMBS at different levels….

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Food research international (Ottawa, Ont.)

The effect of Mesona blume straw fermented by Ganoderma lucidum to improve physicochemical, in vitro digestion and gut bacteria of noodles.

Mesona blume straw (MBS) is a class of high-fiber, low-value Mesona blume's colloid by-products. We investigated the changes in dietary fiber (DF), triterpenoid, and polysaccharide contents of fermented Mesona blume straw (FMBS) by Ganoderma lucidum (GL), we also examined the effect of adding FMBS at different levels….

Immune supportMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2024 · Research Article · Foods (Basel, Switzerland)

The Effects of Tremella fuciformis Polysaccharide on the Physicochemical, Multiscale Structure and Digestive Properties of Cyperus esculentus Starch.

In this study, we have investigated the effects of Tremella fuciformis polysaccharide (TP) on the pasting, rheological, structural and in vitro digestive properties of Cyperus esculentus starch (CS)..

Immune supportGut & microbiomeSkin & hydration

High relevance

Maitake · 2024 · Research Article · Life (Basel, Switzerland)

The Role of Grifola frondosa Polysaccharide in Preventing Skeletal Muscle Atrophy in Type 2 Diabetes Mellitus.

Type 2 diabetes mellitus (T2DM) is a burgeoning public health challenge worldwide. Individuals with T2DM are at increased risk for skeletal muscle atrophy, a serious complication that significantly compromises quality of life and for which effective prevention measures are currently inadequate..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Shiitake · 2024 · Journal Article · Biological & pharmaceutical bulletin

The Tumor Growth Inhibitory Effect of a Standardized Extract of Cultured Lentinula edodes Mycelia Using Patient Derived Xenograft Model

Patient derived xenograft (PDX) is a powerful tool to confirm pharmacological efficacy in non-clinical studies for the development of various drugs including anti-cancer agents and therapeutic research. A standardized extract of cultured Lentinula edodes mycelia, a product name AHCC® is produced by Amino Up Co., Ltd..

OncologyImmune support

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Snow Fungus · 2024 · Research Article · Nutrients

Tremella fuciformis Berk Alleviated Atherosclerosis Symptoms via Nuclear Factor-Kappa B-Mediated Inflammatory Response in ApoE-/- Mice.

BACKGROUND: Atherosclerosis, a persistent inflammatory disease marked by the presence of atherosclerotic plaques or fibrous plaques, is a significant contributor to the onset of the development of cardiovascular disease..

Immune supportGut & microbiome

High relevance

Almond Mushroom · 2024 · Journal Article · International journal of biological macromolecules

Troxerutin associated with Agaricus blazei Murill polysaccharides in films improves full-thickness wound healing.

The present study aimed to associate troxerutin (TRX) with polysaccharides from Agaricus blazei Murill mushroom (PolyAb) in alginate/PVA films and evaluate their effect on wound healing..

Immune supportSkin & hydration

High relevance

Lion's Mane · 2024 · Research Article · Food chemistry: X

Ultrasound-assisted enzymatic extraction of soluble dietary Fiber from Hericium erinaceus and its in vitro lipid-lowering effect.

Dietary fiber (DF) is an important active polysaccharide in Hericium erinaceus. Obesity can lead to a wide range of diseases.

Immune supportMetabolic health

High relevance

Reishi · 2023 · Review · Chinese medicine

A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer.

Gastrointestinal (GI) cancer is the most common cancer in the world and one of the main causes of cancer-related death. Clinically, surgical excision and chemotherapy are the main treatment methods for GI cancer, which is unfortunately accompanied with serious adverse reactions and drug toxicity, bringing irreversible….

OncologyImmune supportGut & microbiome

High relevance

Reishi · 2023 · Review · International journal of biological macromolecules

A review of Ganoderma lucidum polysaccharides: Health benefit, structure-activity relationship, modification, and nanoparticle encapsulation.

Ganoderma lucidum polysaccharides possess unique functional properties. Various processing technologies have been used to produce and modify G.

Immune supportLiver support

High relevance

Niu-Chang-Chih · 2023 · Review · Journal of ethnopharmacology

A review on the protective effect of active components in Antrodia camphorata against alcoholic liver injury.

ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata is a genus of wood-rot basidiomycete in the family Fomitopsidaceae. It is a valuable medicinal fungus in China that contains more than 78 kinds of active compounds.

Immune supportGut & microbiomeLiver support

High relevance

Reishi · 2023 · Review · Cancer cell international

Exploring the anti-cancer potential of Ganoderma lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer.

There has been a growing global interest in the potential health benefits of edible natural bioactive products in recent years. Ganoderma lucidum, a medicinal mushroom, has gained attention for its decadent array of therapeutic and pharmaceutical compounds.

OncologyImmune supportEnergy & fatigueLiver support

High relevance

Reishi · 2023 · Review · Foods (Basel, Switzerland)

Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections.

Ganoderma lucidum is a medicinal mushroom that has been traditionally used in Chinese medicine for centuries. It has been found to have a wide range of medicinal properties, including antioxidant, anti-inflammatory, and immune-boosting effects.

Immune supportMetabolic healthRespiratory

High relevance

Yellow Morel · 2023 · Review · International journal of medicinal mushrooms

Food and Antioxidant Supplements with Therapeutic Properties of Morchella esculenta (Ascomycetes): A Review.

Morchella esculenta, commonly known as yellow morels, is an edible and medicinal mushroom popular worldwide for its unique flavor and culinary purposes. The traditional medical system effectively uses morels against infertility, fatigue, cancer, muscular pain, cough, and cold.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2023 · Review · Nutrients

Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action.

Ganoderma lucidum (G. lucidum) has been widely used for its health benefits as an edible and traditional medicinal mushroom for thousands of years in Asian countries.

OncologyImmune supportLiver supportRespiratory

High relevance

Lion's Mane · 2023 · Review · World journal of gastroenterology

Hericium erinaceus, a medicinal fungus with a centuries-old history: Evidence in gastrointestinal diseases.

Hericium erinaceus is an edible and medicinal mushroom commonly used in traditional Chinese medicine for centuries. Several studies have highlighted its therapeutic potential for gastrointestinal disorders such as gastritis and inflammatory bowel diseases..

OncologyImmune supportGut & microbiome

High relevance

Oyster Mushroom · 2023 · Review · Foods (Basel, Switzerland)

Modulation of the Gut Microbiota with Prebiotics and Antimicrobial Agents from Pleurotus ostreatus Mushroom.

Pleurotus ostreatus (Jacq. ex Fr.) P.

Immune supportGut & microbiomeRespiratory

High relevance

Reishi · 2023 · Review · Antioxidants (Basel, Switzerland)

Natural Bio-Compounds from Ganoderma lucidum and Their Beneficial Biological Actions for Anticancer Application: A Review.

Ganoderma lucidum (G. lucidum) has been known for many centuries in Asian countries under different names, varying depending on the country.

OncologyImmune support

High relevance

Lion's Mane · 2023 · Review · International journal of molecular sciences

Neurotrophic and Neuroprotective Effects of Hericium erinaceus.

Hericium erinaceus is a valuable mushroom known for its strong bioactive properties. It shows promising potential as an excellent neuroprotective agent, capable of stimulating nerve growth factor release, regulating inflammatory processes, reducing oxidative stress, and safeguarding nerve cells from apoptosis..

OncologyImmune supportCognition & nerves

High relevance

Reishi · 2023 · Review · Cureus

Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review.

Ganoderma lucidum is traditionally used to prevent and treat some diseases such as liver disorders, hypertension, insomnia, diabetes, and cancer. G.

OncologyImmune supportMetabolic healthLiver support

High relevance

Reishi · 2023 · Review · Molecules (Basel, Switzerland)

Potential Anti-Rheumatoid Arthritis Activities and Mechanisms of Ganoderma lucidum Polysaccharides.

Rheumatoid arthritis (RA) is a chronic and autoimmune disease characterized by inflammation, autoimmune dysfunction, and cartilage and bone destruction. In this review, we summarized the available reports on the protective effects of Ganoderma lucidum polysaccharides (GLP) on RA in terms of anti-inflammatory,….

Immune support

High relevance

Snow Fungus · 2023 · Review · Archives of dermatological research

The potential cutaneous benefits of Tremella fuciformis.

Tremella fuciformis, also known as snow mushroom, is an edible mushroom that has historically been popular in herbal and Asian medicine and cuisine. The main polysaccharide ingredients have been extracted and used as treatment in a variety of conditions, demonstrating positive effects in a range of biological….

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Reishi · 2022 · Review · Frontiers in pharmacology

Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview.

Ganoderma lucidum is a very medicinal mushroom that has been utilized in Oriental medicine for many years. It has a wide range of pharmacological and therapeutic properties, and has been used for many years as a health promoter..

OncologyImmune supportRespiratory

High relevance

Yellow Morel · 2022 · Review · Food research international (Ottawa, Ont.)

Mycochemical profile and health-promoting effects of morel mushroom Morchella esculenta (L.) - A review.

Mushrooms have been well known for centuries in traditional Chinese medicine for their medicinal properties. Morchella esculenta (L.) Pers.

OncologyImmune supportMetabolic healthLiver support

High relevance

Enoki · 2021 · Review · International journal of biological macromolecules

Advances in the extraction, purification, structural-property relationships and bioactive molecular mechanism of Flammulina velutipes polysaccharides: A review.

With the further research in recent years, Flammulina velutipes (F. velutipes), an edible mushroom, has great application value in many fields.

OncologyImmune supportMetabolic healthLiver support

High relevance

Chaga · 2021 · Review · Journal of ethnopharmacology

Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus.

ETHNOPHARMACOLOGICAL RELEVANCE: The crude extracts of the medicinal mushroom Inonotus obliquus have been used as an effective traditional medicine to treat malicious tumors, gastritis, gastric ulcers, and other inflammatory conditions in Russia and most Baltic countries..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Chaga · 2021 · Review · Journal of traditional and complementary medicine

Inonotus obliquus - from folk medicine to clinical use.

The Inonotus obliquus (I. obliquus) mushroom was traditionally used to treat various gastrointestinal diseases.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2021 · Review Article · 3 Biotech

Novel formulation development from Ophiocordyceps sinensis (Berk.) for management of high-altitude maladies.

Ophiocordyceps sinensis (Berk.) is a fungus closely related to medicinal mushroom, which belongs to the family Ophiocordycipitaceae. It is a well-known and rich herbal source of bioactive active constituents.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Zhu Ling · 2021 · Review · International journal of biological macromolecules

Polysaccharides from Polyporus umbellatus: A review on their extraction, modification, structure, and bioactivities.

Polyporus umbellatus (Pers.) Fries, a well-known medicinal fungus, has been reported to exhibit important functions of diuresis and dampness infiltration in traditional Chinese Medicine. Accumulating evidences have demonstrated that the P..

OncologyImmune supportLiver supportSkin & hydration

High relevance

Yellow Morel · 2021 · Review · Applied biochemistry and biotechnology

Recent Advances on Bioactive Ingredients of Morchella esculenta.

Morchella esculenta (M. esculenta) is a delicious edible mushroom prized for its special flavor and strong health promoting abilities.

OncologyImmune supportMetabolic health

High relevance

Wood Ear · 2021 · Review · Journal of agricultural and food chemistry

Review on Auricularia auricula-judae as a Functional Food: Growth, Chemical Composition, and Biological Activities.

Although the application of Auricularia auricula-judae (AAJ) for health purposes has a long tradition in Asia, there is a lack of research on the functional nutrition of AAJ; the current research focused on polysaccharides has been too unitary compared to other mushrooms in recent years..

Immune support

High relevance

Turkey Tail · 2021 · Review · Acta pharmaceutica (Zagreb, Croatia)

The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges in medicine. Fungi are the most common organisms in the ecosystem and the most interesting in this respect..

OncologyImmune supportCognition & nerves

High relevance

Turkey Tail · 2014 · Randomized Controlled Trial · Gut microbes

Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial.

BACKGROUND: Interactions between the microbial flora of the intestine and the human host play a critical role inmaintaining intestinal health and in the pathophysiology of a wide variety of disorders such as antibiotic associated diarrhea, Clostridium difficile infection, and inflammatory bowel disease..

Immune supportGut & microbiome

High relevance

Maitake · 2026 · Journal Article · Journal of complementary & integrative medicine

Black maitake induces apoptosis and enhances the efficacy of standard chemotherapy in 2D and 3D U-87 MG glioblastoma cell models.

OBJECTIVES: Glioblastoma is an aggressive primary brain tumor marked by rapid growth, invasiveness, poor prognosis, and an over 90 % tumor recurrence rate. Current radiation and chemotherapy treatments are limited by non-selectivity and toxicity, creating a need for safer complementary treatments..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Shiitake · 2025 · Journal Article · Natural product research

A novel method for detecting conformation-dependent β-glucans-single, double, and triple-helical from Shiitake mushroom.

This pioneering study explores the structural intricacies of therapeutic β-glucan in Shiitake (Lentinula edodes), i.e. Lentinan (LNT).

Immune support

High relevance

Chaga · 2025 · Research Article · International journal of molecular sciences

INO10, a Chaga Mushroom Extract, Alleviates Alzheimer's Disease-Related Pathology and Cognitive Deficits in 3xTg-AD Mice.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment with amyloid-β (Aβ) accumulation, tau hyperphosphorylation, and neuroinflammation. Among these pathological features, microglial activation is hallmark of neuroinflammation..

Immune supportCognition & nerves

High relevance

Cordyceps · 2025 · Research Article · Scientific reports

Quantitative detection of β-glucans in Cordyceps species using a validated Congo red assay.

β-Glucan is extensively utilized in the food industry for its functional benefits, including blood glucose and lipid regulation, enhanced food texture, and a prolonged shelf life..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Chaga · 2023 · Review · Frontiers in pharmacology

Chaga mushroom: a super-fungus with countless facets and untapped potential.

Inonotus obliquus (Chaga mushroom) is an inexpensive fungus with a broad range of traditional and medicinal applications. These applications include therapy for breast, cervix, and skin cancers, as well as treating diabetes..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Shiitake · 2022 · Research Article · Animals: an open access journal from MDPI

Effect of Lentinula edodes on Morphological and Biochemical Blood Parameters of Horses.

Shiitake mushrooms have been highly regarded as possessing enormous nutritive and medicinal values. No clinical studies have yet investigated the effect of shitake supplementation on the health of horses..

Immune supportMetabolic health

High relevance

Maitake · 2022 · Randomized Controlled Trial · Acta biochimica Polonica

Effect of Maitake D-fraction in advanced laryngeal and pharyngeal cancers during concurrent chemoradiotherapy: A randomized clinical trial.

BACKGROUND: Concurrent chemo-radiotherapy (CCRT) is an ideal treatment for advanced head and neck squamous cell carcinoma (HNSCC). The performance of CCRT induces severe toxicities in HNSCC patients and decreases the quality of life (QOL)..

OncologyImmune supportEnergy & fatigue

High relevance

Maitake · 2019 · Meta-Analysis · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Meta-analysis on effect of Grifola frondosa polysaccharide in regulating in vivo immunoregulatory function on animal disease models].

The study aimed to explore the in vivo immunoregulatory function of Grifola frondosa polysaccharide( GFP) on animal disease models. Databases of PubMed,Embase,Web of Scinece,CNKI,CBM and Wan Fang Data were searched from the date of their establishment to February 2018..

Immune support

High relevance

Chaga · 2023 · English Abstract · Voprosy virusologii

[Antiviral activity of basidial fungus Inonotus obliquus aqueous extract against SARS-CоV-2 virus (Coronaviridae: Betacoronavirus: Sarbecovirus) in vivo in BALB/c mice model].

INTRODUCTION: The COVID-19 pandemic combined with seasonal epidemics of respiratory viral diseases requires targeted antiviral prophylaxis with restorative and immunostimulant drugs. The compounds of natural origin are low-toxic, but active against several viruses at the same time..

Immune supportRespiratory

High relevance

Chaga · 2023 · English Abstract · Voprosy virusologii

[Screening of antiviral activity of samples from chaga Inonotus obliquus and humic acid from brown coal on Vero cell culture against ectromelia virus (Poxviridae: Orthopoxvirus; ECTV)].

INTRODUCTION: The mouse-specific orthopoxvirus, ectromelia virus, is one of the best models that can be used to study key issues of pathogenesis, prevention, and treatment of smallpox, and to develop measures to increase virulence, transmissibility, or the ability to overcome vaccine immunity..

OncologyImmune supportRespiratory

High relevance

Almond Mushroom · 2023 · English Abstract · Zhongguo shi yan xue ye xue za zhi

[Study on the Mechanism of Multi-Drug Resistance of Agaricus Blazei Extract FA-2-b-β Mediated Wnt Signaling Pathway to Reverse Acute T Lymphoblastic Leukemia].

OBJECTIVE: To investigate the mechanism of drug reversing resistance of Agaricus blazei extract FA-2-b-β on T cell acute lymphoblastic leukemia (T-ALL) cell lines..

OncologyImmune supportEnergy & fatigue

High relevance

Reishi · 2023 · Comparative Study · International journal of medicinal mushrooms

Differential Analysis of Korean and Chinese Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Spore Powder by Infrared Spectroscopy with Stoichiometry.

To investigate the differences between Korean Ganoderma lucidum spore powder (KP), broken-spo-roderm KP (BSKP), Chinese traditional G. lucidum spore powder (CP), and broken-sporoderm CP (BSCP), they were identified by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), second….

Immune support

High relevance

Yellow Morel · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Elucidating the molecular mechanisms underlying anti-inflammatory effects of Morchella esculenta in the arachidonic acid metabolic pathway by network pharmacology and molecular docking.

Morchella esculenta is an edible fungus with a uniquely delicious flavor and remarkable benefits for health. Herein, the molecular mechanism underlying the anti-inflammatory effects of Morchella esculenta was elucidated using molecular docking and network pharmacology..

Immune supportCognition & nervesMetabolic health

High relevance

Chaga · 2023 · Research Support, Non U.S. Gov'T · International journal of biological sciences

Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism.

Skeletal muscle wasting related to aging or pathological conditions is critically associated with the increased incidence and prevalence of secondary diseases including cardiovascular diseases, metabolic syndromes, and chronic inflammations..

OncologyImmune supportEnergy & fatigueMetabolic health