MycoData

Reishi · 2025 · Journal Article · Fitoterapia

Six new metabolites from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activities.

Six undescribed trichophthalides A-F (1-6) and a known phthalide derivative (7) were isolated from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02.

Immune supportGut & microbiomeLiver supportSkin & hydration

Snow Fungus · 2025 · Journal Article · Langmuir: the ACS journal of surfaces and colloids

Soy Protein Isolate/Tremella Fuciformis Polysaccharide Complex-Stabilized High Internal Phase Pickering Emulsions: Andrographolide Delivery, Digestive Behavior, and 3D Printability.

The development of advanced bioactive delivery systems is critical for enhancing nutraceutical stability, controlled release, and functional food design. This study presented the fabrication of high internal phase Pickering emulsions (HIPPEs) stabilized by soy protein isolate (SPI) and Tremella fuciformis….

Reishi · 2025 · Journal Article · Food chemistry

Spatiotemporal digestion and intestinal microbial fermentation properties of Ganoderma lucidum based on in vitro digestive system.

Ganoderma lucidum (GL) is a renowned medicinal fungus. In this study, the structure of GL was characterized using ion chromatography and nuclear magnetic resonance spectroscopy..

Gut & microbiome

Oyster Mushroom · 2025 · Journal Article · Journal of microbiological methods

Spawn-based pellets of Pleurotus ostreatus as an applied approach for the production of laccase in different types of water.

In recent years, oxidoreductase enzymes such as laccases have received considerable attention for their ability to degrade and eliminate organic micropollutants from contaminated water in a process known as enzyme-based wastewater treatment..

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Sporoderm-broken of Ganoderma lucidum spore polysaccharides alleviate dextran sulfate sodium-induced colon inflammation in mice by regulating Th17/Treg homeostasis and restore gut microbiota balance

Sporoderm-Broken Ganoderma lucidum spore polysaccharides (BGLSPs) have demonstrated therapeutic potential in inflammatory bowel disease (IBD), however, their mechanisms of action in colitis remain unclear..

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Sporoderm-broken of Ganoderma lucidum spore polysaccharides alleviate dextran sulfate sodium-induced colon inflammation in mice by regulating Th17/Treg homeostasis and restore gut microbiota balance.

Reishi · 2025 · Journal Article · Applied biochemistry and biotechnology

Structural and Catalytic Characterization of β-1,3-Glucan Synthases of Mushroom Ganoderma lucidum.

β-Glucans are regarded as the key contributors to nutritional and supplementary credits of well-known edible/medicinal mushroom Ganoderma lucidum. However, the biosynthesis pathways of β-glucans and the involved key enzymes/genes in G.

Metabolic health

Energy & fatigueMetabolic healthGut & microbiomeSkin & hydration

Reishi · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Structural characterisation and cholesterol and bile salts adsorption properties of Ganoderma lucidum dietary fiber

This study prepared Ganoderma lucidum insoluble dietary fiber (GIDF) and soluble dietary fiber (GSDF) via enzymatic methods. The structural and physicochemical properties of GIDF and GSDF were systematically characterized using scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, X-ray….

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Structural Characterization and Gastrointestinal Fate of a High-Molecular-Weight Hericium erinaceus Polysaccharide during Digestion and Fermentation.

This study systematically isolated a high-molecular-weight polysaccharide (HHEP; 9.14 × 103 kDa) from Hericium erinaceus, consisting predominantly of glucose (59.16% ± 0.09%), galactose (26.29% ± 0.59%), and mannose (5.69% ± 0.58%)..

Immune supportMetabolic healthGut & microbiomeLiver support

Enoki · 2025 · Research Article · Foods (Basel, Switzerland)

Structural Characterization of Polysaccharide from Flammulina velutipes and Its Impact on Hyperlipidemia Through Modulation of Hepatic Cholesterol Metabolism and Gut Microbiota.

FVPB1, a novel heteropolysaccharide, was extracted from the Flammulina velutipes fruiting body, and its structure was determined by methylation analysis, nuclear magnetic resonance (NMR) spectroscopy..

Lion's Mane · 2025 · Journal Article · Food chemistry

Structural characterization of β-glucan in Hericium erinaceus pretreated by steam explosion and its effects on human gut microbiota in vitro.

To investigate the impact of steam explosion on the structure of β-glucan and its regulation human gut microbiota (GM), two polysaccharides were prepared from Hericium erinaceus fruit bodies treated by steam explosion and conventional crushing, respectively..

Immune supportSkin & hydration

Reishi · 2025 · Journal Article · Carbohydrate polymers

Structural insights into polysaccharides in Ganoderma lucidum cell walls by solid-state NMR

Ganoderma lucidum is a medicinal mushroom long esteemed in Asian traditional medicine for its health-promoting and longevity-enhancing properties. It contains over 400 bioactive compounds, among which its polysaccharides (GLPs) are especially significant due to their diverse biological functions..

Immune supportSkin & hydration

Reishi · 2025 · Journal Article · Carbohydrate polymers

Structural insights into polysaccharides in Ganoderma lucidum cell walls by solid-state NMR.

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Structural-functional relationship of soluble dietary Fiber from Ganoderma lucidum-fermented sweet potato residue and its regulatory effects on gut microbiota

Sweet potato residue (SPR), a by-product of sweet potato processing, is rich in dietary fiber and other is rich in dietary fiber and other essential nutrients; however, its industrial utilization remains limited..

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Structural-functional relationship of soluble dietary Fiber from Ganoderma lucidum-fermented sweet potato residue and its regulatory effects on gut microbiota.

Maitake · 2025 · Research Article · NPJ science of food

Structure characterization of Grifola frondosa polysaccharide and its effect on insulin resistance in HFD-fed mice.

Polysaccharide extracted from Grifola frondosa (GFP) was selected in this study. After preliminary separation, four factions were collected, named GFP-F1, GFP-F2, GFP-F3 and GFP-F4.

Oyster Mushroom · 2025 · Journal Article · Food Chemistry

Structure characterization, simulated digestion, and microbial modulation of Pleurotus ostreatus polysaccharides

Edible mushrooms polysaccharides are widely recognized for their biological activities, yet the prebiotic potential of Pleurotus ostreatus polysaccharides (POP) remains underexplored. In this study, POP was isolated, structurally characterized, and evaluated for digestibility and impact on gut microbiota..

Oyster Mushroom · 2025 · Journal Article · Food chemistry

Structure characterization, simulated digestion, and microbial modulation of Pleurotus ostreatus polysaccharides.

OncologyImmune supportCognition & nervesMetabolic health

Snow Fungus · 2025 · Journal Article · Journal of food science

Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review

Tremella fuciformis (TF) is a valuable edible fungus rich in various nutrients, with TF polysaccharide (TFP) as its primary bioactive component. Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory‐enhancing, anti‐inflammatory,….

OncologyImmune supportGut & microbiomeSkin & hydration

Reishi · 2025 · Research Article · Scientific reports

Study on the anti-tumor effect of Wall-broken ganoderma lucidum spore powder on papillary thyroid cancer.

Wall-broken Ganoderma lucidum spore powder (BGLSP), a traditional Chinese medicinal substance, contains bioactive triterpenoids with anti-tumor potential. However, its efficacy and mechanisms against papillary thyroid cancer (PTC) remain unclear..

Enoki · 2025 · Journal Article · International journal of biological macromolecules

Studying on the structure-activity relationship of Flammulina velutipes polysaccharides via ultrasonic degradation: Insights into molecular weight, chain conformation, and anti-inflammatory activity.

Flammulina velutipes (F. velutipes) polysaccharides have been shown to play a crucial role in preventing inflammatory diseases.

Energy & fatigueGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Surface-modifying Ganoderma lucidum spores as improved microcarriers in protein delivery

Bioactive proteins and peptides hold significant potential in the food industry, particularly for the development of functional foods and nutraceuticals. However, their effectiveness is often limited by poor oral bioavailability..

Cognition & nervesEnergy & fatigueSkin & hydration

Shiitake · 2025 · Preprint · journal metadata

Sustainable Memristors from Shiitake Mycelium for High-Frequency Bioelectronics

Neuromorphic computing, inspired by the structure of the brain, offers advantages in parallel processing, memory storage, and energy efficiency. However, current semiconductor-based neuromorphic chips require rare-earth materials and costly fabrication processes, whereas neural organoids need complex bioreactor….

Shiitake · 2025 · Research Article · Journal of agricultural and food chemistry

Tailoring the Regioselectivity of Lentinula edodes O-Methyltransferases for Precise O-Methylation of Flavonoids.

A novel O-methyltransferase, LeOMT4, from Lentinula edodes was identified, expressed, and characterized. Although its catalytic activity was lower than that of the previously reported LeOMT2, LeOMT4 displayed strong regioselectivity for the meta-hydroxy group across different catecholic compounds, producing e.g.,….

Energy & fatigueGut & microbiome

Maitake · 2025 · Research Article · Foods (Basel, Switzerland)

The Effects of Iterative Freeze-Thaw Cycles on the Structure, Functionality, and Digestibility of Grifola frondosa Protein.

To improve the processing performance and application potential of Grifola frondosa protein (GFP), this study employed multiple freeze-thaw (F-T) cycles to modify GFP and systematically evaluated the changes in its structure, functional properties, and digestive behavior..

Immune supportEnergy & fatigueLiver support

Wood Ear · 2025 · Journal Article · International journal of medicinal mushrooms

The In Vitro and In Vivo Antioxidant Capacities of Auricularia auricula-judae (Agaricomycetes) Polysaccharides Prepared via Free Radical-Mediated Methods.

As a basidiomycete fungus, the cell wall of the Auricularia auricula-judae fruiting body is extremely tough and complex, making it difficult to extract the polysaccharides. In this study, A..

Reishi · 2025 · Research Article · Frontiers in microbiology

The influence of intercropping Paris polyphylla with Polygonatum cyrtonema or Ganoderma lucidum on rhizosphere soil microbial community structure and quality of Paris polyphylla.

INTRODUCTION: Prolonged monoculture cultivation of Paris polyphylla has been linked to challenges such as disruption of rhizosphere soil microbial balance and deterioration in crop quality. Intercropping has emerged as a viable strategy to address these issues.

Maitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

The Nearly Complete Genome of Grifola frondosa and Light-Induced Genes Screened Based on Transcriptomics Promote the Production of Triterpenoid Compounds.

Grifola frondosa, commonly known as turkey tail, is a valuable fungus with medicinal and culinary uses, rich in bioactive compounds like triterpenoid polysaccharides that contribute to health benefits. Here, we constructed a nearly complete genome of G..

Immune supportLiver supportRespiratory

Reishi · 2025 · Research Article · Journal of advanced veterinary and animal research

The protective effects of Ganoderma lucidum polysaccharides on blood physiology, immune function, and organ architecture in growing stressed rabbits.

OBJECTIVE: This experiment explored the plausible effects of Ganoderma lucidum polysaccharides (GLP) to reduce the deterioration effects of heat stress (HS) in growing rabbits by studying blood physiology, growth, immunity, inflammation, and organ structure..

Immune supportMetabolic healthLiver support

Oyster Mushroom · 2025 · Journal Article · International journal of radiation biology

The role of polysaccharide POM extracted from Pleurotus ostreatus in curbing and treating the harmful effects on liver and kidney resulting from radiation exposure.

PURPOSE: This research assesses the radioprotective and antioxidant activity of polysaccharide (POM) derived from Pleurotus ostreatus strain on rats suffering from metabolic problems due to irradiation..

Shiitake · 2025 · Research Article · Toxics

The Toxicological Impact of the Ultraviolet Filter Oxybenzone on Antioxidant Profiles in In Vitro Cultures of Lentinula edodes.

A detailed understanding of the toxic effects of organic UV filters, such as oxybenzone, on living organisms is crucial for assessing the feasibility of bioremediation methods..

Skin & hydration

Oyster Mushroom · 2025 · Research Article · Mycology

The transcription factor PoMbp1 promotes the growth and development of Pleurotus ostreatus by regulating polysaccharide utilisation.

The transcription factor Mbp1 was reported to regulate cell growth and proliferation in some fungi; however, its role in Pleurotus ostreatus remains largely unexplored. Here, we cloned the PoMbp1 gene, which encodes a protein contains an APSES domain and is localised in the nucleus..

OncologyImmune supportSkin & hydration

Oyster Mushroom · 2025 · Journal Article · International journal of biological macromolecules

The use of Pleurotus ostreatus by-products for the preparation of a gel-like polysaccharide with bioactive properties.

The mushroom Pleurotus ostreatus is widely produced in Brazil and its stipes are discarded before commercialization. In the present study, this agricultural fungal waste (mushroom stipes), was analyzed by preparing an aqueous extract and obtaining the polysaccharides by ethanol precipitation (POS-extract)..

Oyster Mushroom · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Total antioxidant activity assessment of Pleurotus ostreatus using a 3D-printed hydrogel nanozyme with peroxidase-like activity

A facile, cost-effective, and portable total antioxidant capacity (TAC) evaluation system was developed for Pleurotus ostreatus using a 3D-printed ferric coordination polymer (FCP) hydrogel nanozyme..

Shiitake · 2025 · Journal Article · Journal of the science of food and agriculture

Transcriptional variation and RNA polymorphism among different Lentinula edodes (Berk.) Pegler strains.

BACKGROUND: Lentinula edodes is a commercially important mushroom known for its nutritional and therapeutic values. However, the molecular mechanisms underlying the distinct nutritional and physiological attributes of various L.

Oyster Mushroom · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Transcriptome Analysis Revealed That Cell Wall Regulatory Pathways Are Involved in the Tolerance of Pleurotus ostreatus Mycelia to Different Heat Stresses.

Pleurotus ostreatus is the third largest cultivated species in China's edible mushroom industry; however, its agricultural cultivation method is easily affected by high-temperature environments. To understand the response mechanism of mycelia to heat stress, the mycelia of P..

OncologyImmune supportCognition & nerves

Snow Fungus · 2025 · Journal Article · Molecular neurobiology

Tremella fuciformis Polysaccharides Alleviate Early Brain Injury in Experimental Subarachnoid Hemorrhage by Inhibiting the KDR-Mediated P38 MAPK/NF-κB Pathway.

Subarachnoid hemorrhage (SAH) is associated with high mortality and morbidity rates. In its early stages, a substantial influx of blood into the subarachnoid space triggers excessive activation of microglia, which markedly contributes to early brain injury (EBI), a pivotal determinant of poor prognosis..

Reishi · 2025 · Journal Article · Fitoterapia

Trichodermanols A-C, three new metabolites from the Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activity.

Trichodermanols A-C (1-3), an uncommon nor-steroid (1) and two novel 5/7 ring system sesquiterpenes (2 and 3), along with two known compounds identified as (1S,7R,10S,11R)-3-oxoguai-4-ene-11,12-diol (4) and cyclo-((S)-Pro-(R)-Leu) (5), were isolated and elucidated from a Ganoderma lucidum-derived endophytic fungus….

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Triterpenes from Ganoderma lucidum inhibit hepatocellular carcinoma by regulating enhancer-associated lncRNA in vivo.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum) has been widely used as adjuvant of anti-tumor therapy for variety tumors.

OncologyLiver support

Immune supportCognition & nerves

Chaga · 2025 · Journal Article · Fitoterapia

Triterpenoids from the edible mushroom Inonotus obliquus attenuates cognitive impairment in vitro and in vivo.

Inonotus obliquus is an edible and medicinal mushroom which is used to multiple products. In this study, 8 secondary metabolites (1-8) were identified from the edible mushroom I.

Reishi · 2025 · Journal Article · Fitoterapia

Triterpenoids with inhibitory effects on lipid accumulation from Ganoderma lucidum.

Eight undescribed lanostane-type triterpenes (1-8) and twenty-seven known analogues (9-35) were isolated from the fruiting bodies of cultivated Ganoderma lucidum. The chemical structures of these compounds were elucidated using a combination of spectroscopic techniques..

Shiitake · 2025 · Research Article · Frontiers in microbiology

Two sexually compatible monokaryons from a heterokaryotic Lentinula edodes strain respond differently to heat stress.

BACKGROUND: Despite the extensive research conducted on heat responses of Lentinula edodes heterokaryotic cells, the responses of the two sexually compatible monokaryons to heat stress (HS) remain largely unknown..

Metabolic health

Cognition & nervesEnergy & fatigueSkin & hydration

Lion's Mane · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Two-Dimensional Chromatographic Isolation of High Purity Erinacine A from Hericium erinaceus.

A simple and robust two-dimensional chromatographic fractionation protocol for the isolation of the neuroprotective compound erinacine A from Hericium erinaceus is proposed. This production platform yielded 19.4 mg of erinacine A from approximately 130 g of mushroom material, with a chromatographic purity of 97.4%..

Enoki · 2025 · Research Article · Food chemistry: X

Ultrasonic assisted three-phase partitioning extraction and bioactivities validation of polysaccharides from Flammulina velutipes residues.

Mushroom residues, especially Flammulina velutipes residues (FVR) rich in bioactive polysaccharides, are under exploited due to inefficient extraction methods conflicting with green chemistry..

Reishi · 2025 · Research Article · Ultrasonics sonochemistry

Ultrasound-assisted extraction of neuroprotective antioxidants from Ganoderma lucidum.

Ganoderma lucidum (GL), a traditional Chinese medicinal fungus, is rich in triterpenoids and phenols with antioxidant properties. Nevertheless, current extraction techniques limit the efficient utilization of bioactive components from GL..

Cognition & nerves

Maitake · 2025 · Research Article · BMC chemistry

Ultrasound-assisted extraction, enrichment, and hypolipidemic potential of triterpenes from Grifola frondosa mycelia.

Triterpenes (GFTs) are the main secondary metabolites of Grifola frondosa, which is a famous porous fungus with multiple biological actions. To enhance the yield of GFTs, the parameters for ultrasound-assisted extraction (UAE) of GFTs were first optimized..

Energy & fatigue

Enoki · 2025 · Research Article · Food science & nutrition

Umami Enhancing Properties of Enzymatically Hydrolyzed Mycelium of Flammulina velutipes Cultured on Potato Pulp.

The aim of this study was to hydrolyze cultivated fungal mycelium and to evaluate the effect on its taste. Potato pulp, a by-product of the potato starch industry, was therefore successfully utilized as a substrate for submerged cultivation of Flammulina velutipes, yielding a product with an estimated fungal content….

Lion's Mane · 2025 · Research Article · Journal of natural products

Uncovering Hericenones from the Fruiting Bodies of Hericium erinaceus through Interdisciplinary Collaboration.

Hericium erinaceus is an edible and medicinal mushroom. Previously, we found hericenones C-H from the fruiting bodies and erinacines A-I from the mycelia of the fungus..

Cognition & nerves