MycoData

This investigation involved the addition of Trametes versicolor mycelium to Pleurotus ostreatus extract, which was subsequently fermented using Lactobacillus plantarum to improve the quality of the fermented beverage..

Gut & microbiome

High relevance

Oyster Mushroom · 2025 · Journal Article · Journal of food composition and analysis

Optimization of selenium biofortification by liquid fermentation based on 2,4-dichlorophenoxyacetic acid and its effect on nutritional value of Pleurotus ostreatus

Pleurotus ostreatus is one of the most popular edible mushrooms worldwide and has been proposed as a candidate for human selenium (Se) supplementation. The objective of this study is to develop a Se-biofortification method by liquid fermentation and evaluate the effect of 2,4-dichlorophenoxyacetic acid (2,4-D),….

Immune support

High relevance

Oyster Mushroom · 2025 · Research Article · Materials (Basel, Switzerland)

Optimized Microbial Scaffolds Immobilized with Pleurotus ostreatus and Aspergillus oryzae on Foaming Bacterial Cellulose.

In this study, we explored the development and characterization of fungus-immobilized foamed bacterial cellulose (FBC) scaffolds using Pleurotus ostreatus and Aspergillus oryzae..

Skin & hydration

High relevance

Wood Ear · 2025 · Journal Article · International journal of biological macromolecules

Oral pharmacokinetics and tissue distribution of a homogeneous polysaccharide from Auricularia auricula-judae: dual-method validation of absorption and distribution.

Polysaccharides encounter significant challenges in vivo pharmacokinetic studies because of their complex structures and the limitations of current detection methods, thereby impeding their development and biomedical applications..

Immune supportLiver supportRespiratory

High relevance

Snow Fungus · 2025 · Journal Article · Food chemistry

Phased characterization of soy protein gel modified by lactobacillus plantarum JYLP-326 in cooperation with acidic tremella fuciformis fruiting body polysaccharide: Focus on structural network, interaction and gel properties.

Soybean protein isolate (SPI) and acidic tremella fuciformis fruiting body polysaccharide (AP) were used to prepare phased products "sterilized soft gel (SPI-AP)" and "fermented strong gel (FSPI-AP)" to study the structural network, interaction and gel characteristics..

Immune supportGut & microbiome

High relevance

Mesima · 2025 · Journal Article · International journal of medicinal mushrooms

Phellinus linteus (Agaricomycetes) Polysaccharides Ameliorate Inflammatory Injury in H2O2-Induced Caco-2 Cells and DSS-Induced Ulcerative Colitis Mice.

Phellinus linteus (Agaricomycetes) is a valuable medicinal mushroom traditionally used as a food supplement and medicinal ingredient. Polysaccharides of Ph.

Immune supportEnergy & fatigueGut & microbiome

High relevance

Mesima · 2025 · Research Article · Foods (Basel, Switzerland)

Phellinus linteus Mycelia Extracts Show Potent Antiviral and Immunomodulatory Effects in H1N1 Influenza Virus-Infected Mice.

Phellinus linteus, a medicinal mushroom with an ancient history in traditional medicine, serves as a valuable raw material for functional foods. While previous studies have shown promising antiviral effects, the present work is the most comprehensive investigation of P..

Immune supportRespiratory

High relevance

Enoki · 2025 · Journal Article · ACS applied materials & interfaces

Photo-Cross-Linked and Photothermal Flammulina velutipes Polysaccharide Hydrogel Loaded with Caffeic Acid-Copper Nanozyme for Diabetic Wound Healing.

Diabetic ulcers remain a persistent global health challenge. Developing therapeutic systems with antibacterial, antioxidant, anti-inflammatory, and pro-angiogenic properties presents a promising strategy for effectively and rapidly treating diabetic wounds and preventing the development of diabetic ulcers..

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

High relevance

Lion's Mane · 2025 · Research Article · ACS omega

Phytoconstituents of Hericium erinaceus Exert Benefits for ADHD Conditions by Targeting SLC6A4: Extraction, Spectroscopic Characterization, Phytochemical Screening, In Vitro, and Computational Perspectives.

Attention-deficit/hyperactivity disorder (ADHD) is a persistent neurodevelopmental disorder. Despite pharmacological interventions, there is a need for effective lead molecules and therapeutic targets.

OncologyCognition & nerves

High relevance

Oyster Mushroom · 2025 · Journal Article · Chemistry & biodiversity

Pleurotus ostreatus Copper Nanoparticles: In Vitro and In Silico Evaluation of the Antioxidant, Antibacterial, and Antidiabetic Activities.

The rapid growth of nanotechnology has opened new frontiers in biomedical applications, particularly through the use of metal nanoparticles. This study explores the green synthesis of copper nanoparticles (CuNPs) using an aqueous extract of Pleurotus ostreatus (PO-CuNPs) and their characterization through UV-visible….

Metabolic health

High relevance

Oyster Mushroom · 2025 · Journal Article · Fungal biology

Pleurotus ostreatus mek1 is essential for meiosis and basidiospore production.

Breeding strains without basidiospores is important for the mushroom industry. However, target genes for sporeless breeding remain limited.

High relevance

Oyster Mushroom · 2025 · Research Article · ACS omega

Pleurotus ostreatus-Mediated Bioremediation of Polylactic Acid Microplastics: Unveiling a Sustainable Solution.

Polylactic acid (PLA) is a compostable biopolymer with strong potential to replace petroleum-based plastics, yet its end-of-life degradation pathways under real-world conditions remain insufficiently understood at the molecular and structural levels..

High relevance

Zhu Ling · 2025 · Journal Article · International journal of biological macromolecules

Polyporus Umbellatus polysaccharide ameliorates rheumatoid arthritis via inhibiting inflammation and regulating gut microbiota.

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that can cause cartilage and bone damage as well as a disability. Polyporus Umbellatus polysaccharide (PUP) as a β-glucan exhibit remarkable anti-inflammatory activity..

Immune supportGut & microbiomeSkin & hydration

High relevance

Cordyceps · 2025 · Journal Article · Journal of functional foods

Polysaccharide from natural Ophiocordyceps sinensis alleviated dextran sulfate sodium-induced colitis through modulating sIgA formation and gut microbiota

Polysaccharide from natural Ophiocordyceps sinensis (NCSP-50) significantly modulated the gut microbiota composition and elevated the levels of sIgA in dextran sodium sulfate (DSS)-induced colitis mice. However, the in-depth mechanism remains unknown..

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Metabolic brain disease

Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation.

Oxidative stress and mitochondrial dynamics imbalance are key contributors to AD pathogenesis. GLPS, an extract from Ganoderma lucidum spores, exhibits anti-inflammatory, antioxidant, and immunomodulatory properties..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

Snow Fungus · 2025 · Journal Article · Chemistry & biodiversity

Polysaccharides from Tremella Fuciformis Enhance Glucose and Lipid Metabolism in HepG2 Cells Through Activating the AMPK Signaling Pathway.

Polysaccharides have gained substantial attention for their diverse biological activities. The present study was conucted to elucidate the effects and molecular mechanisms of Tremella fuciformis-derived polysaccharides (PTP-3a) on glucose and lipid metabolism in palmitic acid (PA) - treated HepG2 cells..

Immune supportMetabolic healthLiver support

High relevance

Reishi · 2025 · Journal Article · Journal of parasitic diseases: official organ of the Indian Society for Parasitology

Pre-administration with Ganoderma lucidum, Vernonia amygdalina and Vitellaria paradoxa methanolic extracts ameliorated haematological changes induced by Eimeria tenella challenge in broiler chickens.

The role of complementary and alternative medicines for the treatment of various diseases is gaining serious attention. This study evaluated the haematological changes induced by Eimeria tenella challenge in broiler chickens following pre-administration with methanol extracts of Ganoderma lucidum, Vernonia amygdalina….

High relevance

Oyster Mushroom · 2025 · Research Article · Scientific reports

Prebiotic properties and antioxidant effect of crude extracts and polysaccharides from Agaricus bisporus and Pleurotus ostreatus mushrooms.

Modifying the gut microbiome, also known as bacteriotherapy, is a key strategy that uses probiotics, prebiotics, or synbiotics to reduce inflammation and fight infection and colonization by pathogenic bacteria..

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Preparation and characterization of Ganoderma lucidum polysaccharide-based multifunctional tellurium nanorods to realize combination cancer therapy

Cancer remains a significant global health challenge. Given the limitations of conventional single-treatment modalities and the potential benefits of combination therapies, this study aimed to develop a multifunctional nanoplatform integrating immunotherapy, chemotherapy, and photothermal therapy for cancer treatment..

OncologyImmune supportEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Preparation and characterization of Ganoderma lucidum polysaccharide-based multifunctional tellurium nanorods to realize combination cancer therapy.

OncologyImmune supportEnergy & fatigue

High relevance

Maitake · 2025 · Journal Article · Chemistry & biodiversity

Preparation and Characterization of Polysaccharides From Grifola frondosa and Their Human Intestinal Flora-modulating Effect.

A novel and efficient hydrogen peroxide/ascorbic acid-assisted extraction method for the preparation of Grifola frondosa polysaccharide (GFP) was developed, and two GFP fractions (GFP-H and GFP-L) with different molecular weights (Mws) were obtained by separation with ultrafiltration..

Immune supportGut & microbiome

High relevance

Yellow Morel · 2025 · Journal Article · Food & function

Preparation of Morchella esculenta protein and its preventive effect on nonalcoholic fatty liver disease in mice.

Morchella esculenta is a valuable edible fungus with multidimensional bioactivities; however, research on M. esculenta protein and its beneficial effects on nonalcoholic fatty liver disease (NAFLD) have been limited.

Metabolic healthGut & microbiomeLiver support

High relevance

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Preparation, Structural Characterization, and In Vitro Modulation of the Gut Microbiota Activity of a Novel α-Glucan in Hericium erinaceus.

Hericium erinaceus (H. erinaceus) is a kind of medicinal and edible fungus that contains polysaccharide as the most studied effective component at present.

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Research Article · Microbial cell factories

PRMT5 promotes cellulase production by regulating the expression of cellulase gene eg2 through histone methylation in Ganoderma lucidum.

BACKGROUND: Cellulase can degrade cellulose into reducing sugar, participating in the natural carbon cycle. Simultaneously, cellulase enhances the efficiency and quality of industrial production while also demonstrating significant potential in environmental protection and bioenergy development..

Energy & fatigue

High relevance

Oyster Mushroom · 2025 · Research Article · Pharmaceutics

Production of Myco-Nanomaterial Products from Pleurotus ostreatus (Agaricomycetes) Mushroom via Pyrolysis.

Background: The study aimed to develop a sustainable method for producing myco-nanomaterials, particularly fluorescent carbon nanodots (CNDs), from freeze-dried Pleurotus ostreatus (Agaricomycetes) mushroom powder via pyrolysis..

Skin & hydration

High relevance

Maitake · 2025 · Journal Article · Biotechnology and applied biochemistry

Protective Effect and Gut Microbiota Modulation of Grifola frondosa Antioxidant Peptides in Sodium Dextran Sulfate-Induced Ulcerative Colitis Mice.

Grifola frondosa antioxidant peptides (GFAP) were prepared through trypsin enzymolysis and characterized. This study conducted a comprehensive assessment of clinical symptoms, colon pathological injuries, levels of inflammatory factors, expression of inflammation-related proteins, and alterations in gut microbiota….

Immune supportGut & microbiome

High relevance

Shiitake · 2025 · Journal Article · Biological & pharmaceutical bulletin

Protective Effects of Maternal Administration of a Standardized Extract of Cultured Lentinula edodes Mycelia against Radiation-Induced Fetal Morphological Abnormalities

Exposure to ionizing radiation during early pregnancy poses serious risks to fetal development, particularly during organogenesis. In this study, we evaluated the protective effects of AHCC®, a standardized extract of Lentinula edodes mycelia with known immunomodulatory and metabolic properties, using an ICR mouse….

Immune supportMetabolic health

High relevance

Mesima · 2025 · Research Article · BMC research notes

Protective mechanism of polysaccharides from Phellinus linteus on H9c2 cardiomyocyte injury induced by hypoxia/reoxygenation.

OBJECTIVE: This study aimed to explore the protective mechanism of Phellinus linteus polysaccharides (Phps) against hypoxia/reoxygenation (H/R)-induced injury in H9c2 cardiomyocytes, focusing on oxidative stress, apoptosis, and PI3K-AKT pathway regulation..

OncologyImmune supportEnergy & fatigue

High relevance

Reishi · 2025 · Research Article · BMC genomics

Proteome study of dikaryotic and monokaryotic mycelia reveals the transfer between biological processes contributing to dikaryon growth advantage of the medicinal fungus Ganoderma lucidum.

BACKGROUND: Ganoderma lucidum, a well-known medicinal fungus in traditional Chinese medicine, exhibits a superior growth rate in its dikaryotic mycelia compared to monokaryons, and this is essential for its fruiting body formation and medicinal utilization..

Energy & fatigueMetabolic health

High relevance

Shiitake · 2025 · Journal Article · Food chemistry

Proteomics and physiologic analysis reveal different response strategies to cadmium stress in Lentinula edodes.

Lentinula edodes (L. edodes) is the second most widely cultivated edible mushroom worldwide.

High relevance

Oyster Mushroom · 2025 · Journal Article · Fungal genetics and biology: FG & B

Putative transcription factor Nrg1 is involved in the hyphal branching and the cell wall structure formation in the filamentous fungus Pleurotus ostreatus.

Nrg1 is a C2H2 zinc finger transcription factor that functions in various cellular processes related to environmental responses and cell wall synthesis in yeast. The present study investigated the function of Nrg1 in filamentous development in the white-rot fungus Pleurotus ostreatus for the first time..

Immune support

High relevance

Lion's Mane · 2025 · Journal Article · International Journal of Biological Macromolecules

Recent insights into Hericium erinaceus polysaccharides: Gastrointestinal, gut microbiota, microbial metabolites, overall health and structure-function correlation

Hericium erinaceus polysaccharides (HEPs) have attracted significant interest due to their potential to support gastrointestinal health and modulate gut microbiota..

Immune supportCognition & nervesGut & microbiomeLiver support

High relevance

Lion's Mane · 2025 · Journal Article · Analytical methods: advancing methods and applications

Recognition of the impact of Hericium erinaceus mycelium extract on ethanol-damaged gastric epithelial cells using atomic force microscopy.

Atomic force microscopy (AFM) is used to measure live cells. Changes in the biomechanical properties of a single cell under Hericium erinaceus mycelium extract (Heme) treatment play a critical role in drug efficacy evaluation and drug development, but they remain underexplored..

Cognition & nervesGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Heliyon

Removal of cyanobacterial harmful algal blooms (HABs) from contaminated local park lake using Ganoderma lucidum mycelial pellets

Eutrophication and hypereutrophication in lakes foster harmful blue-green algal blooms, which pose a significant threat to the ecological health of freshwater reservoirs..

Energy & fatigueGut & microbiome

High relevance

Reishi · 2025 · Research Article · Heliyon

Removal of cyanobacterial harmful algal blooms (HABs) from contaminated local park lake using Ganoderma lucidum mycelial pellets.

Eutrophication and hypereutrophication in lakes foster harmful blue-green algal blooms, which pose a significant threat to the ecological health of freshwater reservoirs..

Energy & fatigueGut & microbiome

High relevance

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Restoring Mitochondrial Function and Remodeling Gut Microbiota by Low-Molecular-Weight β-Glucan of Hericium erinaceus in Alcohol-Induced Gastrointestinal Injury.

Excessive alcohol consumption poses significant risks for gastrointestinal injury; β-glucans from Hericium erinaceus are known for gastroprotective properties; however, the efficacy of its high-molecular-weight β-glucan is often limited by poor solubility and bioavailability, leaving its protective mechanisms against….

Immune supportEnergy & fatigueGut & microbiomeRespiratory

High relevance

Turkey Tail · 2025 · Journal Article · Phytochemistry

Reverse chemical ecology to study the defense of the plant host Sextonia rubra and the chemical mediators of its endophyte Fusarium falciforme against phytopathogen Trametes versicolor

Sextonia rubra is a tropical tree endemic to the Guiana Shield and the Brazilian Amazon. Despite its renowned wood durability, it remains susceptible to degradation by white-rot fungi such as Trametes versicolor..

Metabolic healthGut & microbiome

High relevance

Turkey Tail · 2025 · Journal Article · Phytochemistry

Reverse chemical ecology to study the defense of the plant host Sextonia rubra and the chemical mediators of its endophyte Fusarium falciforme against phytopathogen Trametes versicolor.

Metabolic healthGut & microbiome

High relevance

Chaga · 2025 · Research Article · Journal of microbiology and biotechnology

Revitalization of the Endophytic Fungus Acremonium sp. MEP2000 and Its Impact on the Growth and Accumulation of Bioactive Compounds in Inonotus obliquus.

Inonotus obliquus is a large, medicinal and edible fungus known for its extremely slow growth. It has garnered significant attention due to its high socioeconomic and pharmaceutical value.

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Environmental geochemistry and health

Risk assessment of potentially toxic elements exposure through ganoderma lucidum consumption in the population of Longquan, China.

As a major production area of Ganoderma lucidum, Longquan City has a population with habitual consumption of this medicinal mushroom. This study employed a relative source contribution (RSC) model, coupled with Monte Carlo simulation, aimed to quantify the probabilistic health risk associated with potentially toxic….

Gut & microbiome

High relevance

Oyster Mushroom · 2025 · Journal Article · Fungal biology

Role of putative APSES family transcription factor Swi6 in cell wall synthesis regulation in the agaricomycete Pleurotus ostreatus.

Clade A APSES family transcription factor Swi6 functions alongside Mbp1 to form the MBF (MluI cell cycle box-binding factor) complex in ascomycetes. In the agaricomycete Pleurotus ostreatus, Mbp1 plays a crucial role in regulating β-glucan and chitin synthesis; however, the role of Swi6 has not been explored in this….

High relevance

Shiitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Screening of Lentinula edodes Strains for High Polysaccharide Production and In Vitro Antioxidant Activities.

Lentinan is one of the main metabolites of Lentinula edodes and exhibits numerous biological properties, such as antitumor and antioxidant activity. Despite recent advancements, its commercialization remains constrained by a lengthy cultivation cycle, low yield, and high cost..

OncologyImmune supportMetabolic health

High relevance

Enoki · 2025 · Journal Article · Food Bioscience

Screening of mixed lactic acid bacteria starter and exploring the sources of flavor substances in co-fermentation of Flammulina velutipes with different vegetables

To augment the flavor components of Flammulina velutipes pickles (FVP) and enhance its acceptability, F. velutipes were co-fermented with various raw materials (cabbages, cowpeas, radishes, millet peppers, gingers, Sichuan peppercorns) using lactic acid bacteria (LAB)..

Energy & fatigueGut & microbiome

High relevance

Maitake · 2025 · Journal Article · International Journal of Biological Macromolecules

Selenium release during the simulated gastrointestinal digestion and antioxidant activity of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates

In the study, Grifola frondosa polysaccharides (GFPs) and gallic acid (GA) were utilized to synthesize selenium nanoparticles (GFPs-GA-SeNPs) through a redox reaction involving sodium selenite and ascorbic acid..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Maitake · 2025 · Journal Article · International journal of biological macromolecules

Selenium release during the simulated gastrointestinal digestion and antioxidant activity of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates.

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Shiitake · 2025 · Research Article · Polymers

Selenium-Enriched Polysaccharides from Lentinula edodes Mycelium: Biosynthesis, Chemical Characterisation, and Assessment of Antioxidant Properties.

Selenium-polysaccharides possess antioxidant properties, making them promising materials for functional foods, pharmaceuticals, and clinical applications. This study examines the incorporation of selenium into polysaccharides via mycelial biosynthesis and its effects on structure and antioxidant activity..

Immune supportMetabolic health

High relevance

Lion's Mane · 2025 · Journal Article · Carbohydrate polymers

Self-assembled near-infrared-photothermal antibacterial Hericium erinaceus β-glucan/tannic acid/Fe (III) hydrogel for accelerating infected wound healing

Bacterial infection severely hinders skin wound healing, highlighting the critical application value of developing antibacterial and anti-inflammatory hydrogel dressings..

Immune supportSkin & hydration

High relevance

Lion's Mane · 2025 · Journal Article · Carbohydrate polymers

Self-assembled near-infrared-photothermal antibacterial Hericium erinaceus β-glucan/tannic acid/Fe (III) hydrogel for accelerating infected wound healing.

Bacterial infection severely hinders skin wound healing, highlighting the critical application value of developing antibacterial and anti-inflammatory hydrogel dressings..

Immune supportSkin & hydration

High relevance

Snow Fungus · 2025 · Journal Article · Journal of agricultural and food chemistry

Simulated Digestion and Metabolic Outcomes of Tremella fuciformis Polysaccharides and Their Effects on the Gut Microbiota.

Tremella fuciformis polysaccharides (TFP) were evaluated for their gastrointestinal stability and microbiota-modulating effects using in vitro digestion and fecal fermentation..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Simulated gut microbiota fermentation of polysaccharide extracts from Ganoderma lucidum and Ganoderma neo-japonicum.

This study compared the chemical composition and effects on the gut microbiota of hot-water extracts from two Ganoderma species: Ganoderma lucidum (GL), a well-studied medicinal mushroom, and Ganoderma neo-japonicum (GN), a lesser-known counterpart..

Immune supportMetabolic healthGut & microbiome