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OncologyLiver supportRespiratory

Oyster Mushroom · 2025 · Research Article · Foods (Basel, Switzerland)

Supercritical Extraction and Compound Profiling of Diverse Edible Mushroom Species.

Mushrooms are a raw material rich in many nutritional compounds, and that is why a number of them are widely known as functional food. They contain fatty acids, carbohydrates, lycopene, sterols, lovastatin, trace elements, and other valuable compounds that show a wide range of properties, such as hepatoprotective,….

Reishi · 2025 · Journal Article · Bioorganic & medicinal chemistry

Thiazolidinedione-based structure modification of ergosterol peroxide provides thiazolidinedione-conjugated derivatives as potent agents against breast cancer cells through a PI3K/AKT/mTOR pathway.

Ergosterol peroxide (EP) is a steroidal compound isolated from the traditional Chinese medicine Ganoderma lucidum. However, EP is limited by its solubility and moderate potency in antitumor studies..

OncologyEnergy & fatigue

Reishi · 2025 · Journal Article · Biomedicines

Using a Natural Triterpenoid to Unlock the Antitumor Effects of Autophagy in B-Cell Lymphoma.

Background and Objective: Diffuse large B-cell lymphoma (DLBCL), a subtype of non-Hodgkin's lymphoma, is the most common lymphoid malignancy in the Western world..

Reishi · 2024 · Journal Article · Talanta

A natural biomaterial promotes hybridization chain reaction for ultra-sensitive detection of miRNA-155.

MicroRNA (miRNA) is an important biomarker for early diagnosis of cancers. However, sensitive and convenient methods for miRNA detection remain a challenge.

OncologyImmune supportRespiratory

Almond Mushroom · 2024 · Research Article · Arhiv za higijenu rada i toksikologiju

An in vitro evaluation of the cytotoxic potential of medicinal mushrooms against human breast cancer cell lines.

Medicinal mushroom extracts, i.e. their dried biomass, have long been known as sources of bioactive compounds with positive effects on the human health.

OncologyImmune supportCognition & nerves

Mesima · 2024 · Research Article · Botanical studies

Antioxidant, anti-acetylcholinesterase, and anti-amyloid-β peptide aggregations of hispolon and its analogs in vitro and improved learning and memory functions in scopolamine-induced ICR mice.

BACKGROUND: Hispolon, one of bioactive phenolic compounds from a medicinal mushroom of sang-huang (Phellinus linteus) has been reported to exhibit anticancer and anti-inflammatory activities. The Alzheimer's disease (AD) is ranked one of the top ten leading causes of death worldwide..

OncologyEnergy & fatigueLiver supportSkin & hydration

Turkey Tail · 2024 · Journal Article · Anticancer research

Antiproliferative and Antimigratory Activity of Poly-gallic Acid in Cancer Cell Lines.

BACKGROUND/AIM: Enzyme-mediated grafting of poly (gallic acid) (PGAL) and L-arginine and a-L-lysine onto PGAL produces reactive oxygen species (ROS)-suppressor multiradical molecules with low cytotoxicity, high thermostability and water solubility with cancer treatment potential..

Turkey Tail · 2024 · Research Article · Frontiers in bioengineering and biotechnology

Biocatalytic degradation of environmental endocrine disruptor chlorobenzene via surfactant-optimized laccase-mediator system.

The emergence of environmental endocrine disruptor chlorobenzene (CB) in surface water and its potential environmental impacts have attracted serious global attention. It is still very difficult to achieve effective degradation of it by catalytic oxidation process under mild conditions..

Reishi · 2024 · Journal Article · Molecules (Basel, Switzerland)

Bioprospecting of Selected Species of Polypore Fungi from the Western Balkans.

Growing mushrooms means meeting challenges while aiming for sustainability and circularity. Wherever the producer is located, commercial strains are the same originating from several producers.

OncologyImmune supportMetabolic healthSkin & hydration

Niu-Chang-Chih · 2024 · Research Article · International journal of biological sciences

Coenzyme Q0 inhibited the NLRP3 inflammasome, metastasis/EMT, and Warburg effect by suppressing hypoxia-induced HIF-1α expression in HNSCC cells.

Coenzyme Q0 (CoQ0), a quinone derivative from Antrodia camphorata, has antitumor capabilities. This study investigated the antitumor effect of noncytotoxic CoQ0, which included NLRP3 inflammasome inhibition, anti-EMT/metastasis, and metabolic reprogramming via HIF-1α inhibition, in HNSCC cells under normoxia and….

Cordyceps · 2024 · Research Article · Food technology and biotechnology

Comparative Cytotoxicity Evaluation of Heat-Assisted vs Cold Water Extractions of Six Medicinal Fungi against Breast and Lung Cancer Cells.

RESEARCH BACKGROUND: Preparation of medicinal fungi for experimental purposes usually involves the extraction and determination of the quality and quantity of bioactive compounds prior to the biological experiment. Water, a common polar solvent, is usually used for traditional preparations for consumption..

OncologyRespiratory

OncologyImmune supportEnergy & fatigue

Chaga · 2024 · Research Article · Brazilian journal of microbiology: [publication of the Brazilian Society for Microbiology]

Comparative genomic analysis of Sanghuangporus sanghuang with other Hymenochaetaceae species.

Sanghuangporus sanghuang is a medicinal macrofungus with antioxidant and antitumor activities, and it is enriched with secondary metabolites such as polysaccharides, terpenes, polyphenols, and styrylpyrone compounds..

OncologyImmune supportGut & microbiome

Chaga · 2024 · Journal Article · International journal of medicinal mushrooms

Crude Polysaccharides from Mushrooms Elicit an Anti-Allergic Effect Against Type 1 Allergy In Vitro.

Type 1 allergic disease is a global challenge, hence the search for alternative therapies. Mushrooms have several medicinal and health benefits.

OncologyMetabolic healthRespiratory

Reishi · 2024 · Research Article · RSC advances

Dual inhibitory potential of ganoderic acid A on GLUT1/3: computational and in vitro insights into targeting glucose metabolism in human lung cancer.

Human glucose transporters (GLUTs) facilitate the uptake of hexoses into cells. In cancer, the increased proliferation necessitates higher expression of GLUTs, with particular emphasis on GLUT1 and GLUT3.

OncologyMetabolic healthLiver support

Reishi · 2024 · Research Article · ACS omega

Early Preclinical Studies of Ergosterol Peroxide and Biological Evaluation of Its Derivatives.

Ganoderma lucidum is a medicinal mushroom that produces various pharmacological compounds, including triterpenoids. A major bioactive component of G.

OncologyImmune supportMetabolic healthGut & microbiome

Shiitake · 2024 · Research Article · Cancer medicine

Edodes Cultured Extract Regulates Immune Stress During Puberty and Modulates MicroRNAs Involved in Mammary Gland Development and Breast Cancer Suppression.

BACKGROUND: Immune stressors, such as lipopolysaccharides (LPS), profoundly affect microbiota balance, leading to gut dysbiosis. This imbalance disrupts the metabolic phenotype and structural integrity of the gut, increasing intestinal permeability..

OncologyCognition & nervesEnergy & fatigueMetabolic health

Reishi · 2024 · Journal Article · Metabolic brain disease

Ganoderic acid a alleviates Aβ25-35-induced HT22 cell apoptosis through the ERK/MAPK pathway: a system pharmacology and in vitro experimental validation.

Alzheimer's disease (AD) is a neurodegenerative disorder that occurs with aging. Ganoderma lucidum (Curtis.) P.

Reishi · 2024 · Journal Article · Chemical biology & drug design

Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.

Osteoarthritis (OA) is a prevalent degenerative pathology, however, there exists a lack of cost-effective pharmacological interventions that efficaciously inhibit its progression. ganoderic acid A (GAA), a triterpenoid derived from Ganoderma lucidum, possesses antiapoptotic and -inflammatory effects..

OncologyImmune supportMetabolic health

Reishi · 2024 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ganoderic acid D attenuates gemcitabine resistance of triple-negative breast cancer cells by inhibiting glycolysis via HIF-1α destabilization.

BACKGROUND: Gemcitabine (GEM) resistance is the primary reason why combination chemotherapy is limited in triple-negative breast cancer (TNBC). Ganoderic acid D (GAD), a natural triterpenoid compound obtained from Ganoderma lucidum, has been shown to have antitumor activities..

Reishi · 2024 · Journal Article · Advances in pharmacological and pharmaceutical sciences

Ganoderma tuberculosum Liquid Culture With Vineyard Pruning Extracts for Bioactive Composite Production With Antiproliferative Activity.

Ganoderma species have been studied for their pharmacological approaches, such as anticancer, antitumor, antiproliferative, and antioxidant activity. Elicitors are used to increase Ganoderma bioactive composite production..

Zhu Ling · 2024 · Research Article · Pharmaceutical biology

Homogeneous Polyporus polysaccharide exerts anti-bladder cancer effects via autophagy induction.

CONTEXT: Polyporus polysaccharide (PPS), the leading bioactive ingredient extracted from Polyporus umbellatus (Pers.) Fr. (Polyporaceae), has been demonstrated to exert anti-bladder cancer and immunomodulatory functions in macrophages..

OncologyImmune supportCognition & nerves

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Investigating immune-modulatory function of α-glucopyranose-rich compound polysaccharides by MC38-N4/OT-I co-culture system.

The potential antitumor function of polysaccharides is well accepted, it is unclear whether polysaccharides have immunoregulatory effect on CD8+ T lymphocyte cells to attack tumor cells. To evaluate the CD8+ T function enhancing role of polysaccharide compounds, the MC38-N4/OT-I co-culture system was established..

Oyster Mushroom · 2024 · Research Article · ACS bio & med chem Au

New Catalytic Residues and Catalytic Mechanism of the RNase T1 Family.

The ribonuclease T1 family, including RNase Po1 secreted by Pleurotus ostreatus, exhibits antitumor activity. Here, we resolved the Po1/guanosine-3'-monophosphate complex (3'GMP) structure at 1.75 Å..

Cordyceps · 2024 · Journal Article · Journal of pharmaceutical and biomedical analysis

New insights into the chemistry and anticancer activity of Ophiocordyceps xuefengensis.

Ophiocordyceps xuefengensis (O. xuefengensis), the sister taxon of Ophiocordyceps sinensis (O.

OncologyEnergy & fatigue

Turkey Tail · 2024 · Journal Article · The Science of the total environment

Removal of the cytostatic drugs bleomycin and vincristine by white-rot fungi under various conditions, and determination of enzymes involved, degradation by-products, and toxicity.

Anticancer drugs show recalcitrance to conventional wastewater treatments; thus, they are present in aquatic systems and pose an environmental threat. Fungi represent a promising biological alternative for wastewater treatments..

OncologyEnergy & fatigue

Reishi · 2024 · Research Article · Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Spore Oil enhances the effect of cyclophosphamide inhibiting programmed death-1 and prolongs the survival of H22 tumor-bearing mice.

OBJECTIVE: To investigate the effect of Ganoderma Lucidum Spore Oil (GLSO) on the tumor growth and survival of H22 tumor-bearing mice treated with cyclophosphamide (CTX), and explore the underlying mechanism..

OncologyLiver support

OncologyImmune supportMetabolic healthRespiratory

Reishi · 2023 · Review · The American journal of Chinese medicine

A Comprehensive Review on the Chemical Composition, Pharmacology and Clinical Applications of Ganoderma.

Ganoderma is the dried fruiting bodiy of Ganoderma lucidum (Leyss.ex Fr.) Karst. or Ganoderma sinense Zhao, Xu et Zhang, belonging to the family Polyporaceae, which grows mainly in tropical, subtropical, and temperate regions..

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2023 · Review · Molecules (Basel, Switzerland)

A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids.

Ganoderma lucidum has long been used as a multi-purpose plant and functional food. The pharmacological properties of G.

OncologyImmune supportGut & microbiome

Reishi · 2023 · Review · International journal of biological macromolecules

Colorectal cancer inhibitory properties of polysaccharides and their molecular mechanisms: A review.

Colorectal cancer (CRC) is one of the three major malignant tumors in the world. The major treatments currently recommended for it are surgery, radiotherapy, and chemotherapy, all of which are frequently accompanied by a poor prognosis and high recurrence rate..

Almond Mushroom · 2023 · Preprint · journal metadata

Dose-volume parameters of MRI-defined active bone marrow spared predict hematologic toxicity in pelvic malignancies patients undergoing radiotherapy: a cohort study

Background: The objective of this investigation is to evaluate the superiority of dose-volume parameters relying on magnetic resonance imaging (MRI)-defined active bone marrow (ABM) over those based on total bone marrow (TBM)contoured via CT in the prediction of hematologic toxicity (HT) occurrence among patients with….

OncologyImmune supportCognition & nerves

Chaga · 2023 · Review · Critical reviews in food science and nutrition

Effects and mechanisms of natural products on Alzheimer's disease.

Alzheimer's disease (AD) is the most common form of dementia in elderly people with a high incidence rate and complicated pathogenesis, and causes progressive cognitive deficit and memory impairment..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2023 · Review · Molecules (Basel, Switzerland)

Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment.

Diabetes mellitus is a complex illness in which the body does not create enough insulin to control blood glucose levels. Worldwide, this disease is life-threatening and requires low-cost, side-effect-free medicine.

OncologyImmune supportRespiratory

Reishi · 2023 · Review · Life (Basel, Switzerland)

Exploring the Bioactive Mycocompounds (Fungal Compounds) of Selected Medicinal Mushrooms and Their Potentials against HPV Infection and Associated Cancer in Humans.

Medicinal mushrooms have been used as a medicinal tool for many centuries and, nowadays, are used in the prevention and therapy of various diseases, including as an adjunct to cancer treatment..

OncologyCognition & nerves

Almond Mushroom · 2023 · Preprint · journal metadata

Fitting agent-based models to tumor images using representation learning

Agent-based models (ABMs) have enabled great advances in the study of tumor development and therapeutic response, allowing researchers to explore the spatiotemporal evolution of the tumor and its microenvironment..

OncologyCognition & nerves

Lion's Mane · 2023 · Review · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Key oncologic pathways inhibited by Erinacine A: A perspective for its development as an anticancer molecule.

In the modern era, cancer can be controlled by chemotherapy treatment, and in many situations a stable disease is obtained. The significant clinical success and subsequent commercialization of naturally derived molecules have further encouraged their exploration as adjunctive therapies in cancer management..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2023 · Review · International journal of biological macromolecules

Preclinical pharmacokinetics-related pharmacological effects of orally administered polysaccharides from traditional Chinese medicines: A review.

Polysaccharides (TCMPs) derived from traditional Chinese medicines (TCMs), such as Ganoderma lucidum, Astragalus membranaceus, Lycium barbarum, and Panax ginseng, are considered to be the main active constituents in TCMs..

Reishi · 2023 · Review · Fitoterapia

Structural diversity, fermentation production, bioactivities and applications of triterpenoids from several common medicinal fungi: Recent advances and future perspectives.

Medicinal fungi are beneficial to human health and it reduces the risk of chronic diseases. Triterpenoids are polycyclic compounds derived from the straight-chain hydrocarbon squalene, which are widely distributed in medicinal fungi..

Reishi · 2023 · Review · The American journal of Chinese medicine

The Phytochemistry of Ganoderma Species and their Medicinal Potentials.

The Ganoderma genus is known for its diverse use as a functional food and therapeutic agent. This fungus has over 428 species, with Ganoderma lucidum being the most studied..

OncologyImmune supportLiver supportSkin & hydration

Reishi · 2022 · Review · International journal of biological macromolecules

A review on plant polysaccharide based on drug delivery system for construction and application, with emphasis on traditional Chinese medicine polysaccharide.

Carbohydrate polymers with unique chemical composition, molecular weight and functional chemical groups show multiple potentials in drug delivery. Most carbohydrate polymers such as plant polysaccharides exhibit advantages of biodegradability, ease of modification, low immunogenicity and low toxicity..

Reishi · 2022 · Review · Pharmaceuticals (Basel, Switzerland)

Anticancer Activities of Mushrooms: A Neglected Source for Drug Discovery.

Approximately 270 species of mushrooms have been reported as potentially useful for human health. However, few mushrooms have been studied for bioactive compounds that can be helpful in treating various diseases..

OncologyRespiratory

OncologyImmune supportCognition & nervesRespiratory

Reishi · 2022 · Review · Nutrients

Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms.

Edible and medicinal fungi, a group of eukaryotic organisms with numerous varieties, including Coriolus versicolor, Ganoderma lucidum, Cordyceps sinensis, Pleurotus ostreatus, and Grifola frondosa, have been demonstrated to possess a board range of pharmaceutical properties, including anti-virus, anti-inflammation,….

OncologyImmune supportCognition & nervesMetabolic health

Almond Mushroom · 2022 · Review · Frontiers in pharmacology

Fungal Mushrooms: A Natural Compound With Therapeutic Applications.

Fungi are extremely diverse in terms of morphology, ecology, metabolism, and phylogeny. Approximately, 130 medicinal activities like antitumor, immunomodulation, antioxidant, radical scavenging, cardioprotective and antiviral actions are assumed to be produced by the various varieties of medicinal mushrooms..

Reishi · 2022 · Review · Applied microbiology and biotechnology

Ganoderma immunomodulatory proteins: mushrooming functional FIPs.

Fungal immunomodulatory protein (FIP) is a novel functional protein family with specific immunomodulatory activity identified from several macro-fungi. A variety of biological activities of FIPs have been reported, such as anti-allergy, anti-tumor, mitogenic activity, and immunomodulation..

OncologyImmune supportEnergy & fatigue

Almond Mushroom · 2022 · Preprint · journal metadata

Quantification of spatial and phenotypic heterogeneity in an agent-based model of tumour-macrophage interactions

We introduce a new spatial statistic, the weighted pair correlation function (wPCF). The wPCF extends the existing pair correlation function (PCF) to describe spatial relationships between points marked with combinations of discrete and continuous labels..

OncologyImmune supportSkin & hydration

Wood Ear · 2022 · Review · Frontiers in microbiology

Research progress of Auricularia heimuer on cultivation physiology and molecular biology.

Auricularia heimuer (A. heimuer F.

Reishi · 2022 · Review · Nutrition and cancer

The Potential of Plant-Derived Extracts and Compounds to Augment Anticancer Effects of Chemotherapeutic Drugs.

Plant extracts comprise a complex mixture of natural compounds with diverse biological activities including anticancer activities. This has made the use of plant extracts a trending strategy in cancer treatment..

Oyster Mushroom · 2021 · Review · Toxins

Ageritin from Pioppino Mushroom: The Prototype of Ribotoxin-Like Proteins, a Novel Family of Specific Ribonucleases in Edible Mushrooms.

Ageritin is a specific ribonuclease, extracted from the edible mushroom Cyclocybe aegerita (synonym Agrocybe aegerita), which cleaves a single phosphodiester bond located within the universally conserved alpha-sarcin loop (SRL) of 23-28S rRNAs..

Almond Mushroom · 2021 · Preprint · journal metadata

Comparison of three treatment methods for simple bone cyst in children

Background: The unicameral bone cyst (UBC) is a kind of benign tumor whose clinical treatments and efficacy are controversial. The purpose of this study was to evaluate the efficacy of the elastic stable intramedullary nail (ESIN), the injection of autologous bone marrow (ABM), and the combination of ESIN and ABM in….