MycoData

Immune supportMetabolic health

Reishi · 2025 · Preprint · journal metadata

Identification of a Ganoderma lucidum Endogenous Reference Gene and Its Validation for Quantitative Analysis of Spore Powders and Fruiting Bodies from Different Land Sources

Background: Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) are believed to be one of the major bioactive components to promote health benefits.

Oyster Mushroom · 2025 · Preprint · journal metadata

Improving Nutrition Facts of Cassava and Soybean Residue through Solid-State Fermentation by Pleurotus ostreatus Mycelium: A Pathway to Safety Animal Feed Production

The overwhelming amount of cassava residues and okara is a foremost challenge for the food processing industry environmental loading. The purpose of this article is to utilize Pleurotus ostreatus mycelium to ferment solid cassava and soybean residue, resulting in mycelial biomass with nutritional values and promising….

Reishi · 2025 · Preprint · journal metadata

In Vitro anti-Leishmania tropica activity of Ganoderma lucidum extracts

Abstract Cutaneous leishmaniasis (CL), which is caused by Leishmania tropica, continues to pose a considerable public health issue in endemic areas such as Iraq. The existing treatment options are constrained by their toxicity and the development of resistance, highlighting the need for safer alternatives..

Shiitake · 2025 · Preprint · journal metadata

Lentinula edodes Cultured Extract Treated Mesenchymal-Derived Extracellular Vesicle Modulated Breast Cancer Stem Cells and Reprogramming of microRNAs

Background: Breast carcinoma represents the most frequent malignancy in women in Canada. The intrinsic or acquired drug resistance significantly contributes to in-creased risk of recurrence and metastasis.

Oncology

Cognition & nervesMetabolic health

Lion's Mane · 2025 · Preprint · journal metadata

Metabolic Profiling and Substrate Utilization of Hericium erinaceus (Lion’s Mane) Mycelia Isolate Using Biolog Phenotype Microarray

Abstract Hericium erinaceus, has long been recognized in traditional Chinese medicine for its extensive health benefits. H.

OncologyImmune supportLiver support

Yellow Morel · 2025 · Preprint · journal metadata

Morchella esculenta Intensifies Testosterone Production and Spermatogenesis in Male Mice with High-Fat Diet-Induced Obesity by Enhancing Antioxidant Capacity

Obesity has become a major health concern worldwide and is strongly correlated with various comorbidities including reproductive dysfunction. Therefore, this study aimed to explore the ef-fects of Morchella esculenta (ME) in improving reproductive dysfunction caused by high-fat di-et-induced obesity..

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · Preprint · journal metadata

Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid Metabolism

Abstract Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action..

Oyster Mushroom · 2025 · Preprint · journal metadata

Mycelium of Pleurotus ostreatus Effectively Reduces the Population of the Sugar Beet Cyst Nematode Heterodera schachtii

Sugar beet (Beta vulgaris L.) is the second sugar crop in the world. One of its pests is Heterodera schachtii, a root-knot nematode.

OncologyImmune supportCognition & nervesGut & microbiome

Shiitake · 2025 · Preprint · journal metadata

Oral Lentinula edodes mycelia extract enhances the antitumor effect of radiotherapy via gut-associated activation of dendritic and cytotoxic T cells

Abstract Oral administration of Lentinula edodes mycelia extract (L.E.M.) has been shown to stimulate systemic T cell–mediated antitumor immunity and inhibit tumor growth in mice, suggesting its potential to modulate host immune responses. However, the route of this systemic antitumor effect remains unclear..

Reishi · 2025 · Preprint · journal metadata

Overexpression of GlATIC gene enhances adenosine production in Ganoderma lucidum

Adenosine recognized for its immunomodulatory, anti-inflammatory, and anti-cancer properties, has limited clinical and commercial applications due to low production levels in Ganoderma lucidum..

OncologyImmune support

Metabolic healthGut & microbiome

Oyster Mushroom · 2025 · Preprint · journal metadata

Pleurotus ostreatus modulates the intestinal glucose absorption by the Na(+)/glucose cotransporter 1 (SGLT1) in C57BL/6 mice

Abstract The use of medicinal mushrooms for the treatment of glycemic metabolism disorders has been extensively tested as a therapeutic alternative. The aim of this study was to analyze the effect of Pleurotus ostreatus extract on intestinal glucose absorption mediated by Na(+)-glucose cotransporter 1 (SGLT1) in….

OncologyImmune supportMetabolic health

Shiitake · 2025 · Preprint · journal metadata

Screening of Lentinula edodes Strains for High Polysaccharide Productions and In Vitro Antioxidant Activities

Lentinan is one of the main metabolites of Lentinula edodes, and exhibits numerous biological activities such as anti-tumor and antioxidant. Despite recent advancements, its commercialization remains constrained by a lengthy cultivation cycle, low yield, and high cost..

Shiitake · 2025 · Preprint · journal metadata

Sequential Enzymatic and Ultrasonic Extraction of Lentinula edodes Mushroom Proteins Leading to Enhanced Yield and Significant Immunoactivity

Abstract Lentinula edodes is a widely consumed edible fungus and a rich source of proteins with both nutritional and medicinal value. This study discovered an effective process to extract proteins from L..

OncologyImmune supportGut & microbiomeSkin & hydration

Reishi · 2025 · Preprint · journal metadata

Study on the anti-tumor effect of Wall-broken Ganoderma lucidum spore powder on papillary thyroid cancer

Abstract Ganoderma lucidum wall-broken spores (BGLSP), traditionally used in Traditional Chinese Medicine for immunity and chronic diseases, contain bioactive triterpenoids with anti-tumor potential, but their mechanisms against papillary thyroid cancer (PTC) remain unclear..

OncologyImmune supportEnergy & fatigueRespiratory

Reishi · 2025 · Preprint · journal metadata

Synergistic Anti-Tumor and Immunomodulatory Effects of Sporoderm-Removed Ganoderma Lucidum Spore Powder and Anti-PD-L1 Antibody in Lung Cancer Mice

Abstract Background The therapeutic efficacy of PD-1/PD-L1 inhibitors in lung cancer management remains suboptimal. Sporoderm-removed Ganoderma Lucidum Spore Powder (RGLS), an immunostimulant, has been shown to amplify the anti-tumor effects of anti-PD-L1 antibodies (αPD-L1)..

Energy & fatigueMetabolic healthLiver support

Shiitake · 2025 · Preprint · journal metadata

The alterations of the synthetic pathway and metabolic flux of auxin indole-3-acetic acid (IAA) govern thermotolerance in Lentinula edodes mycelia subjected to heat stress

ABSTRACT Heat stress poses a significant constraint on the annual production of Lentinula edodes(L. edodes), a challenge that has been intensified by global warming.

OncologyImmune supportCognition & nervesGut & microbiome

Reishi · 2024 · Preprint · journal metadata

Bioactive compounds and nanoparticles in Ganoderma lucidum: New perspectives on health benefits

The unique medicinal properties of Ganoderma lucidum have led to a growing demand for it as an essential source of dietary supplements in the food sector. The wide array of therapeutic and pharmacological effects of G.

Lion's Mane · 2024 · Preprint · journal metadata

Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis

Biological Activities of ethanol extracts of Hericium erinaceus obtained as a result of optimization analysis.

Oyster Mushroom · 2024 · Preprint · journal metadata

Development and Characterization of a Value-Added Product Suitable for Food Applications from Agaricus bisporus and Pleurotus ostreatus Stems: Evaluation of Particle Size Influence and In Vitro Antioxidant Activity

The mushroom industry generates large amounts of stems, a co-product with valuable sensory and health characteristics. This work aimed to study the influence of particle size (L — >0.510 mm; LI — 0.510-0.315 mm; SI—0.315-0.180 mm; S — <0.180 mm) and species in the characterization and antioxidant activity of….

Skin & hydration

Oyster Mushroom · 2024 · Preprint · journal metadata

Evaluation of Physiological and Biochemical Reactions of Pleurotus ostreatus Cultivated in Varied Juncao Grass Substrates

Background: Pleurotus ostreutus is one of the world’s most commonly consumed mushrooms. Cultivation of mushrooms using wood resources usually results in environmental issues of deforestation..

Immune supportMetabolic healthLiver support

Maitake · 2024 · Preprint · journal metadata

Grifola frondosa polysaccharide Ameliorates Inflammation and Insulin Resistance by Regulating Macrophage Polarization of liver in Type 2 diabetes mellitus Rats

Type 2 diabetes mellitus (T2DM) is a common metabolic disease characterized by a lack of insulin secretion, insulin resistance (IR), and hyperglycemia. Given its high prevalence and multifarious complications, diabetes is globally ranked as the third leading cause of mortality..

Lion's Mane · 2024 · Preprint · journal metadata

Identification and partial reconstitution of the biosynthetic pathway of bioactive meroterpenoids from Hericium erinaceus (Lion’s Mane mushroom)

ABSTRACT Hericium erinaceus (Lion’s Mane mushroom) is widely consumed for its numerous reported benefits for brain health. A growing body of evidence suggests that these benefits are likely attributable to aromatics contained in its fruiting bodies, including the meroterpenoids hericenones..

Cognition & nerves

Immune supportCognition & nerves

Reishi · 2024 · Preprint · journal metadata

Investigating the neuroprotective mechanism of Ganoderma lucidum in glaucoma treatment through network pharmacology and molecular docking analysis

Abstract Ganoderma lucidum(GL), a medicinal fungus belonging to the polyporaceae family, has been extensively utilized in the treatment of glaucoma. To elucidate the underlying mechanisms of GL in glaucoma therapy, network pharmacology methods were employed for screening its active compounds, potential targets, and….

Cordyceps · 2024 · Preprint · journal metadata

Ophiocordyceps sinensis infection alters the immune system of the host Thitarodes xiaojinensis investigated by the interaction between immunity and gut microbiota escaping to hemolymph

Abstract Background Ophiocordyceps sinensis as one typical entomopathogenic fungus (EPF) has the long-term symbiosis process with its host Thitarodes xiaojinensis. O.

OncologyImmune supportMetabolic healthSkin & hydration

Snow Fungus · 2024 · Preprint · journal metadata

Overcharged lipid metabolism in mechanisms of antitumor by Tremella Fuciformis Polysaccharide

Tremella Fuciformis polysaccharides (TFP) is a natural macromolecular compound well-known for whitening, lipid and immunity regulation. To evaluate the effect of TFP on melanogenesis, lipid metabolism programmes and immune system of B16 cells in vitro and in vivo, the cell proliferation, cell cycle and apoptosis were….

Oyster Mushroom · 2024 · Preprint · journal metadata

Pretreatment of pine and poplar particleboards with Pleurotus ostreatus (Jacq.) P. Kumm: wood structure decomposition, potential of solid fuel and biogas production

Abstract The study evaluated the effects of biological pretreatment on comminuted pine and poplar shavings and particleboards with urea-formaldehyde resin (UF), utilising Pleurotus ostreatus..

Oyster Mushroom · 2024 · Preprint · journal metadata

SIRT2-mediated deacetylation of Glutathione transferase alleviates oxidative damage and increases heat tolerance of Pleurotus ostreatus

Abstract High-temperature stress (HS) is the most important environmental factor that affects crop growth. It seriously threatens agricultural production.

Metabolic health

Immune supportCognition & nervesRespiratory

Cordyceps · 2024 · Preprint · journal metadata

The Preventive Potential of the Mycelial Submerged Culture of Ophiocordyceps sinensis against Neurodegenerative Diseases and Its Possible Active Compounds

The pharmacological effects of the fruiting body of Ophiocordyceps sinensis (Os) exerted antioxidant, anti-virus, and immunomodulatory, whereas the anti-inflammatory effects and active components of Os mycelial submerged culture (OMSC) are not known..

Shiitake · 2024 · Preprint · journal metadata

The Two Sexually Compatible Monokaryons from a Heterokaryotic Lentinula edodes Strain Respond Differently to Heat Stress

A comprehensive understanding of the mechanisms underlying how Lentinula edodes handles heat stress (HS) is crucial for the development of superior HS-resistant strains. However, the mechanism by which the two sexually compatible haploid nuclei respond to heat stress remains largely unknown..

Metabolic health

OncologyImmune supportCognition & nerves

Snow Fungus · 2024 · Preprint · journal metadata

Tremella fuciformis polysaccharides alleviate early brain injury in experimental subarachnoid hemorrhage by inhibiting the KDR-mediated P38 MAPK/NF-κB pathway

Abstract Background Subarachnoid hemorrhage is associated with high mortality and morbidity rates. In its early stages, the substantial influx of blood into the subarachnoid space triggers excessive activation of microglial cells, which markedly contributes to early brain injury, a pivotal determinant of poor….

King Oyster · 2023 · Journal Article · Mushroom Science and Biotechnology

Development of a new variety of mushroom produced by cross-breeding Pleurotus eryngii and Pleurotus nebrodensis

Metadata-grounded summary: This journal article indexes research on Pleurotus eryngii in Mushroom Science and Biotechnology in 2023. MycoData maps the paper to gut & microbiome based on its title, species context, article metadata, and study classification..

Gut & microbiome

Shiitake · 2023 · Journal Article · Mushroom Science and Biotechnology

Effects of 137Cs concentration in mushroom logs and yield on 137Cs transfer from logs to shiitake (Lentinula edodes) fruiting bodies

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2023. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Shiitake · 2023 · Journal Article · Journal of wood science

Fuel and material utilization of a waste shiitake (Lentinula edodes) mushroom bed derived from hardwood chips II thermal conductivity of compression-dried waste mushroom beds

This study investigated using waste mushroom beds as insulation material and applied compression-drying to eliminate the coarse voids that are unfavorable for insulation. The relationship between air-dry density and thermal conductivity was investigated..

Cordyceps · 2023 · Journal Article · Journal of biochemical and molecular toxicology

Network pharmacology and molecular docking analysis on the mechanism of Cordyceps militaris polysaccharide regulating immunity through TLR4/TNF-α pathwayss.

The role of polysaccharide components in the immune system, especially immunomodulatory effects, has received increasing attention. In this context, in this study, network pharmacology was adopted to explore the hypothesis of a multitarget mechanism for immune modulation by Chrysalis polysaccharides..

Shiitake · 2022 · Journal Article · Journal of The National Institute of Technology, Asahikawa College

Attempt of the Cryopreservation of Shiitake (Lentinula edodes) Mycelia at a Temperature Zone around -18°C using a Domestic Freezer

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Journal of The National Institute of Technology, Asahikawa College in 2022. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Cordyceps · 2022 · Journal Article · Andrologia

Cordycepin, a major bioactive component of Cordyceps militaris, ameliorates diabetes-induced testicular damage through the Sirt1/Foxo3a pathway.

Diabetes-induced male dysfunction is considered as a worldwide challenge, and testicular damage mainly caused by oxidative stress is its most common manifestation. Cordycepin, a natural antioxidant, has been used in the treatment of diabetic complications..

Metabolic health

Cordyceps · 2022 · Journal Article · Journal of biomolecular structure & dynamics

Cordycepin: a bioactive metabolite of Cordyceps militaris and polyadenylation inhibitor with therapeutic potential against COVID-19.

Spike protein and main proteases of SARS-CoV-2 have been identified as potential therapeutic targets and their inhibition may lead to the reticence of viral entry and replication in the host body. Despite several efforts; till now no specific drugs are available to treat SARS-CoV-2..

Respiratory

Maitake · 2022 · Journal Article · Mushroom Science and Biotechnology

Determination of the mating system of Grifola frondosa (maitake) IM-BM21

Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Mushroom Science and Biotechnology in 2022. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Immune supportRespiratory

Cordyceps · 2022 · Research Article · Microorganisms

Immunostimulatory Activity of Cordyceps militaris Fermented with Pediococcus pentosaceus SC11 Isolated from a Salted Small Octopus in Cyclophosphamide-Induced Immunocompromised Mice and Its Inhibitory Activity against SARS-CoV 3CL Protease.

In this study, we investigated the immune-enhancing and anti-viral effects of germinated Rhynchosia nulubilis (GRC) fermented with Pediococcus pentosaceus SC11 (GRC-SC11) isolated from a salted small octopus. The cordycepin, β-glucan, and total flavonoid contents increased in GRC after SC11 fermentation..

King Oyster · 2022 · Research Article · Foods (Basel, Switzerland)

Incorporation of Mycelium (Pleurotus eryngii) in Pea Protein Based Low Moisture Meat Analogue: Effect on Its Physicochemical, Rehydration and Structural Properties.

The protein content of a plant-based ingredient is generally lower than its animal food counterpart, and research into novel alternative protein is required that can provide similar protein content, texture and appearance as meat..

Skin & hydration

Shiitake · 2022 · Journal Article · The Japanese Forest Society Congress

Relationship between Cs concentration of shiitake(Lentinula edodes)fruiting body and Cs distribution in oak log

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in The Japanese Forest Society Congress in 2022. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Shiitake · 2022 · Journal Article · Mokuzai Gakkaishi

The Antioxidant Activity of the Extracts from Disposition of the Waste Sawdust Substrate from Shiitake Mushroom (Lentinula edodes) Cultivation by the Two-step Hot/hot-compressed Water Percolation

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mokuzai Gakkaishi in 2022. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportMetabolic health

Cordyceps · 2022 · Journal Article · Food & function

The polysaccharide-peptide complex from mushroom Cordyceps militaris ameliorates atherosclerosis by modulating the lncRNA-miRNA-mRNA axis.

An N-glycosidic polysaccharide-peptide complex CMPS-80 was obtained from the fruiting body of C. militaris.

Shiitake · 2021 · Journal Article · Mushroom Science and Biotechnology

Content of several ingredients in log-cultivated shiitake (Lentinula edodes) dried under different conditions

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2021. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Shiitake · 2021 · Journal Article · Mushroom Science and Biotechnology

Influence of water-permeable weed control sheets on additional radioactive cesium contamination of Shiitake (Lentinula edodes) bed logs in open-field cultivation

Cordyceps · 2021 · Journal Article · European journal of medicinal chemistry

Large-scale isolation and antitumor mechanism evaluation of compounds from the traditional Chinese medicine Cordyceps Militaris.

We established a large-scale separation and purification platform to obtain kilogram amounts of natural compounds from the extraction of the fruiting bodies of C. militaris..

Oncology

Immune supportMetabolic health

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris.

Hyperlipidemia is one major cause of atherosclerosis, which is a basic pathological change of cardiovascular diseases. Polysaccharide is a water-soluble component with lipid-lowering effects.

Immune supportLiver support

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris.

One novel alkali-extracted polysaccharide, CM3-SII, was obtained from the fruiting body of C. militaris via column chromatography.