MycoData

Maitake · 2018 · Journal Article · International journal of biological macromolecules

A novel iron supplements preparation from Grifola frondosa polysaccharide and assessment of antioxidant, lymphocyte proliferation and complement fixing activities.

Grifola frondosa polysaccharide-iron (III) complex (GFP-iron) was synthesized and characterized. Based on single factor and orthogonal optimization experiments of GFP-iron (III) complex synthesis, the optimum conditions were the reaction temperature 80°C, pH 8, reaction time 90min and ratio of catalyst to GFP….

Immune supportCognition & nerves

Almond Mushroom · 2018 · Journal Article · Nutritional neuroscience

Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice.

Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson's disease (PD). The current study was aimed to study the possible anti-oxidant and anti-inflammatory effects of the methanolic extract of Agaricus blazei (A..

Almond Mushroom · 2018 · Journal Article · Biological trace element research

Agaricus blazei Murill Polysaccharides Protect Against Cadmium-Induced Oxidative Stress and Inflammatory Damage in Chicken Spleens.

Agaricus blazei Murill polysaccharide (ABP) has exhibited antioxidant and immunoregulatory activity. The aim of this study was to investigate the effect of ABP on cadmium (Cd)-induced antioxidant functions and inflammatory damage in chicken spleens..

Immune supportLiver support

Shiitake · 2018 · Journal Article · International journal of biological macromolecules

Antioxidant and anti-inflammation of enzymatic-hydrolysis residue polysaccharides by Lentinula edodes.

The present work investigated the antioxidative, anti-inflammatory and organ protective effects of residue polysaccharide (RPS) and its enzymatic-RPS (ERPS) of Lentinula edodes against the LPS-induced sepsis in mice..

OncologyImmune supportLiver support

Niu-Chang-Chih · 2018 · Research Article · Frontiers in pharmacology

Antrodia camphorata Mycelia Exert Anti-liver Cancer Effects and Inhibit STAT3 Signaling in vitro and in vivo.

Hepatocellular carcinoma (HCC), the major form of primary liver cancer, is a common cause of cancer-related death worldwide. Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in HCC and has been proposed as a chemotherapeutic target for HCC..

Immune supportMetabolic healthSkin & hydration

Enoki · 2018 · Journal Article · Pakistan journal of pharmaceutical sciences

Cellulase-assisted extraction and anti-ultraviolet activity of polysaccharides from the root of Flammulina velutipes on Caenorhabditis elegans.

We investigated the cellulase-assisted extraction and anti-ultraviolet activity of water-soluble polysaccharides from the root of Flammulina velutipes on Caenorhabditis elegans..

Maitake · 2018 · Journal Article · Carbohydrate polymers

Chemical structure of a partially 3-O-methylated mannofucogalactan from edible mushroom Grifola frondosa.

An unusual heteropolysaccharide was isolated from the fruiting bodies of the medicinal mushroom Grifola frondosa, via successive cold aqueous extraction, followed by fractionation through freeze-thawing, precipitation with Fehling solution and dialysis using a membrane with a size exclusion cut-off of 500 kDa..

OncologyImmune supportCognition & nerves

Enoki · 2018 · Journal Article · International journal of biological macromolecules

Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer's disease by compatibilizing with ginsenosides.

This study was performed to evaluate the cognitive-enhancing effect Flammulina velutipes polysaccharides (FVP) by compatibilizing with ginsenosides on D-galactose-induced Alzheimer's disease (AD) rats..

Immune supportSkin & hydration

Lion's Mane · 2018 · Journal Article · Carbohydrate polymers

Comparative study of physicochemical properties and bioactivity of Hericium erinaceus polysaccharides at different solvent extractions.

In this study, hot water, 0.9% NaCl, citric acid, and 1.25 M NaOH/0.05% NaBH4 were separately used for the extraction of water-soluble H. erinaceus polysaccharides (HEPs; HEP-W, HEP-S, HEP-C, and HEP-A) from the fruit body of Hericium erinaceus..

OncologyImmune supportEnergy & fatigueRespiratory

Enoki · 2018 · Research Article · Asian-Australasian journal of animal sciences

Effect of golden needle mushroom (Flammulina velutipes) stem waste on laying performance, calcium utilization, immune response and serum immunity at early phase of production.

OBJECTIVE: This experiment was conducted to evaluate the effects of golden needle mushroom (Flammulina velutipes) stem waste (FVW), on organic eggs production, calcium utilization, antibody response, serum immunoglobulin, and serum cytokine concentration at early phase of production in laying hens..

Enoki · 2018 · Journal Article · Food chemistry

Effect of nanocomposite packaging on postharvest senescence of Flammulina velutipes.

A polyethylene based packaging material containing nano-Ag, nano-TiO2, nano-SiO2, and attapulgite has been prepared. The effect of nanocomposite packaging material (Nano-PM) on the senescence of Flammulina velutipes during 15 days of postharvest storage at 4 °C and a relative humidity of 90% were analyzed..

OncologyImmune supportSkin & hydration

Yellow Morel · 2018 · Journal Article · Food & function

Effect of polysaccharide FMP-1 from Morchella esculenta on melanogenesis in B16F10 cells and zebrafish.

Polysaccharides from Morchella esculenta are known to exhibit diverse bioactivities, while an anti-melanogenesis effect has been barely addressed. Herein, the anti-melanogenesis activity of a heteropolysaccharide from M.

Almond Mushroom · 2018 · Journal Article · Biological trace element research

Effects of Agaricus blazei Murill Polysaccharide on Cadmium Poisoning on the MDA5 Signaling Pathway and Antioxidant Function of Chicken Peripheral Blood Lymphocytes.

This experimental study investigated the effect of Agaricus blazei Murill polysaccharide (ABP) on cadmium (Cd) poisoning on the melanoma differentiation-associated gene 5 (MDA5) signaling pathway and antioxidant function of peripheral blood lymphocytes (PBLs) in chickens..

Immune supportEnergy & fatigueMetabolic healthLiver support

Chaga · 2018 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Effects of polysaccharides from Inonotus obliquus and its chromium (III) complex on advanced glycation end-products formation, α-amylase, α-glucosidase activity and H2O2-induced oxidative damage in hepatic L02 cells.

In the present study, the antioxidant activity, anti-glycation activity, α-amylase, α-glucosidase inhibitory activity of polysaccharides from Inonotus obliquus (UIOPS) and its chromium (III) complex (UIOPC) were investigated..

Immune supportMetabolic healthGut & microbiome

Chaga · 2018 · Journal Article · Food research international (Ottawa, Ont.)

Effects of simulated gastrointestinal digestion in vitro on the chemical properties, antioxidant activity, α-amylase and α-glucosidase inhibitory activity of polysaccharides from Inonotus obliquus

This study was aimed to investigate the impacts of gastrointestinal digestion in vitro on the physicochemical properties and the biological activities of polysaccharides from Inonotus obliquus (UIOPS-1)..

OncologyImmune supportEnergy & fatigueMetabolic health

Maitake · 2018 · Journal Article · Journal of food science

Enzymatic Modification of Rice Bran Polysaccharides by Enzymes from Grifola Frondosa: Natural Killer Cell Cytotoxicity and Antioxidant Activity.

UNLABELLED: Rice bran polysaccharides (RBPSs) are the major active constituents of rice bran (RB). In this study, we utilized intracellular enzymes from Grifola frondosa to modify RBPSs, which were extracted from RB using ultrasound..

Maitake · 2018 · Journal Article · Bioscience, biotechnology, and biochemistry

Ergosterol and its derivatives from Grifola frondosa inhibit antigen-induced degranulation of RBL-2H3 cells by suppressing the aggregation of high affinity IgE receptors.

Grifola frondosa is an edible mushroom consumed as a health food and/or traditional medicine in Asia. However, the anti-allergic effects of G.

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2018 · Research Article · International journal of molecular sciences

Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice.

Antidepressant-like effects of ethanolic extract of Hericium erinaceus (HE) mycelium enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) were examined. HE at 100, 200 or 400 mg/kg body weight/day was orally given to mice for four weeks..

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Enoki · 2018 · Journal Article · Food & function

Flammulina velutipes polysaccharides improve scopolamine-induced learning and memory impairment in mice by modulating gut microbiota composition.

Flammulina velutipes polysaccharides (FVP) have been proved to be effective in improving learning and memory impairment in mice. However, their underlying mechanism remains unclear.

Wood Ear · 2018 · Journal Article · Food Hydrocolloids

Gelation mechanism of polysaccharides from Auricularia auricula-judae

In the current study, dynamic frequency sweep and stress relaxation tests were performed to elucidate the possible gelation mechanisms of a unique thermal stable polysaccharides from Auricularia auricula-judae (AP)..

Immune supportCognition & nerves

Lion's Mane · 2018 · Journal Article · Journal of medicinal food

Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain.

Versatile biological activities of Hericium erinaceus (HE) have been reported in many brain diseases. However, roles of HE in major psychiatric disorders such as depression and anxiety remain to be investigated..

Immune supportGut & microbiomeRespiratory

Lion's Mane · 2018 · Journal Article · International journal of biological macromolecules

Hericium erinaceus polysaccharide facilitates restoration of injured intestinal mucosal immunity in Muscovy duck reovirus-infected Muscovy ducklings.

To elucidate the effect of Hericium erinaceus polysaccharide (HEP) on the intestinal mucosal immunity in normal and Muscovy duck reovirus (MDRV)-infected Muscovy ducklings, 1-day-old healthy Muscovy ducklings were pretreated with 0.2g/L HEP and/or following by MDRV infection in this study, duodenal samples were….

Almond Mushroom · 2018 · Research Article · BMC complementary and alternative medicine

Hot water extract of Agaricus blazei Murrill specifically inhibits growth and induces apoptosis in human pancreatic cancer cells.

BACKGROUND: Pancreatic cancer is one of the most aggressive human malignancies. The development of a novel drug to treat pancreatic cancer is imperative, and it is thought that complementary and alternative medicine (CAM) could yield such a candidate..

Immune supportMetabolic healthGut & microbiome

Lion's Mane · 2018 · Research Article · Journal of evidence-based integrative medicine

Lactobacillus fermentum HP3-Mediated Fermented Hericium erinaceus Juice as a Health Promoting Food Supplement to Manage Diabetes Mellitus.

The current study investigated the antidiabetic property of Lactobacillus fermentum HP3-mediated fermented Hericium erinaceus juice (FHJ) using male Wistar rats with streptozotocin-induced diabetes mellitus (DM). FHJ was prepared using boiled mushroom juice and L.

Almond Mushroom · 2018 · Research Article · Oncology letters

Low-molecular-weight polysaccharides from Agaricus blazei Murrill modulate the Th1 response in cancer immunity.

To assess the effect of low-molecular-weight polysaccharides from Agaricus blazei Murrill (ABP-AW1) as an immunoadjuvant therapy for type 1 T-helper (Th1) responses in tumorigenesis, C57BL/6 mice were inoculated subcutaneously with ovalbumin (E.G7-OVA)..

OncologyImmune supportRespiratory

Cordyceps · 2018 · Research Article · International journal of chronic obstructive pulmonary disease

Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1-nuclear factor-κB/p65 pathway in RAW264.7 macrophages and in COPD mice.

BACKGROUND: Ophiocordyceps sinensis (C. sinensis) extracts have been found to have a therapeutic effect on patients with chronic obstructive pulmonary disease (COPD)..

OncologyImmune supportRespiratory

Yellow Morel · 2018 · Journal Article · International journal of biological macromolecules

Polysaccharide FMP-1 from Morchella esculenta attenuates cellular oxidative damage in human alveolar epithelial A549 cells through PI3K/AKT/Nrf2/HO-1 pathway.

Oxidative stress is considered to involve cell death in severe pulmonary diseases like idiopathic pulmonary fibrosis (IPF). Polysaccharide FMP-1 from Morchella esculenta can exert significant antioxidant activity.

Immune supportGut & microbiome

Mesima · 2018 · Journal Article · Carbohydrate polymers

Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways.

In the present study, the anti-inflammatory function of Phellinus linteus polysaccharide (PLP) was investigated in animal and cell inflammation models, and the anti-inflammatory mechanism of PLP was also explored..

Immune supportMetabolic healthGut & microbiomeLiver support

Mesima · 2018 · Journal Article · Carbohydrate polymers

Polysaccharides extracted from Phellinus linteus ameliorate high-fat high-fructose diet induced insulin resistance in mice.

Phellinus linteus polysaccharide (PLP) has hypoglycemic effects, but mechanisms remain unclear. Male C57BL/6 J mice were either fed a normal diet (CON) or a high-fat high-fructose diet (HFD) for 16 weeks, and starting from week 12, HFD-fed animals in PLP group were orally given PLP..

OncologyImmune supportEnergy & fatigue

Lion's Mane · 2018 · Journal Article · Gene

Proteome analysis provides insight into the regulation of bioactive metabolites in Hericium erinaceus.

BACKGROUND: Hericium erinaceus, a famous edible mushroom, is also a well-known traditional medicinal fungus. To date, a large number of bioactive metabolites with antitumor, antibacterial, and immune-boosting effects were isolated from the free-living mycelium and fruiting body of H.

Lion's Mane · 2018 · Journal Article · International journal of biological macromolecules

Purification and characterization of a novel protease-resistant GH27 α-galactosidase from Hericium erinaceus.

A novel 57-kDa acidic α-galactosidase designated as HEG has been purified from the dry fruiting bodies of Hericium erinaceus. The isolation protocol involved ion-exchange chromatography and gel filtration on a Superdex75 column.

Maitake · 2018 · Journal Article · International journal of biological macromolecules

Purification and structural elucidation of a water-soluble polysaccharide from the fruiting bodies of the Grifola frondosa.

Grifola frondosa is a polypore mushroom, which has been used for many centuries by traditional Chinese and Japanese herbalists as a medicinal mushroom. A water-soluble polysaccharide (code as GFP30-2-a, molecular weight: 2.04×106Da) was isolated from the fruiting bodies of G..

OncologyImmune supportEnergy & fatigue

Maitake · 2018 · Journal Article · International journal of biological macromolecules

Purification, characterization and immunomodulatory activity of a novel polysaccharide from Grifola frondosa.

A novel bioactive polysaccharide, GFP-22, was isolated from the fruit bodies of Grifola frondosa by anion-exchange and gel filtration chromatography. Structure of GFP-22 was investigated using gas chromatography-mass spectrometry (GC-MS), methylation, nuclear magnetic resonance (NMR), high-performance size exclusion….

OncologyImmune supportMetabolic healthLiver support

Enoki · 2018 · Journal Article · Carbohydrate polymers

Structural characteristics and bioactive properties of a novel polysaccharide from Flammulina velutipes.

A new water-soluble polysaccharide (FVP1) was extracted from Flammulina velutipes by traditional method "water extraction and alcohol precipitation" and purified by column chromatography. Physicochemical characterization showed that FVP1 was a homogeneous polysaccharide with a relative molecular weight of 54.78 kDa..

Maitake · 2018 · Journal Article · Carbohydrate polymers

Structural characterization and antidiabetic potential of a novel heteropolysaccharide from Grifola frondosa via IRS1/PI3K-JNK signaling pathways.

A novel heteropolysaccharide from Grifola frondosa named GFP-W has been isolated and purified by DEAE Sephadex A-52 chromatography. Gas chromatography, fourier transform infrared spectroscopy, one-dimensional (1H- and 13C-) and two-dimensional (1H-1H COSY, 1H-13C HSQC, and 1H-13C HMBC) nuclear magnetic resonance….

Wood Ear · 2018 · Journal Article · International journal of biological macromolecules

Structural characterization and immunomodulatory activity of exopolysaccharides from submerged culture of Auricularia auricula-judae.

Submerged culture of Auricularia auricula-judae has been documented, but there have been few studies on the structural characterization and medicinal properties of its exopolysaccharides. In present study, two exopolysaccharides, named CEPSN-1 and CEPSN-2, were isolated from submerged culture of A..

Enoki · 2018 · Journal Article · Carbohydrate polymers

Structural characterization and macrophage activation of a hetero-galactan isolated from Flammulina velutipes.

We isolated and purified a new polysaccharide (WFVP-N-b1) with a molecular weight of 20 kDa from Flammulina velutipes. Results showed that WFVP-N-b1 is composed of an α (1 → 6)-linked D-galactan backbone and branched at the O-2 of its Galp residues by an α-D-(1 → 6)-linked Manp attached to t-β-D-Glcp or t-α-D-Fucp….

Yellow Morel · 2018 · Journal Article · Carbohydrate polymers

Structural characterization, in vitro and in vivo antioxidant activities of a heteropolysaccharide from the fruiting bodies of Morchella esculenta.

This study aimed to investigate the structural features, in vitro and in vivo antioxidant activities of a heteropolysaccharide from the fruiting bodies of Morchella esculenta (FMP-1). FMP-1 had an average molecular weight of 4.7 × 103 Da and consisted of mannose, glucose and galactose..

Lion's Mane · 2018 · Research Article · Polymers

Structural Properties and Macrophage Activation of Cell Wall Polysaccharides from the Fruiting Bodies of Hericium erinaceus.

In this study, water-soluble and alkali-soluble cell wall polysaccharides were obtained from fruiting body extracted residual micropowders of Hericium erinaceus, harvested at seven different growing stages..

Immune supportMetabolic healthSkin & hydration

Chaga · 2018 · Research Article · Molecules (Basel, Switzerland)

Structure Characterization and Hypoglycaemic Activities of Two Polysaccharides from Inonotus obliquus.

In the present study, two polysaccharides (HIOP1-S and HIOP2-S) were isolated and purified from Inonotus obliquus using DEAE-52 cellulose and Sephadex G-100 column chromatography. The structural characterization and in vitro and in vivo hypoglycaemic activities of these molecules were investigated..

Lion's Mane · 2018 · Journal Article · Food & function

Structure characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its immunomodulatory activities.

A novel polysaccharide fraction (HEP-S) was extracted and isolated from the fruiting bodies of Hericium erinaceus. Structural characterization revealed that HEP-S had an average molecular weight of 1.83 × 104 Da and consisted of rhamnose, fucose, mannose, glucose and galactose at a molar ratio of 1.47: 0.93: 1.36:….

Immune supportLiver supportSkin & hydration

Niu-Chang-Chih · 2018 · Journal Article · Journal of dermatological science

The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata.

BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disease with an associated barrier dysfunction and Staphylococcus aureus infection. The mainstay steroid and calcineurin inhibitor therapy shows some adverse effects..

Immune supportRespiratory

Cordyceps · 2018 · Research Article · Canadian respiratory journal

The Function of Ophiocordyceps sinensis in Airway Epithelial Cell Senescence in a Rat COPD Model.

Ophiocordyceps sinensis (O. sinensis) seems to be able to alleviate airway epithelial cell senescence in chronic obstructive pulmonary disease (COPD).

Immune supportRespiratory

Shiitake · 2018 · Journal Article · International journal of biological macromolecules

The regulation of inflammation and oxidative status against lung injury of residue polysaccharides by Lentinula edodes.

In present study, two hydrolyzed residue polysaccharides (RPS) of enzymatic-RPS (ERPS) and acidic-RPS (ARPS) were successfully obtained from the residue of Lentinula edodes, and the anti-inflammatory as well as antioxidative effects on lipopolysaccharide-induced (LPS-induced) lung injured mice were investigated..

OncologyImmune supportEnergy & fatigue

Yellow Morel · 2018 · Journal Article · Microbial pathogenesis

Total flavones of fermentation broth by co-culture of Coprinus comatus and Morchella esculenta induces an anti-inflammatory effect on LPS-stimulated RAW264.7 macrophages cells via the MAPK signaling pathway.

The inflammatory cellular model of RAW264.7 cells induced by lipopolysaccharide (LPS) has always been used to investigate the effect of anti-inflammatory agents in vitro..

Immune supportEnergy & fatigue

Snow Fungus · 2018 · Research Article · Analytical cellular pathology (Amsterdam)

Tremella fuciformis Polysaccharides Attenuate Oxidative Stress and Inflammation in Macrophages through miR-155.

AIM: To investigate the function of Tremella fuciformis polysaccharides (TFPS) in LPS-induced inflammation and oxidative stress of macrophages. METHODS: RAW264.7 cells were pretreated with TFPS and then stimulated with 0.1 μg/ml LPS.

Niu-Chang-Chih · 2017 · Research Article · Polymers

A Novel Heterogalactan from Antrodia camphorata and Anti-Angiogenic Activity of Its Sulfated Derivative.

A heterogalactan, named ACW0, was extracted from Antrodia camphorata and purified by anion exchange and gel permeation chromatography. It was composed of galactose (94.98%), traces of mannose (2.41%), and fucose (2.61%), with its molecular weight estimated to be 13.5 k Da..

Immune supportEnergy & fatigue

Lion's Mane · 2017 · Research Article · PloS one

A unique polysaccharide purified from Hericium erinaceus mycelium prevents oxidative stress induced by H2O2 in human gastric mucosa epithelium cell.

Hericium erinaceus (HE) has been used both as a traditional Chinese medicine and home remedy for treatment of gastric and duodenal ulcers and gastritis. EP-1, a purified polysaccharide isolated from HE mycelium, has recently been identified as the active component responsible for HE anti-gastritis activity..

Maitake · 2017 · Research Article · Oncotarget

A water-soluble polysaccharide from Grifola frondosa induced macrophages activation via TLR4-MyD88-IKKβ-NF-κB p65 pathways.

Here, the immunomodulatory effects of water-soluble polysaccharide from Grifola frondosa on RAW264.7 macrophages and its molecular mechanisms were investigated. G.