MycoData

This study aimed to investigate the role of ganoderma lucidum polysaccharides (GLP) in mitigating dexamethasone (DEX)-induced immune injury in goslings. Dexamethasone (DEX) is commonly used to establish an animal model of immune suppression, which mimics the immune injury caused by stress or certain pathological….

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2025 · Journal Article · Frontiers in bioscience (Elite edition)

Effects of Natural Metabolites from Fungi, Bacteria, and Plants on the Degradation of Polycyclic Aromatic Hydrocarbons by Pleurotus ostreatus var. Florida.

BACKGROUND: Ligninolytic fungi are promising organisms in developing bioremediation technologies due to their ability to degrade various pollutants. Fungi and their extracellular enzymes in soil inevitably collide with metabolites produced by other organisms..

Energy & fatigue

High relevance

Maitake · 2025 · Journal Article · Journal of food science

Effects of Simulated Digestion on the Structure and Macrophages and Dendritic Cells Activation of Grifola frondosa Polysaccharides.

The present work was analyzed the effects of simulated digestion on the structure of a multibranched polysaccharide (PM) from Grifola frondosa. Additionally, the activation effect of PM on macrophages and dendritic cells was compared before and after simulated digestion..

Immune supportMetabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2025 · Journal Article · Food Chemistry

Effects of solid-state fermentation with Pleurotus ostreatus on the nutritional and techno-functional properties of alternative protein ingredients

Nutritional and techno-functional properties of alternative protein sources are limiting factors for their use in food products. Here, we evaluated the effect of solid-state fermentation (SSF) with Pleurotus ostreatus on quinoa, chickpea, oat and Chlorella vulgaris with oat (Cv + O), exemplifying a diverse range of….

High relevance

Oyster Mushroom · 2025 · Journal Article · Food chemistry

Effects of solid-state fermentation with Pleurotus ostreatus on the nutritional and techno-functional properties of alternative protein ingredients.

High relevance

Wood Ear · 2025 · Research Article · Clinical nutrition research

Effects of the Intestinal Status and Clinical Factors of Korean Middle-Aged People Through the Consumption of Functional Foods Containing Auricularia auricula-judae Powder: Prospective, Randomized, Open-Label, and Control Comparative Trial.

This study aimed to evaluate the effects of functional foods containing Auricularia auricula-judae powder on gut health and clinical indicators in middle-aged and older adults..

Metabolic healthGut & microbiome

High relevance

Snow Fungus · 2025 · Research Article · International journal of molecular sciences

Effects of ε-Poly-L-Lysine/Chitosan Composite Coating on the Storage Quality, Reactive Oxygen Species Metabolism, and Membrane Lipid Metabolism of Tremella fuciformis.

This study aimed to investigate the efficacy of a composite coating composed of 150 mg/L ε-Poly-L-lysine (ε-PL) and 5 g/L chitosan (CTS) in extending the shelf life and maintaining the postharvest quality of fresh Tremella fuciformis. Freshly harvested T..

Energy & fatigueMetabolic health

High relevance

Maitake · 2025 · Journal Article · International journal of biological macromolecules

Efficient production, structural characterization and bioactivity of an extracellular polysaccharide from Grifola frondosa endophytic Burkholderia sp.

Endophytic bacteria Burkholderia sp. (GFB) was firstly identified and isolated from Grifola frondosa.

Immune supportMetabolic healthGut & microbiome

High relevance

Enoki · 2025 · Journal Article · Chemistry & biodiversity

Elicitor-Induced Modulation of Secondary Metabolites in Laetiporus Sulphureus and Flammulina Velutipes With Extraction Efficiency Evaluation in Artificial Digestive Juices.

Mushrooms are increasingly being studied for the development of new dietary supplements and drugs, which necessitates the analysis of their chemical profiles to assess their nutritional and health benefits. This research focused on the mycelium of edible mushrooms, Laetiporus sulphureus and Flammulina velutipes..

Gut & microbiome

High relevance

Turkey Tail · 2025 · Journal Article · Environmental Pollution

Eliminating antibiotics by white-rot-fungi Trametes versicolor from manure solids and synthetic wastewater

Antibiotics have been abused in livestock as veterinary drug and feed additive. Their incomplete metabolization by animals resulted in heavy accumulation in livestock manure, and therefore they can pose a threat to the environment..

High relevance

Turkey Tail · 2025 · Journal Article · Environmental pollution (Barking, Essex: 1987)

Eliminating antibiotics by white-rot-fungi Trametes versicolor from manure solids and synthetic wastewater.

High relevance

Reishi · 2025 · Journal Article · Current microbiology

Elucidation of Foraging Strategies of Ganoderma lucidum and Ganoderma neo-japonicum on Different Nutrients Composition Using Fractal Morphology.

Ganoderma species are major wood-decaying fungus found everywhere due to its nutritional benefits. Challenges include connecting 2D imaging of mycelium growth morphology analysis to fractal morphology and determining optimum nutrient composition to increase production yield on a larger scale in mushroom industries..

High relevance

Lion's Mane · 2025 · Journal Article · International journal of biological macromolecules

Engineering a native signal peptide and N-glycosylation sites enables active production of a mushroom Hericium erinaceus laccase in the Pichia pastoris expression system.

Recombinant fungal laccase production in a yeast expression system is one of way to enhance its yield for biotechnological applications. However, fungal laccase genes are sometime not expressed in heterologous hosts..

High relevance

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells

Phellinus linteus (PL) is a medicinal fungus known for producing hispolon, a bioactive compound with antioxidant, anti-inflammatory, and anticancer properties. However, the natural scarcity of PL and the unsuccessful cultivation of its fruiting bodies have led to the exploration of alternative methods for enhancing….

OncologyImmune supportEnergy & fatigue

High relevance

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells

OncologyImmune supportEnergy & fatigue

High relevance

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells.

OncologyImmune supportEnergy & fatigue

High relevance

Oyster Mushroom · 2025 · Research Article · Food science & nutrition

Enhancing Nutritional Quality and Functionality of Legumes: Application of Solid-State Fermentation With Pleurotus ostreatus.

Legumes are recognized for their nutritional and economic value as a high-quality protein source. However, antinutrients present in legumes can hinder digestibility and nutrient absorption, ultimately limiting the bioavailability of essential dietary components..

Gut & microbiome

High relevance

Oyster Mushroom · 2025 · Journal Article · Brazilian journal of biology = Revista brasleira de biologia

Enhancing Pleurotus ostreatus P. Kumm cultivation on peel of the fruit of Astrocaryum aculeatum (Jacq.) G. Mey by investigating the influence of moisture and supplementation with wheat bran.

This study investigates the impact of moisture and wheat bran supplementation on the biological efficiency (BE) and nutritional profile of Pleurotus ostreatus (Jacq.) P. Kumm cultivated on peels of Astrocaryum aculeatum G.

High relevance

Oyster Mushroom · 2025 · Research Article · AIMS microbiology

Ensiled Pleurotus ostreatus based spent mushroom substrate from corn: In vitro gas production, greenhouse gas emissions, nutrient degradation, and ruminal fermentation characteristics.

The present study evaluated varying inclusion levels (10%, 20%, 30%, 40%, and 50%) of spent mushroom substrate (SMS) derived from Pleurotus ostreatus, ensiled for 0, 21, 42, and 64 d, using an in vitro batch culture technique..

High relevance

Shiitake · 2025 · Journal Article · World journal of microbiology & biotechnology

Enzymatic analysis of eucalyptus harvest residue decomposition by lentinula edodes for enhanced crop management and conservation.

Eucalypt wastes (EW), comprising bark, leaf and branches, when retained and distributed on-site are a valuable source of nutrients for soil and microbial biomass. This study investigates the acceleration of EW biodegradation through the introduction of the edible fungus Lentinula edodes in-vitro cultures..

High relevance

Shiitake · 2025 · Journal Article · Neuroscience

Ergothioneine-rich Lentinula edodes mushroom extract restores mitochondrial functions in senescent HT22 cells.

A decline in mitochondrial functions associated with ageing is the key factor of free radical generation which contributes to age-related pathologies. Protecting healthy functional mitochondrial networks with antioxidants is critical in promoting healthy ageing..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Evaluation of Anticancer Potential of Ganoderma lucidum on MCF-7 Breast Cancer Cells Through Genetic Transcription of Energy Metabolism.

Ganoderma lucidum has long been recognized for its medicinal properties, particularly due to its antioxidant, anti-inflammatory, and pro-apoptotic components such as polysaccharides and triterpenoids. This study aimed to evaluate the cytotoxic and molecular effects of ethanol and methanol extracts of G..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · Research Article · Current issues in molecular biology

Evaluation of Bioactive Compounds, Antioxidant Activity, and Anticancer Potential of Wild Ganoderma lucidum Extracts from High-Altitude Regions of Nepal.

Wild Ganoderma lucidum from Nepal's high-altitude regions was studied to identify key bioactive compounds and assess the influence of solvent type-water, ethanol, methanol, and acetone-on extraction efficiency and biological activity..

Oncology

High relevance

Reishi · 2025 · Journal Article · Neurochemical research

Evaluation of the Potential Anticonvulsant and Neuroprotective Effects of Ganoderma Lucidum Extract in an Animal Model of Pentylenetetrazol-Induced Seizures.

Ganoderma lucidum extract (GLE) has neuro-therapeutic and anticonvulsant effects. This study aimed to evaluate the potential neuroprotective and antioxidant effects of ethanolic extract on pentylenetetrazol-induced brain damage in male Wistar rats and to analyze behavioral manifestations in vivo..

Cognition & nerves

High relevance

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Evidence to support cultivated fruiting body of Ophiocordyceps sinensis (Ascomycota)'s role in relaxing airway smooth muscle.

ETHNOPHARMACOLOGICAL RELEVANCE: Ophiocordyceps sinensis (O. sinensis) is a genus of Ascomycete fungus that is endemic to the alpine meadows of the Tibetan Plateau and adjoining Himalayas..

Immune supportEnergy & fatigueMetabolic healthRespiratory

High relevance

Oyster Mushroom · 2025 · Journal Article · Letters in applied microbiology

Exo and endopolysaccharides production from Pleurotus ostreatus cultivated in medium containing fruit wastes.

Studies have demonstrated the potential for utilizing agro-industrial byproducts for Pleurotus spp. Extracts containing polysaccharides from mushrooms obtained through solid culture, as well as from mycelial biomass obtained through liquid culture (endopolysaccharides), can regulate the immune response and increase….

Immune supportMetabolic health

High relevance

Shiitake · 2025 · Journal Article · International journal of biological macromolecules

Exogenous trehalose increased polysaccharide content and altered their properties and metabolism in Lentinula edodes mycelium.

Trehalose promotes polysaccharide synthesis in edible mushrooms, yet its effect on the antioxidant activity and structure of Lentinula edodes mycelium polysaccharides is still unknown. We investigated the effect of trehalose on the antioxidant activity of L.

Immune supportMetabolic health

High relevance

Reishi · 2025 · Journal Article · Mycopathologia

Exopolysaccharides of Ganoderma lucidum Activate the NLRP3 Inflammasome, Modulating Phagocytes and the Response of Mice to Infection with Cryptococcus neoformans.

Interleucin-1β (IL-1β) is a pivotal cytokine in pro-inflammatory response induction, and it is regarded as protective in various diseases. IL-1β secretion is mainly associated with activation of the inflammasome complex, which normally is tightly regulated, depending on two signals for significant activity..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Agarikon · 2025 · Research Article · Frontiers in pharmacology

Exploration of the role of Fomitopsis officinalis Ames in the treatment of gastric cancer using network pharmacology, molecular docking, and in vitro experiments.

BACKGROUND: Gastric cancer (GC) is one of the most common malignant tumors worldwide, with approximately one million people diagnosed with gastric cancer each year..

OncologyImmune supportCognition & nervesRespiratory

High relevance

Oyster Mushroom · 2025 · Journal Article · Applied biochemistry and biotechnology

Exploring Botryosphaeran, a (1 → 3)(1 → 6)-β-D-Glucan, as a Matrix for the Stabilization of Laccase from Pleurotus ostreatus Florida onto a Zinc Oxide Quantum Dots Platform for the Electrochemical Determination of 2,6-Dimethoxyphenol.

This work describes the development of a novel biosensor obtained by immobilizing laccase from Pleurotus ostreatus Florida onto a glassy carbon electrode platform modified with zinc oxide quantum dots. For enzyme immobilization, the exopolysaccharide botryosphaeran from Botryosphaeria rhodina MAMB-05 was used..

Immune support

High relevance

Reishi · 2025 · Journal Article · Environmental science and pollution research international

Exploring Ganoderma lucidum as a sustainable bioleather alternative from sawdust.

The global leather industry faces pressing ethical and environmental challenges due to animal exploitation and the use of hazardous tanning chemicals. To develop a sustainable and eco-friendly alternative, this study investigates bioleather derived from the mycelium of Ganoderma lucidum, a medicinal fungus..

High relevance

Yellow Morel · 2025 · Journal Article · International Journal of Biological Macromolecules

Exploring Morchella esculenta polysaccharide extracts: In vitro digestion, fermentation characteristics, and prebiotic potential for modulating gut microbiota and function

Morchella esculenta, a nutritious and medicinal edible mushroom, has gained an increasing attention due to the bioactive properties of its polysaccharides. This study employed in vitro simulated human digestion and fecal fermentation models to evaluate the effects of M..

Immune supportMetabolic healthGut & microbiome

High relevance

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Exploring Morchella esculenta polysaccharide extracts: In vitro digestion, fermentation characteristics, and prebiotic potential for modulating gut microbiota and function.

Immune supportMetabolic healthGut & microbiome

High relevance

Yellow Morel · 2025 · Journal Article · International Journal of Biological Macromolecules

Exploring the mechanism of Morchella esculenta polysaccharides ameliorating liver lipid metabolism in high-fat diet mice by transcriptomics

This study isolated a high-molecular-weight Morchella esculenta polysaccharide (MEP-1), mainly composed of glucose with a triple-helix structure. MEP-1 alleviated high-fat diet (HFD)-induced hepatic lipid metabolic disorders and inflammation by significantly reducing the levels of TC, TG, LDL-C, TNF-α, IL-6, and….

Immune supportMetabolic healthLiver support

High relevance

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Exploring the mechanism of Morchella esculenta polysaccharides ameliorating liver lipid metabolism in high-fat diet mice by transcriptomics.

Immune supportMetabolic healthLiver support

High relevance

Oyster Mushroom · 2025 · Journal Article · Animal feed science and technology

Extracellular enzymes of Pleurotus ostreatus vary among the proportions of acid detergent fiber and lignin of corn stover (Zea mays L.) hybrids with similar contents of cell walls

The objective was to analyze the effect of corn stover neutral detergent fiber (NDF) composition on endoglucanase (End), exoglucanase (Exo), xylanase (Xyl), β-glucosidase (β-glu), and laccase (Lac), enzyme activities (EA) in enzyme extracts of Pleurotus ostreatus cultivated in liquid culture media were amended with….

High relevance

Enoki · 2025 · Research Article · Frontiers in nutrition

Flammulina velutipes mycorrhizae dietary fiber attenuates the development of obesity via regulating lipid metabolism in high-fat diet-induced obese mice.

INTRODUCTION: Mounting evidence has shown that Flammulina velutipes mycorrhizae dietary fiber (Fv-DF) has the potential to significantly improve health outcomes by addressing lipid metabolic disorders..

Metabolic healthLiver support

High relevance

Enoki · 2025 · Journal Article · International journal of biological macromolecules

Flammulina velutipes polysaccharide exerts immunomodulatory function involving RSAD2 to regulate the NF-κB/MAPK signaling pathway in RAW264.7 macrophage cells and in mouse spleen cells.

There are ongoing efforts to explore the potential of natural bioactive substances including polysaccharides in immunological regulation and understand the mechanisms under their immune-regulating function..

Immune supportEnergy & fatigue

High relevance

Enoki · 2025 · Journal Article · International journal of biological macromolecules

Flammulina Velutipes polysaccharides ameliorate cisplatin-induced acute kidney injury in mice via regulation of gut microbiota and Ferroptosis pathway.

Acute kidney injury (AKI) is a common and serious clinical complication with high incidence. Polysaccharides extracted from Flammulina velutipes (FVPs) have been proven to possess anti-inflammatory and antioxidant properties..

Immune supportMetabolic healthGut & microbiome

High relevance

Enoki · 2025 · Journal Article · Journal of food engineering

Flammulina velutipes polysaccharides as an alternative cryoprotectant for frozen shrimp

Flammulina velutipes polysaccharides (FVPs) have shown promise as cryoprotectants in food preservation. This study investigates the specific role of FVP in inhibiting ice recrystallization and preserving the quality of Pacific white peeled shrimp during freeze-thaw cycles..

Immune support

High relevance

Enoki · 2025 · Journal Article · Journal of agricultural and food chemistry

Flammulina velutipes residue Polysaccharide Alleviates Immunosuppression and Intestinal Injury by Modulating Gut Microbiota and Associated Metabolites.

This study elucidated the mechanisms underlying the immunoregulatory and gut-microbiota-modulating effects of Flammulina velutipes residue polysaccharide (FVRP) using cyclophosphamide (CTX)-induced mouse models..

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Research Article · Foods (Basel, Switzerland)

Fortification of Chinese Steamed Bread Through Broken Ganoderma lucidum Spore Powder Incorporation: Effects on Physicochemical and Quality Properties.

Broken Ganoderma lucidum spore powder (BGLSP) is abundant in nutrients and bioactive compounds, rendering it a suitable functional raw material for food applications..

High relevance

Reishi · 2025 · Research Article · Molecules (Basel, Switzerland)

From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications.

Fungi are a prolific source of diverse bioactive metabolites, yet many remain unexplored. Among these, depsidones are a rare class of compounds with significant biological potential, but they are seldom reported in mushrooms..

OncologyImmune support

High relevance

Turkey Tail · 2025 · Journal Article · Enzyme and microbial technology

Functional analysis of cytochrome P450 monooxygenases from the white-rot basidiomycete Trametes versicolor: CYP502B15 decorates cadinane-type sesquiterpenoids

Cytochrome P450 monooxygenases (P450) play crucial roles in the diversification of secondary metabolic systems in living organisms. Basidiomycetes produce a wide variety of natural products as secondary metabolites, with their relevance to pharmaceutical and agricultural applications garnering significant interest..

Energy & fatigueMetabolic health

High relevance

Turkey Tail · 2025 · Journal Article · Enzyme and microbial technology

Functional analysis of cytochrome P450 monooxygenases from the white-rot basidiomycete Trametes versicolor: CYP502B15 decorates cadinane-type sesquiterpenoids.

Energy & fatigueMetabolic health

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Functional characterization of Ganoderma lucidum polysaccharide and the mechanism of inducing tomato resistance to Tomato yellow leaf curl virus.

Using functional polysaccharides as elicitors to induce plant disease resistance has emerged as an effective plant protection strategy. In this study, we found that crude polysaccharides derived from by-products of Ganoderma lucidum can effectively prevent and control the Tomato Yellow Leaf Curl Virus (TYLCV)..

Immune supportEnergy & fatigueMetabolic healthRespiratory

High relevance

Oyster Mushroom · 2025 · Journal Article · Environmental science and pollution research international

Fungal-assisted harvesting of Chlorella sorokiniana cultivated in diluted anaerobic digestate using the edible mushroom Pleurotus ostreatus.

The use of fungi as a bio-flocculant for microalgae harvesting has gained great attention in recent years. However, most of the examined fungi were pathogenic, making the harvested biomass unsuitable for human or animal consumption..

Gut & microbiome

High relevance

Cordyceps · 2025 · Research Article · Ecology and evolution

Future Habitat Shifts and Economic Implications for Ophiocordyceps sinensis Under Climate Change.

Ophiocordyceps sinensis is a vital and unique traditional medicine native to the Tibetan Plateau (TP) and its adjacent regions. Its habitat has significantly diminished in recent years due to commercial harvesting and climate change.

High relevance

Reishi · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Ganoderma lucidum and Robinia pseudoacacia Flower Extract Complex Alleviates Kidney Inflammation and Fibrosis by Modulating Oxidative Stress.

Chronic kidney disease (CKD) is characterized by functional and structural abnormalities, with its progression strongly influenced by oxidative stress and inflammatory responses, ultimately leading to renal fibrosis..

Immune support

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum dietary fiber and lactobacillus fermentum CECT5716 alleviate constipation via regulation of gut barrier and microbiota.

The rising incidence of constipation, as well as the side effects of constipation medications, have prompted people to look for substances of natural origin to treat constipation..

Immune supportGut & microbiome