MycoData

Water extract (WE) of Cordyceps militaris has been reported to produce antitumor and immunomodulatory activities in vivo and in vitro. However, the therapeutic mechanism has not been known.

OncologyImmune support

High relevance

Mesima · 2026 · Journal Article · Experimental eye research

3,4-dihydroxybenzalacetone from Phellinus linteus reduces glial activation, mitigates oxidative stress and inflammation, and preserves retinal function in ischemia-reperfusion-like injury.

Retinal ischemia-reperfusion (I/R) injury is a key pathological feature of acute glaucoma that induces oxidative stress, inflammation, and retinal glial activation, ultimately leading to retinal degeneration and neuronal dysfunction..

Immune supportCognition & nerves

High relevance

Wood Ear · 2026 · Research Article · Medicine

AMBP gene activation promotes cholangiocarcinoma progression through the WNT/β-catenin signaling pathway: Regulatory effect of polysaccharides from Auricularia auricula-judae.

Cholangiocarcinoma (CCA), an aggressive hepatobiliary malignancy with poor prognosis, involves abnormal molecular regulatory networks. This study explores α-1-microglobulin/bikunin precursor's (AMBP's) role in CCA, its pro-carcinogenic mechanisms via the wingless/integrated (WNT) pathway, and Huaier polysaccharide's….

OncologyImmune supportLiver support

High relevance

Reishi · 2026 · Journal Article · Journal of natural medicines

Anti-asthmatic effects and ingredient annotation of the active fraction from Ganoderma lucidum.

This research aims to screen the active fraction and explore the action mechanism of Ganoderma lucidum to combat asthma using asthmatic mice induced by OVA. In this study, three Ganoderma lucidum fractions, including GLEF40, GLEF60, and GLEF100, were obtained through the separation of D101 macroporous adsorption….

Immune supportRespiratory

High relevance

Oyster Mushroom · 2026 · Journal Article · Journal of medicinal chemistry

Design, Synthesis, and Biological Evaluation of Oligosaccharides Derived from Pleurotus ostreatus Polysaccharide as Potential Neuroprotective Agents.

Neurodegeneration has attracted considerable attention due to its extensive damage to the nervous system and broad impact on the population. Studies have shown that fungal polysaccharides, particularly those from mushrooms, have neuroprotective effects.

OncologyImmune supportCognition & nerves

High relevance

Turkey Tail · 2026 · Research Article · Biochemistry and biophysics reports

Nutritional, Anti-inflammatory, and in-silico inhibitory Studies of Trametes versicolor (L.) Lloyd and Flammulina velutipes (Curtis) on HER2 breast cancer protein.

This study evaluated the phytochemical, nutritional, anti-inflammatory, and in-silico anticancer properties of T. versicolor and F.

OncologyImmune supportEnergy & fatigue

High relevance

Oyster Mushroom · 2026 · Research Article · Microbial cell factories

Pleurotus ostreatus L-asparaginase's use in food safety and biotechnology: from processing assistance to bioactive agent.

BACKGROUND AND AIM: L-ASNase has attracted attention in many biomedical and food safety applications. Therefore, this study was designed to identify a novel and promising candidate for the sustainable biosynthesis of extracellular L-ASNase from P..

OncologyImmune support

High relevance

Snow Fungus · 2026 · Journal Article · Food Science and Technology Research

Study on the production and structure of a novel Tremella fuciformis polysaccharide by fermentation

Metadata-grounded summary: This journal article indexes research on Tremella fuciformis in Food Science and Technology Research in 2026. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Immune support

High relevance

Reishi · 2026 · Journal Article · Applied biochemistry and biotechnology

Transcriptomic and Metabolomic Profiling of Heat Stress Responses and Ganoderic Acid Biosynthesis in Ganoderma lucidum.

Ganoderma lucidum (G. lucidum) produces ganoderic acids (GAs), which are pharmacologically important triterpenoids with hepatoprotective, anti-inflammatory, and immunomodulatory properties..

Immune supportMetabolic healthLiver support

High relevance

Oyster Mushroom · 2026 · Research Article · Foods (Basel, Switzerland)

Ultrasound-Assisted Extraction of Polysaccharides from Pleurotus ostreatus By-Products: Box-Behnken Optimization and Low-Fat Cookies Formulation.

Spent mushroom substrate (SMS), the main by-product of mushroom production, is rich in valuable compounds that could be recovered by ultrasound-assisted extraction (UAE) and exploited as fat-mimetic functional ingredients in food formulations..

Immune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · Journal Article · Mushroom Science and Biotechnology

Analysis of functional components in preserving Ganoderma lucidum fruiting bodies

Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Mushroom Science and Biotechnology in 2025. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..

OncologyImmune supportMetabolic healthLiver support

High relevance

Shiitake · 2025 · Journal Article · Engineering in Agriculture, Environment and Food

Assessment of influence of indoor environmental conditions on the growth of Chamsong-I mushroom (Lentinula edodes)

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Engineering in Agriculture, Environment and Food in 2025. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

DCs-targeted full-cell nanovaccine based on chitosan oligosaccharide self-assembled with ganoderma lucidum polysaccharide for enhancing tumor immunotherapy.

Tumor vaccines, designed to deliver immunogenic antigens and initiate tumor-specific immune responses, hold significant promise for cancer prevention and therapy. However, their efficacy remains limited by the inherently low immunogenicity of tumor antigens and inefficient antigen presentation..

OncologyImmune supportLiver supportRespiratory

High relevance

Enoki · 2025 · Journal Article · Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan

Gene-disruption of Fv.ligIV involved in non-homologous end joining and gene targeting of Flammulina velutipes

Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan in 2025. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Immune support

High relevance

Almond Mushroom · 2025 · Journal Article · International journal of biological macromolecules

Periodate oxidation of polysaccharides from Agaricus blazei edible mushroom and their toxicity in adult zebrafish (Denio rerio).

This study characterizes periodate-oxidized polysaccharides through FTIR, NMR, and thermogravimetric analysis, confirming successful oxidation with degrees ranging from 5.4 % to 36.3 % (theoretical degrees: 10 to 50 %)..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Snow Fungus · 2025 · Journal Article · Food Chemistry: X

Possible role of Tremella fuciformis polysaccharide in modulating in vitro digestion of potato starch digesta

The effect of deproteinized Tremella olysaccharide (DTP) on the in vitro digestion of potato starch (PS) was investigated. DTP reduced the hydrolysis rate of PS in a concentration-dependent manner, with digestion rates of 76.99 %, 72.03 %, and 29.73 % after 180 min for 0.3, 0.6, and 1.2 mg/mL DTP, respectively..

Immune supportMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2025 · Research Article · Food chemistry: X

Possible role of Tremella fuciformis polysaccharide in modulating in vitro digestion of potato starch digesta.

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Preprint · journal metadata

Potential Mechanism of Ganoderma lingzhi (lingzhi) in Treating Diabetes Mellitus via Bioinformatics and Network Pharmacology

This study used bioinformatics and network pharmacology to explore Ganoderma lingzhi’s ”multi-component-multi-target-multi-pathway” mechanism in treating diabetes by comparing active components of its fruiting bodies and spore powder.Active components/targets of lingzhi were from TCMSP/CNKI, diabetes-related targets….

Immune supportEnergy & fatigueMetabolic health

High relevance

Turkey Tail · 2025 · Journal Article · Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan

Regulation of lignocellulolytic genes in Trametes versicolor

Metadata-grounded summary: This journal article indexes research on Trametes versicolor in Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan in 2025. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

OncologyImmune support

High relevance

Reishi · 2025 · Research Article · NPJ science of food

Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.

The study established a mouse model of NAFLD induced by a 12-week high-fat diet (HFD). Utilizing hepatic transcriptomics, 16S rDNA sequencing, and metabolomics, the study examined the mechanisms by which GIDF exerts hepatic protection and modulates lipid metabolism in NAFLD through the gut-liver axis.The results….

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Structure-activity relationship of synthesized glucans from Ganoderma lucidum with in vitro hypoglycemic activity.

The synthetic polysaccharides, which have precise structure, can be used to design new drugs by comparing structure-activity relationships (SAR). Improved protein stability may be due to the interaction between the polysaccharides and protein, which includes covalent and noncovalent interactions..

Immune supportMetabolic health

High relevance

Enoki · 2025 · Journal Article · Mushroom Science and Biotechnology

Suppression of plant diseases by reductive soil disinfestation using spent mushroom substrate of Flammulina velutipes

Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Mushroom Science and Biotechnology in 2025. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Immune support

High relevance

Chaga · 2025 · Journal Article · International journal of biological macromolecules

Therapeutic potential of Inonotus obliquus polysaccharide-induced tolerogenic bone marrow-derived dendritic cells via regulation of CD4+ T cell differentiation in a colitis mouse model.

Over-proliferation, activation, or aberrant CD4+ T cell differentiation causes various immune-related diseases. DCs are significant professional APCs that regulate the differentiation of CD4+ T cells to participate in an inflammatory response..

Immune supportGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[UPLC-Q-TOF-MS/MS qualitative analysis and HPLC determination of triterpenoids in Ganoderma lucidum spores].

Ganoderma spores are the dry and mature spores of G. lucidum or G.

OncologyImmune supportSkin & hydration

High relevance

Maitake · 2024 · Research Article · Applied microbiology and biotechnology

A newly discovered glycosyltransferase gene UGT88A1 affects growth and polysaccharide synthesis of Grifola frondosa.

Grifola frodosa polysaccharides, especially β-D-glucans, possess significant anti-tumor, antioxidant and immunostimulatory activities. However, the synthesis mechanism remains to be elucidated.

OncologyImmune supportMetabolic health

High relevance

Niu-Chang-Chih · 2024 · Research Article · Nutrients

Antrodia camphorata Supplementation during Early Life Alters Gut Microbiota and Inhibits Young-Onset Intestinal Tumorigenesis in APC1638N Mice Later in Life.

Young-onset colorectal cancer is an increasing concern worldwide due to the growing prevalence of Westernized lifestyles in childhood and adolescence. Environmental factors during early life, particularly early-life nutrition, significantly contribute to the increasing incidence..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2024 · Preprint · journal metadata

Cordyceps caterpillar polysaccharide CCP activates innate immune responses via the TLR4/MyD88/p38 signaling pathway

Background: and Purpose Cordyceps is a widely used traditional Chinese medicine due to its many health benefits, such as immune regulation. As Cordyceps’ major component, polysaccharides are of great attention serving as a potential drug or vaccine with nontoxicity..

Immune support

High relevance

Cordyceps · 2024 · Preprint · journal metadata

Cordyceps Sinensis Mycelium polysaccharides CP1 display anti-lung cancer activity mediated by inhibiting M2 polarization of tumor-associated macrophages

Cordyceps sinensis mycelium polysaccharide has been reported to regulate immune function, but its anti-lung cancer efficacy and its role in regulating the polarization of TAMs remain unelucidated..

OncologyImmune supportRespiratory

High relevance

Reishi · 2024 · Research Article · Veterinary sciences

Effects of Ganoderma lucidum Powder on the Growth Performance, Immune Organ Weights, Cecal Microbiology, Serum Immunoglobulins, and Tibia Minerals of Broiler Chickens.

A total of 640 one-day-old Cobb 500 MV × Cobb 500 FF mixed broilers were randomly assigned to one of four experimental treatments with four replicates per treatment and 40 birds per replicate for 32 days..

Immune supportEnergy & fatigueMetabolic health

High relevance

Nameko · 2024 · Journal Article · Bulletin of the Forestry and Forest Products Research Institute

Genetic mosaics in a commercially available Pholiota microspora (Berk.) Sacc. Spawn based on variable fruiting profiles of protoplast isolates from a single cultivar

Metadata-grounded summary: This journal article indexes research on Pholiota microspora in Bulletin of the Forestry and Forest Products Research Institute in 2024. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Immune support

High relevance

Maitake · 2024 · Research Article · Acta pharmacologica Sinica

GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation.

Adjuvants for vaccines with characteristics of improving adaptive immunity particularly via leverage of antigen presenting cells (APCs) are currently lacking. In a previous work we obtained a new soluble 300 kDa homogeneous β-glucan named GFPBW1 from the fruit bodies of Granola frondosa..

OncologyImmune support

High relevance

Zhu Ling · 2024 · Journal Article · Fungal biology

Insight into the nuclear distribution patterns of conidia and the asexual life cycle of Polyporus umbellatus.

P. umbellatus sclerotium is a traditional Chinese medicine that is widely utilized in China, Korea, Japan, and other countries due to its diverse medicinal activities, such as diuretic, antitumor, anticancer, and immune system enhancement effects..

OncologyImmune support

High relevance

Oyster Mushroom · 2024 · Journal Article · International journal of biological macromolecules

Low molecular weight chitosan from Pleurotus ostreatus waste and its prebiotic potential.

The booming mushroom industry envisages economic merits, and massive unutilized waste production (∼ 20 %) creates an opportunity for valorization. Chitosan, a bioactive polysaccharide, has drawn immense attention for its invaluable therapeutic potential..

Immune supportGut & microbiome

High relevance

Oyster Mushroom · 2024 · Journal Article · Food & function

Oat protein isolate-Pleurotus ostreatus β-glucan conjugate nanoparticles bound to β-carotene effectively alleviate immunosuppression by regulating gut microbiota.

Individuals with immune disorders cannot establish an adequate defense to pathogens, leading to gut microbiota dysbiosis. β-Carotene can regulate immune response, but its bioavailability in vivo is very low..

Immune supportGut & microbiome

High relevance

Shiitake · 2024 · Journal Article · Photochemical & photobiological sciences: Official journal of the European Photochemistry Association and the European Society for Photobiology

Photoregulation of the biosynthetic activity of the edible medicinal mushroom Lentinula edodes in vitro.

The findings of the study demonstrate the impact of low-intensity laser and quasi-monochromatic light on the biosynthetic activity of the edible medicinal fungus L. edodes during submerged cultivation..

Immune support

High relevance

Shiitake · 2024 · Journal Article · Mushroom Science and Biotechnology

Screening of potential microbial biomarkers on the brown film formed by Lentinula edodes for distinguishing different stages of L. edodes cultivation

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2024. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportGut & microbiome

High relevance

Reishi · 2023 · Review · Food research international (Ottawa, Ont.)

Potentialities of Ganoderma lucidum extracts as functional ingredients in food formulation.

Owing to the recognized therapeutic characteristics of G. lucidum, it is one of the most extensively researched mushrooms as a chemopreventive agent and as a functional food..

OncologyImmune supportGut & microbiome

High relevance

Reishi · 2021 · Review · European cardiology

Oral Presentation Award Winner: Polysaccharide Peptide of Ganoderma lucidum Reduces Endothelial Injury in Stable Angina and High-risk Patients.

Metadata-grounded summary: This review indexes research on Ganoderma lucidum in European cardiology in 2021. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Immune support

High relevance

Niu-Chang-Chih · 2021 · Review · Natural product reports

Terpenoids from the medicinal mushroom Antrodia camphorata: chemistry and medicinal potential.

Covering: up to February 2020Antrodia camphorata is a medicinal mushroom endemic to Taiwan for the treatment of intoxication, liver injury, cancer, and inflammation..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Almond Mushroom · 2020 · Journal Article · Zhongguo shi yan xue ye xue za zhi

[Inhibitory Effects of Agaricus Blazei Murrill (FA-2-b-β) on Proliferation of Chronic Myeloid Leukemia Cells in vivo and Its Mechanism].

OBJECTIVE: To investigated the anti-tumor in vivo effect and mechanism of the acid RNA protein complex (FA-2-b-β) of Agaricus blazei Murrill extract. METHODS: CCK-8 method was used to detected the inhibitory effect of FA-2-b-β on proliferation of primary CML cells from newly diagnosed CML patients, the CML mouse model….

OncologyImmune supportMetabolic health

High relevance

Enoki · 2020 · Journal Article · Journal of animal physiology and animal nutrition

A novel polysaccharide isolated from Flammulina velutipes, characterization, macrophage immunomodulatory activities and its impact on gut microbiota in rats.

The structural characteristics of a novel Flammulina velutipes polysaccharide (FVP2) were explored in this study. Besides, immunomodulatory activities of FVP2 on RAW 264.7 cell and its impact on gut microbiota in rats were investigated..

Immune supportMetabolic healthGut & microbiome

High relevance

Maitake · 2020 · Journal Article · International journal of biological macromolecules

A polysaccharide from Grifola frondosa fruit body induces HT-29 cells apoptosis by PI3K/AKT-MAPKs and NF-κB-pathway.

BACKGROUND: A neutral polysaccharide was isolated from the fruiting body of a mushroom Grifola frondosa (GFP-A). The tumor suppressive activity of GFP-A on protein expressions of PI3K/AKT, MAPKs, nuclear factor κB and caspase pathways in HT-29 cells were investigated..

OncologyImmune support

High relevance

Shiitake · 2020 · Randomized Controlled Trial · International journal of medicinal mushrooms

A Quality-of-Life Study in Healthy Adults Supplemented with Lentinex® Beta-Glucan of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes).

Lentinus edodes (=Lentinula edodes) is a culinary-medicinal mushroom with a long tradition of use in Asia. The major active substance in L.

Immune support

High relevance

Snow Fungus · 2020 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Active biodegradable films based on water soluble polysaccharides from white jelly mushroom (Tremella fuciformis) containing roasted peanut skin extract

This study aimed to manufacture biodegradable films based on water soluble polysaccharides from the white jelly mushroom (Tremella fuciformis), containing various concentrations (0, 0.25, 0.5, and 1.0 g/100 mL) of peanut skin extract (PSE), as well as, evaluate the mechanical properties, microstructure, and….

Immune supportSkin & hydration

High relevance

Maitake · 2020 · Journal Article · Journal of ethnopharmacology

Anti-diabetic effects of Grifola frondosa bioactive compound and its related molecular signaling pathways in palmitate-induced C2C12 cells.

ETHNOPHARMACOLOGICAL RELEVANCE: Grifola frondosa (GF), a high value medicinal mushroom, is popularly consumed as traditional medicines and health foods in China and Japan. It is a herbal medicine traditionally used for treating inflammation, cancer and diabetes..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Shiitake · 2020 · Journal Article · Applied microbiology and biotechnology

Anti-intoxication and protective effects of a recombinant serine protease inhibitor from Lentinula edodes against acute alcohol-induced liver injury in mice.

Serine protease inhibitors (serpins) are involved in inflammation, coagulation, fibrinolysis, tumor suppression, molecular chaperone, chromatin densification, and hormone transport. However, their anti-intoxication activity has not been determined..

OncologyImmune supportLiver support

High relevance

Shiitake · 2020 · Journal Article · International journal of biological macromolecules

Antioxidant, anti-inflammatory and renoprotective effects of acidic-hydrolytic polysaccharides by spent mushroom compost (Lentinula edodes) on LPS-induced kidney injury.

Increasing evidences have demonstrated that the reactive oxygen species play important roles in the initiation and progress of LPS-induced kidney injury (KI). The present work investigated the antioxidant, anti-inflammatory and renoprotective effects of acidic spent mushroom compost polysaccharides (ASMCP) by….

Immune supportEnergy & fatigue

High relevance

Niu-Chang-Chih · 2020 · Journal Article · Journal of ethnopharmacology

Antrodin A from mycelium of Antrodia camphorata alleviates acute alcoholic liver injury and modulates intestinal flora dysbiosis in mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata (A. camphorata) is a rare functional fungus in Taiwan and contains a variety of biologically active ingredients.

Immune supportGut & microbiomeLiver support

High relevance

Oyster Mushroom · 2020 · Journal Article · Journal of environmental management

Application of Pleurotus ostreatus to efficient removal of selected antidepressants and immunosuppressant.

Disposed pharmaceuticals constitute a significant threat to the environment due to the high consumption of drugs and inefficient treatment of wastewater. In this paper, we first described the efficient removal of a series of antidepressants and immunosuppressant from a cultivation medium carried out by white-rot….

Immune supportCognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2020 · Journal Article · Journal of food science

Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota.

Cancer represents a major disease burden worldwide. Despite continuous advances obtained in medical therapies recently, resistance to standard drugs and adverse effects still represent important causes of therapeutic failure..

OncologyImmune supportGut & microbiome