MycoData

Metabolic healthGut & microbiome

Oyster Mushroom · 2025 · Journal Article · Food Research International

Understanding the impact of different post-digestion enzymatic inhibition methods and storage conditions on standardized gastrointestinal model (INFOGEST): A case study of Pleurotus ostreatus mushroom biomass

INFOGEST became the standard digestion protocol to address inconsistencies in gastrointestinal tract (GIT) digestion protocols. However, sample collection, enzymatic inactivation methods, and storage conditions can significantly impact the accurate assessment of food compounds..

Metabolic healthGut & microbiome

Oyster Mushroom · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Understanding the impact of different post-digestion enzymatic inhibition methods and storage conditions on standardized gastrointestinal model (INFOGEST): A case study of Pleurotus ostreatus mushroom biomass.

Lion's Mane · 2025 · Journal Article · Food Research International

Unraveling novel umami peptides in Hericium erinaceus and its umami mechanism by ion exchange chromatography, peptidomics and molecular dynamics simulations

Efficient enrichment of umami peptides is crucial for their industrial application. Statistical analysis of 353 known umami peptides revealed that approximately 80 % possess net negative charges, a property exploited by ion exchange purification for targeted capture and elution..

Lion's Mane · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Unraveling novel umami peptides in Hericium erinaceus and its umami mechanism by ion exchange chromatography, peptidomics and molecular dynamics simulations.

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Untargeted Metabolomics-Based Characterization of the Metabolic Profile and Antioxidant Activity of Ophiocordyceps sinensis and Its Substitutes.

Ophiocordyceps sinensis represents a valuable medicinal resource. In this study, mechanisms underlying differences in chemical composition and antioxidant capacity among wild O.

Reishi · 2025 · Research Article · Frontiers in nutrition

Unveiling triterpenoid superiority in a newly developed Ganoderma lucidum variety through untargeted metabolomics approach.

The fruiting bodies of Ganoderma lucidum are renowned for their therapeutic properties, primarily due to their triterpenoid content. Variability in G.

OncologyEnergy & fatigueGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Journal of pharmaceutical and biomedical analysis

UPLC-Q-TOF/MS-based study on chemical composition, in vivo metabolites, and tissue distribution of ethanol extract of Ganoderma lucidum.

Ganoderma lucidum (G. lucidum), a medicinal fungus, exhibits diverse pharmacological effects against many diseases.

Cognition & nervesGut & microbiome

Yellow Morel · 2025 · Journal Article · International journal of medicinal mushrooms

Valorization of Morchella esculenta (Ascomycota) Using a Healthy Extraction Method: Investigation of Bioavailability, Anti-Acetylcholinesterase, and Antioxidant Potentials.

Edible fungi are unexploited natural sources of high added value biomolecules, such as phenolic compounds. This study used an innovative and green extraction method based on the quick, easy, new, cheap, reproducible (QUENCHER) process of Morchella esculenta..

Reishi · 2025 · Journal Article · Letters in applied microbiology

Water supply from various sources has different effects on solid-state fermentation of Ganoderma lucidum.

Water is essential in solid-state fermentation (SSF), but the impact of different water sources on SSF efficiency remains unclear. This study investigated the effects of different water sources on water-supply SSF of Ganoderma lucidum..

Oyster Mushroom · 2025 · Journal Article · Journal of food composition and analysis

Wild-grown, tissue-cultured, and market Pleurotus ostreatus: Implications for chemical characteristics

Chemical composition of mushrooms from various sources is critical concern, especially with rising global consumption. This study compared mineral profile, total phenolics (TP), and low molecular weight organic acids (LMWOAs) in oyster mushrooms (Pleurotus ostreatus) from three sources: wild-growing (WGM),….

Reishi · 2024 · Journal Article · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Oscillation-static cycle cultivation enhances the synthesis of triterpenes and mycelium activity in Ganoderma lucidum].

Ganoderma lucidum is a precious fungus with both edible and medicinal values and has a long history of medical use. Triterpenes as the main active components endow G.

Oncology

Reishi · 2024 · Journal Article · Gene

4-Coumarate-CoA ligase (4-CL) enhances flavonoid accumulation, lignin synthesis, and fruiting body formation in Ganoderma lucidum.

It is now understood that 4-Coumarate-CoA ligases (4-CL) are pivotal in bridging the phenylpropanoid metabolic pathway and the lignin biosynthesis pathway in plants. However, limited information on 4-CL genes and their functions in fungi is available..

Agarikon · 2024 · Journal Article · International journal of biological macromolecules

A fungal polysaccharide from Fomitopsis officinalis as a multi-target molecule to combat cancer.

Some macrofungi have a long history of being used as traditional or folk medicines, making significant contributions to human health. To discover bioactive molecules with potential anticancer properties, a homogeneous heteropolysaccharide (FOBP90-1) was purified from the medicinal macrofungus Fomitopsis officinalis..

OncologyImmune support

Almond Mushroom · 2024 · Journal Article · Carbohydrate polymers

A low-molecular-weight α-glucan from edible fungus Agaricus blazei Murrill activates macrophage TFEB-mediated antibacterial defense to combat implant-associated infection.

Implant-associated infection (IAI) is a prevalent and potentially fatal complication of orthopaedic surgery. Boosting antibacterial immunity, particularly the macrophage-mediated response, presents a promising therapeutic approach for managing persistent infections..

Reishi · 2024 · Journal Article · Talanta

A nanozyme multifunctional platform based on iron doped carbon dots derived from Tibetan Ganoderma lucidum waste for glucose sensing, anti-counterfeiting applications, and anticancer cell effect.

Implementing the concept of turning waste into treasure, the conversion of biomass waste into high-value carbon materials, especially carbon dots (CDs), has pointed out a new direction for disease diagnosis, tumor treatment, and other aspects..

OncologyMetabolic health

OncologyCognition & nervesEnergy & fatigueGut & microbiome

Enoki · 2024 · Journal Article · Food & function

A novel neuroprotective peptide YVYAETY identified and screened from Flammulina velutipes protein hydrolysates attenuates scopolamine-induced cognitive impairment in mice.

Flammulina velutipes protein hydrolysates are known for their abundant amino acids and excellent developmental values. This study aimed to identify and screen neuroprotective peptides from F..

OncologyImmune supportMetabolic healthGut & microbiome

Maitake · 2024 · Journal Article · Molecular nutrition & food research

A Water Polysaccharide-Protein Complex from Grifola frondosa Inhibit the Growth of Subcutaneous but Not Peritoneal Colon Tumor under Fasting Condition.

SCOPE: Grifola frondosa has been shown to induce immune modulatory, modulate autophagy, and apoptosis in cancer cells. However, little is known about its potential for managing tumor progression as an adjunct to nutrient restriction.

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2024 · Journal Article · Plant foods for human nutrition (Dordrecht, Netherlands)

Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice.

The hepatoprotective effect of the alcoholic extracts of Ganoderma lucidum fermentation products (GFE) was investigated. C57BL/6 mice were pretreated with GFE for 7 days and then subjected to the chronic-binge ethanol feeding model..

OncologyImmune supportGut & microbiome

Mesima · 2024 · Journal Article · International journal of biological macromolecules

Ameliorative effect of an acidic polysaccharide from Phellinus linteus on ulcerative colitis in a DSS-induced mouse model.

Phellinus linteus, a rare medicinal fungus, displays strong antitumor and anti-inflammatory activities because of its active metabolites, particularly polysaccharides. We investigated effects of P..

OncologyImmune supportMetabolic health

Agarikon · 2024 · Journal Article · International journal of biological macromolecules

An antitumor fungal polysaccharide from Fomitopsis officinalis by activating immunity and inhibiting angiogenesis.

Macrofungi, a class of unique natural resources, are gaining popularity owing to their potential therapeutic benefits and edibility. From Fomitopsis officinalis, a medicinal macrofungus with anticancer activity, a homogeneous heteropolysaccharide (FOBP50-1) with a molecular weight of 2.21 × 104 g/mol has been….

Reishi · 2024 · Research Article · Frontiers in dentistry

Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial.

Objectives: This study aimed to compare the antifungal efficacy of Ganoderma lucidum (G. lucidum) and clotrimazole for treatment of denture stomatitis (DS).

Yellow Morel · 2024 · Journal Article · International journal of medicinal mushrooms

Antimicrobial Activity of Three Italian Strains of Morchella esculenta (Ascomycota).

Three genetically identified and morphologically characterized strains (MesAQ2-C, MesAQ6-2 and MesFI2-3) of the culinary-medicinal ascomycete mushroom Morchella esculenta (L.) Pers. collected in central-north Italy have been studied for their antifungal and antibacterial activities..

Gut & microbiome

Oyster Mushroom · 2024 · Research Article · AMB Express

Antioxidant capacity of Pleurotus ostreatus (Jacq.) P. Kumm influenced by growth substrates.

Functional constituents are the main concern in food production and consumption. Because foods rich in functional constituents have antioxidant capacity and are important in keeping consumers healthy.

Immune supportMetabolic healthLiver support

Yellow Morel · 2024 · Journal Article · International journal of medicinal mushrooms

Antioxidation and Hepatoprotection of Selenium Mycelium Polysaccharides Against Alcoholic Liver Diseases from the Cultivated Morel Mushroom Morchella esculenta (Ascomycota).

The liver was regarded as the most important metabolic and detoxification organ in vivo, and Morchella esculenta had been reported as the admittedly rare edible fungus belonging to Ascomycetes contributing to the abundant bioactivities..

Oyster Mushroom · 2024 · Journal Article · Food Hydrocolloids

Antiviral and technological properties of β-glucan-rich aqueous fractions from Pleurotus ostreatus waste biomass

In the present work, aqueous fractions were extracted from the discarded Pleurotus ostreatus biomass (AF) and from a waste product (RAF) generated from it in the industry (stipes) with the aim of valorizing these wastes into new food ingredients..

Respiratory

Reishi · 2024 · Journal Article · Environmental science and pollution research international

Atmosphere-dependent combustion of Ganoderma lucidum biomass toward its enhanced transformability into green energy.

Globally, the circular efficiency of biomass resources has become a priority due to the depletion and negative environmental impacts of fossil fuels. This study aimed to quantify the atmosphere-dependent combustion of Ganoderma lucidum (GL) biomass and its thermodynamic and kinetic parameters toward enhancing its….

Energy & fatigue

Immune supportMetabolic healthGut & microbiomeLiver support

Wood Ear · 2024 · Research Article · Foods (Basel, Switzerland)

Auricularia auricula-judae Attenuates the Progression of Metabolic Syndrome in High-Fat Diet-Induced Obese Rats: Enzymatic Pre-Digestion Technology Is Superior to Superfine Grinding Method.

Auricularia auricula-judae (AAJ) has been cultivated for food in China for centuries, and is also used as a folk medicine for the regulation of glucose and lipid metabolism. However, there are few studies on the effects of different processing technologies on the therapeutic efficacy of AAJ to date..

Oyster Mushroom · 2024 · Research Article · PeerJ

Beeswax waste improves the mycelial growth, fruiting body yield, and quality of oyster mushrooms (Pleurotus ostreatus).

Heilongjiang Province has the third largest bee population in China, producing over 2,000 tons of beeswax waste (BW) each year. Most of this BW is discarded or burned.

Oyster Mushroom · 2024 · Research Article · Foods (Basel, Switzerland)

Bio-Valorization of Spent Coffee Grounds and Potato Peel as Substrates for Pleurotus ostreatus Growth.

Pleurotus ostreatus, due to its saprophytic nature, can extract nutrients and bioactive compounds from the substrate on which it is grown. This study aimed to assess the effect of adding spent coffee grounds (SCG) and potato peel (PPW) in the wheat straw substrate formulation to grow over the production indicators,….

Yellow Morel · 2024 · Research Article · In silico pharmacology

Bioactive compounds from Morchella esculenta as potential inhibitors of RNA-binding protein La in ovarian cancer: a molecular modeling and quantum mechanics approach.

La protein is significantly expressed in various malignant tumors, including ovarian cancer (OC), which is related to the poor response to platinum-based chemotherapy..

Oncology

OncologyImmune supportEnergy & fatigue

Yellow Morel · 2024 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Bioactive extract of Morchella esculenta ameliorates cyclophosphamide-induced mitochondrial dysfunction and cardiotoxicity by modulating KEAP1/NRF2 and pro-inflammatory genes expression.

Prevention of anticancer drugs-induced cardiotoxicity remains an imperative area of oncology research as it continues to be a major challenge in cancer chemotherapy..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2024 · Journal Article · Heliyon

Bioactivities and industrial standardization status of Ganoderma lucidum: A comprehensive review

Ganoderma lucidum (GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. Its popularity as a dietary supplement, herbal remedy, and wellness product is steadily on the rise..

Yellow Morel · 2024 · Research Article · Frontiers in microbiology

Biocontrol potential of endophytic Bacillus subtilis A9 against rot disease of Morchella esculenta.

INTRODUCTION: Morchella esculenta is a popular edible fungus with high economic and nutritional value. However, the rot disease caused by Lecanicillium aphanocladii, pose a serious threat to the quality and yield of M.

Turkey Tail · 2024 · Journal Article · Bulletin of environmental contamination and toxicology

Biodegradation of Trichloroethylene by Trametes versicolor and its Physiological Response to Contaminant Stress.

Trichloroethylene (TCE) poses a potentially toxic threat to humans and the environment and widely exists in contaminated sites. White rot fungi effectively degrade refractory pollutants, while a few research studies use white rot fungi to degrade TCE..

OncologyCognition & nerves

Lion's Mane · 2024 · Research Article · Foods (Basel, Switzerland)

Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis.

Mushrooms are one of the indispensable elements of human diets. Edible mushrooms stand out with their aroma and nutritional properties.

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Bone protective effects of the polysaccharides from Grifola frondosa on ovariectomy-induced osteoporosis in mice via inhibiting PINK1/Parkin signaling, oxidative stress and inflammation.

BACKGROUND: Polysaccharides from Grifola frondosa(GFP) have gained worldwide attention owing to their promising biological activities and potential health benefits..

OncologyImmune support

Reishi · 2024 · Journal Article · Frontiers in microbiology

Breeding a new Ganoderma lucidum strain with increased contents of individual ganoderic acids by mono-mono crossing of genetically modified monokaryons.

Ganoderic acids (GAs) are major functional components of Ganoderma lucidum. The study aimed to breed a new G.

Oyster Mushroom · 2024 · Journal Article · Fungal biology

Cadmium and calcium ions' effects on the growth of Pleurotus ostreatus mycelia are related to phosphatidylethanolamine content.

Heavy metal Cd2+ can easily be accumulated by fungi, causing significant stress, with the fungal cell membrane being one of the primary targets. However, the understanding of the mechanisms behind this stress remains limited..

OncologyImmune supportMetabolic health

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Carbon starvation drives biosynthesis of high mannose-composition polysaccharides in Ganoderma lucidum.

Polysaccharides with high mannose composition exhibit favorable antitumor activity, but there is currently a lack of well-defined and practical approaches to efficiently manufacture this type of polysaccharide..

Reishi · 2024 · Research Article · Molecules (Basel, Switzerland)

Carbonized Ganoderma Lucidum/V2O3 Composites as a Superior Cathode for High-Performance Aqueous Zinc-Ion Batteries.

In response to the suboptimal electrochemical performance of low-valence vanadium oxides, Ganoderma lucidum biomass-derived carbon@V2O3 (V2O3@CGL) composites were prepared by evaporative self-assembly technology and high-temperature calcination..

Energy & fatigue

Shiitake · 2024 · Journal Article · Food chemistry

Changes in flavor and biological activities of Lentinula edodes hydrolysates after Maillard reaction.

This study aimed to elucidate how the Maillard reaction (MR) affects the flavor and bioactivities of Lentinula edodes hydrolysates (LEHs). Changes in flavor were investigated using non-targeted metabolomics techniques (GC-MS and LC-MS/MS) and sensory evaluation..

Immune supportMetabolic health

Reishi · 2024 · Research Article · Molecules (Basel, Switzerland)

Changes of Active Substances in Ganoderma lucidum during Different Growth Periods and Analysis of Their Molecular Mechanism.

Ganoderma lucidum, renowned as an essential edible and medicinal mushroom in China, remains shrouded in limited understanding concerning the intrinsic mechanisms governing the accumulation of active components and potential protein expression across its diverse developmental stages..

Shiitake · 2024 · Research Article · Foods (Basel, Switzerland)

Characterization of a Novel Acid-Stable Chitosanase from Lentinula edodes Suitable for Chitooligosaccharide Preparation.

As high-value chitosan derivatives, chitooligosaccharides (COSs) with biodegradable, biocompatible, nontoxic, antimicrobial, and antioxidant activities have been widely applied in food-related fields. Chitosanases can hydrolyze chitosan to produce COSs..

Oyster Mushroom · 2024 · Journal Article · International journal of biological macromolecules

Characterization of free radical-mediated Pleurotus ostreatus polysaccharide-EGCG conjugates for chilled minced pork preservation.

To improve the functions of Pleurotus ostreatus polysaccharide (POP), POP-EGCG conjugates were prepared using free radical graft polymerization reactions and were characterized using UV-vis, FT-IR, SEM, XRD, DSC, TG, particle size and potential, three-phase contact angle, and rheological tests; The antioxidant and….

Immune supportGut & microbiome

Enoki · 2024 · Journal Article · International journal of biological macromolecules

Chitosan from the base of Flammulina velutipes stipe alleviates oral Candida albicans infection via modulating Th-17 cell differentiation and Streptococcus mutans.

The base of Flammulina velutipes (F. velutipes) stipe are agricultural wastes generated during the cultivation of edible fungus F.

OncologyEnergy & fatigueMetabolic healthLiver support

Reishi · 2024 · Journal Article · Food Research International

Combined NMR and MS-based metabonomics and real-time PCR analyses reveal dynamic metabolic changes of Ganoderma lucidum during fruiting body growing

Ganoderma lucidum (G. lucidum) is a rare medicinal fungus with various beneficial properties.

OncologyEnergy & fatigueMetabolic healthLiver support

Reishi · 2024 · Journal Article · Food research international (Ottawa, Ont.)

Combined NMR and MS-based metabonomics and real-time PCR analyses reveal dynamic metabolic changes of Ganoderma lucidum during fruiting body growing.

Ganoderma lucidum (G. lucidum) is a rare medicinal fungus with various beneficial properties.

Reishi · 2024 · Research Article · Food chemistry: X

Comparative analysis of multifaceted properties of Agaricus bisporus and Ganoderma lucidum macro-fungi powder: Techno-functional and structural characterization, mineral uptake, and photocatalytic activity.

Macro-fungi are recognized for food, medicinal, and environmental applications, therefore, the study focuses on multifaceted nutritional, techno-functional, and bioremediation-related uses of Agaricus bisporus and Ganoderma lucidum powders. Herein, A..

Reishi · 2024 · Journal Article · Food chemistry

Comparative investigation of selenium-enriched Pleurotus ostreatus and Ganoderma lucidum as natural sources of selenium supplementation.

Selenium (Se) is an essential trace element for human health, but its nutritional supply is insufficient in large parts of the world. Mushrooms can be enriched in selenium and can serve as alternative and natural source of selenium supplementation..