MycoData

Immune supportEnergy & fatigueMetabolic healthRespiratory

Cordyceps · 2023 · Research Support, Non U.S. Gov'T · PloS one

The mechanism of action of Ophiocordyceps sinensis mycelia for prevention of acute lung injury based on non-targeted serum metabolomics.

Ophiocordyceps sinensis is a fungus with medicinal value in treating lung diseases, but no study has reported how to prevent acute lung injury using this fungus. The mice were divided into normal, model, positive control, and O..

Immune supportLiver support

Niu-Chang-Chih · 2023 · Research Support, Non U.S. Gov'T · Aging

Triterpene acid from Antrodia camphorata alleviates inflammation in acute liver injury.

This study aimed to investigate the role and mechanism of Anctin A, the Antrodia camphorata terpene component, in resisting liver injury. Network pharmacology analysis revealed that MAPK3 was the major action target of Antcin A..

OncologyImmune supportEnergy & fatigue

Zhu Ling · 2022 · Research Support, Non U.S. Gov'T · Scientific reports

Acetylome analysis of acetylation providing new insight into sclerotial generation in medicinal fungus Polyporus umbellatus.

Sclerotium-forming fungi are ecologically diverse and possess notable pathogenic or medicinal properties. The sclerotial generation mechanism is still elusive though Polyporus umbellatus sclerotia are typical Traditional Chinese Medicine with diuretic and antitumor effects..

OncologyImmune supportGut & microbiome

Shiitake · 2022 · Brief Report · Frontiers in immunology

AHCC®, a Standardized Extract of Cultured Lentinula Edodes Mycelia, Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer.

Treatment strategies combining immune checkpoint blockade (ICB) with other agents have emerged as a promising approach in the treatment of cancers. AHCC®, a standardized extract of cultured Lentinula edodes mycelia, has been reported to inhibit tumor growth and enhance immune cell function..

Immune supportSkin & hydration

Reishi · 2022 · Research Support, Non U.S. Gov'T · Aging

An active ingredient isolated from Ganoderma lucidum promotes burn wound healing via TRPV1/SMAD signaling.

The mushroom Ganoderma lucidum is a traditional Chinese medicine and G. lucidum spore oil (GLSO) is the lipid fraction isolated from Ganoderma spores.

OncologyImmune supportRespiratory

Reishi · 2022 · Video Audio Media · Journal of visualized experiments: JoVE

Co-Fermentation of Marsdenia tenacissima with Ganoderma lucidum and Anti-Lung Cancer Effect of the Fermentation Products.

Marsdenia tenacissima (Roxb.) Wight et Arn. (MT), as a traditional Chinese and Dai herbal medicine, has anti-inflammatory, antibacterial, and antitumor properties.

Immune supportEnergy & fatigue

Maitake · 2022 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Effect of low-intensity magnetic field on the growth and metabolite of Grifola frondosa in submerged fermentation and its possible mechanisms.

This study aimed to investigate the effects of low intensity alternating magnetic field on the submerged fermentation of Grifola frondosa, and its possible mechanism was also explored..

Lion's Mane · 2022 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Hericium erinaceus ethanol extract and ergosterol exert anti-inflammatory activities by neutralizing lipopolysaccharide-induced pro-inflammatory cytokine production in human monocytes.

Edible mushrooms are known to exert anti-inflammatory effects. In this study, the effects of ethanol extracts from edible mushrooms, such as Hericium erinaceus, and other edible mushrooms on inflammatory responses were investigated..

Oyster Mushroom · 2022 · Research Support, Non U.S. Gov'T · Immunotherapy

Immunomodulation with β-glucan from Pleurotus ostreatus in patients with endocrine-dependent breast cancer.

Aim: To evaluate the effect of pleuran (β-glucan from Pleurotus ostreatus) administration on the immune profile of patients with endocrine-dependent breast cancer (clinical stages I-II) in clinical and imaging remission..

Snow Fungus · 2022 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

In vitro fecal fermentation properties of polysaccharides from Tremella fuciformis and related modulation effects on gut microbiota.

Tremella fuciformis is an edible and medicinal mushroom. Polysaccharides from T.

Immune supportEnergy & fatigueLiver support

Mesima · 2022 · Research Support, Non U.S. Gov'T · Aging

Phellinus linteus polysaccharides mediates acetaminophen-induced hepatotoxicity via activating AMPK/Nrf2 signaling pathways.

Overdose of acetaminophen (APAP) is currently one of the main causes of hepatoxicity and acute liver injury, which is often linked to oxidative stress. Phellinus linteus polysaccharides (Phps) have shown many hepatoprotective effects, however, the mechanism of Phps on APAP-induced acute liver injury has not been….

Immune supportMetabolic healthLiver support

Maitake · 2022 · Research Support, Non U.S. Gov'T · Frontiers in immunology

The anti-obesity effects of a water-soluble glucan from Grifola frondosa via the modulation of chronic inflammation.

Polysaccharides from Grifola frondosa (G. frondosa) have anti-obesity and anti-inflammatory activities.

Shiitake · 2022 · Research Support, Non U.S. Gov'T · Biomolecules

The Effect of Novel Selenopolysaccharide Isolated from Lentinula edodes Mycelium on Human T Lymphocytes Activation, Proliferation, and Cytokines Synthesis.

Polysaccharides isolated from Lentinula edodes are bioactive compounds with immunomodulatory properties. In our previous studies from L.

Immune supportRespiratory

Turkey Tail · 2022 · Research Support, Non U.S. Gov'T · Viruses

β-Glucans from Trametes versicolor (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection.

Coriolus versicolor (C. versicolor) is a higher fungi or mushroom which is now known by its accepted scientific names as Trametes versicolor (L.) Lloyd.

Immune supportEnergy & fatigueMetabolic health

Lion's Mane · 2021 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

A novel polysaccharide from Hericium erinaceus: Preparation, structural characteristics, thermal stabilities, and antioxidant activities in vitro.

A novel polysaccharide fraction (HEP) from Hericium erinaceus was successively isolated and purified in the present study. We researched its structure and thermal stabilities, and further studied its antioxidant activities in vitro..

Lion's Mane · 2021 · Comparative Study · International journal of biological macromolecules

Immunomodulatory effects of polysaccharides enzymatic hydrolysis from Hericium erinaceus on the MODE-K/DCs co-culture model.

The aim of this study was to explore the indirect immunomodulatory activities and its mechanism of enzymatic hydrolysis of Hericium erinaceus polysaccharides (EHEP) in the MODE-K/DCs co-culture model..

Immune supportMetabolic health

Snow Fungus · 2021 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Moisture and caking resistant Tremella fuciformis polysaccharides microcapsules with hypoglycemic activity.

Tremella fuciformis polysaccharides (TPs) have attracted extensive attention as functional food constituents due to their bioactivity. However, β-D-glucan obtained from TPs is readily degraded by oxidation and easy to absorb water and agglomerate..

Shiitake · 2021 · Research Support, Non U.S. Gov'T · Biomolecules

Selective Biological Effects of Selenium-Enriched Polysaccharide (Se-Le-30) Isolated from Lentinula edodes Mycelium on Human Immune Cells.

A common edible mushroom Lentinula edodes, is an important source of numerous biologically active substances, including polysaccharides, with immunomodulatory and antitumor properties..

Chaga · 2021 · Letter · Magnetic resonance in chemistry: MRC

Structure elucidation of a new triterpene from Inonotus obliquus.

Ethyl acetate (EtOAc) fraction of the Inonotus obliquus (Hymenochaetaceae) significantly inhibited nitric oxide production in lipopolysaccharide (LPS)-induced murine BV2 microglial cells..

Oyster Mushroom · 2021 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

Targeted disruption of hir1 alters the transcriptional expression pattern of putative lignocellulolytic genes in the white-rot fungus Pleurotus ostreatus.

Pleurotus ostreatus is frequently used in molecular genetics and genomic studies on white-rot fungi because various molecular genetic tools and relatively well-annotated genome databases are available. To explore the molecular mechanisms underlying wood lignin degradation by P..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Shiitake · 2021 · Research Support, Non U.S. Gov'T · Journal of translational medicine

β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis.

BACKGROUND: Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes (L.

Immune supportEnergy & fatigueMetabolic health

Oyster Mushroom · 2026 · Preprint · journal metadata

Ultrasound-Assisted Extraction of Polysaccharides from Pleurotus ostreatus By-Products: Box–Behnken Optimization and Low-Fat Cookies Formulation

Spent mushroom substrate (SMS), the main by-product of mushroom production, is rich in valuable compounds that could be recovered by ultrasound-assisted extraction (UAE) and exploited as fat-mimetic functional ingredients in food formulations..

OncologyImmune supportCognition & nerves

Almond Mushroom · 2025 · Preprint · journal metadata

Agaricus blazei extract FA-2b-β inhibits microglial pyroptosis by regulating the activation of the NF-κB signaling pathway mediated by Aβ 1-42 through the NLRP3 pathway

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Intracellular neurofibrillary tangles (NFTs) and neuroinflammatory plaques formed by amyloid-β (Aβ) are the main pathological features of AD..

OncologyImmune supportMetabolic healthSkin & hydration

Chaga · 2022 · Case Reports · Medicine

Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report.

RATIONALE: The Chaga mushroom (Hymenochaetaceae, Inonotus obliquus) is a fungus belonging to the Hymenochaetaceae family. It is parasitic on birch and other tree species.

Immune supportEnergy & fatigueLiver supportSkin & hydration

Reishi · 2021 · Research Support, Non U.S. Gov'T · Experimental eye research

PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage.

Oxidative stress-related ocular surface epithelial damage can be initiated by ambient oxygen, UV radiation, and chemical burns. The oxidative damage to cornea can lead to inflammation and even vision loss..

Zhu Ling · 2020 · Preprint · journal metadata

Cell Wall Strengthening and Remodeling Provide New Insights on Sclerotia Development of Medicinal Fungus Polyporus Umbellatus

Sclerotium is a special form of many species of fungi and cell wall thickening is a common phenomenon in sclerotium. Rational manipulation of sclerotium would be an innovative approach for pathogenic control as well as for medicinal fungal resource revival..

Shiitake · 2020 · Preprint · journal metadata

Comparative phosphoproteome analysis to identify candidate phosphoproteins involved in blue light-induced brown film formation in Lentinula edodes

Background: Light plays an important role in the growth and differentiation of Lentinula edodes mycelia, and mycelial morphology is influenced by light wavelengths. The blue light-induced formation of brown film on the vegetative mycelial tissues of L.

Mesima · 2020 · Clinical Trial Protocol · Medicine

Efficacy of Phellinus linteus (sanghuang) extract for improving immune functions: Study protocol for a randomized, double-blinded, placebo-controlled pilot trial.

BACKGROUND: With the increase in the prevalence of chronic diseases, enhancing immunity has become an important challenge. Health functional foods, such as Phellitus linteus (PL), are known to improve immune function.

Immune supportMetabolic health

Lion's Mane · 2020 · Preprint · journal metadata

Key metabolism pathways and regulatory mechanisms of high polysaccharide yielding in Hericium erinaceus

Abstract Background Hericium erinaceus, a rare edible and medicine fungus, is widely used in the food and medical field. H.

OncologyImmune supportCognition & nerves

Chaga · 2020 · Preprint · journal metadata

Polysaccharides from the fungus Inonotus obliquus activate macrophages into a tumoricidal phenotype via interaction with TLR2, TLR4 and Dectin-1a

Background Tumor-associated macrophages (TAMs) may both promote and suppress tumor development. Therefore, molecules that are able to activate and repolarize these cells into a tumoricidal phenotype could be of great interest as a new strategy for cancer immunotherapy..

OncologyImmune supportGut & microbiome

Chaga · 2020 · Preprint · journal metadata

The apoptotic effect of polysaccharides with specific molecular weight extracted from Inonotus obliquus on HT-29 colon cancer cells

Background: Recently, natural products, particularly Inonotus obliquus ( I. obliquus ), have attracted lots of attention due to their effective anticancer effects with relatively low toxicity.

Immune supportCognition & nervesMetabolic healthGut & microbiome

Shiitake · 2020 · Preprint · journal metadata

β-glucan from Lentinula Edodes Prevents Cognitive Impairments in High-Fat Diet-Induced Obese Mice: Involvement of Colon-Brain Xxis

Abstract Background: Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes ( L.

Cordyceps · 2015 · Journal Article · JOURNAL OF THE BREWING SOCIETY OF JAPAN

Anti-inflammatory effect from an extract of cordyceps militaris soaked in sweetpotato shochu

Metadata-grounded summary: This journal article indexes research on Cordyceps militaris in JOURNAL OF THE BREWING SOCIETY OF JAPAN in 2015. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Shiitake · 2015 · Journal Article · Mushroom Science and Biotechnology

Autoradiography of the fruiting body and spore print of wood-cultivated shiitake mushroom (Lentinula edodes) from a restricted habitation area

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2015. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Shiitake · 2015 · Journal Article · Mushroom Science and Biotechnology

Quadrat method for measurement of injurious effects of Hypoxylon truncatum on bed logs used for shiitake (Lentinula edodes) cultivation

Shiitake · 2013 · Journal Article · Mushroom Science and Biotechnology

Effects of volcanic ash from eruption of Shinmoedake on shiitake (Lentinula edodes) cultivation in sawdust media: Effects of ash mixed in sawdust on mycelial growth and fruit-body formation

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2013. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Shiitake · 2013 · Research Article · Natural products and bioprospecting

In vitro bone inducing effects of Lentinula edodes (shiitake) water extract on human osteoblastic cell cultures

Metadata-grounded summary: This research article indexes research on Lentinula edodes in Natural products and bioprospecting in 2013. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportEnergy & fatigue

Oyster Mushroom · 2012 · Journal Article · The Journal of Poultry Science

Evaluation of Oyster Mushroom (Pleurotus Ostreatus) as a Biological Growth Promoter on Performance, Humoral Immunity, and Blood Characteristics of Broiler Chicks

Metadata-grounded summary: This journal article indexes research on Pleurotus ostreatus in The Journal of Poultry Science in 2012. MycoData maps the paper to immune support, energy & fatigue based on its title, species context, article metadata, and study classification..

Maitake · 2011 · Journal Article · Mushroom Science and Biotechnology

Bioactive substances from the maitake (Grifola frondosa) mushroom generally inhibit differentiation of adipocytes derived from humans and other animals

Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Mushroom Science and Biotechnology in 2011. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Shiitake · 2011 · Journal Article · Mushroom Science and Biotechnology

Simple strain typing of shiitake mushroom (Lentinula edodes) using the FTA card

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2011. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Shiitake · 2010 · Journal Article · Mushroom Science and Biotechnology

Bacterial brown rot, a new disease of Shiitake (Lentinula edodes) caused by Ewingella americana

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2010. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Shiitake · 2009 · Journal Article · Mushroom Science and Biotechnology

Shiitake (Lentinula edodes) cultivation in sawdust media supplemented with soba-shochu distiller waste

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2009. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Shiitake · 2009 · Journal Article · Mushroom Science and Biotechnology

Spent substrate of shiitake (Lentinula edodes) inhibits symptoms of anthracnose in cucumber

Shiitake · 2008 · Journal Article · Breeding Science

Genetic map of a basidiomycete fungus, Lentinula edodes (shiitake mushroom), constructed by tetrad analysis

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Breeding Science in 2008. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Maitake · 2008 · Journal Article · Shokubutsu Kankyo Kogaku

Mushroom Farming using Illumination Control by Synchronization with the Spontaneous Rhythm of the Bio-electric Potential of Grifola frondosa (Maitake Mushroom)

Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Shokubutsu Kankyo Kogaku in 2008. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Reishi · 2008 · Journal Article · Biological and Pharmaceutical Bulletin

Possible Involvement of Long Chain Fatty Acids in the Spores of Ganoderma lucidum (Reishi Houshi) to Its Anti-tumor Activity

During our isolation of biologically active substances from the spores of Ganoderma lucidum (Reishi Houshi, G. lucidum) guided by the inhibitory activity on HL-60 cell proliferation, NMR spectroscopic and mass spectrometric data indicate the substance contains a mixture of several long chain fatty acids..

Maitake · 2008 · Journal Article · Journal of Cookery Science of Japan

Tenderizing of Meat by Using Maitake (Grifola frondosa) Extract with Low Temperature Steam Cooking

Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Journal of Cookery Science of Japan in 2008. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Shiitake · 2007 · Journal Article · Mushroom Science and Biotechnology

Effect of the light emitting diode irradiation on mycelial growth and yield of Shiitake (Lentinula edodes)

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2007. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Shiitake · 2006 · Journal Article · Mycoscience

Construction of a linkage map of Lentinula edodes (shiitake) with the HEGS (high-efficiency genome scanning) system: use of versatile AFLP and PCR-based gene markers

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mycoscience in 2006. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..