MycoData

In this study, the enzyme degradation of Hericium erinaceus polysaccharide (HEP) was successfully modified with endo-rhamnosidase to obtain the enzymatic hydrolysis of Hericium erinaceus polysaccharide product (EHEP)..

Immune supportEnergy & fatigue

High relevance

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Structure analysis and antioxidant activity of polysaccharide-iron (III) from Cordyceps militaris mycelia.

Iron-enriched Cordyceps militaris was obtained by adding FeSO4 solution to the mycelia for biotransformation. The polysaccharide-iron (III) was extracted by water extraction and alcohol precipitation.

Immune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Structure and hypoglycemic activity of a novel exopolysaccharide of Cordyceps militaris.

A novel neutral exopolysaccharide (EPS-III) was isolated from culture broth of Cordyceps militaris (C. militaris).

Immune supportMetabolic health

High relevance

Lion's Mane · 2021 · Research Article · Food chemistry: X

Study on the interaction of Hericium erinaceus mycelium polysaccharides and its degradation products with food additive silica nanoparticles.

Gastric mucosal injury is a common gastrointestinal disorder. Hericium erinaceus polysaccharide, the major active ingredient in Hericium erinaceus, can reduce gastric mucosal damage to some extent..

Immune supportGut & microbiome

High relevance

Almond Mushroom · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Subcritical Water Extracts from Agaricus blazei Murrill's Mycelium Inhibit the Expression of Immune Checkpoint Molecules and Axl Receptor.

Agaricus blazei Murrill or Himematsutake is an edible and medicinal mushroom. Agaricus blazei Murrill's fruiting body extracts have anticancer properties, although the mechanism is unknown..

OncologyImmune supportRespiratory

High relevance

Cordyceps · 2021 · Research Article · Animal bioscience

Tenderness-related index and proteolytic enzyme response to the marination of spent hen breast by a protease extracted from Cordyceps militaris mushroom.

OBJECTIVE: The effects of a crude protease extracted from Cordyceps militaris (CM) mushrooms on the postmortem tenderization mechanism and quality improvement in spent hen breast were investigated..

Skin & hydration

High relevance

King Oyster · 2021 · Journal Article · Andrologia

The antioxidant and anti-apoptotic potential of Pleurotus eryngii extract and its chitosan-loaded nanoparticles against doxorubicin-induced testicular toxicity in male rats.

This study was conducted to evaluate the protective role of Pleurotus eryngii extract (PE) and Pleurotus eryngii extract-loaded chitosan nanoparticles (PE-CSNP) against doxorubicin (DOX)-induced testicular toxicity in rats..

Oncology

High relevance

Reishi · 2021 · Journal Article · Tissue & cell

The association between testicular toxicity induced by Li2Co3 and protective effect of Ganoderma lucidum: Alteration of Bax & c-Kit genes expression.

Ganoderma lucidum has received a lot of attention recently due to its medicinal potential activities. The aim of this designed experiment was to evaluate the beneficial effects of Ganoderma lucidum extract against lithium carbonate induced testicular toxicity and related lesions in mice testis..

OncologyImmune support

High relevance

Yellow Morel · 2021 · Journal Article · Food & function

The chemical structure and immunomodulatory activity of an exopolysaccharide produced by Morchella esculenta under submerged fermentation.

The extracellular polysaccharide of Morchella esculenta cultivated under submerged fermentation was extracted. A single polysaccharide was purified through DEAE-Cellulose 52 and Sephadex G 100, and named as MEP 2a.

Immune supportMetabolic health

High relevance

Chaga · 2021 · Research Article · Food science & nutrition

The difference of regulatory effect of two Inonotus obliquus extracts on high-fat diet mice in relation to the fatty acid elongation function of gut microbiota.

Obesity is a disease that causes metabolic disorders in the human body and is closely related to intestinal microbes. This experiment compares the therapeutic effects of two Inonotus obliquus extracts on high-fat diet (HFD) mice and explores the effects and mechanisms of intestinal flora and its metabolites..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Cordyceps · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

The Feasibility of Utilizing Cultured Cordyceps militaris Residues in Cosmetics: Biological Activity Assessment of Their Crude Extracts.

Solid-based residues (SBRs) left from harvesting the fruiting bodies of cultured Cordyceps mushrooms are a challenge to sustainability. Therefore, in this study, the SBRs from the cultivation of Cordyceps militaris (C..

OncologySkin & hydration

High relevance

Maitake · 2021 · Journal Article · Food & function

The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury via the miR-122-Nrf2/ARE pathways.

Polysaccharides can be used as a potential hepatoprotective agent in the treatment of acute liver injury. However, the underlying mechanism governing how polysaccharides protect against acute liver injury induced by lipopolysaccharide/d-galactosamine (LPS/d-GalN) remains unclear..

OncologyImmune supportLiver supportRespiratory

High relevance

King Oyster · 2021 · Journal Article · Chemosphere

The remediation of sulfonamides from the environment by Pleurotus eryngii mycelium. Efficiency, products and mechanisms of mycodegradation.

The objective of the study was to assess the applicability of the mycelium obtained from the in vitro cultures of nontoxic bracket fungus, Pleurotus eryngii, to sulfonamides mycodegradation. Samples containing one of the six selected sulfonamides, sulfanilamide derivatives, were incubated with the mycelium of P..

High relevance

Enoki · 2021 · Journal Article · Gene

The transcription factor FvHmg1 negatively regulates fruiting body development in Winter Mushroom Flammulina velutipes.

Fruiting body formation in Agaricomycetes represents the most complex and unclear process in the fungi. Mating type pathways (matA and matB) and transcription factors are important regulators in the process..

High relevance

Chaga · 2021 · Research Article · Molecules (Basel, Switzerland)

Total Triterpenoid Extraction from Inonotus Obliquus Using Ionic Liquids and Separation of Potential Lactate Dehydrogenase Inhibitors via Ultrafiltration High-Speed Countercurrent Chromatography.

Extracts of the fungus Inonotus obliquus exhibit cytotoxic properties against different cancers; hence, this fungal species has been extensively studied. This study aimed to extract total triterpenoids from Inonotus obliquus using ionic liquids (ILs) and separate potential lactate dehydrogenase (LDH) inhibitors via….

Oncology

High relevance

King Oyster · 2021 · Research Article · International journal of molecular sciences

Transcriptome Analysis Reveals Candidate Genes Involved in Light-Induced Primordium Differentiation in Pleurotus eryngii.

Pleurotus eryngii, a highly valued edible fungus, is one of the major commercially cultivated mushrooms in China. The development of P.

High relevance

Cordyceps · 2021 · Research Article · Frontiers in nutrition

Transcriptomic Responses of Cordyceps militaris to Salt Treatment During Cordycepins Production.

Cordycepin is a major bioactive compound found in Cordyceps militaris (C. militaris) that exhibits a broad spectrum of biological activities.

Skin & hydration

High relevance

Snow Fungus · 2021 · Journal Article · Journal of cosmetic dermatology

Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways.

BACKGROUND: UVA radiation can cause skin oxidative stress. Tremella fuciformis polysaccharides (TFPS) are the main active ingredient in Tremella.

Immune supportEnergy & fatigueSkin & hydration

High relevance

King Oyster · 2021 · Research Article · Applied microbiology and biotechnology

Two adjacent C-terminal mutations enable expression of aryl-alcohol oxidase from Pleurotus eryngii in Pichia pastoris.

Fungal aryl-alcohol oxidases (AAOs) are attractive biocatalysts because they selectively oxidize a broad range of aromatic and aliphatic allylic primary alcohols while yielding hydrogen peroxide as the only by-product. However, their use is hampered by challenging and often unsuccessful heterologous expression..

High relevance

Yellow Morel · 2021 · Journal Article · Preparative biochemistry & biotechnology

Utilization of Morchella esculenta-mediated green synthesis golden nanoparticles in biomedicine applications.

This study aimed to synthesize gold nanoparticles (AuNPs) by hot water extract in room conditions using edible Morchella esculenta (ME) and investigate the bioactive properties of the synthesized Morchella esculenta-based gold nanoparticles (ME-AuNPs)..

OncologyEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2021 · Research Article · Molecules (Basel, Switzerland)

Virtual Screening for Biomimetic Anti-Cancer Peptides from Cordyceps militaris Putative Pepsinized Peptidome and Validation on Colon Cancer Cell Line.

Colorectal cancer is one of the leading causes of cancer-related death in Thailand and many other countries. The standard practice for curing this cancer is surgery with an adjuvant chemotherapy treatment.

OncologyCognition & nervesGut & microbiome

High relevance

King Oyster · 2021 · Research Article · Foods (Basel, Switzerland)

Volatile Profiling of Pleurotus eryngii and Pleurotus ostreatus Mushrooms Cultivated on Agricultural and Agro-Industrial By-Products.

The influence of genetic (species, strain) and environmental (substrate) factors on the volatile profiles of eight strains of Pleurotus eryngii and P. ostreatus mushrooms cultivated on wheat straw or substrates enriched with winery or olive oil by products was investigated by headspace solid-phase microextraction….

High relevance

King Oyster · 2021 · Journal Article · Carbohydrate polymers

Water-soluble polysaccharides from Pleurotus eryngii fruiting bodies, their activity and affinity for Toll-like receptor 2 and dectin-1.

The mushroom cell wall contains polysaccharides that can activate cells of the innate immune system through receptors such as Toll-like receptors (TLR) and dectin-1..

Immune support

High relevance

Cordyceps · 2023 · Preprint · journal metadata

Evaluation of the biological activity of Cordyceps militaris as an antioxidant, anti-bacterial, and anti-inflammatory agent for natural healthcare

Abstract This study presents the bioactive compounds and the antioxidant, anti-bacteria, and anti-inflammatory activities of C. militaris fruiting body (FB) and fruiting body with substrate (FBS).

Immune supportGut & microbiome

High relevance

Reishi · 2022 · Journal Article · Molecular biology reports

Investigation of HER-3 gene expression under the influence of carbohydrate biopolymers extract of shiitake and reishi in MCF-7 cell line.

INTRODUCTION: Edible-medicinal fungi are mainly used in Asian countries to prevent various diseases. These mushrooms are also used to treat lung diseases and cancer.

OncologyImmune supportRespiratory

High relevance

Cordyceps · 2015 · Systematic Review · International journal of medicinal mushrooms

Review on Natural Enemies and Diseases in the Artificial Cultivation of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes).

Ophiocordyceps sinensis (syn. Cordyceps sinensis), well known as DongChongXiaCao (DCXC), is one of the most valuable traditional Chinese medicinal species.

High relevance

Maitake · 2009 · Systematic Review · Journal of the Society for Integrative Oncology

Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration.

The objective of this study was to evaluate the scientific evidence on maitake, including expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. This review serves as a clinical support tool..

OncologyImmune supportMetabolic health

High relevance

Lion's Mane · 2026 · Preprint · journal metadata

A randomized, double□blind, placebo□controlled study evaluating the impact of Hericium erinaceus (Lion’s Mane) on cognitive performance and subjective wellbeing

Hericium erinaceus (Lion’s Mane) is a functional mushroom with a long history of culinary and traditional use, as well as potential neurotrophic and mood□modulating properties. Evidence for its effects on cognitive performance under real□world conditions, however, remains limited..

Cognition & nervesEnergy & fatigue

High relevance

Oyster Mushroom · 2026 · Preprint · journal metadata

Antifungal and Bioactive Potential of Pleurotus ostreatus Cultivated on Agro-Waste Substrates with Molecular Identification and Functional Characterization

The increasing prevalence of antifungal resistance among clinically relevant pathogens such as Candida albicans and Aspergillus fumigatus necessitates the exploration of novel bioactive compounds from sustainable sources..

Metabolic health

High relevance

Snow Fungus · 2026 · Preprint · journal metadata

Beyond Conventional Drying: Improving the Quality of Dried Tremella fuciformis via a Heat-Integrated Pretreatment

Abstract Hot-air drying (HAD) of Tremella fuciformis often leads to poor rehydration, yellowing, and long preparation times, lowering its industrial value. This study introduces a heat-integrated pretreatment (HIP) as a simple and viable strategy to enhance the quality of dried product..

Immune supportSkin & hydration

High relevance

Oyster Mushroom · 2026 · Preprint · journal metadata

Comparative Study of Pleurotus ostreatus Cultivated Through Different Disinfection Methods Utilizing Coffee Parchment and Cenchrus fungigraminus

Conventional sterilization limits smallholder mushroom cultivation in Papua New Guinea. This study evaluated alternative disinfection methods for Pleurotus ostreatus using coffee parchment and Juncao grass substrates.

Gut & microbiome

High relevance

Cordyceps · 2026 · Published Erratum · Food research international (Ottawa, Ont.)

Corrigendum to "Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide" [Food Res. Int. 230 (2026) 118574].

Metadata-grounded summary: This published erratum indexes research on Cordyceps militaris in Food research international (Ottawa, Ont.) in 2026. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportGut & microbiome

High relevance

Lion's Mane · 2026 · Preprint · journal metadata

Evaluating the Neurotrophic Mechanisms of Hericium erinaceus in Mood Regulation: Emerging Evidence and Translational Barriers

Background: The limitations of current monoaminergic antidepressants in treating major depressive disorder (MDD) have driven exploratory interest in neurotrophic compounds..

Cognition & nerves

High relevance

Chaga · 2026 · Preprint · journal metadata

Heterologous expression and biochemical characterization of a novel multifunctional endo-β-1,4- glucanase (Cel12A) exhibiting transglycosylation and weak cellobiohydrolase activities from the medicinal mushroom Inonotus obliquus

Abstract A novel endo-β-1,4-glucanase (Cel12A) from glycoside hydrolase family 12 of Inonotus obliquus was successfully heterologously expressed and biochemical characterized..

High relevance

Oyster Mushroom · 2026 · Preprint · journal metadata

Integrated in silico pharmacology of Pleurotus ostreatus derived bioactive compounds targeting EGFR using network pharmacology and molecular simulations

Abstract Cancer remains a most important worldwide health burden, demanding the progress of pioneering and mechanism-driven therapeutic strategies. In this study, we employed an consolidative in silico pharmacology approach combination network pharmacology, molecular docking, ADMET profiling, and molecular dynamics….

OncologyLiver supportRespiratory

High relevance

Oyster Mushroom · 2026 · Preprint · journal metadata

Mapping of levels of oxidative enzymes in the fruiting bodies of the fungus, Pleurotus ostreatus to different substrates for use as an agent in bioremediation

Abstract A significant volume of waste is generated across diverse agricultural sectors and various food industries worldwide. This waste primarily comprises cellulose, hemicellulose, and lignin, collectively called lignocellulosic materials..

High relevance

Shiitake · 2026 · Preprint · journal metadata

Regulatory Mechanism of Iron, Potassium, and Manganese on the Mycelial Growth of Lentinula edodes Revealed by Transcriptome Analysis

Lentinula edodes (L. edodes) is a significant edible and medicinal mushroom with essential nutrient elements for its growth, including Fe²⁺, K⁺, and Mn²⁺.

Energy & fatigue

High relevance

Reishi · 2026 · Preprint · journal metadata

Research on the Structural Features and Regulatory Effect of Polysaccharides in Ganoderma lucidum on TAMs

Abstract This experiment purified GLAP-2 from Ganoderma lucidum through Sepharose 6B and Sephacryl S-300 HR gradient elution, collected it by freeze-drying, and obtained GLAP-2 with a uniform molecular weight of 3.7×10⁴ Da. Its total polysaccharide content was 79.79%, and the content of galacturonic acid was 23.82%..

Immune support

High relevance

Mesima · 2025 · Preprint · journal metadata

A combination of the extract from Phellinus linteus with Smilax spp. attenuates colorectal and prostate cancers

The current study investigated the effects of Thai remedy herbal extracts from Phellinus linteus (PL) and a combination of P. linteus with Smilax corbularia and S..

OncologyImmune support

High relevance

Yellow Morel · 2025 · Preprint · journal metadata

A Comparative Study on Phenolic Compounds and Antioxidant Potential of Morchella elata and Morchella esculenta

Abstract Wild and edible lamb's ear mushrooms ( Morchella spp.) are highly nutritious and have a distinctive aroma, making them popular worldwide. In this study, the nutritional components and bioactive contents of Morchella elata and Morchella esculenta species collected from the Artvin region of the Eastern Black….

High relevance

Lion's Mane · 2025 · Preprint · journal metadata

Calm Under Challenge: Immune Balancing and Stress Quenching Effects of Hericium erinaceus Mycelium in Human Immune Cells

Hericium erinaceus is a medicinal mushroom valued for its neuroprotective, immunomodulatory, and antioxidant activities. While many extracts and bioactive compounds from both mycelium and fruit bodies have been characterized, the mechanisms driving their effects are not fully understood..

Immune supportCognition & nerves

High relevance

Cordyceps · 2025 · Preprint · journal metadata

Core Habitat Resilience and Marginal Contraction: Projected Mid-Century Distribution Dynamics of Ophiocordyceps sinensis across the Tibetan Plateau under Climate Scenarios

Abstract Ophiocordyceps sinensis is a precious fungal resource primarily found on the Tibetan Plateau. Its habitat has been reduced by overharvesting and climate change, and has been classified as Vulnerable on the IUCN Red List.

High relevance

Chaga · 2025 · Published Erratum · Frontiers in pharmacology

Corrigendum: Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing.

[This corrects the article DOI: 10.3389/fphar.2025.1556739.]..

Immune support

High relevance

Cordyceps · 2025 · Published Erratum · Frontiers in pharmacology

Corrigendum: Protective effects of Cordyceps militaris against hepatocyte apoptosis and liver fibrosis induced by high palmitic acid diet.

[This corrects the article DOI: 10.3389/fphar.2024.1438997.]..

OncologyLiver support

High relevance

Oyster Mushroom · 2025 · Preprint · journal metadata

Decolourisation of a Mixture of Dyes from Different Classes Using a Bioreactor with Immobilised Pleurotus ostreatus Mycelium

Dyes are widely used in various industries, but their removal from wastewater remains a challenge due to their resistance to biodegradation. While substantial research exists regarding the removal of individual dyes, there is much less about the removal of their mixtures..

High relevance

Lion's Mane · 2025 · Preprint · journal metadata

Effects of nystatin on discrete unit 150-3000 Hz extracellular spikes in biofilm forming Hericium erinaceus liquid cultures recorded using custom microelectrode arrays

Extracellular electrical potentials have been observed in a number of filamentous mycelial species with incommensurable and non-stereotypic features. In Basidiomycetes, detecting these signals reliably is dependent on the properties of the cell wall and plasma membrane and requires implementation of microelectrode….

High relevance

Reishi · 2025 · Preprint · journal metadata

Evaluation of Bioactive Compounds, Antioxidant Activity, and Anticancer Potential of Wild Ganoderma lucidum Extracts from High-Altitude Regions of Nepal

Wild Ganoderma lucidum from Nepal’s high-altitude regions was studied to identify key bioactive compounds and assess the influence of solvent type—water, ethanol, methanol, and acetone—on extraction efficiency and biological activity..

Oncology

High relevance

Reishi · 2025 · Preprint · journal metadata

Exploring Ganoderma lucidum as a sustainable bioleather alternative from sawdust

Abstract The global leather market faces ethical and environmental challenges due to animal use and hazardous chemical processing. To address these issues, this study explores a sustainable leather substitute derived from Ganoderma lucidum mycelium, a fungus known for its medicinal properties..

High relevance

Snow Fungus · 2025 · Preprint · journal metadata

Exploring the polymorphism and origins of accessory chromosomes in Tremella fuciformis: insights into genome divergence and structural variation

Abstract Accessory chromosomes, while not essential for normal growth and development, have been extensively studied in Ascomycota fungi, but their presence in basidiomycetes is less documented..

High relevance

Cordyceps · 2025 · Comparative Study · Applied biochemistry and biotechnology

GC-MS Analysis of Polysaccharides from an Intergeneric Hybrid of Pleurotus florida and Cordyceps militaris: A Comparative Study.

Edible and medicinal mushrooms are valuable sources of polysaccharides, known for their dual roles as immunostimulants and immunosuppressants. This study aimed to enhance polysaccharide content by fusing two mushroom species, P.

OncologyImmune supportMetabolic healthRespiratory