MycoData

High feed costs and compromised meat quality are among the major issues perturbing the global broiler industry. This study therefore investigated Vachellia erioloba pods-derived oyster mushroom spent substrate (OMSS) as a potential nutraceutical feed ingredient to replace wheat bran for enhancing meat quality in….

Immune supportEnergy & fatigueMetabolic health

Medium relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Temperature-Dependent Modeling and Spatial Predictions for Identifying Geographical Areas in Brazil Suitable for the Use of Cordyceps javanica in Whitefly Control.

Lalguard C99 WP, based on the Cordyceps javanica BRM 27666 strain, is registered in Brazil for whitefly control. Spatial prediction is crucial for optimizing its field use and efficacy.

Energy & fatigue

Medium relevance

Cordyceps · 2024 · Research Article · Nutrients

Anti-Inflammatory Effects of Cordyceps Cs-HK1 Fungus Exopolysaccharide on Lipopolysaccharide-Stimulated Macrophages via the TLR4/MyD88/NF-κB Pathway.

Chronic inflammation is a common factor in the pathological processes of multiple human diseases. EPS-LM, an exopolysaccharide (EPS) from the Cordyceps sinensis fungus Cs-HK1, has shown notable anti-inflammatory activities in previous studies..

Immune supportEnergy & fatigue

Medium relevance

Cordyceps · 2024 · Research Article · Chinese herbal medicines

Chemical components in cultivated Cordyceps sinensis and their effects on fibrosis.

OBJECTIVE: Cultivated Cordyceps sinensis powder has been used as clinical drug and healthy food to nourish the lung and kidney, which solves the problem of serious shortage of wild C. sinensis.

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

Medium relevance

Agarikon · 2024 · Research Article · Journal of traditional and complementary medicine

Chemical profiling and mechanisms of Agarikon pill in a rat model of cigarette smoke-induced chronic obstructive pulmonary disease.

BACKGROUND AND AIM: Agarikon pill (AGKP), a traditional Chinese herbal formula, and has been used for chronic obstructive pulmonary disease (COPD) treatment clinically. However, the active components and exact pharmacological mechanisms are still unclear..

Immune supportEnergy & fatigueRespiratory

Medium relevance

Oyster Mushroom · 2024 · Research Article · Computational and structural biotechnology journal

Comparative analyses of Pleurotus pulmonarius mitochondrial genomes reveal two major lineages of mini oyster mushroom cultivars.

Pleurotus pulmonarius, commonly known as the mini oyster mushroom, is highly esteemed for its crisp texture and umami flavor. Limited genetic diversity among P.

Energy & fatigue

Medium relevance

Cordyceps · 2024 · Research Article · Immunity, inflammation and disease

Cordyceps cicadae ameliorates inflammatory responses, oxidative stress, and fibrosis by targeting the PI3K/mTOR-mediated autophagy pathway in the renal of MRL/lpr mice.

BACKGROUND: The vast majority of systemic lupus erythematosus patients develop lupus nephritis (LN) with severe renal manifestations, such as inflammatory responses, oxidative stress, and fibrosis..

Immune supportEnergy & fatigueSkin & hydration

Medium relevance

Oyster Mushroom · 2024 · Research Article · Scientific reports

Dietary oyster mushroom fermented Vachellia erioloba pods enhance Boschveld chicken meat healthiness without altering its physicochemical quality, growth performance and physiology.

The high content of fibre and antinutritional phytochemicals limit the utilization of Vachellia erioloba tree pods as nutraceutical feed additive for indigenous chicken diets..

Energy & fatigueMetabolic health

Medium relevance

Cordyceps · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

Evaluation of Cordyceps sinensis Quality in 15 Production Areas Using Metabolomics and the Membership Function Method.

Cordyceps sinensis is a precious medicinal and edible fungus, which is widely used in body health care and disease prevention. The current research focuses on the comparison of metabolite characteristics between a small number of samples and lacks a comprehensive evaluation of the quality of C..

Energy & fatigueMetabolic health

Medium relevance

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

Investigation of cellular uptake and transport capacity of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles with different particle sizes in Caco-2 cell monolayer.

Cordyceps sinensis exopolysaccharide‑selenium nanoparticles (EPS-SeNPs) were successfully constructed, characterized, and its Se release kinetics and mechanism were also evaluated in our previous studies. However, the intestinal cellular uptake and transport capacities of EPS-SeNPs remain unknown..

Immune supportEnergy & fatigueGut & microbiome

Medium relevance

Cordyceps · 2024 · Journal Article · Journal of ethnopharmacology

Multi-omics reveals the testosterone promotion effect mechanism of Cordyceps Sobolifera on Leydig cells.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps sobolifera (CS) has been traditionally utilized as an ethnic remedy for various health conditions, including chronic kidney diseases, anti-fatigue interventions, and management of chronic inflammation..

Immune supportEnergy & fatigueMetabolic health

Medium relevance

Shiitake · 2024 · Journal Article · Food chemistry

Natural deep eutectic solvents for the extraction of lentinan from shiitake mushroom: COSMO-RS screening and ANN-GA optimizing conditions.

Using natural deep eutectic solvents (NDES) for green extraction of lentinan from shiitake mushroom is a high-efficiency method. However, empirical and trial-and-error methods commonly used to select suitable NDES are unconvincing and time-consuming..

Energy & fatigue

Medium relevance

Nameko · 2024 · Journal Article · Journal of environmental management

Performance of co-composting Pholiota nameko spent mushroom substrate and pig manure at different proportions: Chemical properties and humification process.

Co-composting is the controlled aerobic degradation of organics, using more than one feedstock. By combining the spent mushroom substrate of Pholiota nameko (SMS) and pig manure (PM), the benefits of each could be used to optimize the composting process and the final product..

Immune supportEnergy & fatigueMetabolic health

Medium relevance

Cordyceps · 2024 · Research Article · International journal of molecular sciences

RNA-Seq-Based Transcriptome Analysis of Chinese Cordyceps Aqueous Extracts Protective Effect against Adriamycin-Induced mpc5 Cell Injury.

Pharmacogenomic analysis based on drug transcriptome characteristics is widely used to identify mechanisms of action. The purpose of this study was to elucidate the molecular mechanism of protective effect against adriamycin (ADM)-induced mpc5 cell injury of Chinese cordyceps aqueous extracts (WCCs) by a systematic….

Immune supportEnergy & fatigueMetabolic health

Medium relevance

Cordyceps · 2024 · Journal Article · Journal of ethnopharmacology

The protective role of Cordyceps cicadae and its active ingredient myriocin against sodium iodate-induced age-related macular degeneration via an anti-necroptotic TNF-RIPK1/3 pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps cicadae (C.cicadae), named "Chan Hua", an anamorph of Isaria cicadae Miquel, is an entomogenous complex formed by fungi parasitizing on the larvae of cicadas and belongs to the Claviciptaceae family and the genus Codyceps, which traditionally holds a significant place in….

Immune supportEnergy & fatigue

Medium relevance

Cordyceps · 2020 · Journal Article · Gene

Expression profiling of Cordyceps DnaJ protein family in Tolypocladium guangdongense during developmental and temperature stress processes.

DnaJ is an important molecular chaperone, with significant roles in growth, development, and stress resistance. Studies on the DnaJ gene family in macro-fungi such as Cordyceps spp.

Energy & fatigue

Medium relevance

King Oyster · 2020 · Journal Article · Protein and peptide letters

Purification, Biochemical Characterization and Decolorization Efficiency of Laccases from Peach and Cherry Cultures of Pleutorus eryngii: A Comparative Study.

BACKGROUND: Laccases (Lacs) are used potentially in industrial and biotechnological applications such as decolorization of dyes, degradation of industrial effluents, delignification, etc. thanks to their large varieties of substrate specificities and excellent catalytic efficiencies..

Energy & fatigue

Medium relevance

Shiitake · 2020 · Journal Article · International journal of medicinal mushrooms

Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): Absence of Changes in Maternal Reproductive Performance and Embryofetal Development In Vivo.

The shiitake culinary-medicinal mushroom Lentinus edodes (=Lentinula edodes) has been used as a nutritional complement. This study evaluated, through reprotox tests, the consumption of L.

Energy & fatigueMetabolic health

Medium relevance

King Oyster · 2026 · Review · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Neuroprotection in the age of emerging infections: The untapped power of medicinal mushrooms.

Infections affecting the nervous system require a rapid expansion of effective therapeutic strategies. The emergence of new viral pathogens continues to pose a substantial threat to brain health worldwide, as evidenced by the recent pandemic..

Immune supportCognition & nervesEnergy & fatigueRespiratory

Medium relevance

Cordyceps · 2024 · Review · Physiologia plantarum

Complete mitochondrial genomes of edible mushrooms: features, evolution, and phylogeny.

Edible mushrooms are an important food source with high nutritional and medicinal value. They are a useful source for studying phylogenetic evolution and species divergence..

Energy & fatigue

Medium relevance

Reishi · 2024 · Preprint · journal metadata

Protective effect and efficacy evaluation of lychee seed fermentation broth on oxidative damage of cells

Abstract Background Lychee seeds were fermented by three kinds of bacteria ( Lactobacillus plantarum, Saccharomyces cerevillus and ganoderma lucidum mycelium ), and two effective strains were selected by two indexes of activity content and antioxidant, so as to further verify whether lychee seeds have waste….

Immune supportEnergy & fatigueGut & microbiomeSkin & hydration

Medium relevance

Maitake · 2022 · Published Erratum · International journal of molecular medicine

[Corrigendum] Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway.

Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 3B on p.

OncologyImmune supportEnergy & fatigue

Medium relevance

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · PloS one

Apoptosis of Hepatocellular Carcinoma Cells Induced by Nanoencapsulated Polysaccharides Extracted from Antrodia Camphorata.

Antrodia camphorata is a well-known medicinal mushroom in Taiwan and has been studied for decades, especially with focus on anti-cancer activity. Polysaccharides are the major bioactive compounds reported with anti-cancer activity, but the debates on how they target cells still remain..

OncologyImmune supportEnergy & fatigueLiver support

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Bioprocess and biosystems engineering

Chitosan multiple addition enhances laccase production from Trametes versicolor.

Chitosan multiple addition strategy was developed to improve laccase production from Trametes versicolor cultures. The optimized multiple addition strategy was carried out by two-time addition of 0.1 g L(-1) chitosan to a 2-day-old culture media, with 24-h interval between the treatments..

Energy & fatigueMetabolic health

Medium relevance

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · Bioresource technology

Efficient production of bioactive metabolites from Antrodia camphorata ATCC 200183 by asexual reproduction-based repeated batch fermentation.

Large-scale submerged fermentation (SmF) of Antrodia camphorata (A. camphorata) usually encounters challenges including tedious preparation of mycelial inoculum, long fermentation period (10-14 d), and poor repeatability..

Energy & fatigue

Medium relevance

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Ergostatrien-3β-ol from Antrodia camphorata inhibits diabetes and hyperlipidemia in high-fat-diet treated mice via regulation of hepatic related genes, glucose transporter 4, and AMP-activated protein kinase phosphorylation.

This study was designed to explore the effects and mechanism of ergostatrien-3β-ol (EK100) from the submerged whole broth of Antrodia camphorata on diabetes and dyslipidemia in high fat diet (HFD)-fed mice for 12 weeks..

Energy & fatigueMetabolic healthLiver support

Medium relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis.

HEG-5 is a novel polysaccharide-protein purified from the fermented mycelia of Hericium erinaceus CZ-2. The present study aims to investigate the effects of HEG-5 on proliferation, cell cycle and apoptosis of human gastric cancer cells SGC-7901..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · World journal of microbiology & biotechnology

Laccase production and metabolic diversity among Flammulina velutipes strains.

Twelve Flammulina velutipes strains originating from Poland were identified using internal transcribed spacer (ITS) region sequencing. Based on the sequences obtained, the genomic relationship of the analyzed strains was determined.

Energy & fatigueMetabolic health

Medium relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of nanomedicine

Neurite outgrowth stimulatory effects of myco synthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells.

BACKGROUND: Hericium erinaceus has been reported to have a wide range of medicinal properties such as stimulation of neurite outgrowth, promotion of functional recovery of axonotmetic peroneal nerve injury, antioxidant, antihypertensive, and antidiabetic properties..

Cognition & nervesEnergy & fatigueMetabolic health

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Chemosphere

Non conventional biological treatment based on Trametes versicolor for the elimination of recalcitrant anticancer drugs in hospital wastewater.

This work presents a study about the elimination of anticancer drugs, a group of pollutants considered recalcitrant during conventional activated sludge wastewater treatment, using a biological treatment based on the fungus Trametes versicolor..

OncologyEnergy & fatigue

Medium relevance

Zhu Ling · 2015 · Research Support, Non U.S. Gov'T · Scientific reports

Oxalic acid and sclerotial differentiation of Polyporus umbellatus.

The present investigation aimed to uncover the effects of exogenous oxalic acid during the sclerotial formation of Polyporus umbellatus, with an emphasis on determining the content of the endogenic oxalic acid in the fungus..

Energy & fatigue

Medium relevance

Lion's Mane · 2015 · Case Reports · Fungal biology and biotechnology

Production of cyathane type secondary metabolites by submerged cultures of Hericium erinaceus and evaluation of their antibacterial activity by direct bioautography.

BACKGROUND: Fungi of the phylum Basidiomycota are well-known to form a broad spectrum of biologically active secondary metabolites, especially low molecular weight compounds such as terpenoids. Hericium erinaceus produces various cyathane type diterpenoids including erinacines..

Cognition & nervesEnergy & fatigue

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Food & function

Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-D-glucan derived from the fruiting body of Antrodia camphorata.

Antrodia camphorata is a fungus native to Taiwan, and it is considered a precious medicinal agent. We analyzed triterpenoids, polysaccharides and 1,3-β-D-glucan, three major effective components in A.

OncologyImmune supportEnergy & fatigue

Medium relevance

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers.

ETHNOPHARMACOLOGICAL RELEVANCE: Hericium is a genus of mushrooms (fungus) in the Hericiaceae family. Hericium erinaceus (HE) has been used for the treatment of digestive diseases for over 2000 years in China..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Wood Ear · 2014 · Research Support, Non U.S. Gov'T · Microbiological research

Cloning, expression and phylogenetic analysis of a divergent laccase multigene family in Auricularia auricula-judae.

Laccases (p-diphenol: oxygen oxidoreductase; EC 1.10.3.2) are multi-copper oxidases encoded by gene family in white rot fungi. Auricularia auricula-judae is one kind of white rot fungi with a soft, jelly-like texture and an ear-like shape..

Energy & fatigue

Medium relevance

Niu-Chang-Chih · 2014 · Comparative Study · Phytomedicine: international journal of phytotherapy and phytopharmacology

Comparison of solid-state-cultured and wood-cultured Antrodia camphorata in anti-inflammatory effects using NF-κB/luciferase inducible transgenic mice.

PURPOSE: Antrodia camphorata (AC), a highly valued polypore mushroom native only to Taiwan, has been traditionally used as a medicine for the treatment of food and drug intoxication, diarrhea, abdominal pain, hypertension, skin itching, and cancer..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Mesima · 2014 · Comparative Study · International journal of food sciences and nutrition

Effects of polysaccharide from fruiting bodies of Agaricus bisporus, Agaricus brasiliensis, and Phellinus linteus on alcoholic liver injury.

In the present study, the curative effects of crude polysaccharides (PSs) from mushrooms on the symptoms of alcoholic liver injury were investigated. PSs from Agaricus bisporus, Agaricus brasiliensis, and Phellinus linteus fruiting bodies were administered by gavage at levels of 100 mg per kg body weight per day for 7….

Immune supportEnergy & fatigueMetabolic healthLiver support

Medium relevance

Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · Oxidative medicine and cellular longevity

Effects of treating old rats with an aqueous Agaricus blazei extract on oxidative and functional parameters of the brain tissue and brain mitochondria.

Dysfunction of the mitochondrial respiratory chain and increased oxidative stress is a striking phenomenon in the brain of aged individuals. For this reason there has been a constant search for drugs and natural products able to prevent or at least to mitigate these problems..

Cognition & nervesEnergy & fatigueRespiratory

Medium relevance

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Food & function

Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways.

Hericium erinaceus (Bull.: Fr.) Pers. is an edible and medicinal mushroom used traditionally to improve memory.

Cognition & nervesEnergy & fatigue

Medium relevance

Mesima · 2014 · Research Support, Non U.S. Gov'T · Chemico-biological interactions

Hispidin derived from Phellinus linteus affords protection against acrylamide-induced oxidative stress in Caco-2 cells.

Acrylamide (AA), a well-known toxicant, has attracted numerous attentions for its presumably carcinogenesis, neurotoxicity and cytotoxicity. Oxidative stress was considered to be associated with acrylamide cytotoxicity, but the link between oxidative stress and acrylamide cytotoxicity is still unclear..

OncologyCognition & nervesEnergy & fatigue

Medium relevance

Zhu Ling · 2014 · Research Support, Non U.S. Gov'T · BMC complementary and alternative medicine

Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.

BACKGROUND: Khz-cp is a crude polysaccharide extract that is obtained after nuclear fusion in Ganoderma lucidum and Polyporus umbellatus mycelia (Khz). It inhibits the growth of cancer cells.

OncologyImmune supportEnergy & fatigue

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Methanol extract of Antrodia camphorata protects against lipopolysaccharide-induced acute lung injury by suppressing NF-κB and MAPK pathways in mice.

Antrodia camphorata (AC) has been used as a herbal medicine for drug intoxication for the treatment of inflammation syndromes and liver-related diseases in Taiwan. This study demonstrates the protective effect of the methanol extract of AC (MAC) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice..

OncologyImmune supportEnergy & fatigueLiver support

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Multiple-fingerprint analysis for investigating quality control of Flammulina velutipes fruiting body polysaccharides.

Quality control issues overshadow potential health benefits of the edible mushroom Flammulina velutipes, with the detection and isolation of polysaccharides posing particular problems..

Immune supportEnergy & fatigue

Medium relevance

Chaga · 2014 · Research Support, Non U.S. Gov'T · Oncology reports

Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via downregulation of NF-κB signaling pathway.

Polysaccharides derived from Inonotus obliquus (PIO) are known to possess multiple pharmacological activities including antitumor activity. However, the possible molecular mechanisms of these activities are unknown..

OncologyImmune supportEnergy & fatigue

Medium relevance

Wood Ear · 2014 · Research Support, Non U.S. Gov'T · World journal of microbiology & biotechnology

Responses of antioxidant defenses and membrane damage to drought stress in fruit bodies of Auricularia auricula-judae.

Fruit bodies of Auricularia auricula-judae are often subjected to drought stress and became dormant. The responses of antioxidant defenses and membrane damage to drought stress were investigated in this study..

Energy & fatigue

Medium relevance

Chaga · 2014 · Research Support, Non U.S. Gov'T · Journal of bioscience and bioengineering

Stimulated production of steroids in Inonotus obliquus by host factors from birch.

Steroids was considered as one of the bioactive components in Inonotus obliquus, while this kind of secondary metabolites are less accumulated in cultured mycelia. In this study, effect of extracts from bark and core of host-related species, birch (Betula platyphylla Suk.), on steroid production of I..

Energy & fatigueMetabolic health

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Enzyme and microbial technology

The use of Trametes versicolor laccase for the polymerization of aniline in the presence of vesicles as templates.

The enzymatic polymerization of aniline to polyaniline (PANI) with Trametes versicolor laccase (TvL) as catalyst and dioxygen (O₂) as oxidant was investigated in an aqueous medium containing unilamellar vesicles with an average diameter of about 80 nm formed from AOT (=sodium bis(2-ethylhexyl) sulfosuccinate)..

Energy & fatigue

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · PloS one

Whole genome and global gene expression analyses of the model mushroom Flammulina velutipes reveal a high capacity for lignocellulose degradation.

Flammulina velutipes is a fungus with health and medicinal benefits that has been used for consumption and cultivation in East Asia. F.

Energy & fatigue

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Antrodia camphorata grown on germinated brown rice inhibits HT-29 human colon carcinoma proliferation through inducing G0/G1 phase arrest and apoptosis by targeting the β-catenin signaling.

Antrodia camphorata (AC) has been used as a traditional medicine to treat food and drug intoxication, diarrhea, abdominal pain, hypertension, pruritis (skin itch), and liver cancer in East Asia..

OncologyEnergy & fatigueMetabolic healthGut & microbiome

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis.

Antrodia camphorata is a unique fungus in Taiwan; the submerged fermentation product is used as the functional food for liver protection. Deep ocean water (DOW) containing rich metals and trace elements is proven to stimulate the production of functional metabolites and health function of functional fungus product in….

Immune supportEnergy & fatigueLiver supportSkin & hydration