MycoData

King Oyster · 2020 · Research Article · Animals: an open access journal from MDPI

Evaluation of Waste Mushroom Compost as a Feed Supplement and Its Effects on the Fat Metabolism and Antioxidant Capacity of Broilers.

Pennisetum purpureum Schum No. 2 waste mushroom compost (PWMC) is the main byproduct when cultivating Pleurotus eryngii.

OncologyImmune supportMetabolic healthGut & microbiome

King Oyster · 2020 · Research Article · Molecules (Basel, Switzerland)

Genoprotective Properties and Metabolites of β-Glucan-Rich Edible Mushrooms Following Their In Vitro Fermentation by Human Faecal Microbiota.

A variety of bioactive compounds, constituents of edible mushrooms, in particular β-glucans, i.e., a group of β-d-glucose polysaccharides abundant in the fungal cell walls, have been linked to immunomodulating, anticancer and prebiotic activities..

King Oyster · 2019 · Journal Article · International journal of biological macromolecules

Analyses of active antioxidant polysaccharides from four edible mushrooms.

Four water-soluble polysaccharides were extracted from Pleurotus eryngii, Flammulina velutipes, Pleurotus ostreatus and white Hypsizygus marmoreus. Using anion exchange and gel permeation chromatography, a neutral and an acidic fraction were purified from each water-soluble polysaccharide..

King Oyster · 2018 · Research Article · Mycology

Comparative study of genome-wide plant biomass-degrading CAZymes in white rot, brown rot and soft rot fungi.

We have conducted a genome-level comparative study of basidiomycetes wood-rotting fungi (white, brown and soft rot) to understand the total plant biomass (lignin, cellulose, hemicellulose and pectin) -degrading abilities..

Metabolic healthGut & microbiomeLiver supportSkin & hydration

Shiitake · 2018 · Journal Article · Food & function

Effect of traditional and modern culinary processing, bioaccessibility, biosafety and bioavailability of eritadenine, a hypocholesterolemic compound from edible mushrooms.

Eritadenine is a hypocholesterolemic compound that is found in several mushroom species such as Lentinula edodes, Marasmius oreades, and Amanita caesarea (1.4, 0.7 and 0.6 mg per g dry weight, respectively)..

Shiitake · 2017 · Journal Article · Journal of natural medicines

Antiosteoporotic activity of a syringic acid diet in ovariectomized mice.

In recent years, the number of patients with osteoporosis has risen with the increase in average longevity. Therefore, the chemoprevention of osteoporosis using food materials or food components has become an increasingly important target..

King Oyster · 2012 · Review · Applied microbiology and biotechnology

Fungal aryl-alcohol oxidase: a peroxide-producing flavoenzyme involved in lignin degradation.

Aryl-alcohol oxidase (AAO) is an extracellular flavoprotein providing the H(2)O(2) required by ligninolytic peroxidases for fungal degradation of lignin, the key step for carbon recycling in land ecosystems..

Immune supportMetabolic healthGut & microbiomeLiver support

Shiitake · 2026 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Active Hexose Correlated Compound Modulates Gut Microbiota and Improves Intestinal Barrier Function in a High-Fat Diet-Induced NAFLD in Rats.

Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, correlating with increased obesity and metabolic disorders. Gut microbiota dysbiosis and impaired intestinal barrier integrity are key factors in NAFLD pathogenesis..

Oyster Mushroom · 2025 · Comparative Study · New biotechnology

Comparative transcriptomics of CAZy enzymes in white- and brown-rot agaricomycetes: Evolutionary insights into lignocellulose degradation and the relevance of GH16 glycoside hydrolase functional divergence.

White-rot and brown-rot fungi (WRF and BRF, respectively) decompose lignocellulose, the main structural component of plant biomass, through distinct mechanisms. This study examines the transcriptomic responses of three WRF species (Pleurotus ostreatus, Phanerochaete chrysosporium, and Heterobasidion irregulare) and….

Immune supportMetabolic healthRespiratory

Oyster Mushroom · 2025 · Brief Report · Current therapeutic research, clinical and experimental

Effect of a Pleuran-Based Supplement on Salivary IgA Secretion in Children With Recurrent Respiratory Infections.

BACKGROUND: ß-glucans isolated from natural sources have demonstrated pluripotent immunomodulatory potential, making them a promising supportive treatment for the management of recurrent respiratory infections (RRIs) in children..

Cognition & nervesMetabolic health

Lion's Mane · 2024 · Research Support, Non U.S. Gov'T · CNS neuroscience & therapeutics

Exploring the Synergistic Effects of Erinacines on Microglial Regulation and Alzheimer's Pathology Under Metabolic Stress.

BACKGROUND: Hericium erinaceus mycelium and its constituents, erinacines A and S, have shown neuroprotective effects in APP/PS1 transgenic mice; however, the precise mechanisms by which they modulate microglial phenotypes remain unclear..

Oyster Mushroom · 2023 · Journal Article · Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

Assessing three industrially produced fungi for the bioremediation of diclofenac.

Diclofenac is an emerging pollutant: toxic, persistent, and bioaccumulative, present in several environmental niches in a concentration of parts per million. This pharmaceutical's biological removal was reported with various fungal species, showing promissory results..

OncologyImmune supportEnergy & fatigueMetabolic health

Niu-Chang-Chih · 2023 · Journal Article · Archives of toxicology

Coenzyme Q0 defeats NLRP3-mediated inflammation, EMT/metastasis, and Warburg effects by inhibiting HIF-1α expression in human triple-negative breast cancer cells.

Coenzyme Q0 (CoQ0) is a derivative quinone from Antrodia camphorata (AC) that exerts anticancer activities. This study examined the anticancer attributes of CoQ0 (0-4 µM) on inhibited anti-EMT/metastasis and NLRP3 inflammasome, and altered Warburg effects via HIF-1α inhibition in triple-negative breast cancer….

Shiitake · 2023 · Journal Article · Heliyon

Combined transcriptomics and metabolomics analysis reveals the molecular mechanism of heat tolerance of Le023M, a mutant in Lentinulaedodes

Lentinula edodes, one of the most highly regarded edible mushrooms in China, is susceptible to damage from high temperatures. However, a mutant strain derived from L.

Shiitake · 2023 · Research Article · Heliyon

Combined transcriptomics and metabolomics analysis reveals the molecular mechanism of heat tolerance of Le023M, a mutant in Lentinulaedodes.

Lentinula edodes, one of the most highly regarded edible mushrooms in China, is susceptible to damage from high temperatures. However, a mutant strain derived from L.

Energy & fatigueMetabolic healthGut & microbiome

Shiitake · 2023 · Journal Article · Food Hydrocolloids

Effects of different sources of β-glucan on pasting, gelation, and digestive properties of pea starch

The effects of Lentinula edodes β-glucan (LG), yeast β-glucan (YG), and oat β-glucan (OG) on pasting, gelation, and digestive properties of pea starch (PeS) were studied. Because of different molecular weights and spatial conformation, β-glucan interacted differently with PeS..

Enoki · 2023 · Research Article · Nutrients

Enokitake Mushroom and Its Active Component, Adenosine, Which Restores Testosterone Production in Impaired and Fatigued Mouse Models.

Several studies have reported the effects of the consumption of various mushroom species on the testes in animal experimental models. Mushrooms, including enokitake mushrooms (Flammulina velutipes), and vegetables contain adenosine may affect testosterone production..

Mesima · 2023 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Hispidin Inhibits Ferroptosis Induced by High Glucose via the miR-15b-5p/GLS2 Axis in Pancreatic Beta Cells.

Type 2 diabetes mellitus (T2DM) is a global health issue that lacks effective treatments. Dysfunction and/or death of pancreatic β-cells (PBCs) are considered a major cause of T2DM.

Lion's Mane · 2023 · Journal Article · International journal of medicinal mushrooms

Hydrophilic Metabolite Composition of Fruiting Bodies and Mycelia of Edible Mushroom Species (Agaricomycetes).

Mushrooms have two components, the fruiting body, which encompasses the stalk and the cap, and the mycelium, which supports the fruiting body underground. The part of the mushroom most commonly consumed is the fruiting body..

Metabolic healthGut & microbiome

Reishi · 2023 · Journal Article · Food science & nutrition

LC/MS analysis of mushrooms provided new insights into dietary management of diabetes mellitus in rats.

Mushrooms possess antihyperglycemic effect on diabetic individuals due to their nonfibrous and fibrous bioactive compounds. This study aimed to reveal the effect of different types of mushrooms on plasma glucose level and gut microbiota composition in diabetic individuals..

Enoki · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Molecular and Functional Analyses of Characterized Sesquiterpene Synthases in Mushroom-Forming Fungi.

Sesquiterpenes are a type of abundant natural product with widespread applications in several industries. They are biosynthesized by sesquiterpene synthases (STSs).

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2023 · Journal Article · Nutrients

Mushroom-Based Supplements in Italy: Let's Open Pandora's Box.

Mushrooms and derivates are well known to the scientific community for having different health benefits and exhibit a wide range of pharmacological activities, including lipid-lowering, antihypertensive, antidiabetic, antimicrobic, antiallergic, anti-inflammatory, anticancer, immunomodulating, neuroprotective and….

Metabolic healthSkin & hydration

Reishi · 2023 · Journal Article · International journal of medicinal mushrooms

Mushroom-Related Ethnomycological, Ethnomedical, and Socio-Economic Practices in Nigeria.

Native mushrooms are valuable non-timber forest products used worldwide, although they are under-exploited in Africa. This study focused on evaluating ethnomycological practices in Nigeria.

OncologyEnergy & fatigueMetabolic healthLiver support

Reishi · 2023 · Journal Article · Frontiers in nutrition

Network pharmacology-based analysis of Resinacein S against non-alcoholic fatty liver disease by modulating lipid metabolism.

BACKGROUND: Ganoderma lucidum is reportedly the best source of traditional natural bioactive constituents. Ganoderma triterpenoids (GTs) have been verified as an alternative adjuvant for treating leukemia, cancer, hepatitis and diabetes..

OncologyEnergy & fatigueMetabolic health

Reishi · 2023 · Journal Article · Antioxidants (Basel, Switzerland)

Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways.

Oxidative stress damage of pancreatic β-cells is a key link in the pathogenesis of type 2 diabetes mellitus. A long-term increase of free fatty acids induces the increase of reactive oxygen species (ROS) in β-cells, leading to apoptosis and dysfunction of β-cells..

Immune supportMetabolic healthGut & microbiomeLiver support

Snow Fungus · 2023 · Research Article · Food science & nutrition

Synergistic mediating effect of edible fungal polysaccharides (Auricularia and Tremellan) and Crataegus flavonoids in hyperlipidemic rats.

Both edible fungal polysaccharides (Auricularia and Tremellan) and Crataegus flavonoids promote the balance of dyslipidemia, which have a positive biological regulating effect on intestinal flora..

OncologyImmune supportMetabolic health

Turkey Tail · 2023 · Research Article · International journal of analytical chemistry

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds.

Secondary metabolites are hidden gems in mushrooms. Understanding these secondary metabolites' biological and pharmacological effects can be aided by identifying them..

Immune supportMetabolic healthGut & microbiomeLiver support

Maitake · 2022 · Research Article · Oxidative medicine and cellular longevity

Ameliorating Effect on Glycolipid Metabolism of Spirulina Functional Formulation Combination from Traditional Chinese Medicine.

Insulin resistance is the major factor involved in the pathogenesis of type 2 diabetes. Although the oral drug metformin (MH) is widely used to reduce hyperglycemia, it is associated with adverse effects..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2022 · Journal Article · Journal of the science of food and agriculture

Association of gut microbiota characteristics and metabolites reveals the regulation mechanisms under cadmium consumption circumstance.

BACKGROUND: Cadmium is a non-biodegradable heavy metal with a long biological half-life. Although its negative impact on human health has been previously reported, the association of cadmium consumption overdose with changes in the gut microbiota and its corresponding metabolites has not been fully elucidated so far..

Niu-Chang-Chih · 2022 · Research Article · Plants (Basel, Switzerland)

Botanical Antcin K Alleviates High-Fat Damage in Palm Acid Oil-Treated Vascular Endothelial Cells and Macrophages.

Lipid metabolism disorder is the most critical risk factor for atherosclerosis, and the process involves lipid deposition in the arterial intima. In Taiwan, antcin K, an active triterpenoid from the fruiting bodies of Antrodia camphorata, has been considered a potential lipid-lowering agent..

Turkey Tail · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

Changes in Chemical Structure of Thermally Modified Spruce Wood Due to Decaying Fungi.

Fungi play a critical role in the decomposition of wood and wood-based products in use. The ability of decaying fungi to cause degradation of polysaccharides and lignin in the thermally modified Norway spruce (Picea abies L..

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2022 · Journal Article · Frontiers in microbiology

Christensenella regulated by Huang-Qi-Ling-Hua-San is a key factor by which to improve type 2 diabetes.

There is a lot of evidence that oral hypoglycemic drugs work by affecting gut microbes, but the key strains responsible for this effect are not well known. Huang-Qi-Ling-Hua-San (HQLHS), composed of Astragalus Membranaceus, Ganoderma lucidum, Inonotus obliquus, and Momordica charantia L., is a specially designed….

OncologyMetabolic healthLiver supportRespiratory

Reishi · 2022 · Journal Article · Plants (Basel, Switzerland)

Cytotoxic Activities and Fingerprint Analysis of Triterpenes by HPTLC Technique for Distinguishing Ganoderma Species from Vietnam and other Asian Countries.

Ganoderma lucidum (Fr.) P. Karst.

Energy & fatigueMetabolic healthGut & microbiome

Shiitake · 2022 · Research Article · Animals: an open access journal from MDPI

Effects of Dietary Incorporation of Grape Stalks Untreated and Fungi-Treated in Growing Rabbits: A Preliminary Study.

This study aimed to evaluate the effect of the incorporation of untreated grape stalks (UGS) and fungi-treated grape stalks (Lentinula edodes, TGS) in rabbits' diets..

Reishi · 2022 · Journal Article · Journal of fungi (Basel, Switzerland)

Effects of Oleic Acid Addition Methods on the Metabolic Flux Distribution of Ganoderic Acids R, S and T's Biosynthesis.

The effects of oleic acid addition methods on the metabolic flux distribution of ganoderic acids R, S and T's biosynthesis from Ganoderma lucidum were investigated..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Lion's Mane · 2022 · Journal Article · Life sciences

Erinacine A attenuates glutamate transporter 1 downregulation and protects against ischemic brain injury.

Maintaining glutamate homeostasis through astrocyte-enriched glutamate transporter 1 (GLT-1) is critical for neuronal survival, but it is often disrupted after brain injury..

OncologyImmune supportMetabolic healthLiver support

Shiitake · 2022 · Research Article · Journal of personalized medicine

Experience with Photodynamic Therapy Using Indocyanine Green Liposomes for Refractory Cancer.

We reported the development of an effective cancer treatment using a multidisciplinary treatment, including photodynamic therapy (PDT) with indocyanine green (ICG) liposomes and a combination of Lentinula edodes mycelia (LEM) and hydrogen gas inhalation therapy..

Immune supportMetabolic healthGut & microbiomeLiver support

Enoki · 2022 · Research Article · Frontiers in microbiology

Flammulina velutipes Polysaccharides Modulate Gut Microbiota and Alleviate Carbon Tetrachloride-Induced Hepatic Oxidative Injury in Mice.

A carbon tetrachloride-induced acute liver injury mouse model is used to study the regulation of gut microbiota and hepatoprotective effect of polysaccharides from Flammulina velutipes (FVPs)..

OncologyImmune supportEnergy & fatigueMetabolic health

Mesima · 2022 · Research Article · Pharmaceutics

Immunomodulatory Effect of Hispolon on LPS-Induced RAW264.7 Cells and Mitogen/Alloantigen-Stimulated Spleen Lymphocytes of Mice.

Hispolon is a potent anticancer, anti-inflammatory, antioxidant, and antidiabetic agent isolated from Phellinus linteus, an oriental medicinal mushroom. However, the immunomodulatory mechanisms by which hispolon affects macrophages and lymphocytes remain poorly characterized..

Energy & fatigueMetabolic healthGut & microbiome

Turkey Tail · 2022 · Research Article · Royal Society open science

In vitro cell composition identification of wood decay fungi by Fourier transform infrared spectroscopy.

Decay pathogens follow dissimilar metabolic mechanisms to cause irreversible damage to woody tissues. The objective of this study is to perform inter- and intra-species microbial cell structural comparison using attenuated total reflectance Fourier transform infrared spectroscopy..

Oyster Mushroom · 2022 · Journal Article · mSphere

Metabolomics Highlights Different Life History Strategies of White and Brown Rot Wood-Degrading Fungi.

White and brown rot fungi efficiently deconstruct lignocellulose in wood, Earth's largest pool of aboveground biotic carbon and an important natural resource. Despite its vital importance, little is known about the metabolomic signatures among fungal species and nutritional modes (rot types)..

Turkey Tail · 2022 · Journal Article · Colloids and surfaces. B, Biointerfaces

Novel laccase from Xylaria polymorpha and its efficiency in the biotransformation of pharmaceuticals: Optimization of operational conditions, comparative effect of redox-mediators and toxicity studies.

The promising potentials of biocatalytic treatment processes in the removal of micropollutants whilst eliminating health and environmental hazards have attracted great attention in recent years..

Turkey Tail · 2022 · Journal Article · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

Production of fungal laccase on pineapple waste and application in detoxification of malachite green.

The main purpose of this work was to use pineapple crowns as substrate for optimizing laccase production by Trametes versicolor in lab-scale experiments. One-factor-at-the-time analysis and response surface methodology were used to optimize production..

Reishi · 2022 · Journal Article · PloS one

Screening of mushrooms from the woodlands of Zimbabwe: Occurrence of lectins and partial purification of a mucin specific lectin from Boletus edulis.

Mushrooms are known to possess a diversity of bioactive compounds that include lectins, which are proteins or glycoproteins that bind specifically to cell surface carbohydrates, culminating in cell agglutination..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2022 · Research Article · Journal of immunology research

Trametenolic Acid Ameliorates the Progression of Diabetic Nephropathy in db/db Mice via Nrf2/HO-1 and NF-κB-Mediated Pathways.

Diabetic nephropathy (DN) is a fatal complication of diabetes and the main cause of end-stage renal disease. Due to the suboptimal effects of current treatments, there is an urgent need to develop new therapeutic strategies for DN..

Metabolic healthGut & microbiome

Oyster Mushroom · 2021 · Journal Article · Biotechnology for biofuels

A comprehensive study of the promoting effect of manganese on white rot fungal treatment for enzymatic hydrolysis of woody and grass lignocellulose.

BACKGROUND: The efficiency of biological systems as an option for pretreating lignocellulosic biomass has to be improved to make the process practical. Fungal treatment with manganese (Mn) addition for improving lignocellulosic biomass fractionation and enzyme accessibility were investigated in this study..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Shiitake · 2021 · Journal Article · Applied microbiology and biotechnology

Antidepressant-like effect of Ganoderma lucidum spore polysaccharide-peptide mediated by upregulation of prefrontal cortex brain-derived neurotrophic factor.

A 28-kDa polysaccharide-peptide (PGL) with antidepressant-like activities was isolated from spores of the mushroom Ganoderma lucidum. It was unadsorbed on DEAE-cellulose.

OncologyEnergy & fatigueMetabolic health

Agarikon · 2021 · Journal Article · International journal of medicinal mushrooms

Effect of Cytokinin-Containing Extracts from Some Medicinal Mushroom Mycelia on HepG2 Cells In Vitro.

Endogenous cytokinins in mycelia of medicinal mushrooms Hericium coralloides and Fomitopsis officinalis grown in vitro were identified using high-performance liquid chromatography coupled with mass spectrometry. High amounts of zeatin-type cytokinins and isopentenyladenine were found..

Oyster Mushroom · 2021 · Journal Article · Environmental science and pollution research international

Element concentration, daily intake of elements, and health risk indices of wild mushrooms collected from Belgrad Forest and Ilgaz Mountain National Park (Turkey).

The aim of this study was to determine the element content of wild edible and inedible mushroom species (Agaricus campestris, Armillaria ostoyae, Boletus reticulatus, Bondarzewia mesenterica, Bovistella utriformis, Cantharellus cibarius, Marasmius oreades, Megacollybia platyphylla, Meripilus giganteus, Neoboletus….