MycoData

OncologyImmune supportEnergy & fatigueGut & microbiome

Reishi · 2023 · Research Article · Antioxidants (Basel, Switzerland)

The Addition of Reishi and Lion's Mane Mushroom Powder to Pasta Influences the Content of Bioactive Compounds and the Antioxidant, Potential Anti-Inflammatory, and Anticancer Properties of Pasta.

The influence of a 2.5% and 5% addition of dried Reishi and Lion's Mane mushrooms on the content of bioactive compounds and some pro-health properties of pasta was studied..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2023 · Research Article · Molecules (Basel, Switzerland)

The Large Molecular Weight Polysaccharide from Wild Cordyceps and Its Antitumor Activity on H22 Tumor-Bearing Mice.

Cordyceps has anti-cancer effects; however, the bioactive substance and its effect are still unclear. Polysaccharides extracted from Cordyceps sinensis, the fugus of Cordyceps, have been reported to have anti-cancer properties..

Reishi · 2022 · Journal Article · Frontiers in microbiology

A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi.

The methyltransferase LaeA is a global regulator involved in the biosynthesis of secondary metabolites by ascomycete fungi. However, little is known of its regulatory role in basidiomycete fungi..

Shiitake · 2022 · Research Article · Nutrients

Astragalus Shiitake-A Novel Functional Food with High Polysaccharide Content and Anti-Proliferative Activity in a Colorectal Carcinoma Cell Line.

The chemical and nutritional constituents of mushrooms can alter significantly when grown on different substrates. Based on this fact, an approach was made to cultivate a new type of mushroom, Hengshan Astragalus Shiitake, by growing Shiitake mushrooms on beds supplemented with the roots of an edible herbal plant,….

Cordyceps · 2022 · Research Article · Brazilian journal of microbiology: [publication of the Brazilian Society for Microbiology]

Enhanced production of cordycepic acid from Cordyceps cicadae isolated from a wild environment.

Cordyceps acid is an active component of Cordyceps cicadae and has a variety of medicinal uses, including anti-tumor effects, the prevention of cerebral hemorrhaging and myocardial infarction, and the inhibition of a wide range of bacteria. The objectives of this study were to identify C..

OncologyCognition & nervesMetabolic healthRespiratory

Chaga · 2022 · Research Article · Computers in biology and medicine

Interference of Chaga mushroom terpenoids with the attachment of SARS-CoV-2; in silico perspective.

Finding a potent inhibitor to the pandemic SARS-CoV-2 is indispensable nowadays. Currently, in-silico methods work as expeditious investigators to screen drugs for possible repurposing or design new ones..

Cordyceps · 2022 · Research Article · Journal of oncology

Network Pharmacology and Molecular Docking Analysis Explores the Mechanisms of Cordyceps sinensis in the Treatment of Oral Lichen Planus.

OBJECTIVE: Oral lichen planus (OLP) is the most common potentially malignant disorder of the oral cavity. This study aimed to investigate the mechanism of action of Cordyceps sinensis in the treatment of OLP and provides a theoretical support for improving current treatment regimens for OLP..

OncologyImmune supportMetabolic health

Cordyceps · 2021 · Research Article · Journal of diabetes research

Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy.

BACKGROUND: Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus and is a major cause of end-stage kidney disease. Cordyceps sinensis (Cordyceps, Dong Chong Xia Cao) is a widely applied ingredient for treating patients with DN in China, while the molecular mechanisms remain unclear..

Cordyceps · 2021 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Cordyceps cicadae polysaccharides inhibit human cervical cancer hela cells proliferation via apoptosis and cell cycle arrest.

The present study presented the extraction and purification of polysaccharides from artificially cultured Cordyceps cicadae and wild Cordyceps cicadae by pre-soaking ultrasonic water extraction..

OncologyImmune supportMetabolic healthSkin & hydration

Nameko · 2021 · Research Article · Antioxidants (Basel, Switzerland)

Effect of Pholiota nameko Polysaccharides Inhibiting Methylglyoxal-Induced Glycation Damage In Vitro.

Advanced glycation end products (AGEs) can induce oxidative stress and inflammation. AGEs are major risk factors for the development of many aging-related diseases, such as cancer and diabetes.

Shiitake · 2021 · Journal Article · Comparative biochemistry and physiology. Toxicology & pharmacology: CBP

Mutated Shiitake extracts inhibit melanin-producing neural crest-derived cells in zebrafish embryo.

The ability of natural extracts to inhibit melanocyte activity is of great interest to researchers. This study evaluates and explores the ability of mutated Shiitake (A37) and wildtype Shiitake (WE) extract to inhibit this activity..

OncologySkin & hydration

OncologyEnergy & fatigueGut & microbiomeSkin & hydration

Oyster Mushroom · 2021 · Journal Article · Environmental science and pollution research international

Two birds with one stone: oyster mushroom mediated bimetallic Au-Pt nanoparticles for agro-waste management and anticancer activity.

Agriculture has the most significant contribution in fulfilling the basic human need, sustaining life, and strengthening the economy of any country. To feed the exploding population of the world, there has been a quantum jump in the production of agricultural commodities, which has led to the production of a….

Cordyceps · 2019 · Comparative Study · Scientific reports

Metabolic profiling of natural and cultured Cordyceps by NMR spectroscopy.

Cordyceps, a type of Chinese herbal medicine that exhibits anti-angiogenesis and tumor growth suppression effects, has recently gained increasing popularity. However, high-quality, natural Cordyceps, such as Ophiocordyceps sinensis, is very rare and difficult to obtain in large amounts..

OncologyMetabolic health

Chaga · 2013 · Journal Article · International immunopharmacology

Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice.

Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity..

OncologyImmune supportGut & microbiome

Maitake · 2009 · Journal Article · International immunopharmacology

Maitake beta-glucan enhances granulopoiesis and mobilization of granulocytes by increasing G-CSF production and modulating CXCR4/SDF-1 expression.

Previous studies have presented that Maitake beta-glucan (MD-Fraction) extracted from the fruit body of Grifola frondosa has an anti-tumor effect by activating the immune system..

Chaga · 2026 · Journal Article · Journal of ethnopharmacology

Lanostane-type triterpenoids from ethnomedicinal fungi inhibit endothelial cell proliferation.

ETHNOPHARMACOLOGICAL RELEVANCE: Ethnomedicinal fungi have a long history of use in the treatment of tumors and inflammatory disorders, pathologies often associated with dysregulated angiogenesis and immune-vascular interactions..

King Oyster · 2026 · Research Article · The FEBS journal

Sensing of cardiolipin exposure on plasma membranes of apoptotic cells by EryA-mCherry protein.

Erylysin A (EryA), an aegerolysin protein produced by the edible king oyster mushroom (Pleurotus eryngii), interacts strongly with an invertebrate-specific membrane sphingolipid ceramide phosphoethanolamine..

OncologyEnergy & fatigue

Chaga · 2025 · Research Article · Apoptosis: an international journal on programmed cell death

Bioactivity of mycosynthesized nanoparticles assists photothermal therapy of breast cancer cells.

Chaga mushroom (Inonotus obliquus) exhibits cytotoxic effects against breast cancer cells. Mycosynthesized nanoparticles, owing to their biodegradability, biocompatibility, and low toxicity, present a promising therapeutic approach..

OncologySkin & hydration

Cordyceps · 2025 · Research Article · MedComm

Cordycepin Targets HRD1 to Promote Cancer Cell PD-L1 Ubiquitin-Proteasome Degradation and Increase Antitumor Immunity.

Immune checkpoint blockade has become an effective strategy for inhibiting tumor growth, especially immune checkpoint inhibitors that target the programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway, which have shown significant effects in tumor immunotherapy..

Almond Mushroom · 2025 · Journal Article · Journal of oncology pharmacy practice: official publication of the International Society of Oncology Pharmacy Practitioners

Grade 3 cytolysis in a patient with metastatic colorectal cancer consuming a mushroom powder-based alternative therapy.

IntroductionThe use of Complementary Alternative Medicine (CAM) in patients with cancer is increasing. CAM is associated with potential toxicity and drug interactions, particularly with chemotherapy..

OncologyLiver support

OncologyImmune supportSkin & hydration

Shiitake · 2025 · Research Article · RSC advances

Synthesis of fungal polysaccharide-based nanoemulsions for cancer treatment.

Long valued for their therapeutic qualities, shiitake mushrooms (Lentinula edodes) are a staple of traditional Asian medicine and cuisine. They are high in bio-actives such as polysaccharides, proteins, lipids, vitamins, minerals, sterols, and phenolic compounds, which exhibit immunomodulatory, anticancer,….

Chaga · 2024 · Journal Article · International journal of medicinal mushrooms

Extracts from Four Species of Xylotrophic Basidiomycetes Growing in the Middle Urals (Russia) Revealed Cytotoxic Effects on Model Object Drosophila melanogaster.

In our study, four species of wood-decaying fungi with perennial fruiting bodies were used as the source of biologically active compounds (BACs) - Inonotus obliquus (chaga), Fomitopsis pinicola, Fomes fomentarius, and Ganoderma applanatum..

Reishi · 2024 · Research Article · Foods (Basel, Switzerland)

Mechanistic and Functional Studies on the Microbial Induction of Wolfiporia cocos Liquid Fermentation Products.

Liquid fermentation is an efficient culture for obtaining polysaccharides from edible mushrooms. In this study, the polysaccharide content and biomass were examined by introducing microorganisms into the Wolfiporia cocos fermentation system..

OncologyImmune supportMetabolic healthRespiratory

Cordyceps · 2023 · Review · International journal of molecular sciences

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer.

Edible/medicinal mushrooms have been traditionally used in Asian countries either in the cuisine or as dietary supplements and nutraceuticals. In recent decades, they have aroused increasing attention in Europe as well, due to their health and nutritional benefits..

OncologyImmune supportCognition & nervesMetabolic health

Almond Mushroom · 2022 · Randomized Controlled Trial · Cytotherapy

Prevention of chronic diabetic complications in type 1 diabetes by co-transplantation of umbilical cord mesenchymal stromal cells and autologous bone marrow: a pilot randomized controlled open-label clinical study with 8-year follow-up.

BACKGROUND AIMS: To explore the long-term safety and benefit of umbilical cord mesenchymal stromal cell (MSCs) plus autologous bone marrow mononuclear cell (aBM-MNC) stem cell transplantation (SCT) without immunotherapy in established type 1 diabetes (T1D)..

Turkey Tail · 2021 · Review · Materials (Basel, Switzerland)

Bioactives from Mushroom: Health Attributes and Food Industry Applications.

It is well-known that the utilization of mushrooms as therapeutic agents is not new. Over the past years, they have been used by local individuals as food, as well as medicines, throughout the world.

OncologyImmune supportMetabolic health

Almond Mushroom · 2021 · Review · International journal of biological macromolecules

Polysaccharides and extracts from Agaricus brasiliensis Murill - A comprehensive review.

Edible mushrooms have been increasingly introduced into the human diet, which has driven research into their functional properties. Thus, Agaricus brasiliensis Murill or Agaricus blazei Murill (ABM) is a species native to the Brazilian biome, whose fruiting body has been used not only for dietary purposes, but also in….

Cordyceps · 2020 · Journal Article · Chemico-biological interactions

Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level.

Herbal medicines and their bioactive compounds are increasingly being recognized as useful drugs for cancer treatments. The parasitic fungus Cordyceps militaris is an attractive anticancer herbal since it shows very powerful anticancer activity due to its phytocompound cordycepin..

Turkey Tail · 2012 · Meta-Analysis · Recent patents on inflammation & allergy drug discovery

Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis.

AIM: Patients with cancer frequently use herbs along with the conventional medical treatment, hoping to enhance recovery. Mushrooms have an established history of use in traditional oriental therapies.

Almond Mushroom · 2025 · Preprint · journal metadata

Analysis and Mean-Field Limit of a Hybrid PDE-ABM Modeling Angiogenesis-Regulated Resistance Evolution

Mathematical modeling is indispensable in oncology for unraveling the complex interplay between tumor growth, vascular remodeling, and therapeutic resistance. Here, we address the critical need for integrative frameworks capturing bidirectional feedback between hypoxia-driven angiogenesis and stochastic resistance….

OncologyEnergy & fatigue

OncologyCognition & nerves

Almond Mushroom · 2024 · Meta-Analysis · Clinical psychology review

Beyond the modified dot-probe task: A meta-analysis of the efficacy of alternate attention bias modification tasks across domains.

Attention biases towards disease-relevant cues have been implicated in numerous disorders and health conditions, such as anxiety, cancer, drug-use disorders, and chronic pain. Attention bias modification (ABM) has shown that changing attention biases can change related emotional processes..

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2020 · Review Article · Frontiers in pharmacology

Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials.

In recent decades, interest in the Cordyceps genus has amplified due to its immunostimulatory potential. Cordyceps species, its extracts, and bioactive constituents have been related with cytokine production such as interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor (TNF)-α, phagocytosis….

Shiitake · 2019 · Review · International journal of medicinal mushrooms

Review of Bioactive Molecules Production, Biomass, and Basidiomata of Shiitake Culinary-Medicinal Mushrooms, Lentinus edodes (Agaricomycetes).

Lentinus edodes (shiitake) is a basidiomycete that has been consumed for more than 2000 years because of its nutritional value and health benefits. It has a low lipid content, high fiber content, and a considerable amount of proteins; it also contains B vitamins and minerals in addition to a wide range of functional….

Mesima · 2005 · Journal Article · Urology

Administration of extract of mushroom Phellinus linteus induces prostate enlargement with increase in stromal component in experimentally developed rat model of benign prostatic hyperplasia.

OBJECTIVES: To clarify the effect of the mushroom extract Phellinus linteus on noncancerous prostate cells using an experimentally developed rat benign prostatic hyperplasia model. A growing number of people take some natural herbal extracts for maintenance of their health..

Mesima · 2005 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Inhibition of IgE-dependent mouse triphasic cutaneous reaction by a boiling water fraction separated from mycelium of Phellinus linteus.

Phellinus linteus, a mushroom, contains constituents that exhibit potent antitumor effects through activating immune cells. Recently, anti-inflammatory and anti-allergic properties of P.

OncologyLiver supportRespiratory

Niu-Chang-Chih · 2005 · Journal Article · Journal of agricultural and food chemistry

Mycelia from Antrodia camphorata in Submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway.

The objective of this study was to investigate the antiproliferative effect and the mechanism of the methanol extracts of mycelia (MEM) form Antrodia camphorata in submerged culture toward HepG2 cells..

OncologyImmune supportMetabolic healthSkin & hydration

Maitake · 2005 · Journal Article · FEMS microbiology letters

Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-1 expression in UV-irradiated human dermal fibroblasts.

Exopolysaccharide (EPS) was prepared by submerged mycelial culture of a newly isolated mushroom Grifola frondosa HB0071 in a 5-l stirred-tank fermenter. This fungus produced a high concentration of biomass (24.8 gl(-1) at day 4), thereby achieving high EPS concentration (7.2 gl(-1) at day 4)..

Mesima · 2004 · Research Article · Hua zhong nong ye da xue xue bao = Journal Huazhong (Central China) Agricultural University

Artificial cultivation of medicinal mushroom, Phellinus linteus using mulberry log

Metadata-grounded summary: This research article indexes research on Phellinus linteus in Hua zhong nong ye da xue xue bao = Journal Huazhong (Central China) Agricultural University in 2004. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Niu-Chang-Chih · 2004 · Journal Article · Journal of natural products

Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line.

Five new maleic and succinic acid derivatives were isolated from the mycelium of Antrodia camphorata. Their structures were determined by various spectroscopic means.

Mesima · 2004 · Journal Article · Bioscience, biotechnology, and biochemistry

Fractionation and Anti-tumor Activity of the Mycelia of Liquid-cultured Phellinus linteus

All the fractions of Phellinus linteus mycelia showed anti-tumor activity toward solid tumors planted in mice. The highest anti-tumor activity of 81.2% was observed in the protein-glucan complex obtained by precipitating the 24% NaOH extract at pH 6.0..

OncologyCognition & nervesRespiratory

Enoki · 2003 · Research Article · Journal of Fujian Agriculture and Forestry University(Natural Science Edition)

The purification of antiviral protein in Flammulina velutipes and its characteristic against tobacco mosaic virus

The clinical picture of a tumour involving the amygdaloid nucleus was characterized over a period of 6 years by generalised epileptic fits, then a state of agitated delirium with oneirism evolving during 2 months and leading finally to pulmonary embolism..

Mesima · 2003 · Journal Article · Mycotaxon

Type studies on Phellinus baumii and Phellinus linteus.

Phellinus linteus is famous for its anti-tumor activity and has been widely reported in Korea. Investigation of samples from China, Korea, Costa Rica, and Mexico revealed that the temperate East Asian species known as P.

OncologyGut & microbiome

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2002 · Research Article · Cytotechnology

Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells.

It was found that an exo-biopolymer (M.W. 1,000,000, molar ratio of 1.5:1.7:1.2:0.6:0.9, glucose:galactose:xylose:mannose:fructose, purity 99%) purified from the liquid culture broth of Hericium erinaceus mycelium enhanced the growth of rat adrenal nerve cells..

Maitake · 2002 · Journal Article · Hua zhong nong ye da xue xue bao = Journal Huazhong (Central China) Agricultural University

Effect of polysaccharide of Grifola frondosa (PGF-1) on immunological function in tumor-bearing mice

The presence and growth of Aspergillus fumigatus and Aspergillus niger in the soil of ornamental plants have been demonstrated. The ecological conditions in the soil of such plants as influenced by temperature, humidity, desiccation, fertilization and ventilation obviously influence such fungal growth..

Maitake · 2001 · Journal Article · Pharmaceutical Biotechnology

Fractionation and antitumor activity of polysaccharide from Grifola frondosa

Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Pharmaceutical Biotechnology in 2001. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

Lion's Mane · 1999 · Journal Article · Edible Fungi of China

A study on submerged fermentation conditions of Hericium erinaceus

The extensive use of the single technic of immunofluorescence has resulted in the detection of an array of melanoma-specific antigens. Those antigens residing in the cytoplasm of the melanoma cell have been shown to cross-react across various melanoma cell lines in tissue culture, as well as across all fresh tumor….

Enoki · 1999 · Journal Article · European journal of biochemistry

Purification and cDNA cloning of a protein derived from Flammulina velutipes that increases the permeability of the intestinal Caco-2 cell monolayer.

A new protein that decreases transepithelial electrical resistance (TEER) in the human intestinal Caco-2 cell monolayer was found in a water-soluble fraction of the mushroom Flammulina velutipes..

OncologyGut & microbiome

OncologyImmune supportRespiratory

Mesima · 1999 · Journal Article · Immunopharmacology

The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis.

It was previously reported that polysaccharides (PL) isolated from Phellinus linteus strongly stimulated cell-mediated and humoral immunity. This study was undertaken to investigate the immunochemotherapeutic activity of PL against tumor growth and metastasis..