MycoData

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and Palmitoylethanolamide.

Oxidative stress, driven by impaired antioxidant defence systems, is a major contributor to cognitive decline and neurodegenerative processes in brain ageing. This study investigates the neuroprotective effects of a natural compound mixture-composed of Hericium erinaceus, Palmitoylethanolamide, Bilberry extract, and….

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Proteomics and Metabolomics Reveal Regulatory Pathways Underlying Quality Differences Between Wild and Cultivated Ophiocordyceps sinensis.

Ophiocordyceps sinensis, is an entomopathogenic fungus renowned for its medicinal properties, thriving in the frigid and high-altitude regions of the Qinghai-Tibet plateau. Given the limited availability of wild resources and the increasing recognition of their medicinal value, the cultivation of O..

Immune supportCognition & nervesLiver support

Reishi · 2025 · Research Article · Frontiers in pharmacology

Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer's disease.

BACKGROUND/OBJECTIVES: Although Alzheimer's disease (AD) is the most prevalent dementia in late life, with amyloid beta (Aβ) deposition and neuroinflammation are recognized among its primary pathological features. Currently, there is currently still a lack of effective therapeutic drugs for AD.

Maitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Isolation, Identification and Prevention of Bacterial Spot Disease on Grifola frondosa.

Grifola frondosa is a rare fungus valued for its nutritional and medicinal properties; however, its bacterial spot disease has been largely overlooked. Thus, this study systematically investigated, isolated, and identified the pathogen and evaluated control strategies for bacterial spot disease affecting G..

Immune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2025 · Research Article · International journal of molecular sciences

Neuroprotective Terpenoids Derived from Hericium erinaceus Fruiting Bodies: Isolation, Structural Elucidation, and Mechanistic Insights.

Hericium erinaceus, a medicinal macrofungus, is renowned for its potential neuroprotective benefits. Here, we isolated and characterized secondary metabolites from H.

Lion's Mane · 2025 · Research Article · ACS omega

Phytoconstituents of Hericium erinaceus Exert Benefits for ADHD Conditions by Targeting SLC6A4: Extraction, Spectroscopic Characterization, Phytochemical Screening, In Vitro, and Computational Perspectives.

Attention-deficit/hyperactivity disorder (ADHD) is a persistent neurodevelopmental disorder. Despite pharmacological interventions, there is a need for effective lead molecules and therapeutic targets.

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Reishi · 2025 · Journal Article · Metabolic brain disease

Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation.

Oxidative stress and mitochondrial dynamics imbalance are key contributors to AD pathogenesis. GLPS, an extract from Ganoderma lucidum spores, exhibits anti-inflammatory, antioxidant, and immunomodulatory properties..

Immune supportCognition & nervesGut & microbiomeLiver support

Lion's Mane · 2025 · Journal Article · International Journal of Biological Macromolecules

Recent insights into Hericium erinaceus polysaccharides: Gastrointestinal, gut microbiota, microbial metabolites, overall health and structure-function correlation

Hericium erinaceus polysaccharides (HEPs) have attracted significant interest due to their potential to support gastrointestinal health and modulate gut microbiota..

Cognition & nervesGut & microbiome

Lion's Mane · 2025 · Journal Article · Analytical methods: advancing methods and applications

Recognition of the impact of Hericium erinaceus mycelium extract on ethanol-damaged gastric epithelial cells using atomic force microscopy.

Atomic force microscopy (AFM) is used to measure live cells. Changes in the biomechanical properties of a single cell under Hericium erinaceus mycelium extract (Heme) treatment play a critical role in drug efficacy evaluation and drug development, but they remain underexplored..

OncologyImmune supportCognition & nervesMetabolic health

Snow Fungus · 2025 · Journal Article · Journal of food science

Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review

Tremella fuciformis (TF) is a valuable edible fungus rich in various nutrients, with TF polysaccharide (TFP) as its primary bioactive component. Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory‐enhancing, anti‐inflammatory,….

Cognition & nervesEnergy & fatigueSkin & hydration

Shiitake · 2025 · Preprint · journal metadata

Sustainable Memristors from Shiitake Mycelium for High-Frequency Bioelectronics

Neuromorphic computing, inspired by the structure of the brain, offers advantages in parallel processing, memory storage, and energy efficiency. However, current semiconductor-based neuromorphic chips require rare-earth materials and costly fabrication processes, whereas neural organoids need complex bioreactor….

OncologyImmune supportCognition & nerves

Snow Fungus · 2025 · Journal Article · Molecular neurobiology

Tremella fuciformis Polysaccharides Alleviate Early Brain Injury in Experimental Subarachnoid Hemorrhage by Inhibiting the KDR-Mediated P38 MAPK/NF-κB Pathway.

Subarachnoid hemorrhage (SAH) is associated with high mortality and morbidity rates. In its early stages, a substantial influx of blood into the subarachnoid space triggers excessive activation of microglia, which markedly contributes to early brain injury (EBI), a pivotal determinant of poor prognosis..

Chaga · 2025 · Journal Article · Fitoterapia

Triterpenoids from the edible mushroom Inonotus obliquus attenuates cognitive impairment in vitro and in vivo.

Inonotus obliquus is an edible and medicinal mushroom which is used to multiple products. In this study, 8 secondary metabolites (1-8) were identified from the edible mushroom I.

Cognition & nervesEnergy & fatigueSkin & hydration

Lion's Mane · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Two-Dimensional Chromatographic Isolation of High Purity Erinacine A from Hericium erinaceus.

A simple and robust two-dimensional chromatographic fractionation protocol for the isolation of the neuroprotective compound erinacine A from Hericium erinaceus is proposed. This production platform yielded 19.4 mg of erinacine A from approximately 130 g of mushroom material, with a chromatographic purity of 97.4%..

Reishi · 2025 · Research Article · Ultrasonics sonochemistry

Ultrasound-assisted extraction of neuroprotective antioxidants from Ganoderma lucidum.

Ganoderma lucidum (GL), a traditional Chinese medicinal fungus, is rich in triterpenoids and phenols with antioxidant properties. Nevertheless, current extraction techniques limit the efficient utilization of bioactive components from GL..

Lion's Mane · 2025 · Research Article · Journal of natural products

Uncovering Hericenones from the Fruiting Bodies of Hericium erinaceus through Interdisciplinary Collaboration.

Hericium erinaceus is an edible and medicinal mushroom. Previously, we found hericenones C-H from the fruiting bodies and erinacines A-I from the mycelia of the fungus..

Cognition & nervesGut & microbiome

Yellow Morel · 2025 · Journal Article · International journal of medicinal mushrooms

Valorization of Morchella esculenta (Ascomycota) Using a Healthy Extraction Method: Investigation of Bioavailability, Anti-Acetylcholinesterase, and Antioxidant Potentials.

Edible fungi are unexploited natural sources of high added value biomolecules, such as phenolic compounds. This study used an innovative and green extraction method based on the quick, easy, new, cheap, reproducible (QUENCHER) process of Morchella esculenta..

OncologyCognition & nervesEnergy & fatigueGut & microbiome

Enoki · 2024 · Journal Article · Food & function

A novel neuroprotective peptide YVYAETY identified and screened from Flammulina velutipes protein hydrolysates attenuates scopolamine-induced cognitive impairment in mice.

Flammulina velutipes protein hydrolysates are known for their abundant amino acids and excellent developmental values. This study aimed to identify and screen neuroprotective peptides from F..

Lion's Mane · 2024 · Research Article · Foods (Basel, Switzerland)

Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis.

Mushrooms are one of the indispensable elements of human diets. Edible mushrooms stand out with their aroma and nutritional properties.

Lion's Mane · 2024 · Research Article · Molecules (Basel, Switzerland)

Discovery of a New Compound, Erinacerin W, from the Mycelia of Hericium erinaceus, with Immunomodulatory and Neuroprotective Effects.

One new compound with an isoindolinone skeleton, along with erinacines A, C, and S, was isolated from the mycelia of Hericium erinaceus, an edible fungus with a long history of use in traditional Chinese medicine..

Cognition & nervesMetabolic health

Oyster Mushroom · 2024 · Research Article · International journal of food science

Effect of Culture Media on the Yield and Protein Content of Pleurotus ostreatus (Jacq.) Kumm Mycelia.

The development of alternative proteins derived from fungi-based sources is gaining recognition due to their health benefits and lower environmental impact, compared to traditional animal-based sources..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Enoki · 2024 · Journal Article · International journal of food science & technology

Effect of extraction and purification on the structure and activity of Flammulina velutipes polysaccharides: a review

Flammulina velutipes (F. velutipes) is one of the most widely consumed edible mushrooms worldwide.

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Chaga · 2024 · Research Article · Frontiers in pharmacology

Effects of Inonotus obliquus on ameliorating podocyte injury in ORG mice through TNF pathway and prediction of active compounds.

BACKGROUND: Podocyte injury is a common pathologic mechanism in diabetic kidney disease (DKD) and obesity-related glomerulopathy (ORG). Our previous study confirmed that Inonotus obliquus (IO) improved podocyte injury on DKD rats..

Cognition & nervesEnergy & fatigue

Reishi · 2024 · Journal Article · Phytochemical analysis: PCA

Efficient and fast screening and separation based on computer-aided screening and complex chromatography methods for lipoxygenase inhibitors from Ganoderma lucidum.

INTRODUCTION: Accurate screening and targeted preparative isolation of active substances from natural medicines have long been technical challenges in natural medicine research..

Lion's Mane · 2024 · Research Article · Antioxidants (Basel, Switzerland)

Erinacine A-Enriched Hericium erinaceus Mycelium Ethanol Extract Lessens Cellular Damage in Cell and Drosophila Models of Spinocerebellar Ataxia Type 3 by Improvement of Nrf2 Activation.

Spinocerebellar ataxia type 3 (SCA3), caused by the abnormal expansion of polyglutamine (polyQ) in the ataxin-3 protein, is one of the inherited polyQ neurodegenerative diseases that share similar genetic and molecular features..

Lion's Mane · 2024 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Erinacine S, a small active component derived from Hericium erinaceus, protects oligodendrocytes and alleviates mood abnormalities in cuprizone-exposed rodents.

Hericium erinaceus mycelium extract (HEM), containing erinacine A (HeA) and erinacine S (HeS), has shown promise in promoting the differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs), crucial for myelin production in the central nervous system (CNS)..

Cognition & nervesGut & microbiome

Reishi · 2024 · Journal Article · Fitoterapia

Explore the mechanisms of triterpenoids from Ganoderma lucidum in the protection against Alzheimer's disease via microbiota-gut-brain axis with the aid of network pharmacology.

Ganoderma lucidum (Curtis) P. Karst.(G.

Immune supportCognition & nervesGut & microbiomeLiver support

Reishi · 2024 · Research Article · Journal of animal science

Functional properties of Ganoderma lucidum supplementation in canine nutrition.

Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunostimulatory and anti-inflammatory capacity, which has been hypothesized to be attributed mainly to the recognition of its cell-surface patterns by cells of the immune system present in the gastrointestinal tract, resulting in a….

Turkey Tail · 2024 · Journal Article · Journal of natural products

Fungal Coculture of Herpotrichia sp. and Trametes versicolor Induces Production of Diverse Metabolites with Anti-Parkinson's Neuroprotective Activity.

Co-cultivation of isopod-associated fungi Herpotrichia sp. SF09 and Trametes versicolor SF09A led to the reciprocal induction of thirteen new compounds (1-7 and 9-13) with diverse architectures..

Lion's Mane · 2024 · Journal Article · Journal of Asian natural products research

Hericium VN, an undescribed compound isolated from Hericium erinaceus and its cytotoxic activity on human brain astrocytoma.

Hericium erinaceus is a species of mushroom with high nutritional value that is used mainly as food in tropical countries. Phytochemical study of H.

Immune supportCognition & nervesEnergy & fatigue

Snow Fungus · 2024 · Journal Article · Talanta

Integration of electronic nose, electronic tongue, and colorimeter in combination with chemometrics for monitoring the fermentation process of Tremella fuciformis.

This study proposes an efficient method for monitoring the submerged fermentation process of Tremella fuciformis (T. fuciformis) by integrating electronic nose (e-nose), electronic tongue (e-tongue), and colorimeter sensors using a data fusion strategy..

Lion's Mane · 2024 · Research Article · Foods (Basel, Switzerland)

Isolation and Evaluation of Erinacine A Contents in Mycelia of Hericium erinaceus Strains.

Hericium erinaceus has long been favored for its remarkable nutritional and health-promoting benefits, and erinacine A is the key component responsible for the neuroprotective properties of H. erinaceus.

Lion's Mane · 2024 · Journal Article · Cell biochemistry and biophysics

Neuroprotective Effects of Dehydroepiandrosterone and Hericium erinaceus in Scopolamine-induced Alzheimer's Diseases-like Symptoms in Male Rats.

BACKGROUND: The neuroprotective effects of Dehydroepiandrosterone (DHEA) and Hericium erinaceus (H. erinaceus) mushroom extract against scopolamine-induced Alzheimer's disease-like symptoms in male Wistar rats were investigated.

OncologyImmune supportCognition & nervesMetabolic health

Oyster Mushroom · 2024 · Journal Article · Food Research International

Preparation, structural characterization and neuroprotective effects to against H2O2-induced oxidative damage in PC12 cells of polysaccharides from Pleurotus Ostreatus

Pleurotus ostreatus is one of the most common edible and medicinal fungi in life, and its polysaccharide has been a hot research topic in recent years. In this paper, a new intracellular polysaccharide component named P.

Immune supportCognition & nervesEnergy & fatigue

Reishi · 2024 · Research Article · BMC complementary medicine and therapies

Protective effect of Ganoderma lucidum-fermented crop extracts against hydrogen peroxide- or β-amyloid-induced damage in human neuronal SH-SY5Y cells.

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of stacked β-amyloid peptides in the brain and associated with the generation of oxidative stress. So far, there is no cure for AD or a way to stop its progression..

OncologyImmune supportCognition & nervesLiver support

Chaga · 2024 · Journal Article · International journal of biological macromolecules

Protective effect of Inonotus obliquus polysaccharide on mice infected with Neospora caninum.

The study aimed to explore the protective effects of Inonotus obliquus polysaccharide (IOP) on Neospora caninum (N. caninum) infection.

Reishi · 2024 · Journal Article · Journal of agricultural and food chemistry

Rapid Discovery of Aβ42 Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer's Disease.

An amyloid-β (Aβ) fibril is a vital pathogenic factor of Alzheimer's disease (AD). Aβ fibril disintegrators possess great potential to be developed into novel anti-AD agents..

Cognition & nervesEnergy & fatigueMetabolic health

Cordyceps · 2024 · Research Article · Current research in food science

Rapid discrimination between wild and cultivated Ophiocordyceps sinensis through comparative analysis of label-free SERS technique and mass spectrometry.

Ophiocordyceps sinensis is a genus of ascomycete fungi that has been widely used as a valuable tonic or medicine. However, due to over-exploitation and the destruction of natural ecosystems, the shortage of wild O.

Shiitake · 2024 · Research Article · International journal of molecular sciences

Selenopolysaccharide Isolated from Lentinula edodes Mycelium Affects Human T-Cell Function.

Lentinula edodes polysaccharides are natural immunomodulators. SeLe30, analyzed in this study, is a new mixture of selenium-enriched linear 1,4-α-glucans and 1,3-β- and 1,6-β-glucans isolated from L.

Reishi · 2024 · Journal Article · Carbohydrate polymers

Structural characterization of a galactoglucomannan with anti-neuroinflammatory activity from Ganoderma lucidum

According to traditional Chinese medicine theory, Ganoderma lucidum (G. lucidum) presents certain effects for nourishing nerves and calming the mind.

Reishi · 2024 · Journal Article · Carbohydrate polymers

Structural characterization of a galactoglucomannan with anti-neuroinflammatory activity from Ganoderma lucidum.

According to traditional Chinese medicine theory, Ganoderma lucidum (G. lucidum) presents certain effects for nourishing nerves and calming the mind.

Immune supportCognition & nervesRespiratory

Cordyceps · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

The Anti-Inflammatory Effects and Mechanism of the Submerged Culture of Ophiocordyceps sinensis and Its Possible Active Compounds.

The pharmacological effects of the fruiting body of Ophiocordyceps sinensis (O. sinensis) such as antioxidant, anti-virus, and immunomodulatory activities have already been described, whereas the anti-inflammatory effects and active components of the submerged culture of O..

Lion's Mane · 2024 · Research Article · Antioxidants (Basel, Switzerland)

The Cerebral Protective Effect of Novel Erinacines from Hericium erinaceus Mycelium on In Vivo Mild Traumatic Brain Injury Animal Model and Primary Mixed Glial Cells via Nrf2-Dependent Pathways.

Hericium erinaceus, a consumable mushroom, has shown a potential to enhance the production of neuroprotective bioactive metabolites. Traumatic brain injury (TBI) often leads to cognitive, physical, and psychosocial impairments, resulting in neuroinflammation and the loss of cortical neurons..

Lion's Mane · 2023 · Review · Journal of fungi (Basel, Switzerland)

Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline?

A growing number of studies is focusing on the pharmacology and feasibility of bioactive compounds as a novel valuable approach to target a variety of human diseases related to neurological degeneration..

OncologyImmune supportCognition & nerves

Lion's Mane · 2023 · Review · International journal of molecular sciences

Neurotrophic and Neuroprotective Effects of Hericium erinaceus.

Hericium erinaceus is a valuable mushroom known for its strong bioactive properties. It shows promising potential as an excellent neuroprotective agent, capable of stimulating nerve growth factor release, regulating inflammatory processes, reducing oxidative stress, and safeguarding nerve cells from apoptosis..

OncologyImmune supportCognition & nervesMetabolic health

Snow Fungus · 2023 · Review · Archives of dermatological research

The potential cutaneous benefits of Tremella fuciformis.

Tremella fuciformis, also known as snow mushroom, is an edible mushroom that has historically been popular in herbal and Asian medicine and cuisine. The main polysaccharide ingredients have been extracted and used as treatment in a variety of conditions, demonstrating positive effects in a range of biological….

OncologyImmune supportCognition & nerves

Turkey Tail · 2021 · Review · Acta pharmaceutica (Zagreb, Croatia)

The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges in medicine. Fungi are the most common organisms in the ecosystem and the most interesting in this respect..

Lion's Mane · 2010 · Randomized Controlled Trial · Biomedical research (Tokyo, Japan)

Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake

Hericium erinaceus, a well known edible mushroom, has numerous biological activities. Especially hericenones and erinacines isolated from its fruiting body stimulate nerve growth factor (NGF) synthesis, which expects H.