MycoData

Snow Fungus · 2018 · Randomized Controlled Trial · Journal of medicinal food

Efficacy and Safety of Tremella fuciformis in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial.

The efficacy and safety of Tremella fuciformis (TF) as a nutritional supplement were assessed in individuals with subjective cognitive impairment (SCI). Seventy-five individuals with SCI were enrolled in an 8-week, randomized, double-blind, placebo-controlled trial of TF (600 mg/day, n = 30 or 1200 mg/day, n = 30) or….

OncologyCognition & nerves

King Oyster · 2023 · Preprint · journal metadata

Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from Pleurotus eryngii Fruiting Bodies

Ribotoxin-like proteins (RL-Ps) are specific ribonucleases found in mushrooms that are able to cleave a single phosphodiester bond located in the Sarcin-Ricin Loop (SRL) of the large rRNA. The cleaved SRL interacts differently with some ribosomal proteins (P-stalk)..

OncologyImmune supportCognition & nerves

King Oyster · 2023 · Preprint · journal metadata

The discovery of ergothioneine biosynthesis genes from Pleurotus eryngii and its combinatorial expression in yeast

Ergothioneine (EGT) is a natural amino acid derived from histidine, which has many active functions such as anti-oxidation, anti-inflammation, anti-cancer and prevention of neurodegenerative diseases. Pleurotus eryngii is a delicious edible fungus with high EGT content..

Cognition & nervesMetabolic health

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

Neurotransmitter acetylcholine mediates the mummification of Ophiocordyceps sinensis-infected Thitarodes xiaojinensis larvae.

Parasites can manipulate host behavior to facilitate parasite transmission. One such host-pathogen interaction occurs between the fungus Ophiocordyceps sinensis and the ghost moth Thitarodes xiaojinensis.

Immune supportCognition & nervesEnergy & fatigue

King Oyster · 2023 · Research Article · Molecules (Basel, Switzerland)

Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii.

In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2023 · Research Article · Molecules (Basel, Switzerland)

Antioxidative Activities of Micronized Solid-State Cultivated Hericium erinaceus Rich in Erinacine A against MPTP-Induced Damages.

The Lion's mane mushroom (Hericium erinaceus, HE) is a traditional medical mushroom with high nutritional and economic value. HE possesses anticancer, antimicrobial, antioxidant, immunomodulating, neurotrophic, and neuroprotective activities..

Immune supportCognition & nervesEnergy & fatigue

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

Cordyceps militaris acidic polysaccharides improve learning and memory impairment in mice with exercise fatigue through the PI3K/NRF2/HO-1 signalling pathway.

Excessive exercise leads to body fatigue and destroys the balance of the oxidation/oxidation resistance system in the body, thus damaging the central nervous system and reducing learning and memory ability. Nrf2 is an important transcription factor that regulates the cell oxidative stress response..

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Cordyceps · 2023 · Research Article · Microbiology spectrum

Dual Transcriptomics Reveals Interspecific Interactions between the Mycoparasite Calcarisporium cordycipiticola and Its Host Cordyceps militaris.

Calcarisporium cordycipiticola is a mycoparasite of the edible fungus Cordyceps militaris, and mycoparasitism causes devastating diseases of mushrooms. In this study, dual-transcriptomic analysis was performed to reveal interspecific interactions between the mycoparasite C.

Shiitake · 2023 · Journal Article · International journal of medicinal mushrooms

Evaluation of Polysaccharide Content in Shiitake Culinary-Medicinal Mushroom, Lentinula edodes (Agaricomycetes), via Near-Infrared Spectroscopy Integrated with Deep Learning.

Polysaccharide is one of the bioactive ingredients extracted from the fruiting body of Lentinula edodes (=L. edodes), which has many medicinal functions.

Cognition & nervesMetabolic health

Reishi · 2023 · Journal Article · Physiology & behavior

Ganoderma lucidum ethanol extract promotes weight loss and improves depressive-like behaviors in male and female Swiss mice.

Metabolic and mood-related disturbances can increase the risks of developing adverse mental health problems. The medicinal mushroom, Ganoderma lucidum, is utilized in indigenous medicine to improve quality of life, promote health, and boost vitality..

Immune supportCognition & nervesEnergy & fatigue

Reishi · 2023 · Journal Article · Comparative biochemistry and physiology. Toxicology & pharmacology: CBP

Ganoderma lucidum polysaccharide alleviates Cd toxicity in common carp (Cyprinus carpio): Neuropeptide, growth performance and lipid accumulation.

Cadmium (Cd) is the most common heavy metal and is easily detected in aquatic environments on a global scale. Common carp (Cyprinus carpio) is a common cultural species in aquaculture.

Yellow Morel · 2023 · Journal Article · Journal of agricultural and food chemistry

Identification and Characterization of Novel Umami Peptides from Protein Hydrolysates of Morchella esculenta and Their Interaction with T1R1/T1R3 Receptor.

The study aimed to explore umami peptides derived from protein hydrolysates of Morchella esculenta. According to the electronic tongue and sensory evaluation, the ultrafiltration fractions (<3 kDa) of the protein hydrolysates exhibited the strongest umami taste..

Cordyceps · 2023 · Research Article · 3 Biotech

Identification of potential inhibitors against Alzheimer-related proteins in Cordyceps militaris ethanol extract: experimental evidence and computational analyses.

UNLABELLED: Laboratory experiments were carried out to identify the chemical composition of Cordyceps militaris and reveal the first evidence of their Alzheimer-related potential. Liquid chromatography-mass spectrometry analysis identified 21 bioactive compounds in the ethanol extract (1-21)..

Reishi · 2023 · Research Article · Aging medicine (Milton (N.S.W))

Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA.

OBJECTIVE: Alzheimer's disease (AD) is one of the most prevalent neurological ailments, affecting around 50 million individuals globally. The condition is characterized by nerve cell damage due to the formation of amyloid-beta plaques and neurofibrillary tangles..

OncologyImmune supportCognition & nervesMetabolic health

King Oyster · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

In Vitro Fermentation of Pleurotus eryngii Mushrooms by Human Fecal Microbiota: Metataxonomic Analysis and Metabolomic Profiling of Fermentation Products.

Edible mushrooms contain biologically active compounds with antioxidant, antimicrobial, immunomodulatory and anticancer properties. The link between their anticancer and immunomodulatory properties with their possible prebiotic activity on gut micro-organisms has been the subject of intense research over the last….

Immune supportCognition & nervesMetabolic healthGut & microbiome

Shiitake · 2023 · Journal Article · Trends in food science & technology

Lentinan, β-glucan from Shiitake (Lentinula edodes): A review on structure, conformational transition, and gastro-intestinal interaction contributing towards its anti-diabetic potential

Lentinan (LNT), a β-glucan in Shiitake mushroom (Lentinula edodes) has attracted attention for its potent biofunctionalities and immune-boosting properties. Despite comprehensive research into its chemical structure and conformation transitions, the exact mechanism of digestion and absorption remains a subject of….

Immune supportCognition & nervesMetabolic health

Chaga · 2023 · Research Article · Nutrition research and practice

Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system.

BACKGROUND/OBJECTIVES: Inonotus obliquus has been used as antidiabetic herb around the world, especially in the Russian and Scandinavian countries. Diabetes is widely believed to be a key factor in Alzheimer's disease (AD), which is widely considered to be type III diabetes.

OncologyCognition & nerves

King Oyster · 2023 · Research Article · International journal of molecular sciences

The Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from Pleurotus eryngii Fruiting Bodies.

Ribotoxin-like proteins (RL-Ps) are specific ribonucleases found in mushrooms that are able to cleave a single phosphodiester bond located in the sarcin-ricin loop (SRL) of the large rRNA. The cleaved SRL interacts differently with some ribosomal proteins (P-stalk)..

Cognition & nervesMetabolic health

Reishi · 2023 · Journal Article · Food & function

The chemical profiling and assessment of antioxidative, antidiabetic and antineurodegenerative potential of Kombucha fermented Camellia sinensis, Coffea arabica and Ganoderma lucidum extracts.

The scientific interest in the medicinal properties of Kombucha beverages, a carbonated drink with live microorganisms, has increased recently. Hence, the aim of this study was to determine the chemical profile and to examine the antioxidant, antidiabetic and antineurodegenerative potential of unfermented and also….

Reishi · 2023 · Research Article · Chinese medicine

Two-dimensional code enables visibly mapping herbal medicine chemome: an application in Ganoderma lucidum.

BACKGROUND: Chemical profile provides the pronounced evidence for herbal medicine (HM) authentication; however, the chemome is extremely sophisticated. Fortunately, two-dimensional (2D) code, as a quick response means, is conceptually able to store abundant information, exactly fulfilling the chemical information….

OncologyCognition & nervesMetabolic health

Lion's Mane · 2022 · Journal Article · Biological & pharmaceutical bulletin

Ameliorating Effect of the Edible Mushroom Hericium erinaceus on Depressive-Like Behavior in Ovariectomized Rats

Estrogen deficiency during menopause causes a variety of neurological symptoms, including depression. The edible Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers..

Reishi · 2022 · Research Article · Biochemistry and biophysics reports

Biochemical and Pharmacological aspects of Ganoderma lucidum: Exponent from the in vivo and computational investigations.

Ganoderma lucidum is known as lingzhi mushroom, which is said to have medicinal properties by the local residents. This research was focused to assess the antidepressant, anxiolytic, and sedative activities of the mentioned mushroom extracts by means of in vivo and in silico approaches..

OncologyCognition & nerves

Chaga · 2022 · Research Article · International journal of molecular sciences

Biological Synthesis of Bioactive Gold Nanoparticles from Inonotus obliquus for Dual Chemo-Photothermal Effects against Human Brain Cancer Cells.

The possibility for an ecologically friendly and simple production of gold nanoparticles (AuNPs) with Chaga mushroom (Inonotus obliquus) (Ch-AuNPs) is presented in this study. Chaga extract's reducing potential was evaluated at varied concentrations and temperatures..

Cognition & nervesEnergy & fatigueLiver supportSkin & hydration

King Oyster · 2022 · Journal Article · Carbohydrate polymers

Chitin-glucan composite sponge hemostat with rapid shape-memory from Pleurotus eryngii for puncture wound

Efficient hemostasis is a great challenge for treating the inaccessible hemorrhage wounds. A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca²⁺ crosslinking..

Cognition & nervesEnergy & fatigueLiver supportSkin & hydration

King Oyster · 2022 · Journal Article · Carbohydrate polymers

Chitin-glucan composite sponge hemostat with rapid shape-memory from Pleurotus eryngii for puncture wound.

Cordyceps · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

Dynamic Genome-Wide Transcription Profiling and Direct Target Genes of CmWC-1 Reveal Hierarchical Light Signal Transduction in Cordyceps militaris.

Light is necessary for primordium differentiation and fruiting body development for most edible fungi; however, light perception and signal transduction have only been well studied in model fungi..

Cognition & nervesEnergy & fatigueMetabolic healthRespiratory

Lion's Mane · 2022 · Research Article · International journal of exercise science

Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition.

Hericium erinaceus (HE), also known as Lion's Mane mushroom, has been found to enhance cognition and metabolic flexibility in various animal models. To date however, only four studies exist in humans and none have evaluated the effects of HE on markers of metabolic flexibility or cognitive performance..

Reishi · 2022 · Research Article · Nutrients

Ganoderma lucidum Modulates Inflammatory Responses following 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration in Mice.

Ganoderma lucidum, one of the most valued medicinal mushrooms, has been used for health supplements and medicine in China. Our previous studies have proved that Ganoderma lucidum extract (GLE) could inhibit activation of microglia and protect dopaminergic neurons in vitro..

OncologyImmune supportCognition & nervesEnergy & fatigue

Reishi · 2022 · Research Article · Pharmaceutical biology

Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation.

CONTEXT: Ganoderma lucidum polysaccharides (GLP), from Ganoderma lucidum (Leyss. ex Fr.) Karst.

Lion's Mane · 2022 · Research Article · Behavioral sciences (Basel, Switzerland)

Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model.

Alzheimer’s disease (AD) significantly impairs the life of an individual both cognitively and behaviorally. Tau and beta-amyloid (Aβ) proteins are major contributors to the etiology of AD.

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2022 · Research Article · Biomedicines

Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice.

BACKGROUND: A growing body of research suggests that oxidative stress and neuroinflammation are early pathogenic features of neurodegenerative disorders. In recent years, the vitagene system has emerged as a potential target, as it has been shown to have a high neuroprotective power..

OncologyCognition & nervesEnergy & fatigue

Cordyceps · 2022 · Journal Article · European journal of nutrition

Neuroprotective potency of a soy whey fermented by Cordyceps militaris SN-18 against hydrogen peroxide-induced oxidative injury in PC12 cells.

PURPOSE: Soy whey is a byproduct generated from the processing of several soybean products. Its valorization has continued to attract significant research interest in recent times due to the nutritional and bioactive potency of its chemical composition..

Immune supportCognition & nervesGut & microbiome

Cordyceps · 2022 · Journal Article · Journal of agricultural and food chemistry

Novel Selenium Peptides Obtained from Selenium-Enriched Cordyceps militaris Alleviate Neuroinflammation and Gut Microbiota Dysbacteriosis in LPS-Injured Mice.

Increasing attention focuses on the relationship between neuroinflammation and Alzheimer's disease (AD). The reports on the microbiota-gut-brain axis reveal that the regulation by gut microbiota is an effective way to intervene in neuroinflammation-related AD..

Cognition & nervesEnergy & fatigueMetabolic health

Reishi · 2022 · Research Article · Metabolites

Pharmacokinetic, Metabolomic, and Stability Assessment of Ganoderic Acid H Based Triterpenoid Enriched Fraction of Ganoderma lucidum P. Karst.

Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major phytoconstituents.

Lion's Mane · 2022 · Journal Article · Symposium on the Chemistry of Natural Products, symposium papers

Proof of the existence of novel hericenones in Yamabushitake (Lion's mane, Hericium erinaceus) in collaboration with synthetic chemistry

Metadata-grounded summary: This journal article indexes research on Hericium erinaceus in Symposium on the Chemistry of Natural Products, symposium papers in 2022. MycoData maps the paper to cognition & nerves based on its title, species context, article metadata, and study classification..

Lion's Mane · 2022 · Research Article · Molecules (Basel, Switzerland)

Secondary Metabolites from Hericium erinaceus and Their Anti-Inflammatory Activities.

Hericium erinaceus, a culinary and medicinal mushroom, is widely consumed in Asian countries. Chemical investigation on the fruiting bodies of Hericium erinaceus led to the isolation of one new ergostane-type sterol fatty acid ester, erinarol K (1); and eleven known compounds: 5α,8α -epidioxyergosta-6,22-dien-3β-yl….

Cordyceps · 2022 · Journal Article · Food chemistry

The molecular recognition of cordycepin arabinoside and analysis of changes on cordycepin and its arabinoside in fruiting body and pupa of Cordyceps militaris.

Cordyceps militaris is an edible fungus that is widely used as a functional food in many countries. In order to objectively evaluate its nutritional value, free and glycosidic cordycepins need to be analyzed..

Immune supportCognition & nervesEnergy & fatigueSkin & hydration

Almond Mushroom · 2021 · Journal Article · Journal of food biochemistry

Agaricus blazei polypeptide exerts a protective effect on D‐galactose‐induced aging mice via the Keap1/Nrf2/ARE and P53/Trim32 signaling pathways

This experiment mainly optimized the extraction technology of Agaricus blazei polypeptide (ABp) and evaluated its protective effect on aging mice. In this study, a novel single component, the M is 3 kD, was isolated and purified from Agaricus blazei.

OncologyImmune supportCognition & nervesEnergy & fatigue

Chaga · 2021 · Journal Article · Phytochemistry

Anti-neuroinflammatory polyoxygenated lanostanoids from Chaga mushroom Inonotus obliquus.

Chaga mushroom, Inonotus obliquus, was used as food and nutrient food and traditional herbs in Russia, China and Japan, with anti-inflammatory and anticancer activities. Chemical investigations of the fruiting bodies of Chaga were carried to uncover the bioactive metabolites..

Cordyceps · 2021 · Journal Article · Journal of ethnopharmacology

Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress-induced animal model.

ETHNOPHARMACOLOGY RELEVANCE: Cordyceps militaris (Linn.) Link (CM) is a medicinal mushroom traditionally used in tonics for treating several neurological disorders, including epilepsy and anxiety, in Asia..

OncologyImmune supportCognition & nervesGut & microbiome

Reishi · 2021 · Research Article · Frontiers in pharmacology

Antimetastatic Effects of Ganoderma lucidum Polysaccharide Peptide on B16-F10-luc-G5 Melanoma Mice With Sleep Fragmentation.

Ganoderma lucidum (Lingzhi) polysaccharide peptide (GL-pp) is a component of the globally acknowledged traditional Chinese medicine Ganoderma lucidum; Ganoderma lucidum is known for its sedative, hypnotic, immune regulatory, antitumor, and other pharmacological effects..

Immune supportCognition & nervesLiver supportSkin & hydration

King Oyster · 2021 · Journal Article · International journal of biological macromolecules

Antioxidant and anti-ageing effects of enzymatic polysaccharide from Pleurotus eryngii residue.

The wide industrial cultivation of Pleurotus eryngii (P. eryngii) has resulted in the massive production of mushroom residues (MR) with low-efficiency utilization.

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2021 · Journal Article · International journal of medicinal mushrooms

Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycota), Attenuates Aβ1-42-Induced Amyloidogenesis and Inflammatory Response by Suppressing Amyloid Precursor Protein Progression and p38 MAPK/JNK Activation.

The deposition of amyloid beta (Aβ) is a neuropathological feature of Alzheimer's disease (AD). Cordyceps militaris is an edible medicinal fungus in Asian countries with antioxidative, antiaging, antitumor, and immunomodulatory effects.

Immune supportCognition & nervesRespiratory

Chaga · 2021 · Journal Article · International journal of medicinal mushrooms

Chaga Medicinal Mushroom Inonotus obliquus (Agaricomycetes) Terpenoids May Interfere with SARS-CoV-2 Spike Protein Recognition of the Host Cell: A Molecular Docking Study.

The most challenging threat facing the global community today is the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)..

Almond Mushroom · 2021 · Journal Article · Brazilian journal of biology = Revista brasleira de biologia

Effect of Agaricus blazei Murill on exploratory behavior of mice-model.

Increased anxiety and depressive symptoms have reported to be its association with long term illness. Because of having unwanted effects of newly available drugs, patients administering anxiolytic drugs usually discontinue the treatment before they are completely recovered..

Cordyceps · 2021 · Research Article · Frontiers in psychiatry

Efficacy and Safety of Cordyceps militaris as an Adjuvant to Duloxetine in the Treatment of Insomnia in Patients With Depression: A 6-Week Double- Blind, Randomized, Placebo-Controlled Trial.

Background: Insomnia is a common clinical manifestation in patients with depression. Insomnia is not only a depression symptom but also an independent risk factor for recurrence.

Lion's Mane · 2021 · Research Article · Antioxidants (Basel, Switzerland)

Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury.

Traumatic brain injury (TBI) is a major health and socioeconomic problem affecting the world. This condition results from the application of external physical force to the brain which leads to transient or permanent structural and functional impairments..

Cognition & nervesRespiratory

Lion's Mane · 2021 · Research Article · BMC complementary medicine and therapies

Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo.

BACKGROUND: Sleep disruption is a major public health issue and may increase the risk of mortality by ten-folds if an individual is sleeping less than 6 h per night. Sleep has changed dramatically during to the COVID-19 pandemic because COVID symptoms can lead to psychological distress including anxiety..

King Oyster · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Identification of the Antidepressant Function of the Edible Mushroom Pleurotus eryngii.

Pleurotus eryngii produces various functional molecules that mediate physiological functions in humans. Recently, we observed that P.