MycoData

BACKGROUND: Dietary β-glucans from diverse sources exhibit varying prebiotic potentials, yet their comparative impacts on gut microbiota composition and short-chain fatty acid (SCFAs) production remain underexplored..

Cognition & nervesMetabolic healthGut & microbiome

Medium relevance

Turkey Tail · 2025 · Research Article · Frontiers in microbiology

Efficient degradation of neomycin by Bacillus velezensis and Cupriavidus basilensis isolated from mangrove soil and pharmaceutical wastewater.

Neomycin, an aminoglycoside antibiotic, is widely utilized for veterinary medicine in disease prevention. Biodegradation is a key pathway for the removal of neomycin from the environment..

Metabolic health

Medium relevance

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

Exploring the Nutraceutical Potential of a Food-Medicine Compound for Metabolic-Associated Fatty Liver Disease via Lipidomics and Network Pharmacology.

Metabolic-associated fatty liver disease (MAFLD) is a prevalent global health issue closely tied to dietary habits, impacting a significant portion of the adult population..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Reishi · 2025 · Research Article · Polymers

Functionalized Micellar Membranes from Medicinal Mushrooms as Promising Self-Growing Bioscaffolds.

Micellar or mycelial membranes from medicinal mushrooms are self-growing fibrous polymeric biocomposites that are biocompatible, biodegradable, cost-effective, and environmentally friendly..

Metabolic healthSkin & hydration

Medium relevance

Enoki · 2025 · Research Article · Scientific reports

Fungal immunomodulatory protein FIP-fve mitigates airway inflammation and metabolic dysfunction in an obese allergic asthma model.

Obesity is a growing global health concern that exacerbates the risk and severity of allergic asthma, yet effective therapies and mechanistic understanding remain limited..

Immune supportMetabolic healthLiver supportRespiratory

Medium relevance

Reishi · 2025 · Research Article · International journal of molecular sciences

Ganoderic Acid Ameliorates Ulcerative Colitis by Improving Intestinal Barrier Function via Gut Microbiota Modulation.

Ulcerative colitis (UC) is a chronic and recurrent gastrointestinal disease that affects millions of humans worldwide and imposes a huge social and economic burden. It is necessary to find safe and efficient drugs for preventing and treating UC..

Immune supportMetabolic healthGut & microbiome

Medium relevance

Reishi · 2025 · Research Article · Theranostics

GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.

Background and Purpose: Vascular aging is a prior marker of human aging and a significant contributor to atherosclerosis and vascular calcification. However, there are limited pharmacological options available to mitigate vascular aging..

Energy & fatigueMetabolic health

Medium relevance

Snow Fungus · 2025 · Research Article · Journal of advanced research

Glycosidic linkages of fungus polysaccharides influence the anti-inflammatory activity in mice.

INTRODUCTION: Over decades, the source-function relationships of bioactive polysaccharides have been progressively investigated, however, it is still unclear how a defined structure may conduce to the bioactivities of polysaccharides..

Immune supportMetabolic healthGut & microbiome

Medium relevance

Oyster Mushroom · 2025 · Research Article · Frontiers in immunology

Gut mycobiota dysbiosis and systemic immune dysfunction in Chinese schizophrenia patients with metabolic syndrome.

While bacterial dysbiosis has been extensively studied in schizophrenia with metabolic syndrome (SZ-MetS), the role of gut mycobiota in this comorbidity remains unclear..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Medium relevance

Reishi · 2025 · Journal Article · Poultry Science

Harnessing mushrooms for poultry nutrition: Boosting health, immunity, and productivity

Edible mushrooms, the fruiting bodies of fungi, are emerging as promising functional feed additives in poultry nutrition, offering a sustainable alternative to synthetic growth promoters..

Immune supportMetabolic healthGut & microbiome

Medium relevance

Reishi · 2025 · Research Article · Nature communications

High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models.

Accumulated senescent cells during the aging process are a key driver of functional decline and age-related disorders. Here, we identify ganoderic acid A (GAA) as a potent anti-senescent compound with low toxicity and favorable drug properties through high-content screening..

Metabolic health

Medium relevance

Shiitake · 2025 · Journal Article · International journal of medicinal mushrooms

Identification and Quantification of α-D-Glucopyranosyl-Isomaltol, α-D-Maltosyl-Isomaltol, and α-Glucan in AHCCŴ Cultured Mushroom Mycelia Extract.

Consumer demand and use of mushrooms and their extracts for health promotion is increasing in the United States and worldwide. In order to further advance the science and quality assurance of mushroom products and ingredients, analytical data is needed to identify and standardize biochemical markers..

Energy & fatigueMetabolic health

Medium relevance

Zhu Ling · 2025 · Journal Article · Journal of ethnopharmacology

Injinoryeong-San attenuates metabolic dysfunction-associated steatohepatitis via regulation of YAP/TAZ-signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Injinoryeong-san (IJO), known as Yinchen-Wuling Powder in Chinese medicine, is a traditional herbal formula comprising six herbal medicinal plants, including Atractylodes macrocephala Koidz., Polyporus umbellatus (Pers.) Fries, Poria cocos (Schw.) Wolf, Cinnamomum cassia Presl, Alisma….

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Maitake · 2025 · Journal Article · Methods in molecular biology (Clifton, N.J.)

Maistero-2, a Novel Probe for Sterols: Application for Visualizing Cellular Cholesterol.

Maistero-2 is a novel, non-toxic cholesterol-binding protein derived from an edible mushroom Grifola frondosa mRNA. Maistero-2 specifically binds to lipid membranes containing 3-hydroxy sterols with a lower cholesterol concentration threshold than cholesterol-binding domain 4 (D4) of perfringolysin O (PFO) and….

Cognition & nervesMetabolic health

Medium relevance

Turkey Tail · 2025 · Journal Article · Journal of hazardous materials

Metabolic pathways for biotransformation of benzalkonium compounds in fungal- and bacteria-based biofilm reactors

Benzalkonium compounds (BACs) are quaternary ammonium biocides widely used in healthcare and industrial animal production, resulting in high concentrations in manure and wastewater..

Metabolic health

Medium relevance

Turkey Tail · 2025 · Journal Article · Journal of hazardous materials

Metabolic pathways for biotransformation of benzalkonium compounds in fungal- and bacteria-based biofilm reactors.

Benzalkonium compounds (BACs) are quaternary ammonium biocides widely used in healthcare and industrial animal production, resulting in high concentrations in manure and wastewater..

Metabolic health

Medium relevance

Turkey Tail · 2025 · Research Article · Communications biology

Metabolic profiling of two white-rot fungi during 4-hydroxybenzoate conversion reveals biotechnologically relevant biosynthetic pathways.

White-rot fungi are efficient organisms for the mineralization of lignin and polysaccharides into CO2 and H2O. Despite their biotechnological potential, WRF metabolism remains underexplored..

Immune supportMetabolic health

Medium relevance

Snow Fungus · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Metagenomics and untargeted metabolomics analyses to unravel the formation mechanism of characteristic metabolites in mung bean sour liquid during different fermentation stages

Mung Bean Sour Liquid (MBSL), a traditional fermented food indigenous to Luoyang, China, acquires its distinctive organic properties and bioactivity through complex microbial metabolic interactions..

Metabolic healthGut & microbiome

Medium relevance

Oyster Mushroom · 2025 · Research Article · Current research in food science

Modified Okara improves Noodle Properties: Effects on digestibility, structure, and functionality.

This study developed a modified okara (the product of co-fermentation with Pleurotus ostreatus and Saccharomyces cerevisiae followed by cellulase treatment), evaluating its effects on noodle quality..

Metabolic healthGut & microbiomeSkin & hydration

Medium relevance

Snow Fungus · 2025 · Research Article · Foods (Basel, Switzerland)

Natural Tremella Polysaccharide Mitigates DEHP-Induced Oxidative Stress and Apoptosis via Dual Regulation of Survival and Antioxidant Pathways.

Diethylhexyl phthalate (DEHP), a common environmental plasticizer, induces oxidative damage and cell apoptosis without efficient treatment. Tremella fuciformis polysaccharides (TFPs) are known natural antioxidants, yet their protection against DEHP toxicity remains unclear..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Enoki · 2025 · Research Article · Frontiers in microbiology

Pyrolysis temperature shapes biochar-mediated soil microbial communities and carbon-nitrogen metabolism.

INTRODUCTION: Biochar derived from agricultural residues has potential to improve soil quality and regulate microbial communities, but its effect depends strongly on pyrolysis temperature..

Metabolic health

Medium relevance

Reishi · 2025 · Journal Article · Carbohydrate polymers

Refined regulation of polysaccharide biosynthesis in edible and medicinal fungi: From pathways to production

Polysaccharides derived from edible and medicinal fungi (EMF) exhibit various biological activities, rendering them useful in the pharmaceutical, nutraceutical, and food industries..

Immune supportMetabolic health

Medium relevance

Lion's Mane · 2025 · Research Article · International journal of molecular sciences

Screening of Basidiomycete Strains Capable of Synthesizing Antibacterial and Antifungal Metabolites.

Recently, the search for new antimicrobial compounds, including the secondary metabolites of basidiomycetes, has become increasingly important. Representatives of this division of higher fungi have high biosynthetic abilities, which contributes to their use as producers..

Metabolic health

Medium relevance

Yellow Morel · 2025 · Journal Article · Journal of food composition and analysis

State-of-the-art review of morel: From chemistry to nutrition and health benefits

Morchella esculenta (L.) Pers. (M.

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Reishi · 2025 · Journal Article · Carbohydrate research

Structural basis of immunomodulation by edible fungal polysaccharides: From molecular characteristics to action mechanisms

Edible Fungal polysaccharides as Immunomodulators: A Systematic Review at the Crossroads of Immunology, Natural Products Chemistry, and Microbiology. The chemical structure—specifically molecular weight, branching degree, and functional group modifications—directly dictates immunological activity..

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Synergistic bio-mechanical pretreatment and fed-batch semi-SSF strategy for enhanced cellulosic ethanol production from ramie straw

The recalcitrant lignocellulosic matrix impedes biorefinery efficiency‌‌. This study developed a mechanical-biological pretreatment combined with fed-batch high-solids semi-simultaneous saccharification and fermentation (S-SSF) strategy for ethanol production from ramie straw..

Metabolic healthGut & microbiome

Medium relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Synergistic bio-mechanical pretreatment and fed-batch semi-SSF strategy for enhanced cellulosic ethanol production from ramie straw.

Metabolic healthGut & microbiome

Medium relevance

Niu-Chang-Chih · 2024 · Research Article · International journal of biological sciences

Coenzyme Q0 inhibited the NLRP3 inflammasome, metastasis/EMT, and Warburg effect by suppressing hypoxia-induced HIF-1α expression in HNSCC cells.

Coenzyme Q0 (CoQ0), a quinone derivative from Antrodia camphorata, has antitumor capabilities. This study investigated the antitumor effect of noncytotoxic CoQ0, which included NLRP3 inflammasome inhibition, anti-EMT/metastasis, and metabolic reprogramming via HIF-1α inhibition, in HNSCC cells under normoxia and….

OncologyImmune supportMetabolic healthSkin & hydration

Medium relevance

Reishi · 2024 · Journal Article · Journal of the science of food and agriculture

Compound chenpi tea consumption reduces obesity-related metabolic disorders by modulating gut microbiota and serum metabolites in mice.

BACKGROUND: Compound chenpi tea (CCT) is a popular herbal beverage made from citri reticulatae pericarpium, Ganoderma lucidum, and pu-erh tea. This study aimed to investigate the anti-obesity effect of CCT in mice fed a high-fat diet (HFD) and to explore the potential mediators by 16S ribosomal RNA sequencing and….

Metabolic healthGut & microbiomeLiver support

Medium relevance

Reishi · 2024 · Research Article · RSC advances

Dual inhibitory potential of ganoderic acid A on GLUT1/3: computational and in vitro insights into targeting glucose metabolism in human lung cancer.

Human glucose transporters (GLUTs) facilitate the uptake of hexoses into cells. In cancer, the increased proliferation necessitates higher expression of GLUTs, with particular emphasis on GLUT1 and GLUT3.

OncologyMetabolic healthRespiratory

Medium relevance

Reishi · 2024 · Research Article · ACS omega

Early Preclinical Studies of Ergosterol Peroxide and Biological Evaluation of Its Derivatives.

Ganoderma lucidum is a medicinal mushroom that produces various pharmacological compounds, including triterpenoids. A major bioactive component of G.

OncologyMetabolic healthLiver support

Medium relevance

Shiitake · 2024 · Research Article · Cancer medicine

Edodes Cultured Extract Regulates Immune Stress During Puberty and Modulates MicroRNAs Involved in Mammary Gland Development and Breast Cancer Suppression.

BACKGROUND: Immune stressors, such as lipopolysaccharides (LPS), profoundly affect microbiota balance, leading to gut dysbiosis. This imbalance disrupts the metabolic phenotype and structural integrity of the gut, increasing intestinal permeability..

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Turkey Tail · 2024 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Effects of dual-strain fermentation on physicochemical properties of Rosa roxburghii Tratt and coix seed beverage

This study delved into the feasibility of fermenting Rosa roxburghii Tratt and coix seed beverage (RRTCSB) using dual-strain fermentation. The impact of Trametes versicolor and Lactiplantibacillus plantarum LB12 fermentation on RRTCSB's physicochemical properties was investigated..

Immune supportMetabolic health

Medium relevance

Turkey Tail · 2024 · Journal Article · Microbiological research

Fungal degradation of phenylacetate focusing on CRISPR/Cas9-assisted characterization of two oxidative enzyme genes of Akanthomyces muscarius AM1091.

The degradation of phenylacetate (PA) was investigated as a model to explore aromatic compound breakdown in the fungal system. Fungal strains capable of utilizing PA as their sole carbon source were isolated using a minimal solid medium supplemented with 0.5 % PA..

Metabolic health

Medium relevance

Reishi · 2024 · Journal Article · Metabolic brain disease

Ganoderic acid a alleviates Aβ25-35-induced HT22 cell apoptosis through the ERK/MAPK pathway: a system pharmacology and in vitro experimental validation.

Alzheimer's disease (AD) is a neurodegenerative disorder that occurs with aging. Ganoderma lucidum (Curtis.) P.

OncologyCognition & nervesEnergy & fatigueMetabolic health

Medium relevance

Reishi · 2024 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ganoderic acid D attenuates gemcitabine resistance of triple-negative breast cancer cells by inhibiting glycolysis via HIF-1α destabilization.

BACKGROUND: Gemcitabine (GEM) resistance is the primary reason why combination chemotherapy is limited in triple-negative breast cancer (TNBC). Ganoderic acid D (GAD), a natural triterpenoid compound obtained from Ganoderma lucidum, has been shown to have antitumor activities..

OncologyImmune supportMetabolic health

Medium relevance

Reishi · 2024 · Journal Article · Atherosclerosis

Ganoderic acids alleviate atherosclerosis by inhibiting macrophage M1 polarization via TLR4/MyD88/NF-κB signaling pathway.

BACKGROUND AND AIMS: Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid infiltration and plaque formation in blood vessel walls. Ganoderic acids (GA), a class of major bioactive compounds isolated from the Chinese traditional medicine Ganoderma lucidum, have multiple pharmacological….

Immune supportMetabolic healthSkin & hydration

Medium relevance

Enoki · 2024 · Research Article · Animals: an open access journal from MDPI

Innovation and Utilization of Functional Feed Additives from Maize By-Products in Broiler Chickens.

Supplementation with spent mushroom substrate (SMS) as an exogenous enzyme in broiler diets represents a promising nutritional strategy to enhance production efficiency and reduce costs..

Energy & fatigueMetabolic healthGut & microbiome

Medium relevance

Cordyceps · 2024 · Journal Article · Food Research International

Integrated metabolomics and transcriptomics reveal metabolites difference between wild and cultivated Ophiocordycpes sinensis

Ophiocordyceps sinensis is a traditional medicinal fungus endemic to the alpine and high-altitude areas of the Qinghai-Tibet plateau. The scarcity of the wild resource has led to increased attention to artificially cultivated O.

Metabolic health

Medium relevance

Shiitake · 2024 · Journal Article · Food Hydrocolloids

Interactions between sorghum starch and mushroom polysaccharides and their effects on starch gelatinization and digestion

This study aimed at gaining insight into the mechanism of interactions between sorghum starch and mushroom polysaccharides (MPs) obtained from three cultivars Lentinula edodes (LEP), Auricularia auricula (AAP), and Tremella fuciformis polysaccharides (TFP) in relation to gelatinization, retrogradation and….

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Medium relevance

Reishi · 2024 · Journal Article · Analytical and bioanalytical chemistry

Novel method for rapid monitoring of OPFRs by LLE and GC-MS as a tool for assessing biodegradation: validation and applicability.

Organophosphate flame retardants (OPFRs) are high-production volume chemicals widely present in environmental compartments. The presence of water-soluble OPFRs (tri-n-butyl phosphate (TnBP), tris(2-butoxyethyl) phosphate (TBEP), tris(2-chloroethyl) phosphate (TCEP), tris(2-chloroisopropyl) phosphate (TCPP), and….

Metabolic health

Medium relevance

Oyster Mushroom · 2024 · Journal Article · World journal of microbiology & biotechnology

Nutritional profiling and in silico analysis of pharmacological activities from local rice Pulu Mandoti fermented with Pleurotus spp.

Pulu Mandoti, a local red rice (Oryza sativa L.) variety popular among Sulawesi residents, has gained recognition for its perceived health benefits, especially as a preferred dietary option for individuals with diabetes or those seeking to prevent obesity..

Cognition & nervesMetabolic health

Medium relevance

Oyster Mushroom · 2024 · Journal Article · World J Microbiol Biotechnol

Nutritional profiling and in silico analysis of pharmacological activities from local rice Pulu Mandoti fermented with Pleurotus spp.

Cognition & nervesMetabolic health

Medium relevance

Reishi · 2024 · Journal Article · Pakistan journal of pharmaceutical sciences

Resinacein S ameliorates the obesity in mice via activating the brown adipose tissue.

Brown adipose tissue (BAT) is an ideal target organ for obesity treatment. Resinacein S is extracted from Ganoderma lucidum and can elevate Uncoupling protein 1 (UCP1) in cells, but its related effects at the animal level are not clear..

Metabolic health

Medium relevance

Reishi · 2024 · Research Article · Foods (Basel, Switzerland)

Synthesis of Ganoderic Acids Loaded Zein-Chitosan Nanoparticles and Evaluation of Their Hepatoprotective Effect on Mice Given Excessive Alcohol.

Ganoderma lucidum, used in East Asia for its health benefits, contains ganoderic acids (GA) which have various pharmacological activities but are limited by poor water solubility and low oral bioaccessibility..

Metabolic healthGut & microbiomeLiver support

Medium relevance

Shiitake · 2024 · Journal Article · Food & function

The dose-dependent mechanism behind the protective effect of lentinan against acute alcoholic liver injury via proliferating intestinal probiotics.

Acute alcoholic liver injury (AALI) is a widespread disease that can develop into hepatitis, liver fibrosis, and cirrhosis. In severe cases, it can be life-threatening, while drug treatment presents various side effects..

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Shiitake · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

Whole-Genome Sequence Analysis of Flammulina filiformis and Functional Validation of Gad, a Key Gene for γ-Aminobutyric Acid Synthesis.

Flammulina filiformis is one of the widely produced edible fungi worldwide. It is rich in γ-aminobutyric acid (GABA), a non-protein amino acid with important physiological functions in humans.

Metabolic health

Medium relevance

Reishi · 2023 · Review · The American journal of Chinese medicine

A Comprehensive Review on the Chemical Composition, Pharmacology and Clinical Applications of Ganoderma.

Ganoderma is the dried fruiting bodiy of Ganoderma lucidum (Leyss.ex Fr.) Karst. or Ganoderma sinense Zhao, Xu et Zhang, belonging to the family Polyporaceae, which grows mainly in tropical, subtropical, and temperate regions..

OncologyImmune supportMetabolic healthRespiratory

Medium relevance

Reishi · 2023 · Review · Molecules (Basel, Switzerland)

A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids.

Ganoderma lucidum has long been used as a multi-purpose plant and functional food. The pharmacological properties of G.

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Reishi · 2023 · Review · Current molecular medicine

Anti-diabetic Effects of Macronutrients via Modulation of Angiogenesis: A Comprehensive Review on Carbohydrates and Proteins.

BACKGROUND: Diabetes is a major global health concern, manifesting the symptoms of chronic hyperglycemia. Either insufficient or excessive angiogenesis is generally involved in the pathogenesis of diabetes and its complications..

Immune supportMetabolic healthSkin & hydration