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Breast cancer represents a persistent global health challenge, with multidrug resistance (MDR) posing a significant obstacle to effective treatment. In this study, we investigate the potential of Ganoderma lucidum extract (GLE) in reversing MDR in breast cancer and delve into the underlying mechanisms..

Oncology

High relevance

Reishi · 2025 · Research Article · Molecules (Basel, Switzerland)

Ganoderma lucidum Glycoprotein Microemulsion: Improved Transdermal Delivery and Protective Efficacy in UV-Induced Cell and Animal Models.

BACKGROUND: Photoaging, induced by chronic ultraviolet (UV) exposure, is a multifactorial skin disorder characterized by oxidative stress, inflammation, and extracellular matrix degradation..

OncologyImmune supportEnergy & fatigueLiver support

High relevance

Reishi · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Ganoderma lucidum Immobilized on Wood Demonstrates High Persistence During the Removal of OPFRs in a Trickle-Bed Bioreactor.

Emerging pollutants such as organophosphate flame retardants (OPFRs) pose a critical threat to environmental and human health, while conventional wastewater treatments often fail to remove them..

High relevance

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant

Oxidative stress after spinal cord injury (SCI) significantly promotes neuronal apoptosis. The imbalance of flora leads to the destruction of the intestinal barrier, so that pro-inflammatory cytokines enter the blood and further aggravate neuroinflammation..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Reproductive biology

Ganoderma lucidum mitigates oxidative stress and apoptosis in chlorpyrifos‑induced testicular toxicity in male rats.

Chlorpyrifos (CPS) is an organophosphate pesticide known to induce oxidative stress, apoptosis, and histopathological damage in male reproductive tissues. Ganoderma lucidum (GDL), a medicinal fungus rich in bioactive polysaccharides and triterpenoids, has demonstrated potent antioxidant and antiapoptotic properties in….

OncologyImmune support

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Ganoderma Lucidum polysaccharide peptide (GL-PP2): A potential therapeutic agent against sepsis-induced organ injury by modulating Nrf2/NF-κB pathways.

Sepsis, characterized by a severe immune response to infection, remains a leading cause of mortality, with few effective strategies to prevent organ damage. Targeting inflammation, oxidative stress, and apoptosis is crucial for improving outcomes and advancing sepsis management..

OncologyImmune support

High relevance

Reishi · 2025 · Journal Article · Biomacromolecules

Ganoderma lucidum Polysaccharide/carboxymethyl Chitosan Hydrogels Modulate Macrophage Polarization for Wound Healing.

Wound healing remains a global challenge for clinical and experimental research. Hydrogels prepared from natural polysaccharides show great potential in the wound healing process..

Immune supportEnergy & fatigueLiver supportSkin & hydration

High relevance

Reishi · 2025 · Research Article · Chinese medicine

Ganoderma lucidum spore oil alleviates psychological stress-evoked tumor progression by enhancing FcγR-mediated macrophage phagocytosis.

BACKGROUND: Ganoderma lucidum (G. lucidum), has been documented as a medicinal herb in classical texts and officially recognized in both Eastern and Western pharmacopeias.

OncologyImmune support

High relevance

Reishi · 2025 · Journal Article · Journal of the science of food and agriculture

Ganoderma lucidum spore powder after oil extraction alleviates microbiota dysbiosis to improve the intestinal barrier function in mice.

BACKGROUND: There are few studies about the differences in the composition of moisture, ash, crude protein, crude fat, crude polysaccharide and ergothioneine in Ganoderma lucidum spore powder (GLSP) from different origins. As for GLSP after oil extraction (OE-GLSP), there are still lots of bioactive substance in it..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Research Article · Frontiers in immunology

Ganoderma lucidum spore powder alleviates rheumatoid arthritis-associated pain hypersensitivity through inhibiting accumulation, N1 polarization, and ROS production of neutrophils in mice.

INTRODUCTION: Rheumatoid arthritis (RA) is a chronic condition characterized by joint pain that significantly impairs patients' work and daily lives. The limited understanding of the pathological mechanisms underlying RA-related pain poses challenges for effective clinical pain management..

Immune supportEnergy & fatigueSkin & hydration

High relevance

Reishi · 2025 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ganoderma lucidum triterpenes ameliorate age-related cognitive impairment via regulating Eubacterium lentum-mediated serine metabolism.

BACKGROUND: Natural aging of the brain is commonly accompanied by a decline in cognitive ability, which is driven by oxidative stress, inflammation, and metabolic dysregulation. These pathological processes are further exacerbated by gut microbiota dysbiosis..

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Current pharmaceutical biotechnology

Ganoderma lucidum: A Medicinal Mushroom with Prebiotic and Anticancer Potential in Gastrointestinal Cancers.

INTRODUCTION: Ganoderma lucidum is considered a medicinal mushroom, as it primarily improves gut health by modulating the gut microbiota. As an abundant source of bioactive metabolites, antioxidants, and industrial enzymes, mushrooms make significant contributions to functional foods, nutrition, and pharmaceuticals..

OncologyImmune supportGut & microbiome

High relevance

Almond Mushroom · 2025 · Journal Article · International Journal of Biological Macromolecules

Gastroprotective effect of polysaccharides from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice

This study aims to isolate and characterize the physicochemical properties and evaluate the cytoprotective and gastroprotective potential of polysaccharides from the Agaricus blazei Murill mushroom (PAbM). The PAbM were isolated and characterized chemically..

OncologyImmune supportMetabolic health

High relevance

Almond Mushroom · 2025 · Journal Article · International journal of biological macromolecules

Gastroprotective effect of polysaccharides from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice.

OncologyImmune supportMetabolic health

High relevance

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

General control nonderepressible 4 activates the transcription of trehalose phosphorylase to improve trehalose production and abiotic stress tolerance in Ganoderma lucidum

Trehalose plays an important role in enhancing abiotic stress tolerance. Although studies have reported the induction of trehalose by adverse environments, the molecular mechanism underlying its induction in fungi is unclear..

Metabolic health

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

General control nonderepressible 4 activates the transcription of trehalose phosphorylase to improve trehalose production and abiotic stress tolerance in Ganoderma lucidum.

Metabolic health

High relevance

Reishi · 2025 · Journal Article · Archives of microbiology

Genome-wide identification and expression analysis of epigenetic regulator gene families in the medicinal mushroom Ganoderma lucidum.

Epigenetic regulator (ER) genes, crucial for fungal growth and development, remain largely unexplored in Ganoderma lucidum, a medicinal mushroom valued for its bioactive compounds. This study identified 81 ER genes in G..

High relevance

Shiitake · 2025 · Journal Article · International Journal of Biological Macromolecules

Genome-wide identification and expression profiles of the superoxide dismutase (SOD) genes in Lentinula edodes

The superoxide dismutase (SOD) enzymes are a group of key enzymes involved in oxidative stress defense and play a significant role in organismal growth and development..

High relevance

Shiitake · 2025 · Journal Article · International journal of biological macromolecules

Genome-wide identification and expression profiles of the superoxide dismutase (SOD) genes in Lentinula edodes.

The superoxide dismutase (SOD) enzymes are a group of key enzymes involved in oxidative stress defense and play a significant role in organismal growth and development..

High relevance

Reishi · 2025 · Journal Article · Archives of microbiology

Genome-wide identification of CYP450 in Ganoderma lucidum and expression analysis of genes related to ganoderic acid synthesis.

The biosynthesis mechanism of ganoderic acid, a class of secondary metabolites of Ganoderma lucidum, is currently unknown. Members of G.

Energy & fatigue

High relevance

Reishi · 2025 · Journal Article · Microbiological research

GlSIRT1 deacetylates and activates pyruvate kinase to improve pyruvate content and enhance heat stress resistance in Ganoderma lucidum.

Heat stress is a prevalent environmental stressor. Previous studies have shown that heat stress drives many cellular changes in Ganoderma lucidum.

High relevance

Reishi · 2025 · Journal Article · Food Research International

Green tea fermented by Ganoderma lucidum presented anti-obesity properties via enhanced thermogenesis in vitro and on C57BL/6J mice

High-fat diets contribute to obesity and metabolic disorders. Ganoderma lucidum is renowned for its abundant bioactive compounds and diverse pharmacological effects.

Metabolic healthLiver support

High relevance

Reishi · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Green tea fermented by Ganoderma lucidum presented anti-obesity properties via enhanced thermogenesis in vitro and on C57BL/6J mice.

High-fat diets contribute to obesity and metabolic disorders. Ganoderma lucidum is renowned for its abundant bioactive compounds and diverse pharmacological effects.

Metabolic healthLiver support

High relevance

Maitake · 2025 · Research Article · Foods (Basel, Switzerland)

Grifola frondosa Polysaccharides Alleviated Cyclophosphamide-Induced Intestinal Injury Based on Microbiota, Metabolite and Immune Axis Modulation.

Grifola frondosa polysaccharides (GFP), which possess antitumor properties, can counteract intestinal injury induced by cyclophosphamide (CTX). The objective of this research was to evaluate the efficacy of GFP in protecting the intestinal barrier of mice and investigate the mechanisms behind this effect..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2025 · Research Article · Mycobiology

Growth Characteristics of Pseudomonas putida and Pleurotus ostreatus After Co-Cultivation.

This study was conducted to investigate the growth characteristics and morphology of Pleurotus ostreatus mycelium during co-cultivation with Pseudomonas putida. For selection of the most effective Pseudomonas species in coculture, Three strains of Pseudomonas putida and one strain of Pseudomonas fluorescens were….

High relevance

Reishi · 2025 · Research Article · Communications biology

GSK3 phosphorylates and activates trehalose-6-phosphate synthase to improve trehalose production and thermotolerance in Ganoderma lucidum.

Glycogen synthase kinase 3 (GSK3) plays crucial roles in diverse organisms, yet its physiological functions in filamentous fungi remain poorly characterized. Here, we show that knockdown of GlGSK3 in Ganoderma lucidum leads to increased glycogen accumulation, reduced pyruvate and ATP production, and impaired hyphal….

High relevance

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Hepatoprotective effects of polysaccharide from Morchella esculenta are associated with activation of the AMPK/Sirt1 signaling pathway in mice with NAFLD.

The functional food application of edible fungus polysaccharides has been widely studied based on their variety of potential pharmacological activities. However, the hepatoprotective effects and mechanisms of Morchella esculenta polysaccharide against nonalcoholic fatty liver disease (NAFLD) remain unknown..

Immune supportMetabolic healthLiver support

High relevance

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Hericinosides A-M, Cyathane Diterpene Glycosides with α-Glucosidase Inhibitory Activity from the Medicinal Fungus Hericium erinaceus.

Thirteen new cyathane diterpene glycosides, hericinosides A-M (1-13), and six known analogs, were isolated from the rice media fermentation of the medicinal fungus Hericium erinaceus. The sugar parts of 1 and 2 were highly modified, forming a unique 5/6/7/5/5/5 ring new skeleton system..

Metabolic health

High relevance

Lion's Mane · 2025 · Journal Article · Animal Nutrition

Hericium erinaceus polysaccharides improve eggshell quality by improving uterine health and modulating uterine microbiota in aged hens

Hericium erinaceus polysaccharide (HEP) is widely regarded as a potential food additive because of its rich nutritional value. This study aimed to explore the effect of HEP on the eggshell quality of aged laying hens and to reveal the mechanisms with particular emphasis on the alterations of uterine microbiota and….

OncologyImmune supportGut & microbiome

High relevance

Lion's Mane · 2025 · Research Article · Animal nutrition (Zhongguo xu mu shou yi xue hui)

Hericium erinaceus polysaccharides improve eggshell quality by improving uterine health and modulating uterine microbiota in aged hens.

OncologyImmune supportGut & microbiome

High relevance

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

Hericium erinaceus Protein Alleviates High-Fat Diet-Induced Hepatic Lipid Accumulation and Oxidative Stress In Vivo.

Dietary interventions with food-derived natural products have emerged as a promising strategy to alleviate obesity. This study aims to investigate the anti-obesity effect of Hericium erinaceus protein (HEP) and its underlying mechanism..

Metabolic healthGut & microbiomeLiver support

High relevance

Enoki · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

High Carbon Dioxide Concentration Inhibits Pileus Growth of Flammulina velutipes by Downregulating Cyclin Gene Expression.

Flammulina velutipes is a widely cultivated edible mushroom in East Asia, recognized for its nutritional benefits and distinct morphology characterized by a long stipe and a compact, hemispherical pileus..

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

High molecular weight polysaccharides from Ganoderma lucidum attenuates inflammatory responses, gut microbiota, and liver metabolomic in lipopolysaccharide-induced liver injury mice.

High molecular weight polysaccharides (GLPH, ≥300 kDa) are the major compounds of Ganoderma lucidum with improving liver function. However, the effect of GLPH on improving acute liver injury (ALI) wasn't revealed..

Immune supportGut & microbiomeLiver support

High relevance

Oyster Mushroom · 2025 · Journal Article · Journal of bioscience and bioengineering

High productivity of cellulase and xylanase enzymes in the mycelial-dispersed Pleurotus ostreatus Δpkac2 strain.

White-rot fungi secrete unique enzymes to degrade plant cell wall components. These enzymes have the potential to improve the effective utilization of lignocellulosic biomass in a bio-based society..

High relevance

Lion's Mane · 2025 · Research Article · Biology

Hypoglycemic Effect of Pleurotus citrinopileatus and Hericium erinaceus Buccal Tablets on Diabetic Mice.

Diabetes mellitus poses a global health challenge, necessitating natural adjuvants with minimal side effects. The aims of this study were to optimize the concentrations of chromium (Cr), zinc (Zn), and germanium (Ge) in the liquid fermentation media of Pleurotus citrinopileatus and Hericium erinaceus and to evaluate….

Metabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2025 · Preprint · journal metadata

Identification and Domestication of a Wild Edible Oyster Mushroom Growing on Loblolly Pine ( Pinus taeda ) in Mississippi

The oyster mushroom is among the most extensively cultivated edible mushrooms worldwide. These mushrooms typically thrive on decaying broadleaf deciduous trees but are rarely found on conifers.

Gut & microbiome

High relevance

Shiitake · 2025 · Journal Article · Journal of the science of food and agriculture

Identification of a novel calcium-binding peptide from Lentinula edodes and structure, stability and absorption evaluation of its calcium chelate.

BACKGROUND: Peptide-Ca chelates are promising calcium supplements. Lentinula edodes (LE) is rich in amino acids with calcium-binding ability, and so it is hypothesized that it can be used to develop peptide-Ca chelates..

Gut & microbiome

High relevance

Reishi · 2025 · Journal Article · Applied biochemistry and biotechnology

Identification of Novel Laccase from Ganoderma lucidum and Application in Biotransformation to Bio-based Fragrances Using Alkaline Lignin as Raw Material.

A novel laccase, Lac3, was purified from Ganoderma lucidum fermentation broth by salting out, gel filtration chromatography, and Native-PAGE protein recovery. The molecular mass of Lac3 was 58.4 kDa as estimated by SDS-PAGE and exhibited catalytic properties with 2,2'-Biazobis-3-ethylbenzothiazoline-6-sulfonic acid….

Energy & fatigue

High relevance

Oyster Mushroom · 2025 · Journal Article · Fungal biology

Identifying the Pleurotus ostreatus α-amylase gene family and analyzing its expression during growth and development.

α-Amylase is a crucial enzyme modulating carbohydrate metabolism that holds a significant role in the growth and development of animals, plants, and microbes. However, its role in mushrooms remains unclear..

Immune support

High relevance

Reishi · 2025 · Journal Article · Ecotoxicology and environmental safety

Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging.

Long-term formaldehyde (FA) exposure causes cognitive dysfunction, often associated with metabolic disorders. While some studies suggest Ganoderma lucidum polysaccharides (GLP) can improve cognitive function, such as Alzheimer's disease..

Immune supportCognition & nervesMetabolic health

High relevance

Turkey Tail · 2025 · Journal Article · International journal of biological macromolecules

Immobilization of Trametes versicolor laccase on LDH/alginate composite beads for improved textile dyes decolorization.

Laccase is an oxido-reductase known for its applications in biomass valorization (lignin depolymerization), in fine chemicals (building-blocks synthesis) or in environment (wastewater treatment). It works with molecular oxygen and produces water as its only by-product..

Energy & fatigue

High relevance

Reishi · 2025 · Research Article · Pharmacological reports: PR

Impact of Hericium erinaceus and Ganoderma lucidum metabolites on AhR activation in neuronal HT-22 cells.

BACKGROUND: The proper functioning of the nervous system determines the homeostasis of the entire body. There are many known approaches designed to positively stimulate the functions of the central nervous system by applying various plants and fungal extracts, but their course of action is poorly understood..

OncologyCognition & nervesMetabolic health

High relevance

Snow Fungus · 2025 · Journal Article · Food chemistry

Improving physicochemical properties and gel formation mechanism of nutty plant-based yogurt with Tremella fuciformis polysaccharides.

Developing nutty plant-based yogurt (NPBY) with desired texture and sensory properties has been challenging. This study sought to investigate the effects of Tremella fuciformis polysaccharides (TFPS) on the physicochemical, textural, rheological, and microstructural properties of NPBY..

Immune support

High relevance

Oyster Mushroom · 2025 · Journal Article · Journal of the science of food and agriculture

In silico identification and structural insight of allergens in Pleurotus ostreatus.

BACKGROUND: Computational approaches offer advantages for initial food allergenicity assessment. This study assesses and confirms the allergenicity based on the cross-reactivity of allergen proteins in Pleurotus ostreatus using computational methods..

High relevance

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and Palmitoylethanolamide.

Oxidative stress, driven by impaired antioxidant defence systems, is a major contributor to cognitive decline and neurodegenerative processes in brain ageing. This study investigates the neuroprotective effects of a natural compound mixture-composed of Hericium erinaceus, Palmitoylethanolamide, Bilberry extract, and….

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

High relevance

Oyster Mushroom · 2025 · Research Article · Metabolites

In Vivo Effectiveness of Pleurotus ostreatus in Degradation of Toxic Metabolites of Filamentous Fungi Such as Aflatoxin B1 and Zearalenone.

BACKGROUND/OBJECTIVES: Mycotoxins, secondary metabolites synthesized by filamentous fungi, have been classified as dangerous substances and proven to be carcinogenic, as well as to have genotoxic, nephrotoxic, hepatotoxic, teratogenic, and mutagenic properties..

Liver support

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Influence and underlying mechanism of soluble dietary fiber derived from Ganoderma Lucidum-fermented sweet potato residue on the physicochemical-digestive characteristics of wheat starch.

Chronic overconsumption of starchy foods has been associated with health risks including cardiovascular diseases and diabetes. Soluble dietary fiber (SDF) presents a promising solution for modifying starch-based food products..

Metabolic healthGut & microbiome

High relevance

Chaga · 2025 · Journal Article · International journal of biological macromolecules

Influence of different bond types and polymerization degrees of glucose polymers on the fermentation of Inonotus obliquus for the production of hypoglycemic activity polysaccharides.

This research aimed to investigate the impact of different glycosidic polymers, such as maltose, cellobiose, starch, and β-glucan, on the production of bioactive polysaccharides via deep liquid fermentation using Inonotus obliquus (I. obliquus)..

Immune supportMetabolic health

High relevance

Lion's Mane · 2025 · Research Article · Molecules (Basel, Switzerland)

Influence of Plant-Based Substrate Composition and Extraction Method on Accumulation of Bioactive Compounds in Hericium erinaceus (Bull.) Pers. Fruiting Bodies.

The selection of plant-based substrates for mushroom cultivation is a key factor influencing their growth and metabolism. The aim of this study was to demonstrate, in an innovative approach, differences in the content of biologically active compounds, bioelements, and antioxidant properties of Hericium erinaceus….