MycoData

The co-culture of Trametes versicolor and Ganoderma applanatum is a model of intense basidiomycete interaction, which induces many newly synthesized or highly produced features. Currently, one of the major challenges is an identification of the origin of induced features during the co-culture..

Metabolic health

High relevance

Turkey Tail · 2017 · Journal Article · Applied biochemistry and biotechnology

Pretreatment of Hardwood and Miscanthus with Trametes versicolor for Bioenergy Conversion and Densification Strategies.

The pretreatment of plant biomass negatively impacts the economics of many bioenergy and bioproduct processes due to the thermochemical requirements for deconstruction of lignocelluluose..

Energy & fatigueMetabolic health

High relevance

Enoki · 2017 · Journal Article · Journal of agricultural and food chemistry

Proteomic Investigation of Metabolic Changes of Mushroom (Flammulina velutipes) Packaged with Nanocomposite Material during Cold Storage.

Metabolic changes of mushroom (Flammulina velutipes) applied with polyethylene (PE) material (Normal-PM) or nanocomposite reinforced PE packaging material (Nano-PM) were monitored using tandem mass tags (TMT) labeling combined with two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS) technique..

Energy & fatigueMetabolic health

High relevance

Turkey Tail · 2017 · Journal Article · International journal of biological macromolecules

Quorum sensing molecule-farnesol increased the production and biological activities of extracellular polysaccharide from Trametes versicolor.

A novel strategy of exposing 2-day-old mycelia cultures to 0.8mM farnesol was developed to stimulate extracellular polysaccharide (EPS) production in Trametes versicolor submerged cultures..

OncologyImmune supportMetabolic health

High relevance

Maitake · 2017 · Journal Article · Food chemistry

Rice bran polysaccharides and oligosaccharides modified by Grifola frondosa fermentation: Antioxidant activities and effects on the production of NO.

Rice bran polysaccharides (RBPSs) are valuable compounds with many biological activities. In this work, a fungus called Grifola frondosa, was selected to ferment defatted rice bran water extracts and modify the RBPSs, which were then isolated by ethanol precipitation and deproteinization..

Immune supportMetabolic health

High relevance

Niu-Chang-Chih · 2016 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Antcin K, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects via Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in Muscles.

The purpose of this study was to screen firstly the potential effects of antcin K (AnK), the main constituent of the fruiting body of Antrodia camphorata, in vitro and further evaluate the activities and mechanisms in high-fat-diet- (HFD-) induced mice..

Energy & fatigueMetabolic healthLiver support

High relevance

Niu-Chang-Chih · 2016 · Research Article · Molecules (Basel, Switzerland)

Antiinflammatory and Antiphotodamaging Effects of Ergostatrien-3β-ol, Isolated from Antrodia camphorata, on Hairless Mouse Skin.

Ergostatrien-3β-ol (EK100), isolated from the submerged whole broth of Antrodia camphorata, has antidiabetic, hyperlipidemic, and hepatoprotective activities. However, the antiphotodamage activity of EK100 has still not been revealed..

Immune supportMetabolic healthLiver supportSkin & hydration

High relevance

Chaga · 2016 · Journal Article · International journal of biological macromolecules

Antioxidant activity of Inonotus obliquus polysaccharide and its amelioration for chronic pancreatitis in mice.

Inonotus obliquus polysaccharide (IOP) was extracted by water with a yield of 9.83% and purified by an anion-exchange DEAE cellulose column and Sephadex G-200 gel with a polysaccharide content of 98.6%..

Immune supportMetabolic health

High relevance

Enoki · 2016 · Journal Article · Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]

Antitumor and Antioxidant Properties of Water-Soluble Polysaccharides from Submerged Mycelium of Flammulina velutipes.

The aim of the study was to evaluate antitumor and antioxidant properties of water-soluble polysaccharides from submerged myceliumn of Flammulina velutipes grown under optimized conditions..

OncologyImmune supportMetabolic health

High relevance

Niu-Chang-Chih · 2016 · Research Article · Frontiers in pharmacology

Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells.

Antrodia camphorata is a Taiwanese-specific fungus which has been used clinically to treat hypertension, immune- and liver-related diseases and cancer; however, it has never been studied in type 2 diabetes mellitus (T2DM). Hyperglycemia in T2DM causes endoplasmic reticulum (ER) stress, leading to β-cell dysfunction..

OncologyImmune supportMetabolic healthLiver support

High relevance

Mesima · 2016 · Journal Article · International journal of medicinal mushrooms

Black Hoof Medicinal Mushroom Phellinus linteus (Agaricomycetes) Extracts Protect Against Radiation-Induced Hematopoietic Abnormality in Mice.

We investigated the effects of Phellinus linteus extracts (PLEs) against radiation damage in mice. First, BALB/c mice were irradiated once with γ-rays at 4, 5, 6, or 8 Gy and allowed to recover for 20 days..

Metabolic health

High relevance

Shiitake · 2016 · Research Article · BioMed research international

Comparative Proteomic Analysis of Light-Induced Mycelial Brown Film Formation in Lentinula edodes.

Light-induced brown film (BF) formation by the vegetative mycelium of Lentinula edodes is important for ensuring the quantity and quality of this edible mushroom. Nevertheless, the molecular mechanism underlying this phenotype is still unclear..

Metabolic health

High relevance

Maitake · 2016 · Journal Article · Applied biochemistry and biotechnology

Control of Grifola frondosa Morphology by Agitation and Aeration for Improving Mycelia and Exo-Polymer Production.

The present study describes the improved mycelia and exo-polymer production under control of Grifola frondosa morphology by changing the aeration rate and agitation intensity in a 25-L stirred fermentor..

Immune supportMetabolic health

High relevance

Niu-Chang-Chih · 2016 · Research Article · International journal of molecular sciences

Dehydroeburicoic Acid from Antrodia camphorata Prevents the Diabetic and Dyslipidemic State via Modulation of Glucose Transporter 4, Peroxisome Proliferator-Activated Receptor α Expression and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice.

This study investigated the potential effects of dehydroeburicoic acid (TT), a triterpenoid compound from Antrodia camphorata, in vitro and examined the effects and mechanisms of TT on glucose and lipid homeostasis in high-fat-diet (HFD)-fed mice..

Energy & fatigueMetabolic healthLiver support

High relevance

Mesima · 2016 · Journal Article · International journal of medicinal mushrooms

Effects of Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes), Polysaccharide Extract in Streptozotocin-Induced Diabetic Rats.

In this article we report the healing effects of a Phellinus linteus fruiting body hot water extract (PLE) in streptozotocin (STZ)-induced diabetic rats. PLE was given before and after STZ..

Immune supportMetabolic health

High relevance

Chaga · 2016 · Journal Article · Molecular medicine reports

Effects of polysaccharides isolated from Inonotus obliquus against hydrogen peroxide-induced oxidative damage in RINm5F pancreatic β-cells.

The purpose of the present study was to elucidate the cytoprotective effects of polysaccharides isolated from Inonotus obliquus. The polysaccharides were extracted from the fruiting body of I.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Shiitake · 2016 · Journal Article · The Science of the total environment

Exploring the potential of novel biomixtures and Lentinula edodes fungus for the degradation of selected pesticides. Evaluation for use in biobed systems.

An approach to reduce the contamination of water sources with pesticides is the use of biopurificaction systems. The active core of these systems is the biomixture.

Metabolic health

High relevance

Enoki · 2016 · Research Article · Pharmacognosy research

Extracts from Flammulina velutipes Inhibit the Adhesion of Pathogenic Fungi to Epithelial Cells.

BACKGROUND: Recently, extracts from natural sources have been tested for their antifungal properties. In this aspect, Flammulina velutipes extracts possess a significant amount of branch-chained carbohydrates with mannose moieties that, hypothetically, can reduce the adhesion..

Immune supportMetabolic health

High relevance

Lion's Mane · 2016 · Journal Article · Journal of ethnopharmacology

Haematological, biochemical and histopathological aspects of Hericium erinaceus ingestion in a rodent model: A sub-chronic toxicological assessment.

ETHNOPHARMACOLOGICAL RELEVANCE: Hericium erinaceus is a culinary-medicinal mushroom and has a long history of usage in traditional Chinese medicine as a tonic for stomach disorders, ulcers and gastrointestinal ailments..

Metabolic healthGut & microbiomeLiver support

High relevance

Turkey Tail · 2016 · Research Article · International journal of environmental research and public health

High Laccase Expression by Trametes versicolor in a Simulated Textile Effluent with Different Carbon Sources and PHs.

Textile effluents are highly polluting and have variable and complex compositions. They can be extremely complex, with high salt concentrations and alkaline pHs.

Metabolic health

High relevance

Snow Fungus · 2016 · Journal Article · International journal of medicinal mushrooms

Morphological and Molecular Analysis Identifies the Associated Fungus ("Xianghui") of the Medicinal White Jelly Mushroom, Tremella fuciformis, as Annulohypoxylon stygium.

White jelly mushroom, Tremella fuciformis, is a popular edible mushroom with interesting medicinal properties (e.g., immunostimulating, antidiabetic). The formation of T.

Immune supportMetabolic health

High relevance

Lion's Mane · 2016 · Journal Article · Current microbiology

Protective Effects of Extracellular and Intracellular Polysaccharides on Hepatotoxicity by Hericium erinaceus SG-02.

The protective effects of extracellular and intracellular polysaccharides from Hericium erinaceus SG-02 on the CCl4-induced hepatic injury of mice were investigated in this work..

Immune supportMetabolic healthLiver support

High relevance

Enoki · 2016 · Research Article · PeerJ

Selenium uptake, tolerance and reduction in Flammulina velutipes supplied with selenite.

Recently, selenium (Se) enriched mushrooms have been exploited as dietary Se supplements, but our knowledge of the metabolic process during the Se enrichment process is far from complete..

Metabolic health

High relevance

Mesima · 2016 · Journal Article · International journal of biological macromolecules

Structure and antioxidative property of a polysaccharide from an ammonium oxalate extract of Phellinus linteus.

In this paper, the novel polysaccharide PL-A11 was purified from an ammonium oxalate extract of Phellinus linteus mycelia. Its physicochemical properties, structural characteristics, and antioxidant activities were investigated..

Immune supportMetabolic healthLiver supportSkin & hydration

High relevance

Maitake · 2016 · Research Article · Frontiers in microbiology

The Mechanisms Underlying the Hypolipidaemic Effects of Grifola frondosa in the Liver of Rats.

The present study investigated the hypolipidaemic effects of Grifola frondosa and its regulation mechanism involved in lipid metabolism in liver of rats fed a high-cholesterol diet. The body weights and serum lipid levels of control rats, of hyperlipidaemic rats, and of hyperlipidaemic rats treated with oral G..

Metabolic healthLiver support

High relevance

Niu-Chang-Chih · 2012 · Review · International journal of medicinal mushrooms

Review of biological and pharmacological activities of the endemic Taiwanese bitter medicinal mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (higher Basidiomycetes).

Antrodia camphorata is an extremely rare fungus native to the forested regions of Taiwan. It is also a traditional Chinese medicine, and Taiwanese aborigines applied it for treating liver diseases and protecting from food and drug intoxication.

OncologyImmune supportMetabolic healthLiver support

High relevance

Niu-Chang-Chih · 2009 · Review · Journal of ethnopharmacology

Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases.

Niuchangchih (Antrodia camphorata (M. Zang & C.H.

OncologyImmune supportMetabolic healthLiver support

High relevance

Maitake · 2005 · Journal Article · Phytochemistry

Grifolisin, a member of the sedolisin family produced by the fungus Grifola frondosa.

The pepstatin-insensitive carboxyl proteinase grifolisin was purified from fruiting bodies of the fungus Grifola frondosa, a maitake mushroom. The enzyme had an optimum pH of 3.0 for the digestion of hemoglobin and 2.8 for milk casein digestion..

Metabolic healthGut & microbiome

High relevance

Chaga · 2005 · Research Article · Mycobiology

Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus.

The immunomodulatory effect of aqueous extract of Inonotus obliquus, called as Chaga, was tested on bone marrow cells from chemically immunosuppressed mice. The Chaga water extract was daily administered for 24 days to mice that had been treated with cyclophosphamide (400 mg/kg body weight), immunosuppressive….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2004 · Research Article · Journal of Hebei Agricultural University

Study on liquid culture and polysaccharide antioxidation of Pleurotus eryngii

Terminal renal failure secondary to the hemolytic uremic syndrome (HUS) developed 18 months after initial transplantation and 4 1/2 months after the child received his second cadaveric renal allograft..

Immune supportMetabolic health

High relevance

Maitake · 2001 · Journal Article · Experimental biology and medicine (Maywood, N.J.)

Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats.

The effects of mushroom fibers on serum cholesterol and hepatic low-density lipoprotein (LDL) receptor mRNA in rats were investigated. Rats were fed a cholesterol-free diet with 50 g/kg cellulose powder (CP), 50 g/kg maitake (Grifola frondosa) fiber (MAF), 50 g/kg shiitake (Lentinus edodes) fiber (SF), or 50 g/kg….

Metabolic healthGut & microbiomeLiver support

High relevance

Maitake · 2001 · Journal Article · Journal of nutritional science and vitaminology

Maitake (Grifola frondosa) Improve Glucose Tolerance of Experimental Diabetic Rats

We have previously reported that rats with diabetes induced by injecting streptozotocin into neonates showed remarkably lower blood glucose, urine volume, and glucosuria after administration of Maitake (Grifola frondosa)..

Metabolic health

High relevance

Maitake · 1997 · Journal Article · Biological & pharmaceutical bulletin

Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I.

Experimental rat models (5-week-old Sprague-Dawley rats) with hyperlipemia were prepared by feeding high-cholesterol feed containing sodium cholate and casein as a protein source. Dried maitake (Grifola frondosa) powder was mixed with the basic high-cholesterol feed and the serum lipids were periodically measured..

Metabolic healthLiver support

High relevance

King Oyster · 1997 · Journal Article · Current microbiology

Induction and Characterization of Laccase in the Ligninolytic Fungus Pleurotus eryngii.

Two protein bands with laccase activity were found after PAGE of culture liquid or mycelium extract of Pleurotus eryngii, grown on glucose-ammonium tartrate-yeast extract medium with and without inducers. A major and a minor laccase band were observed in the basal medium..

Metabolic health

High relevance

Maitake · 1994 · Journal Article · Biological & pharmaceutical bulletin

Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I.

The fruit body of Grifola frondosa (maitake), Basidiomycetes was confirmed to contain substances with anti-diabetic activity. When 1 g/d of powdered fruit body of maitake was given orally to a genetically diabetic mouse (KK-Ay), blood glucose reduction was observed, in contrast to the control group in which the blood….

Metabolic health

High relevance

Enoki · 1991 · Journal Article · Journal of food protection

Evaluation of the Botulism Hazard from Vacuum-packaged Enoki Mushrooms ( Flammulina velutipes ).

Flammulina velutipes, commonly known as the enoki or winter mushroom, is cultured aseptically in Japan and the United States and is vacuum-packaged in polyethylene film for retail sale..

Metabolic health

High relevance

Reishi · 2026 · Research Article · Food science & nutrition

A Triterpenoid-Enriched GLE70 Fraction From Ganoderma lingzhi Ameliorates Alcoholic Liver Disease via Multi-Target Regulation.

Alcoholic liver disease (ALD) arises from chronic alcohol consumption and progresses toward severe hepatic injury. Ganoderma lingzhi (G.

Immune supportMetabolic healthLiver support

High relevance

Maitake · 2026 · Journal Article · Annals of clinical biochemistry

Application of ergosterol as a maitake mushroom intake biomarker.

BackgroundDyslipidemia is a lifestyle-related disease; therefore, cholesterol biosynthesis inhibitors in foods can be easily ingested on a daily basis and are effective in aiding treatment and prevention..

Metabolic health

High relevance

Almond Mushroom · 2026 · Journal Article · European spine journal: official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Bioactive glass-ceramic spacer alone versus spacer augmented with ABM/P-15 in single-level ACDF: a retrospective cohort study comparison of fusion rates and clinical outcomes.

PURPOSE: Achieving early fusion is a critical goal when selecting graft material for anterior cervical discectomy and fusion (ACDF). As bioactive glass-ceramic (BGC-7) cages demonstrate favorable osteoconductive properties, their fusion potential may be enhanced through augmentation with osteoinductive materials..

Metabolic health

High relevance

Nameko · 2026 · Research Article · Scientific reports

Chemical composition, metabolomics, and functional potential of Pholiota nameko pre-cooking liquid.

The liquid generated during the pre-cooking process of Pholiota nameko is frequently considered waste, and its large-scale disposal may pose environmental risks. This study undertook a comparative analysis of the liquid and the fruiting bodies, focusing on their chemical composition, physicochemical properties, and….

Immune supportMetabolic healthSkin & hydration

High relevance

Chaga · 2026 · Research Article · Journal of Korean medical science

Kidney Injury Induced by High-Dose Chaga Mushroom Consumption: Experimental Evidence in a Rat Model.

BACKGROUND: Kidney damage can result not only from the overproduction of endogenous oxalate but also from excessive dietary intake. This study investigated whether oxalate-rich Chaga mushroom induces kidney injury..

OncologyImmune supportMetabolic health

High relevance

King Oyster · 2026 · Journal Article · Food Hydrocolloids

Novel insights into selenium-biofortified P. eryngii polysaccharides: Unveiling selenium release patterns and gut microbiota modulation through in vitro models

Selenium biofortification of P. eryngii was achieved through exogenous selenium supplementation during cultivation, significantly increasing its selenium content.

Immune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2026 · Journal Article · Applied biochemistry and biotechnology

Quantitative Proteomics Analysis Insights into the Cordyceps Polysaccharides Biosynthesis.

Cordyceps polysaccharides, as bioactive macromolecules derived from Cordyceps sinensis, exhibit pharmacological activities such as immune modulation and anti-tumor properties. However, the understanding of their biosynthetic mechanisms remains limited..

OncologyImmune supportMetabolic health

High relevance

Shiitake · 2025 · Journal Article · Food chemistry

4D-DIA quantitative proteomics unveiled the mechanisms underlying ATP induced quality variation with spore release in shiitake mushrooms.

Spore release, a critical indicator of postharvest quality deterioration in shiitake mushrooms, accompanied by energy consumption. This study investigated the role of adenosine triphosphate (ATP) treatment on the quality of shiitake mushrooms during spore release through microstructural observation, physicochemical….

Energy & fatigueMetabolic health

High relevance

Cordyceps · 2025 · Research Article · IMA fungus

Chemical clues to infection: A pilot study on the differential secondary metabolite production during the life cycle of selected Cordyceps species.

Cordyceps species are widespread entomopathogens and promising biocontrol agents that produce diverse secondary metabolites, yet the roles of these molecules during the infection process remain unclear..

Metabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Clerodendranthus spicatus-Cordyceps cicadae regulates mitophagy and protects renal tubular epithelial cells from hyperuricemic nephropathy.

ETHNOPHARMACOLOGICAL RELEVANCE: Clerodendranthus spicatus (CS) and Cordyceps cicadae (CC) are both medicine and food. They have long been used to treat kidney disease, but their mechanisms for treating hyperuricemic nephropathy (HN) are not yet clear..

Immune supportMetabolic health

High relevance

Cordyceps · 2025 · Research Article · Biology

Comparative Metabolite Profiling Between Cordyceps sinensis and Other Cordyceps by Untargeted UHPLC-MS/MS.

Cordyceps sinensis is a second-class, nationally protected, medicinal fungi and serves as a functional nutrient in China. C.

Metabolic health

High relevance

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Decoding the difference of four species of Cordyceps based on polysaccharides and immunomodulation activity.

Nucleosides and polysaccharides are the main bioactive ingredients of Cordyceps genus. Nucleosides shows significant differences in different Cordyceps species.

Immune supportMetabolic health

High relevance

Shiitake · 2025 · Research Article · Frontiers in nutrition

Enhancing yield and quality: research and practice of agro-forest waste for Lentinus edodes (shiitake mushroom) cultivation.

INTRODUCTION: Current research primarily focuses on exploring and developing innovative substrates for cultivating Lentinus edodes, aiming to address substrate shortages and the continuous rise in production costs..

Energy & fatigueMetabolic health

High relevance

Chaga · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Impact of a Formulation Containing Chaga Extract, Coenzyme Q10, and Alpha-Lipoic Acid on Mitochondrial Dysfunction and Oxidative Stress: NMR Metabolomic Insights into Cellular Energy.

OBJECTIVES: The aim of this study was to evaluate the impact of a novel antioxidant formulation (RE:PAIR, RP-25) containing CoQ10, alpha-lipoic acid, and Chaga extract on mitochondrial dysfunction and oxidative stress..

Cognition & nervesEnergy & fatigueMetabolic health