MycoData

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Insights into the Mycosphere Fungal Community and Its Association with Nucleoside Accumulation in Ophiocordyceps sinensis.

Soil microbiomes are critical environmental factors influencing the occurrence and quality formation of Ophiocordyceps sinensis, a valuable medicinal fungus endemic to the Qinghai-Tibet Plateau..

Gut & microbiome

Oyster Mushroom · 2025 · Journal Article · Journal of hazardous materials

Integrated enzymatic, transcriptomic, and metabolite identification insights into the degradation of diverse endocrine-disrupting compounds by Pleurotus ostreatus GEMB-PO1.

Endocrine-disrupting compounds (EDCs) represent a significant class of micropollutants that persist in environments and threaten ecological and human health. In this study, the white-rot fungus Pleurotus ostreatus GEMB-PO1 was investigated for its ability to degrade eight representative EDCs-bisphenol A (BPA),….

Metabolic health

OncologyImmune supportMetabolic healthRespiratory

Reishi · 2025 · Research Article · Frontiers in pharmacology

Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules.

Granulomatous pulmonary nodules represent a substantial health threat, with no available targeted therapies. Interventions based on medicinal plants approaches are pivotal for prevention and treatment.

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Proteomics and Metabolomics Reveal Regulatory Pathways Underlying Quality Differences Between Wild and Cultivated Ophiocordyceps sinensis.

Ophiocordyceps sinensis, is an entomopathogenic fungus renowned for its medicinal properties, thriving in the frigid and high-altitude regions of the Qinghai-Tibet plateau. Given the limited availability of wild resources and the increasing recognition of their medicinal value, the cultivation of O..

Cordyceps · 2025 · Research Article · BMC genomics

Integrated transcriptomic and metabolomic analysis reveals stage-associated molecular profiles in Ophiocordyceps sinensis.

Ophiocordyceps sinensis is globally recognized for its exceptional nutritional and medicinal properties. Variations in the edible qualities and tonic values of O.

Metabolic health

OncologyImmune supportLiver support

Reishi · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of Ganoderma lucidum.

Ganoderma lucidum is a traditional Chinese medicinal fungus, and ganoderma triterpenoids (GTs) are one of the main bioactive compounds. These compounds have various pharmacological functions, including anti-tumor, antioxidant, anti-inflammatory, liver-protective, and immune-regulating effects..

OncologyImmune supportGut & microbiomeSkin & hydration

Chaga · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Integrating Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Inonotus obliquus Polysaccharide in the Treatment of Rheumatoid Arthritis.

Background/Objectives: Rheumatoid arthritis (RA) is a chronic, systemic, and progressive autoimmune-inflammatory disease primarily affecting small joints. Inonotus obliquus polysaccharide (IOP) is the main component of the parasitic fungus obliquus, which has anti-tumor, anti-inflammatory, and antioxidant effects..

Reishi · 2025 · Research Article · Frontiers in microbiology

Intercropping with Paris polyphylla and Ganoderma lucidum: regulatory effects on the rhizosphere microbial community and the quality of Polygonatum cyrtonema.

INTRODUCTION: Optimizing the cultivation of Polygonatum cyrtonema requires a comprehensive understanding of how intercropping influences both its quality and the rhizosphere microenvironment. METHODS: This study conducted a comparative analysis between monoculture cultivation of P..

Immune supportCognition & nervesLiver support

Reishi · 2025 · Research Article · Frontiers in pharmacology

Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer's disease.

BACKGROUND/OBJECTIVES: Although Alzheimer's disease (AD) is the most prevalent dementia in late life, with amyloid beta (Aβ) deposition and neuroinflammation are recognized among its primary pathological features. Currently, there is currently still a lack of effective therapeutic drugs for AD.

OncologyImmune supportMetabolic healthGut & microbiome

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Investigation of the fingerprint-activity relationship of Tremella fuciformis polysaccharides and its mitigating effect on radiation-induced intestinal injury.

The aim of this study was to conduct a comprehensive analysis of the relationship between the fingerprint of Tremella fuciformis polysaccharides (TFPs) sourced from China and their bioactivities, with an emphasis on identifying the most bioactive TFP variety that significantly mitigated radiation-induced intestinal….

Turkey Tail · 2025 · Journal Article · Applied biochemistry and biotechnology

Investigation on the Detoxification of Indoxyl Sulfate (IS) and Indole-3-Acetic Acid (IAA) Protein-Bound Uremic Toxins (PBUTs) Using Trametes versicolor Biocompatible Laccase: In Situ Synchrotron Imaging, Experimental and Computational Studies.

The removal of protein-bound uremic toxins (PBUTs), such as indoxyl sulfate (IS) and indole-3-acetic acid (IAA), from hemodialysis (HD) patients remains a significant challenge due to their strong binding to serum proteins, such as albumin..

Liver support

Reishi · 2025 · Journal Article · Drug development and industrial pharmacy

Investigation on the protective effect of Ganoderma Lucidum spore oil on pustular acne based on molecular dynamics simulation and experimental validation.

Ganoderma lucidum spore oil (GLSO), a bioactive natural product, demonstrates notable antioxidant, anti-inflammatory, and immunomodulatory properties, suggesting therapeutic potential. Pustular acne, characterized by intrafollicular pus accumulation, is primarily mediated by oxidative stress..

Oyster Mushroom · 2025 · Journal Article · Industrial crops and products

Isolation and purification of Pleurotus ostreatus polysaccharides by corn distiller dried grains cultivation: Structural characterization and study the protective capacity against cells

Edible fungi have been used as food for thousands of years, and mushroom derived polysaccharides have received a lot of attention for their health benefits. In this study, Pleurotus ostreatus (P.ostreatus) was cultivated using corn distillers dried grains (CDDG), and P..

Maitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Isolation, Identification and Prevention of Bacterial Spot Disease on Grifola frondosa.

Grifola frondosa is a rare fungus valued for its nutritional and medicinal properties; however, its bacterial spot disease has been largely overlooked. Thus, this study systematically investigated, isolated, and identified the pathogen and evaluated control strategies for bacterial spot disease affecting G..

Cognition & nerves

Chaga · 2025 · Journal Article · Natural product research

Lanostane-type triterpenoids from the fungus Inonotus obliquus.

Triterpenoids of the lanostane type are the primary characteristic compounds isolated from Inonotus obliquus. Phytochemical investigations on the EtOAc extract of the fungus led to the isolation of three new lanostane-type triterpenoids (compounds 1-3) and 18 known derivatives..

OncologyEnergy & fatigueGut & microbiomeLiver support

Lion's Mane · 2025 · Research Article · Frontiers in fungal biology

LED light spectra influence the stimulation of mycelial growth and anticancer activity in Hericium erinaceus mycelium.

INTRODUCTION: Hericium erinaceus is a medicinal mushroom known for producing diverse bioactive metabolites with therapeutic potential. However, cultivation strategies aimed at enhancing both fungal yield and metabolite bioactivity, particularly through light-mediated physiological modulation, remain insufficiently….

Immune supportGut & microbiome

Shiitake · 2025 · Research Article · Scientific reports

Lentinula edodes cultured extract intake alleviates long-term immune deregulation induced by early-life gut microbiota dysbiosis.

The establishment of gut microbiota during early life is crucial for immune system development and its disturbance within this critical period exerts enduring adverse effects on health. Perinatal antibiotic exposure perturbs early-life microbiota and leads to long-term immune dysregulation..

Immune supportSkin & hydration

Reishi · 2025 · Research Article · Bioresources and bioprocessing

Light repair effect of polysaccharides component from white Ganoderma lucidum and Laminaria japonica fermentation broth attenuates epidermal barrier dysfunction via TRPV4-Keap-1/Nrf2 pathway.

Epidermal photoinflammation has emerged as an atypical pathological response that poses a growing global threat to human health and well-being. In this study, a polysaccharide component (named LJGp) was isolated from Laminaria japonica and white Ganoderma lucidum fermentation broth, and its reparative effects on….

Shiitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Mechanism of Enzyme Activity Regulation and Strain-Specific Response of Lentinula edodes Cultivation Adaptability Under Peach Wood Substrate.

The resource utilization of peach wood as agricultural waste holds significant importance for the sustainable development of the edible fungi industry, yet its regulatory effects on the physiology and safety of Lentinula edodes (L. edodes) remain unclear.

Immune supportMetabolic health

Reishi · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Mechanism Underlying Ganoderma lucidum Polysaccharide Biosynthesis Regulation by the β-1,3-Glucosyltransferase Gene gl20535.

Ganoderma lucidum polysaccharides (GLPs) are natural compounds with a broad spectrum of biological activities. β-1,3-glucosyltransferase (GL20535) plays an important role in polysaccharide synthesis by catalyzing the transfer of UDP-glucose to extend sugar chains, but its underlying mechanism remains unclear..

OncologyEnergy & fatigueGut & microbiomeRespiratory

Maitake · 2025 · Research Article · Food science & nutrition

Mesenchymal Stem Cell-Conditioned Media-Derived Exosomes Loaded With Grifola frondosa Extract Inhibit Lung Cancer via NF-κB and MAPK Pathway Modulation.

The increasing prevalence of drug resistance diminishes the efficacy of chemotherapy and other therapeutic modalities for individuals diagnosed with lung cancer. Therefore, it is imperative to develop novel treatment approaches..

Immune supportEnergy & fatigueMetabolic health

Chaga · 2025 · Journal Article · Chemistry & biodiversity

Microwave Extraction of New Polysaccharides From Inonotus obliquus, Structural Characterization, and Antioxidant Activity.

To address the low extraction yield and structural degradation issues of conventional methods, this study optimized microwave-assisted extraction (61°C, 64 min, 30:1 mL/g ratio) to obtain Inonotus obliquus polysaccharides (IOP), followed by DEAE-52 and Sephadex G-100 purification to isolate two fractions: neutral….

Energy & fatigueMetabolic healthRespiratory

Lion's Mane · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Mitochondrial energy homeostasis-mediated respiration suppression: A novel mechanism for combating wilting of Hericium erinaceus via electron beam generated X-ray irradiation

This study explored the mechanism of Hericium erinaceus wilting delayed by 1.0 kGy electron-beam generated X-ray (EBGX) irradiation from modulating respiratory pathways and energy homeostasis perspectives..

Immune supportGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Food & function

Modification of Ganoderma lucidum spore shells into probiotic carriers: selective loading and colonic delivery of Lacticaseibacillus rhamnosus and effective therapy of inflammatory bowel disease.

Inflammatory bowel disease (IBD) is a chronic inflammation with a high incidence rate. Many probiotics, including Lacticaseibacillus rhamnosus (L.

Immune supportEnergy & fatigueGut & microbiome

Mesima · 2025 · Research Article · Frontiers in microbiology

Modulating effects of Phellinus linteus polysaccharides on antioxidant capacity, immune function, intestinal function and microbiota in lipopolysaccharide-challenged broilers.

Phellinus linteus polysaccharides (PLP) have been shown to have beneficial effects on gut function and gut microbiota in animals. The intention of this study was to examine the effects of PLP on growth performance, immune function, intestinal barrier function and intestinal microbial community in broilers under….

Immune supportMetabolic healthLiver support

Cordyceps · 2025 · Journal Article · Environmental toxicology

Modulatory Effects of Ophiocordyceps sinensis Mycelia on Hepatosteatosis Development in a High-Fat Dietary Habit.

The global rise in obesity is closely associated with the increasing prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndromes, posing significant health challenges..

Oyster Mushroom · 2025 · Journal Article · Physiological and Molecular Plant Pathology

Molecular characterization of thermostable chitinases from Indian Pleurotus ostreatus and their effectiveness against the plant pathogenic Alternaria solani and Fusarium oxysporum

Chitinase has diverse applications across agriculture, energy production, food processing, pharmaceuticals, and human healthcare. Characterizing chitinase is essential for understanding its potential uses in these fields..

Oyster Mushroom · 2025 · Research Article · Bioinformatics and biology insights

Molecular Docking Appraisal of Pleurotus ostreatus Phytochemicals as Potential Inhibitors of PI3K/Akt Pathway for Breast Cancer Treatment.

INTRODUCTION: Breast cancer (BC) is a heterogeneous disease involving a network of numerous extracellular signal transduction pathways. The phosphoinositide 3-kinase (PI3K)/serine/threonine kinase (Akt)/mechanistic target of rapamycin (mTOR) pathway is crucial for understanding the BC development..

Oncology

Reishi · 2025 · Journal Article · Food chemistry

Molecular networking and Paterno-Büchi reaction guided glycerides characterization and antioxidant activity assessment of Ganoderma lucidum spore oil.

Ganoderma lucidum spore oil (GLSO) is a dietary supplement, with glycerides (GLs) recognized as its important active component. However, comprehensive profiling and accurate structural characterization of GLs in GLSO remain underexplored..

Yellow Morel · 2025 · Journal Article · Chinese journal of integrative medicine

Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation.

OBJECTIVE: To explore the potential apoptotic mechanisms of 3 Morchella extracts (Morchella conica, Morchella esculenta and Morchella delicosa) on breast and colon cancer cell lines using apoptotic biomarkers..

OncologyGut & microbiome

Yellow Morel · 2025 · Research Article · Biochemistry research international

Morchella esculenta (L.) Pers. Wild of the Province of Taza, Morocco: Toxicity Assessment in In Vitro and In Vivo Models, Antioxidant Activities and Correlation With the Chemical Composition of Aqueous and Organic Extracts.

Mushrooms are a source of nutrients and bioactive substances. This work, carried out for the first time, aims to evaluate in vitro and in vivo toxicity and antioxidant potential of the wild edible mushroom from the province of Taza, Morocco: Morchella esculenta (L.) Pers., the extraction is carried out using two….

Metabolic health

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · Research Article · Scientific reports

Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid metabolism.

Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action..

OncologyEnergy & fatigueMetabolic health

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Multiomics Provides a New Understanding of the Effect of Temperature Change on the Fermentation Quality of Ophiocordyceps sinensis.

Ophiocordyceps sinensis is a medicinal fungus with significant nutritional and utilization value. Temperature is a crucial factor influencing its growth, as temperature changes can impact enzyme activity, metabolite content, and gene expression during fungal cultivation..

Turkey Tail · 2025 · Journal Article · International journal of biological macromolecules

Myco-macromolecular symbiosis: Chitosan-folate ZnO nanoplatforms from Trametes versicolor for dual-functional oncological and antibacterial therapy.

The increasing prevalence of antibiotic-resistant bacteria and cancer necessitates the development of novel, targeted therapeutic strategies. This study aimed to develop a multifunctional nanoplatform combining antibacterial and anticancer properties through green synthesis and strategic surface functionalization..

OncologyLiver support

Oyster Mushroom · 2025 · Journal Article · Environmental toxicology and chemistry

Mycoremediation of Louisiana sweet crude oil with Pleurotus ostreatus and nutrient amendments.

Oyster mushrooms (Pleurotus ostreatus) are known to metabolize polycyclic aromatic hydrocarbons in petroleum crude oil, making them candidates for oil spill remediation studies. This work aimed to assess P.

Oyster Mushroom · 2025 · Journal Article · Brazilian journal of biology = Revista brasleira de biologia

Mycosynthesis of silver nanoparticles from Pleurotus ostreatus extracts: antibacterial and catalytic activity evaluation.

Biosynthesized silver nanoparticles (AgNPs) are attracting increasing attention due to their unique properties, including simplicity, cost-effectiveness, and eco-friendliness. In this study, AgNPs were successfully synthesized at room temperature using extracts from Pleurotus ostreatus (P.

Immune supportMetabolic health

Enoki · 2025 · Journal Article · Food chemistry

Naringenin-loaded Flammulina velutipes chitin-glucan complexes gel system: structural modulation and dual lipid-lowering mechanisms.

This study developed a synergistic lipid-lowering system using chitin-glucan complex (CGC) from Flammulina velutipes through green preparation and structural optimization..

Reishi · 2025 · Journal Article · Fitoterapia

Natural cyclic peptides produced by the Ganoderma lucidum-associated endophytic Trichoderma sp. GLQ02.

Eight natural cyclopeptides (1-8), including three previously undescribed compounds (1, 4, and 7), were isolated from the endophytic fungus Trichoderma sp. GLQ02 derived from Ganoderma lucidum..

OncologyImmune supportLiver supportSkin & hydration

Niu-Chang-Chih · 2025 · Research Article · International journal of molecular sciences

Natural Polysaccharide-Based Nanoparticles Enhance Intracellular Delivery and Cytotoxicity of Antrodia camphorata in Breast Cancer Cells.

Antrodia camphorata (AC), a medicinal fungus native to Taiwan, contains bioactive compounds such as triterpenoids with anticancer properties. However, their high lipophilicity results in poor aqueous solubility and limited bioavailability, restricting their therapeutic application..

Almond Mushroom · 2025 · Journal Article · Chemistry & biodiversity

Network Pharmacology and In Vitro Experiments Reveal the Mechanism of Agaricus blazei Murill Extract in Treating Chronic Myeloid Leukemia.

Chronic myeloid leukemia (CML) is a malignant hematological neoplasm. FA-2-b-β, extracted from Agaricus blazei Murrill, has demonstrated antitumor activity against multiple cancer types.

Oncology

Immune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2025 · Research Article · International journal of molecular sciences

Neuroprotective Terpenoids Derived from Hericium erinaceus Fruiting Bodies: Isolation, Structural Elucidation, and Mechanistic Insights.

Hericium erinaceus, a medicinal macrofungus, is renowned for its potential neuroprotective benefits. Here, we isolated and characterized secondary metabolites from H.

Turkey Tail · 2025 · Research Article · Molecules (Basel, Switzerland)

Nicotine Degradation by Trametes versicolor: Insights from Diverse Environmental Stressors and Wastewater Medium.

Nicotine, a major alkaloid in tobacco, poses significant environmental risks due to its persistence in wastewater. This study explores the degradation of naturally extracted nicotine from tobacco leaves by the white-rot fungus Trametes versicolor, aiming to assess its biodegradation capacity under diverse….

Reishi · 2025 · Journal Article · Microbiological research

Nitrogen-dependent regulation of extracellular and intracellular polysaccharide content in Ganoderma lucidum via the transcription factor AreA.

Fungal polysaccharides serve as vital components and hold significant value in food and medicinal applications. Nitrogen plays a crucial role in the biosynthesis of fungal polysaccharides, yet our comprehension of its specific influence on fungal polysaccharides biosynthesis remains limited..

Chaga · 2025 · Research Article · International journal of molecular sciences

NO Activates the Triterpenoid Biosynthetic Pathway in Inonotus obliquus Through Multilevel Signaling Regulation to Enhance Its Production.

Triterpenoids are the bioactive components in Inonotus obliquus with extensive medicinal prospects, but their low content in fermentation production is the main limiting factor for their application..

Oyster Mushroom · 2025 · Journal Article · Innovative Food Science and Emerging Technologies

Nutritional improvement of wheat grains and soybeans by solid-state fermentation with Pleurotus ostreatus mycelium

The nutritional quality of plant-based substrates can be improved through fungi-based fermentation. This study evaluates changes in the nutritional and non-nutritional composition of food substrates biotransformed with the edible mushroom Pleurotus ostreatus over time..

Maitake · 2025 · Journal Article · Fungal biology

Olive oil additive enhances hyphal growth and triterpenes accumulation in submerged fermentation of Grifola frondosa.

Grifola frondosa, a famous mushroom worldwide, is highly valued for its multiple health benefits. However, the limited mycelial biomass and low triterpenes (GFTs) yield remain critical constraints for large-scale utilization of this fungus..

Immune supportGut & microbiome

Cordyceps · 2025 · Research Article · BMC biology

Ophiocordyceps sinensis-induced changes in Thitarodes xiaojinensis: from intestinal barrier destruction, microbiome dysbiosis to immune responses at the molecular level.

BACKGROUND: The entomopathogenic fungus (EPF) Ophiocordyceps sinensis has a long-term coexistence with its host insect, Thitarodes xiaojinensis, making it a unique model for host-pathogen interactions..

Immune supportLiver support

Oyster Mushroom · 2025 · Journal Article · Chemistry & biodiversity

Optimization and Hepatoprotective Potential of Sulfated Polysaccharide From Pleurotus ostreatus.

In this study, we explored an efficient method for synthesizing sulfated Pleurotus ostreatus polysaccharides (SPOP) with a higher degree of substitution. The structure conformation was characterized and confirmed by the Fourier transform infrared (FT-IR) spectroscopy analysis..

Enoki · 2025 · Research Article · Ultrasonics sonochemistry

Optimization of bioactive polyphenols recovery from Flammulina velutipes stem waste using nonionic surfactant-integrated ultrasound-assisted extraction.

The process of cultivating edible and medicinal mushrooms results in considerable biomass waste, which can be a rich source of bioactive compounds. This research aimed at optimizing the yield of polyphenols and improving the antioxidant potential of extracts derived from the stem waste of Flammulina velutipes (FVS)..