MycoData

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2018 · Retracted Publication · Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology

Erinacine Facilitates the Opening of the Mitochondrial Permeability Transition Pore Through the Inhibition of the PI3K/ Akt/GSK-3β Signaling Pathway in Human Hepatocellular Carcinoma.

BACKGROUND/AIMS: Erinacine, which is extracted from the medicinal mushroom Hericium erinaceus, is known to play anticancer roles in human cancers. The following study aims to investigate the role of erinacine in the opening of the mitochondrial permeability transition pore (MPTP) in hepatocellular carcinoma (HCC)….

OncologyImmune supportMetabolic health

Mesima · 2018 · Research Support, Non U.S. Gov'T · Anti-cancer agents in medicinal chemistry

Molecular Characterization of Two Polysaccharides from Phellinus vaninii Ljup and their Cytotoxicity to Cancer Cell Lines.

BACKGROUND: Phellinus vaninii, a medicinal basidiomycete fungus, is often confused with Phellinus igniarius and Phellinus linteus. Polysaccharides extract from P.

Turkey Tail · 2017 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Breast Cancer Integrative Oncology Care and Its Costs.

BACKGROUND: Naturopathic oncology in conjunction with conventional treatment is commonly referred to as integrative oncology (IO). Clinics directed by oncology board certified NDs (Fellows of the American Board of Naturopathic Oncology or FABNOs) provide high-quality data for describing IO therapies, their costs and….

OncologySkin & hydration

OncologyEnergy & fatigueSkin & hydration

Niu-Chang-Chih · 2017 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Coenzyme Q0 Enhances Ultraviolet B-Induced Apoptosis in Human Estrogen Receptor-Positive Breast (MCF-7) Cancer Cells.

Coenzyme Q0 (CoQ0; 2,3-dimethoxy-5-methyl-1,4-benzoquinone), a major active constituent of Antrodia camphorata, has been shown to inhibit human triple-negative breast cancer (MDA-MB-231) cells through induction of apoptosis and cell-cycle arrest..

Turkey Tail · 2017 · Dissertation · journal metadata

Fungus-bacteria interactions in decomposing wood: unravelling community effects

Metadata-grounded summary: This dissertation indexes research on Trametes versicolor in 2017. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

Chaga · 2017 · Research Support, Non U.S. Gov'T · Food and environmental virology

Inhibition of Murine Norovirus and Feline Calicivirus by Edible Herbal Extracts.

Human noroviruses (HuNoVs) cause foodborne and waterborne viral gastroenteritis worldwide. Because HuNoV culture systems have not been developed thus far, no available medicines or vaccines preventing infection with HuNoVs exist..

OncologyRespiratory

OncologyImmune supportEnergy & fatigue

Zhu Ling · 2017 · Case Reports · Medicine

The therapeutic effect of modified Huangqi Guizhi Wuwu Tang for multiple myeloma: An 18-year follow-up case report.

RATIONALE: Multiple myeloma (MM) is a hematologic malignancy characterized by proliferation of clonal plasma cells in the bone marrow. The median survival has increased to 6 years in recent years.

OncologyImmune supportCognition & nervesLiver support

Mesima · 2016 · Research Support, Non U.S. Gov'T · Scientific reports

A proteomic analysis of mushroom polysaccharide-treated HepG2 cells.

The anti-tumor properties of fungal polysaccharides have gained significant recognition in Asia and tropical America. In this study, the differential expression of proteins in normal HepG2 cells and those treated with polysaccharides that had been isolated from Phellinus linteus (PL), Ganoderma lucidum (GL) and….

Turkey Tail · 2016 · Research Support, Non U.S. Gov'T · Journal of natural products

Dihydrobenzofuran Neolignanamides: Laccase-Mediated Biomimetic Synthesis and Antiproliferative Activity.

The biomimetic synthesis of a small library of dihydrobenzofuran neolignanamides (the natural trans-grossamide (4) and the related compounds 21-28) has been carried out through an eco-friendly oxidative coupling reaction mediated by Trametes versicolor laccase..

OncologyGut & microbiome

Shiitake · 2015 · Journal Article · Journal of microbiological methods

A high throughput colorimetric assay of β-1,3-D-glucans by Congo red dye.

Mushroom strains contain complex nutritional biomolecules with a wide spectrum of therapeutic and prophylactic properties. Among these compounds, β-d-glucans play an important role in immuno-modulating and anti-tumor activities..

Niu-Chang-Chih · 2015 · Research Article · Molecular and clinical oncology

A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen.

Antroquinonol is isolated from Antrodia camphorata, a camphor tree mushroom, and is a valuable traditional Chinese herbal medicine that exhibits pharmacological activities against several diseases, including cancer..

OncologyRespiratory

OncologyImmune supportRespiratory

Niu-Chang-Chih · 2015 · Research Article · BioMed research international

Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.

The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum..

Yellow Morel · 2015 · Journal Article · South African journal of botany

Pharmacological activities of selected wild mushrooms in South Waziristan (FATA), Pakistan

This study investigates the pharmacological importance of selected wild mushrooms viz., Morchella esculenta (common morel), Calvatia gigantea (Giant puffball) and Astraeus hygrometricus (False earthstar) collected from South Waziristan Agency, Federally Administered Tribal Areas (FATA), Pakistan..

Shiitake · 2015 · Journal Article · Journal of industrial microbiology & biotechnology

Pilot studies on scale-up biocatalysis of 7-β-xylosyl-10-deacetyltaxol and its analogues by an engineered yeast.

Paclitaxel content in yew tree is extremely low, causing a worldwide shortage of this important anticancer drug. Yew tree can also produce abundant 7-β-xylosyl-10-deacetyltaxol that can be bio-converted into 10-deacetyltaxol for semi-synthesis of paclitaxel..

Turkey Tail · 2015 · Journal Article · International journal of medicinal mushrooms

Significant Correlation between TLR2 Agonist Activity and TNF-α Induction in J774.A1 Macrophage Cells by Different Medicinal Mushroom Products.

In the US market, there is a variety of mushroom preparations available, even within the same species of mushroom. Nonetheless, little is known about whether species or the various extraction methods affect biological activity and potency of the immune modulatory activity of mushroom extracts..

Turkey Tail · 2015 · Journal Article · Journal of natural medicines

The TLR2 agonist in polysaccharide-K is a structurally distinct lipid which acts synergistically with the protein-bound β-glucan.

Protein-bound polysaccharide-K (Krestin; PSK) is a hot-water extract of Trametes versicolor with immune stimulatory activity. It has been used for the past 30 years and has demonstrated anti-tumor efficacy in multiple types of cancer..

Niu-Chang-Chih · 2014 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells.

Antroquinonol is the smallest anticancer molecule isolated from Antrodia camphorata thus far. The ubiquinone-like structure of Antroquinonol exhibits a broad spectrum of activity against malignancies in vivo and in vitro.

Chaga · 2014 · Research Article · Molecules (Basel, Switzerland)

CARI III inhibits tumor growth in a melanoma-bearing mouse model through induction of G0/G1 cell cycle arrest.

Mushroom-derived natural products have been used to prevent or treat cancer for millennia. In this study, we evaluated the anticancer effects of CARI (Cell Activation Research Institute) III, which consists of a blend of mushroom mycelia from Phellinus linteus grown on germinated brown rice, Inonotus obliquus grown on….

Chaga · 2014 · Research Article · MethodsX

Conservation of the mycelia of the medicinal mushroom Humphreya coffeata (Berk.) Stey. in sterile distilled water.

Currently, there is a growing interest in obtaining and studying the biologically active compounds from higher basidiomycetes, such as Ganoderma lucidum, Lentinus edodes and Inonotus obliquus[1], but the techniques for safe long-term storage are time-consuming, susceptible to contamination, and do not prevent genetic….

OncologyImmune supportMetabolic health

Turkey Tail · 2013 · Journal Article · International journal of medicinal mushrooms

Polysaccharide production by submerged and solid-state cultures from several medicinal higher Basidiomycetes.

Polysaccharides produced by microorganisms represent an industrially unexploited market. An important number of polysaccharides have been isolated from fungi, especially mushrooms, with many interesting biological functions, such as antitumor, hypoglycemic, and immunostimulating activities..

Turkey Tail · 2013 · Journal Article · Immunobiology

Protein-bound polysaccharide activates dendritic cells and enhances OVA-specific T cell response as vaccine adjuvant.

Protein-bound polysaccharide-K (PSK) is a hot water extract from Trametes versicolor mushroom. It has been used traditionally in Asian countries for its immune stimulating and anti-cancer effects.

Turkey Tail · 2013 · Journal Article · International journal of molecular medicine

Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by the combination of Coriolus versicolor and Ganoderma lucidum.

Medicinal mushrooms have served as the mainstay of treatment for a variety of human illnesses in Asian countries, mostly as supplements by cancer patients. Extracts prepared from Trametes versicolor under the trade name of I'm-Yunity exhibit anti-tumorigenic activities, as supported by inhibition of the proliferation….

Mesima · 2012 · Journal Article · Food research international (Ottawa, Ont.)

Inhibitory effect and mechanism on melanogenesis from fermented herbal composition for medical or food uses

Nowadays, herbal foods of skin-whitening cosmetics are popular with Asian women. To investigate the efficacy of Korean herbs having skin-whitening activity, we screened eight kinds of herbs exhibiting high inhibition activity of mushroom tyrosinase among traditional herbs selected based on the Korean herbal foods….

OncologySkin & hydration

Turkey Tail · 2012 · Journal Article · International journal of oncology

Polysaccharide-K augments docetaxel-induced tumor suppression and antitumor immune response in an immunocompetent murine model of human prostate cancer.

Advanced castration-resistant prostate cancer has high mortality rates and limited treatment options. Novel therapies are needed to better contend with this disease.

OncologyMetabolic healthGut & microbiome

Niu-Chang-Chih · 2012 · Journal Article · Journal of cancer research and therapeutics

The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate.

CONTEXT: The compound 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) has been isolated from several different plant species, including Petroselinum sativum..

OncologyImmune supportGut & microbiome

Maitake · 2011 · Journal Article · Food chemistry

Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents.

We evaluated the effects of seven mushroom extracts (Grifola frondosa, Pholiota nameko, Panellus serotinus, Hypsizygus marmoreus, Pleurotus cornucopiae, Armillaria mellea, and Flammulina velutipes) on cytotoxic activity and cytokine production of lamina propria leukocytes (LPLs) isolated from rat small (S) and large….

Turkey Tail · 2011 · Journal Article · Clinical cancer research: an official journal of the American Association for Cancer Research

TLR2 agonist PSK activates human NK cells and enhances the antitumor effect of HER2-targeted monoclonal antibody therapy.

PURPOSE: The therapeutic effect of trastuzumab monoclonal antibody (mAb) therapy has been shown to be partially dependent on functional natural killer (NK) cells. Novel agents that enhance NK cell function could potentially improve the antitumor effect of trastuzumab..

OncologyImmune supportCognition & nervesGut & microbiome

Mesima · 2010 · Journal Article · Molecular nutrition & food research

Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure?

Mushrooms are known for their immune-modulating and anti-tumour properties. The polysaccharide fraction, mainly beta-glucans, is responsible for the immune-modulating effects.

Turkey Tail · 2010 · Journal Article · Nutrition journal

Immunomodulatory dietary polysaccharides: a systematic review of the literature.

BACKGROUND: A large body of literature suggests that certain polysaccharides affect immune system function. Much of this literature, however, consists of in vitro studies or studies in which polysaccharides were injected.

Maitake · 2009 · Research Article · Clinical and molecular allergy: CMA

An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy.

BACKGROUND: Agaricus blazei Murill (AbM) is an edible Brazilian mushroom that has been used in traditional medicine for a range of diseases. It has been shown to have anti-infection and anti-tumor properties in the mouse, which are due to induction of Th1 responses..

OncologyImmune supportGut & microbiomeRespiratory

Lion's Mane · 2009 · Journal Article · Journal of acupuncture and meridian studies

Antimetastatic and immunomodulating effect of water extracts from various mushrooms.

This experiment was conducted to evaluate inhibitory effects against lung metastasis and promotion of splenocytes by water extracts from various mushrooms including Armillaria mellea, Grifola frondosa, Garnoderma frondosa, Codyceps militaris, Hericium erinaceus, Coriolus versicolor, Agaricus Blazei with Lycium….

OncologyCognition & nerves

Yellow Morel · 2009 · Journal Article · Food chemistry

Isolation and quantitative determination of ergosterol peroxide in various edible mushroom species

Ergosterol peroxide, the steroidal derivative with cytotoxic activity, has been isolated for the first time from the mycelium of edible and medicinal mushroom Hericium erinaceum (lion's mane mushroom) together with erinacine A..

Mesima · 2008 · Research Article · Journal of clinical biochemistry and nutrition

Antioxidative and antimutagenic activities of 70% ethanolic extracts from four fungal mycelia-fermented specialty rices.

The health-promoting potential of 70% ethanolic extracts of 4 rice varieties fermented with Monascus ruber, Phellinus linteus, Cordyceps sinensis and Agaricus blazei was evaluated mainly focusing on their antioxidative and antimutagenic capacities based on the following parameters: phenolic compound and phytic acid….

Chaga · 2008 · Journal Article · Bulletin of experimental biology and medicine

Evaluation of antitumor activity of peptide extracts from medicinal plants on the model of transplanted breast cancer in CBRB-Rb(8.17)1Iem mice.

We studied antitumor effects of peptide extracts from plants on slowly growing mammary adenocarcinoma in CBRB-Rb(8.17)1Iem mice used as a model of breast cancer in humans..

Lion's Mane · 2007 · Journal Article · Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]

[Preparation and biological properties of basidiomycete aqueous extracts and their mycelial compositions].

The basidiomycetes Ganoderma lucidum, Hericium erinaceus, Lentinus edodes and Trametes versicolor were used for preparation of aqueous extracts. A polysaccharide preparation (VPG) was isolated from the G.

OncologyMetabolic healthGut & microbiome

Mesima · 2006 · Research Article · Mycobiology

The Culture Conditions for the Mycelial Growth of Phellinus spp.

Phellinus genus belonged to Hymenochaetaceae of Basidiomycetes and has been well known as one of the most popular medicinal mushrooms due to high antitumor activity. This study was carried out to obtain the basic information for mycelial culture conditions of Phellinus linteus, P.

OncologyImmune supportCognition & nervesGut & microbiome

Agarikon · 2013 · Comparative Study · International journal of medicinal mushrooms

Cytotoxicity of blended versus single medicinal mushroom extracts on human cancer cell lines: contribution of polyphenol and polysaccharide content.

The use of mushrooms contributes to human nutrition by providing low lipid content of lipids and high dietary fiber content, as well as significant content of other biologically active compounds such as polysaccharides, minerals, vitamins, and polyphenolic antioxidants..

OncologyImmune supportGut & microbiome

Chaga · 2010 · Dissertation · journal metadata

The effect of oxidative stress in lymphocytes from patients with inflammatory bowel disease and various cancer states compared with healthy control individuals

Metadata-grounded summary: This dissertation indexes research on Inonotus obliquus in 2010. MycoData maps the paper to oncology, immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Maitake · 2008 · Research Support, Non U.S. Gov'T · Vaccine

Evaluation of widely consumed botanicals as immunological adjuvants.

BACKGROUND: Many widely used botanical medicines are claimed to be immune enhancers. Clear evidence of augmentation of immune responses in vivo is lacking in most cases.

Maitake · 2006 · Patent · journal metadata

Immune system activating formula composed of selected long chain polysaccharides from natural sources

A combination of two, specialized, high molecular weight-long chain fractions isolated from Aloe Vera and Maitake TD to stimulate immune system activity comprise long chain-high molecular weight polysaccharides which activate the body's natural immune response, triggering an increase in the production of macrophages,….

Mesima · 2005 · Patent · journal metadata

AN ELM SANGHWANG MUSHROOM

Metadata-grounded summary: This patent indexes research on Phellinus linteus in 2005. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Mesima · 2005 · Patent · journal metadata

CULTURING METHOD OF SANGHWANG MUSHROOM MYCELIA ADDING SOY BEAN EXTRACT

Mesima · 2005 · Patent · journal metadata

OLIVINE SANGHWANG MUSHROOM

Maitake · 2002 · Comment · Alternative medicine review: a journal of clinical therapeutic

Several apparent errors surfaced on reading the article in the June 2002 issue of Alternative Medicine Review by Kodama et al. entitled "Can maitake MD-fraction aid cancer patients"?

Metadata-grounded summary: This comment indexes research on Grifola frondosa in Alternative medicine review: a journal of clinical therapeutic in 2002. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

OncologyImmune supportGut & microbiomeRespiratory

Maitake · 2000 · Review · Alternative medicine review: a journal of clinical therapeutic

The use of mushroom glucans and proteoglycans in cancer treatment.

Immunoceuticals can be considered as substances having immunotherapeutic efficacy when taken orally. More than 50 mushroom species have yielded potential immunoceuticals that exhibit anticancer activity in vitro or in animal models and of these, six have been investigated in human cancers..

OncologyImmune supportMetabolic health

Maitake · 1996 · Review · Nutrition reviews

Functional properties of edible mushrooms.

Edible mushrooms such as shiitake may have important salutary effects on health or even in treating disease. A mushroom characteristically contains many different bioactive compounds with diverse biological activity, and the content and bioactivity of these compounds depend on how the mushroom is prepared and….

Maitake · 1995 · Comparative Study · Annals of the New York Academy of Sciences

Activity of maitake D-fraction to inhibit carcinogenesis and metastasis.

Metadata-grounded summary: This comparative study indexes research on Grifola frondosa in Annals of the New York Academy of Sciences in 1995. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Enoki · 2005 · Journal Article · Journal of agricultural and food chemistry

The antiproliferative and differentiating effects of human leukemic U937 cells are mediated by cytokines from activated mononuclear cells by dietary mushrooms.

Proliferation of human leukemic U937 cells was remarkably inhibited by conditioned medium (CM) of human peripheral blood mononuclear cells (MNC-CM) stimulated with cold-water extracts (CWE) (10-800 microg/mL of medium) of dietary mushrooms, Hypsizigus mamoreus (HM), Agrocybe aegerita (AA), Flammulina velutipes (FV),….