MycoData

This study investigated the purification, preliminary structure and in vivo immunomodulatory activities of polysaccharides from the spores of Cordyceps cicadae (CCSP)..

OncologyImmune supportMetabolic health

Medium relevance

Cordyceps · 2022 · Journal Article · Journal of ethnopharmacology

Preparation of the sphingolipid fraction from mycelia of Cordyceps sinensis and its immunosuppressive activity.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps sinensis (CS) is an herbal tonic in traditional Chinese medicine and is used to treat a wide range of disorders, including immune, kidney, respiratory, lung and cardiovascular diseases, in China..

OncologyImmune supportRespiratory

Medium relevance

Cordyceps · 2021 · Journal Article · Journal of biochemical and molecular toxicology

Cordyceps acid alleviates lung cancer in nude mice.

The aim of this study is to examine the effect of cordyceps acid (CA) on lung cancer in mice. A lung cancer animal model was established by inoculating lung cancer cells under the armpit of nude mice.

OncologyImmune supportMetabolic healthRespiratory

Medium relevance

Cordyceps · 2021 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Cordyceps sinensis-derived fungus Isaria felina ameliorates experimental autoimmune thyroiditis in mice.

AIMS: This study aimed to investigate the therapeutic effect of Cordyceps sinensis-derived fungus Isaria felina on experimental autoimmune thyroiditis (EAT). METHODS: A NaI-induced EAT mouse model was established..

OncologyImmune support

Medium relevance

Almond Mushroom · 2020 · Randomized Controlled Trial · International journal of radiation oncology, biology, physics

A Multi-atlas Approach for Active Bone Marrow Sparing Radiation Therapy: Implementation in the NRG-GY006 Trial.

PURPOSE: Sparing active bone marrow (ABM) can reduce acute hematologic toxicity in patients undergoing chemoradiotherapy for cervical cancer, but ABM segmentation based on positron emission tomography/computed tomography (PET/CT) is costly..

OncologyMetabolic healthGut & microbiome

Medium relevance

Shiitake · 2017 · Research Support, Non U.S. Gov'T · Scientific reports

Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production.

Lentinan extracted from shiitake (Lentinula edodes) is a β-glucan that has been reported as an intravenous anti-tumor polysaccharide via enhancement of the host immune system. In this study, we determined the effect of lentinan on inflammasome activation, a multi-protein platform, in myeloid cells..

OncologyImmune support

Medium relevance

Enoki · 2016 · Review · Frontiers in pharmacology

Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties.

Flammulina velutipes (enoki, velvet shank, golden needle mushroom or winter mushroom), one of the main edible mushrooms on the market, has long been recognized for its nutritional value and delicious taste..

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Maitake · 2009 · Journal Article · International immunopharmacology

Maitake beta-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice.

Cisplatin is broadly used clinically as an anticancer drug. Despite its significant anticancer activity, cisplatin-induced nephrotoxicity and myelosuppression limit its use..

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Cordyceps · 2026 · Journal Article · International journal of molecular sciences

Antithrombotic Effects of Cordycepin-Enriched WIB-801CE via Inhibition of Thromboxane A2-Induced αIIbβ3 Activation and Thrombin-Mediated Fibrin Clot Retraction.

WIB-801CE, a standardized Cordyceps militaris extract containing 7.0% cordycepin, suppresses platelet activation induced by thrombin, collagen, and adenosine diphosphate (ADP)..

OncologyImmune supportSkin & hydration

Medium relevance

Cordyceps · 2026 · Journal Article · Journal of chromatography. A

Construction of porous adsorbent for selective enrichment of cis-diol-containing flavonoids and evaluation of green performance based on life cycle analysis.

Flavonoids exhibit anti-inflammatory, anti-cancer, antibacterial and anti-aging properties. However, their complex structures make the separation and purification of flavonoids pharmacologically significant..

OncologyImmune supportEnergy & fatigueSkin & hydration

Medium relevance

Cordyceps · 2026 · Journal Article · Journal of clinical laboratory analysis

Edible Fungus Compound Cordycepin Protects Against Acetaminophen-Induced Liver Injury.

BACKGROUND: Medicinal-edible natural products like Cordyceps militaris (C.militaris), a functional food rich in cordycepin (COR), are promising for health maintenance..

OncologyImmune supportLiver support

Medium relevance

Cordyceps · 2026 · Journal Article · Bioresource technology

Efficient production of cordycepin in engineered Saccharomyces cerevisiae.

Cordycepin (COR) is an important bioactive nucleoside with antitumor and immunomodulatory activities, but its conventional production via Cordyceps militaris fermentation is limited by long cultivation periods and low titers. Therefore, microbial heterologous synthesis represents an attractive alternative..

OncologyImmune supportMetabolic health

Medium relevance

Cordyceps · 2025 · Journal Article · Molecular biotechnology

Cordycepin Ameliorates Psoriasis-Like Skin Lesion by Regulating p53/MDM2 Feedback Loop.

Apoptosis is a natural physiological process of programmed cell death. It is essential for maintaining the homeostasis of the body and the immune system.

OncologyImmune supportSkin & hydration

Medium relevance

Oyster Mushroom · 2025 · Journal Article · Journal of agricultural and food chemistry

Discovery and Characterization of Two Novel Sesquiterpene Synthases Producing Pleostene in Oyster and Honey Mushrooms.

Basidiomycetous fungi are prolific producers of terpenoids, yet many biosynthetic pathways remain unexplored. Here, we report the discovery of two novel terpene synthases: PoTS6 from the oyster mushroom (Pleurotus ostreatus) and AgTS2 from the bulbous honey fungus (Armillaria gallica)..

Oncology

Medium relevance

King Oyster · 2025 · Research Article · Foods (Basel, Switzerland)

Identification and Nutrient Composition of a Wild Pleurotus pulmonarius Strain from Tibet, and the Antioxidant and Cytotoxic Activities of Polysaccharides from This Fungus.

The selection and breeding of high-quality wild edible fungal strains can bring significant economic and social benefits. A wild fungal strain (X21185) from the Tibetan Plateau was isolated and identified as a novel Pleurotus pulmonarius (P.

OncologyImmune supportLiver support

Medium relevance

Reishi · 2025 · Journal Article · Physical chemistry chemical physics: PCCP

Molecular dynamics simulations reveal a strong binding capacity of colossolactone H to the EGFR inactive conformation.

The major side effects of in-use drugs, such as gefitinib, erlotinib and osimetinib, have led to inherent limitations and considerable concerns regarding the use of tyrosine kinase inhibitors (TKIs) in cancer treatment..

OncologySkin & hydration

Medium relevance

Cordyceps · 2024 · Research Article · Bioactive materials

Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease.

Radiation-induced heart disease (RIHD), characterized by severe oxidative stress and immune dysregulation, is a serious condition affecting cancer patients undergoing thoracic radiation. Unfortunately, clinical interventions for RIHD are lacking..

OncologyImmune supportLiver support

Medium relevance

Cordyceps · 2024 · Journal Article · South African journal of botany

Biotic elicitors influence boeravinone B production from cell suspension cultures of Boerhavia diffusa Linn.

Boerhavia diffusa L., (punarnava) is known for its rich, secondary metabolite content and potential pharmacological properties. Boeravinone B, a flavonoid, is a significant plant secondary metabolite found in punarnava, exhibiting various pharmacological properties that translate into anticancer, antioxidant,….

OncologyImmune support

Medium relevance

Cordyceps · 2024 · Research Article · Biomolecules & therapeutics

Cordycepin Enhanced Therapeutic Potential of Gemcitabine against Cholangiocarcinoma via Downregulating Cancer Stem-Like Properties.

Cordycepin, a valuable bioactive component isolated from Cordyceps militaris, has been reported to possess anti-cancer potential and the property to enhance the effects of chemotherapeutic agents in various types of cancers..

OncologySkin & hydration

Medium relevance

Maitake · 2024 · Research Article · NeuroImmune pharmacology and therapeutics

Neuroprotective Mushrooms.

Alternative medicines commonly supplement or, at times, replace standard medical treatment. One area of increasing attention is disease-modifying medicines for neurodegenerative diseases..

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Cordyceps · 2023 · Review · Molecules (Basel, Switzerland)

Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review.

Medicinal mushrooms, e.g., Lion's Mane (Hericium erinaceus (Bull.) Pers.), Reishi (Ganoderma lucidum (Curtis) P. Karst.), Chaga (Inonotus obliquus (Ach.

OncologyImmune supportMetabolic health

Medium relevance

Almond Mushroom · 2023 · Randomized Controlled Trial · Cancer

Single-photon emission computed tomography-defined active bone marrow-sparing volumetric-modulated arc therapy reduces the incidence of acute hematologic toxicity in locally advanced cervical cancer patients who receive chemoradiotherapy: A single-center prospective randomized controlled trial.

BACKGROUND: This study aims to test the efficacy of single-photon emission computed tomography (SPECT)-defined active bone marrow-sparing (ABMS) volumetric-modulated arc therapy (VMAT) in reducing grade 3+ acute hematologic toxicity (HT) in locally advanced cervical cancer patients treated with chemoradiotherapy..

OncologyLiver support

Medium relevance

Shiitake · 2022 · Clinical Trial Protocol · Trials

Efficacy of active hexose correlated compound on survival of patients with resectable/borderline resectable pancreatic cancer: a study protocol for a double-blind randomized phase II study.

BACKGROUND: The prognosis of pancreatic ductal adenocarcinoma remains very poor. One possible reason for the short survival of patients with this disease is malnutrition, which can be present at the initial diagnosis, and continue after pancreatectomy..

Oncology

Medium relevance

Cordyceps · 2021 · Review · Food & function

Dietary agents in mitigating chemotherapy-related cognitive impairment (chemobrain or chemofog): first review addressing the benefits, gaps, challenges and ways forward.

Chemobrain or chemofog is one of the important but less investigated side effects, where the cancer survivors treated with chemotherapy develop long-term cognitive impairments, affecting their quality of life. The biological mechanisms triggering the development of chemobrain are largely unknown..

OncologyImmune supportCognition & nerves

Medium relevance

Chaga · 2020 · Journal Article · Voprosy virusologii

[Antiviral activity of extracts of basidiomycetes and humic compounds substances against Human Immunodeficiency Virus (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus 1) and Herpes Simplex Virus (Herpesviridae: Simplexvirus: Human alphaherpesvirus 1)].

INTRODUCTION: One of the most urgent problem of modern medicine is the fight against the disease caused by the Human Immunodeficiency Virus (HIV) - HIV infection..

OncologyImmune supportLiver supportSkin & hydration

Medium relevance

Chaga · 2019 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells.

BACKGROUND: Inonotus obliquus, namely as Chaga mushroom, is a medicinal and edible fungus, which is widely used in food and medical fields. Inotodiol, a natural lanostane-type triterpenoid with remarkable pharmacological activities, was isolated from Inonotus obliquus, which its potential anti-tumor molecular….

OncologySkin & hydration

Medium relevance

Cordyceps · 2026 · Preprint · journal metadata

Fungal Cordyceps Nucleosides and Analogs as Potential PD-L1 Inhibitors as Anti-Glioblastoma: An In Silico Multiparameter Optimization (MPO) Design

Immune checkpoint modulation has emerged as a promising strategy in cancer therapy, including the treatment of aggressive tumors such as glioblastoma. Among these targets, programmed death-ligand 1 (PD-L1) plays a key role in tumor immune evasion and represents an attractive target for small-molecule inhibitor….

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Almond Mushroom · 2025 · Preprint · journal metadata

Multiscale Modeling of Tumor Angiogenesis and Resistance Evolution: A Hybrid PDE–ABM Framework for Cancer Prediction and Therapy Planning

Tumor drug resistance involves intrinsic cellular mechanisms, microenvironmental regulation, and epigenetic alterations. Hypoxia, drug distribution, and microvascular heterogeneity critically mediate resistance within the tumor microenvironment (TME)..

OncologyEnergy & fatigue

Medium relevance

Reishi · 2023 · Journal Article · Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)

Effect of Supplemental Antioxidant-Based Therapy on the Oxidative Stress Level in COVID-19 Patients.

Background: COVID-19 is a disease in several stages starting with virus replication to dysregulation in immune system response, organ failure and recovery/death. Our aim was to determine the effect of Ganoderma lucidum, lycopene, sulforaphane, royal jelly and resveratrol extract on markers of oxidative stress,….

OncologyImmune supportRespiratory

Medium relevance

Reishi · 2023 · Research Article · Aging medicine (Milton (N.S.W))

Ganoderic Acid A targeting leucine-rich repeat kinase 2 involved in Parkinson's disease-A computational study.

OBJECTIVE: This study aims to find the most promising Ganoderma lucidium targeting LRRK2 involved in PD. METHODS: First ADMET analysis was performed for five compounds followed by molecular docking of each compound..

OncologyCognition & nervesLiver support

Medium relevance

Reishi · 2022 · Journal Article · Toxicology reports

Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib.

Herbal products are widely used in cancer patients via co-administration with chemotherapy. Previous studies have demonstrated that pharmacokinetic interactions between herbs and anticancer drugs exist due to inhibition of drug-metabolizing enzymes, particularly cytochrome P450s (CYPs)..

OncologyEnergy & fatigueLiver support

Medium relevance

Turkey Tail · 2022 · Research Article · Iranian journal of pharmaceutical research: IJPR

Polysaccharide Peptide Induced Colorectal Cancer Cells Apoptosis by Down-Regulating EGFR and PD-L1 Expression.

BACKGROUND: Colorectal cancer (CRC) is the most frequent death-causing disease in the world. The Trametes versicolor mushroom, a traditional Chinese medicine, has been used as anti-cancer medicine with long history..

OncologyImmune supportSkin & hydration

Medium relevance

Oyster Mushroom · 2025 · Journal Article · Heliyon

A comprehensive review on multifunctional bioactive properties of elm oyster mushroom Hypsizygus ulmarius (Bull.) Redhead (Agaricomycetes): Current research, challenges and future trends

Mushrooms have evolved as a nutritional powerhouse, harnessing a diverse spectrum of bioactive molecules to fortify human health. Hypsizygus ulmarius represents a pioneering species within the oyster mushrooms distinguished by its unique characteristics and potential abilities..

OncologyImmune support

Medium relevance

Mesima · 2023 · Research Support, Non U.S. Gov'T · Micron (Oxford, England: 1993)

Analysis of phellinus igniarius effects on gastric cancer cells by atomic force microscopy.

Gastric cancer is one of the common malignant tumors in the world, which originates from the gene mutation of human cells. In this work, an atomic force microscope was used to quantitatively detect the changes of multiple physical parameters such as the cell morphology, surface roughness, elasticity modulus and….

OncologySkin & hydration

Medium relevance

Almond Mushroom · 2021 · Systematic Review · International journal of medicinal mushrooms

A Systematic Review on Bioactivity of Brazilian Mushrooms (Agaricomycetes).

The medicinal properties of Agaricomycetes mushrooms have been explored for millennia. Several biological activities produced by mushrooms have been evaluated worldwide.

OncologyImmune support

Medium relevance

Shiitake · 2021 · Review · Molecules (Basel, Switzerland)

The Health-Promoting Properties and Clinical Applications of Rice Bran Arabinoxylan Modified with Shiitake Mushroom Enzyme-A Narrative Review.

Rice bran arabinoxylan compound (RBAC) is derived from defatted rice bran hydrolyzed with Lentinus edodes mycelial enzyme. It has been marketed as a functional food and a nutraceutical with health-promoting properties..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Mesima · 2020 · Published Erratum · Medicine

A clinical pilot study to evaluate the efficacy of oral intake of phellinus linteus (sanghuang) extract on knee joint and articular cartilage: Study protocol clinical trial (SPIRIT Compliant): Erratum.

Metadata-grounded summary: This published erratum indexes research on Phellinus linteus in Medicine in 2020. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Oncology

Medium relevance

Shiitake · 2020 · Research Support, Non U.S. Gov'T · PloS one

Preliminary study on Se-enriched Lentinula edodes mycelium as a proposal of new feed additive in selenium deficiency.

The presence of selenium in European soil is low and this causes its deficiency in livestock and, in consequence, in humans. This study aimed to obtain Lentinula (L.) edodes mycelium with the maximum content of selenium.

OncologyImmune supportMetabolic health

Medium relevance

Agarikon · 2020 · Journal Article · Phytochemistry

Structural investigation and comparative cytotoxic activity of water-soluble polysaccharides from fruit bodies of the medicinal fungus quinine conk.

The structures and cytotoxic activities of water-soluble polysaccharides were investigated to search for biologically active polysaccharides from the fruit bodies of quinine conks (Fomitopsis officinalis)..

OncologyImmune supportSkin & hydration

Medium relevance

Mesima · 2018 · Published Erratum · Phytomedicine: international journal of phytotherapy and phytopharmacology

Hispolon from Phellinus linteus possesses mediate caspases activation and induces human nasopharyngeal carcinomas cells apoptosis through ERK1/2, JNK1/2 and p38 MAPK pathway Phytomedicine 21 (2014) 1746-1752.

Metadata-grounded summary: This published erratum indexes research on Phellinus linteus in Phytomedicine: international journal of phytotherapy and phytopharmacology in 2018. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Oncology

Medium relevance

Mesima · 2017 · Research Support, Non U.S. Gov'T · The Journal of antibiotics

γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination.

Metadata-grounded summary: This research support, non u.s. gov't indexes research on Phellinus linteus in The Journal of antibiotics in 2017.

Oncology

Medium relevance

Mesima · 2016 · Research Support, Non U.S. Gov'T · Oncology reports

Hispolon from Phellinus linteus induces apoptosis and sensitizes human cancer cells to the tumor necrosis factor-related apoptosis-inducing ligand through upregulation of death receptors.

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent anticancer agent possessing the ability to induce apoptosis in various cancer cells but not in non‑malignant cells..

Oncology

Medium relevance

Reishi · 2015 · Journal Article · Journal of Applied Glycoscience

Structural Characterization of a Heterogalactan from Antler-shaped Ganoderma lucidum

Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Journal of Applied Glycoscience in 2015. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Reishi · 2014 · Journal Article · Mushroom Science and Biotechnology

Angiotensin-converting enzyme inhibitor in water extracts from the fruiting body of Ganoderma lucidum

Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Mushroom Science and Biotechnology in 2014. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Enoki · 2013 · Journal Article · Food Science and Technology Research

In Vitro Antioxidant and Antitumor Activities of Polysaccharides Extracted from the Mycelia of Liquid-Cultured Flammulina velutipes

Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Food Science and Technology Research in 2013. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

OncologyImmune support

Medium relevance

Turkey Tail · 2013 · Journal Article · Tree and Forest Health

Patterns of mating and morphological variation in Trametes versicolor

Metadata-grounded summary: This journal article indexes research on Trametes versicolor in Tree and Forest Health in 2013. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

OncologyImmune support

Medium relevance

Niu-Chang-Chih · 2013 · Journal Article · Integrative cancer therapies

Taiwanofungus camphoratus (Syn Antrodia camphorata) extract and amphotericin B exert adjuvant effects via mitochondrial apoptotic pathway.

The use of multiple drugs in cancer therapy increases the efficacy of the potential therapeutic effects. In this study, the authors investigated the adjuvant effects of an ethanol extract of solid-state cultivated Taiwanofungus camphoratus (TCEE) and amphotericin B (AmB) in the human cancer cell lines RPMI7951 and….

OncologyEnergy & fatigue

Medium relevance

Oyster Mushroom · 2013 · Journal Article · Bioscience, Biotechnology, and Biochemistry

The Inhibition of Human Tumor Cell Proliferation by RNase Pol, a Member of the RNase T1 Family, from Pleurotus ostreatus

RNase Po1 is a guanylic acid-specific ribonuclease (a RNase T1 family RNase) from Pleurotus ostreatus. We determined the cDNA sequence encoding RNase Po1 and expressed RNase Po1 in Escherichia coli..

OncologyCognition & nerves

Medium relevance

Reishi · 2012 · Journal Article · Bioscience, Biotechnology, and Biochemistry

Enhanced Production of Ganoderic Acids and Cytotoxicity of Ganoderma lucidum Using Solid-Medium Culture

Submerged cultures of Ganoderma lucidum are used to produce fungal mycelium, which is used as a functional food and in the production of various triterpenoids, including ganoderic acids (GAs)..

OncologyImmune supportRespiratory

Medium relevance

Turkey Tail · 2012 · Journal Article · Japanese Journal of Mycology

Inhibitory effects of Trichoderma spp. immobilized on charcoal-particles on wood degradation by Fomitopsis palustris and Trametes versicolor

Metadata-grounded summary: This journal article indexes research on Trametes versicolor in Japanese Journal of Mycology in 2012. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

OncologyImmune support