MycoData

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2023 · Preprint · journal metadata

Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism

Abstract Background Skeletal muscle wasting related to aging or pathological conditions is critically associated with the increased incidence and prevalence of secondary diseases including cardiovascular diseases, metabolic syndromes, and chronic inflammations..

Shiitake · 2022 · Preprint · journal metadata

Combining UV-irradiation and alkaline deacetylation to obtain vitamin D- and chitosan-enriched fractions from shiitake mushrooms (Lentinula edodes)

Shiitake mushrooms ( Lentinula edodes ) contain compounds with hypocholesterolemic and immune-modulatory activities such as ergosterol and chitin that can be partially transformed into vitamin D and chitosan to yield extracts with enhanced bioactivities..

Lion's Mane · 2022 · Preprint · journal metadata

Effects of Polysaccharide from Hericium Erinaceus on Diarrhea Rats Induced by Lincomycin Hydrochloride: A Potential Treatment for Gut Microbiota Dysbiosis

Abstract In China, the fungus Hericium erinaceus is known as a healthy food crop which possesses digestive tract protection functionality. This research was focus on the effects of polysaccharides extracted from Hericium erinaceus (WHP) on rats with diarrhea induced by antibiotic, specifically on the shifts of gut….

Energy & fatigueMetabolic healthLiver support

Shiitake · 2022 · Preprint · journal metadata

Effects of supplementation with Shiitake powder, Lentinula edodes, on anti-oxidative activities and energy/ lipid metabolism in healthy dogs

Abstract Obesity is the number one health problem pets face. Effective food and supplement should be developed to improve anti-oxidative activities and energy /lipid metabolism in obese animals..

OncologyImmune supportEnergy & fatigueMetabolic health

Oyster Mushroom · 2021 · Preprint · journal metadata

In-silico Study Of Oyster Mushroom (Pleurotus Ostreatus ) Targeting PARP Protein (4UND)

Oyster mushroom( Pleurotus ostreatus) is belong to the group of healthy foods, as they contain high levels of proteins, vitamins and different classes of compounds, it is discovered that oyster mushrooms could play a key role in maintaining good health..

OncologyEnergy & fatigueMetabolic health

Cordyceps · 2021 · Preprint · journal metadata

Transcriptome Analysis of Ophiocordyceps Sinensis Under Low-Temperature Treatment

Abstract This study aims to investigate the effect of low temperature on the gene expression in Ophiocordyceps Sinensis. To set up the experiments, two groups of Ophiocordyceps Sinensis were grown at 4°C and 18°C, respectively, for 60 days..

Metabolic healthGut & microbiomeLiver support

Cordyceps · 2026 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Biotransformation-derived metabolites from Astragalus membranaceus and Cordyceps militaris alleviate hyperuricemia via multi-target regulation.

Hyperuricemia is a common metabolic disorder, and current pharmacological treatments are often associated with adverse effects. This study evaluated the anti-hyperuricemic activity of an ethanol extract obtained from bidirectional solid-state fermentation of Astragalus membranaceus and Cordyceps militaris (AMC-BFE) in….

Chaga · 2025 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Mechanism studies on α-glucosidase inhibition and glycemic regulation of inotodiol from Inonotus obliquus.

Inonotus obliquus is a medicinal fungus that has been valued for its anti-diabetic properties in China for thousands of years. Inotodiol is a characteristic triterpenoid isolated from Inonotus obliquus..

Energy & fatigueMetabolic healthRespiratory

Cordyceps · 2025 · Data Paper · Data in brief

Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissues.

Ophiocordyceps sinensis is a medicinal mushroom that has been traditionally used for promoting respiratory health and addressing diverse therapeutic needs. The data in this article provides insights into the metabolic profile of the cultivated fruiting body of Ophiocordyceps sinensis (xOs™) across different molecular….

Immune supportMetabolic healthGut & microbiomeRespiratory

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Frontiers in immunology

Cordyceps militaris solid medium extract alleviates lipopolysaccharide-induced acute lung injury via regulating gut microbiota and metabolism.

Acute lung injury (ALI) is a common respiratory disease, Cordycepin has been reported to reduce ALI, which is an effective component in Cordyceps militaris solid medium extract (CMME). Therefore, we aimed to explore the alleviating effect and mechanism of CMME on ALI..

Oyster Mushroom · 2024 · Research Support, Non U.S. Gov'T · Microbial biotechnology

Genome-wide analysis of bZIP gene family members in Pleurotus ostreatus, and potential roles of PobZIP3 in development and the heat stress response.

The basic leucine zipper (bZIP) transcription factor (TF) is widespread among eukaryotes and serves different roles in fungal processes including nutrient utilization, growth, stress responses and development..

King Oyster · 2024 · Research Support, Non U.S. Gov'T · Journal of proteomics

Label-free comparative proteomic analysis of Pleurotus eryngii grown on sawdust, bagasse, and peanut shell substrates.

The white rot fungi Pleurotus eryngii are environmental microorganisms that can effectively break down lignocellulosic biomass. However, understanding of the mechanisms by which P.

Cognition & nervesMetabolic health

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

Neurotransmitter acetylcholine mediates the mummification of Ophiocordyceps sinensis-infected Thitarodes xiaojinensis larvae.

Parasites can manipulate host behavior to facilitate parasite transmission. One such host-pathogen interaction occurs between the fungus Ophiocordyceps sinensis and the ghost moth Thitarodes xiaojinensis.

OncologyImmune supportMetabolic healthGut & microbiome

Shiitake · 2024 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Simulated human digestion and fermentation of a high-molecular weight polysaccharide from Lentinula edodes mushroom and protective effects on intestinal barrier.

Lentinula edodes (Shiitake) is an important edible mushroom and polysaccharides are its major constituents with proven health benefits. The study was to investigate the gut bacterial fermentation and subsequent effects on gut barrier function of a glucan-rich polysaccharide, LePS40 precipitated from the mushroom water….

Reishi · 2024 · Research Support, Non U.S. Gov'T · Scientific reports

The impact of continuous cultivation of Ganoderma lucidum on soil nutrients, enzyme activity, and fruiting body metabolites.

To explore the impacts of continuous Ganoderma lucidum cultivation on soil physicochemical factors, soil enzyme activity, and the metabolome of Ganoderma lucidum fruiting bodies, this study conducted two consecutive years of cultivation on the same plot of land..

Reishi · 2023 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

A 26-week repeated dose toxicity evaluation of sporoderm-removed Ganoderma lucidum spores in rats.

Ganoderma lucidum spore powder is a traditional Chinese medicine with a variety of health benefits. Sporoderm-removed Ganoderma lucidum spores (RGLS) can be more effectively absorbed and utilized by the body..

Energy & fatigueMetabolic healthSkin & hydration

Reishi · 2023 · Journal Article · Journal of ethnopharmacology

A proteoglycan isolated from Ganoderma lucidum attenuates diabetic kidney disease by inhibiting oxidative stress-induced renal fibrosis both in vitro and in vivo.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum) was regarded as "miraculous herb" by the Chinese and recorded detailly in the "Shen Nong Ben Cao Jing" as a tonic to improve health and prolong life..

Energy & fatigueMetabolic healthSkin & hydration

Oyster Mushroom · 2023 · Journal Article · Food research international (Ottawa, Ont.)

Activation of mycelial defense mechanisms in the oyster mushroom Pleurotus ostreatus induced by Tyrophagus putrescentiae

Fungal chemicals are vital in processes recognizing damage- and microbe-associated molecules (DAMPs/MAMPs) that trigger defense responses in fungi. Pleurotus ostreatus is a widely cultivated edible fungus that is prone to attack from fungivorous insects and mites.

OncologyImmune supportMetabolic healthGut & microbiome

Almond Mushroom · 2023 · Research Article · Nutrients

Agaricus blazei Polysaccharide Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier and Remodeling Metabolism.

Ulcerative colitis (UC) is a chronic noninfectious intestinal disease that severely affects patients' quality of life. Agaricus blazei Murrill polysaccharide (ABP) is an effective active ingredient extracted from Agaricus blazei Murrill (ABM)..

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2023 · Research Article · Molecules (Basel, Switzerland)

Antioxidative Activities of Micronized Solid-State Cultivated Hericium erinaceus Rich in Erinacine A against MPTP-Induced Damages.

The Lion's mane mushroom (Hericium erinaceus, HE) is a traditional medical mushroom with high nutritional and economic value. HE possesses anticancer, antimicrobial, antioxidant, immunomodulating, neurotrophic, and neuroprotective activities..

Oyster Mushroom · 2023 · Research Article · Frontiers in nutrition

Assessing the nutritional quality of Pleurotus ostreatus (oyster mushroom).

There is a huge gap between food production and the exploding population demands in various parts of the world, especially developing countries. This increases the chances of malnutrition, leading to increased disease incidence and the need for functional foods to reduce mortality..

OncologyMetabolic healthLiver supportSkin & hydration

Cordyceps · 2023 · Research Article · Pharmaceutics

CD44-Targeted Lipid Polymer Hybrid Nanoparticles Enhance Anti-Breast Cancer Effect of Cordyceps militaris Extracts.

This study aimed to improve the anticancer effect of Cordyceps militaris herbal extract (CME) on breast cancer cells with hyaluronic acid (HYA) surface-decorated lipid polymer hybrid nanoparticles (LPNPs) and evaluate the applicability of a synthesized poly(glycerol adipate) (PGA) polymer for LPNP preparation..

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

CM3-SII polysaccharide obtained from Cordyceps militaris ameliorates hyperlipidemia in heterozygous LDLR-deficient hamsters by modulating gut microbiota and NPC1L1 and PPARα levels.

Accumulating evidence has demonstrated that polysaccharides derived from edible fungi have lipid-lowering effects in mice. However, the lipid metabolism mechanisms in mice and humans are different..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2023 · Research Article · Chinese medicine

Cordycepin from Cordyceps militaris ameliorates diabetic nephropathy via the miR-193b-5p/MCL-1 axis.

BACKGROUND: Diabetic nephropathy (DN) is a chronic kidney disease that develops in patients with diabetes mellitus. Cordycepin (CRD), a secondary metabolite produced by Cordyceps militaris, has a variety of bioactive properties..

Cordyceps · 2023 · Research Article · Frontiers in pharmacology

Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites.

Introduction: Cordyceps militaris, which has many potential medicinal properties, has rarely been reported to alleviate type 2 diabetes mellitus (T2DM). Methods: The effects of C..

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

Cordyceps militaris polysaccharide alleviates diabetic symptoms by regulating gut microbiota against TLR4/NF-κB pathway.

The relationship between gut microbiota and type 2 diabetes mellitus (T2DM) has attracted increasing attention. In our work, one purified fraction a (AEPSa) was obtained from Cordyceps militaris polysaccharides, and its hypoglycemic activity and underlying mechanisms were investigated in high-fat diet (HFD)- and….

Cordyceps · 2023 · Journal Article · Journal of the science of food and agriculture

Cordyceps militaris polysaccharides modulate gut microbiota and improve metabolic disorders in mice with diet-induced obesity.

BACKGROUND: Cordyceps militaris is an edible and medicinal fungus, and its polysaccharides are among its main pharmacological components. They can display immunomodulation, anti-oxidation, anti-inflammation, anti-hypolipidemic, and other functions.

Cordyceps · 2023 · Journal Article · Letters in applied microbiology

Development of an animal-free nitrogen source for the liquid surface culture of Cordyceps militaris.

Cordyceps militaris is a medicinal mushroom in Asia in the 21st century, which cordycepin is a significant bioactive compound. This study, investigated the effect of culture conditions and vegetable seed extract powder as a supplementary source of animal-free nitrogen on the production of cordycepin by C..

Metabolic healthGut & microbiome

Oyster Mushroom · 2023 · Research Article · Animals: an open access journal from MDPI

Dietary Oyster Mushroom (Pleurotus ostreatus) Waste Inhibits Experimentally Induced Eimeria tenella Challenge in Japanese Quails Model.

The aim of this study was to investigate the potential of dietary 3% oyster mushroom (Pleurotus ostreatus) waste in enhancing the anticoccidial effects in broilers challenged with Eimeria tenella infection..

Immune supportEnergy & fatigueMetabolic healthLiver support

Mesima · 2023 · Journal Article · Journal of trace elements in medicine and biology: organ of the Society for Minerals and Trace Elements (GMS)

Dietary supplementation with selenium polysaccharide from selenium-enriched Phellinus linteus improves antioxidant capacity, immunity and production performance of laying hens.

BACKGROUND: Selenium (Se) plays a beneficial role in the physiological function of humans and animals. Selenium polysaccharide, improving enzyme activity and regulating immunity, is the extraction from selenium-rich plants or mushrooms..

Cordyceps · 2023 · Research Article · Nutrients

Effect of Cordyceps militaris Powder Prophylactic Supplementation on Intestinal Mucosal Barrier Impairment and Microbiota-Metabolites Axis in DSS-Injured Mice.

Ulcerative colitis (UC) is a chronic and recurrent inflammatory disease with an unknown pathogenesis and increasing incidence. The objective of this study is to investigate the impact of prophylactic treatment with Cordyceps militaris on UC.

Reishi · 2023 · Journal Article · International journal of medicinal mushrooms

Effect of the Lingzi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on Hyperglycemia and Dyslipidemia with Experimental Metabolic Syndrome.

The effect of Ganoderma lucidum hot water extract of submerged cultivated mycelium suspensia on carbohydrate metabolism and lipid profile during fructose-induced metabolic syndrome in rats was studied..

Immune supportEnergy & fatigueMetabolic health

Reishi · 2023 · Research Article · Frontiers in nutrition

Effects of Ganoderma lucidum polysaccharide peptide ameliorating cyclophosphamide-induced immune dysfunctions based on metabolomics analysis.

Ganoderma lucidum polysaccharide peptide (GLPP) is one of the most abundant constituents of Ganoderma lucidum (G. lucidum), with a wide range of functional activities.

Energy & fatigueMetabolic healthLiver support

Reishi · 2023 · Journal Article · Applied microbiology and biotechnology

Effects of glutamate oxaloacetate transaminase on reactive oxygen species in Ganoderma lucidum.

Nitrogen metabolism can regulate mycelial growth and secondary metabolism in Ganoderma lucidum. As an important enzyme in intracellular amino acid metabolism, glutamate oxaloacetate transaminase (GOT) has many physiological functions in animals and plants, but its function in fungi has been less studied..

Shiitake · 2023 · Journal Article · International journal of biological macromolecules

Efficient isolation of immunostimulatory polysaccharides from Lentinula edodes by autoclaving-ultrasonication extraction and fractional precipitation.

A hyphenated process, autoclaving followed by ultrasonication (AU), was evaluated for efficient extraction of polysaccharides (PS) from Lentinula edodes (Shiitake) mushroom. The PS yield (w/w) was 8.44 % from hot-water extraction (HWE), 11.01 % by autoclaving extraction (AE), and 16.3 % by AUE..

OncologyImmune supportEnergy & fatigueMetabolic health

Enoki · 2023 · Journal Article · The Science of the total environment

Flammulina velutipes polysaccharide counteracts cadmium-induced gut injury in mice via modulating gut inflammation, gut microbiota and intestinal barrier.

Cadmium (Cd), as Group I carcinogen, can induce damage to various organs including the gut. It is of great importance to meet the rising demand for effective therapies against Cd-induced damage and investigate the mechanism..

Cordyceps · 2023 · Journal Article · Physical chemistry chemical physics: PCCP

Functional insight into Cordyceps militaris sugar transporters by structure modeling, network analysis and allosteric regulation.

Insights into the structures, functions and dynamics of Cordyceps militaris (C. militaris) sugar transporters are necessary for understanding their versatile metabolic capability for fungal growth.

Cognition & nervesMetabolic health

Reishi · 2023 · Journal Article · Physiology & behavior

Ganoderma lucidum ethanol extract promotes weight loss and improves depressive-like behaviors in male and female Swiss mice.

Metabolic and mood-related disturbances can increase the risks of developing adverse mental health problems. The medicinal mushroom, Ganoderma lucidum, is utilized in indigenous medicine to improve quality of life, promote health, and boost vitality..

Immune supportEnergy & fatigueMetabolic health

King Oyster · 2023 · Research Article · Frontiers in nutrition

Hypolipidemic mechanism of Pleurotus eryngii polysaccharides in high-fat diet-induced obese mice based on metabolomics.

OBJECTIVE: In this study, the structure of Pleurotus eryngii polysaccharides (PEPs) was characterized, and the mechanism of PEP on obesity and hyperlipidemia induced by high-fat diet was evaluated by metabonomic analysis..

Cordyceps · 2023 · Research Article · Food chemistry: X

Impacts of selenium enrichment on nutritive value and obesity prevention of Cordyceps militaris: A nutritional, secondary metabolite, and network pharmacological analysis.

This study aimed to compare the nutritive value and obesity prevention of ordinary Cordyceps militaris (CM) and selenium-enriched CM (SeCM). The results indicated that Se enrichment significantly increased the total carbohydrate and soluble dietary fiber content, while the protein and insoluble dietary fiber content….

OncologyImmune supportCognition & nervesMetabolic health

King Oyster · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

In Vitro Fermentation of Pleurotus eryngii Mushrooms by Human Fecal Microbiota: Metataxonomic Analysis and Metabolomic Profiling of Fermentation Products.

Edible mushrooms contain biologically active compounds with antioxidant, antimicrobial, immunomodulatory and anticancer properties. The link between their anticancer and immunomodulatory properties with their possible prebiotic activity on gut micro-organisms has been the subject of intense research over the last….

Cordyceps · 2023 · Journal Article · Heliyon

Influence of Cordyceps militaris-fermented grain substrate extracts on alleviating food allergy in mice

Cordyceps militaris is recognized as a tonic in traditional Chinese medicine, and there have been documented findings on the anti-allergic properties of its extract derived from the fruiting body. Due to the limited availability of wild C..

Cordyceps · 2023 · Research Article · Heliyon

Influence of Cordyceps militaris-fermented grain substrate extracts on alleviating food allergy in mice.

BACKGROUND: Cordyceps militaris is recognized as a tonic in traditional Chinese medicine, and there have been documented findings on the anti-allergic properties of its extract derived from the fruiting body. Due to the limited availability of wild C..

Immune supportEnergy & fatigueMetabolic health

Reishi · 2023 · Journal Article · International journal of biological macromolecules

Inhibition of intrarenal PRR-RAS pathway by Ganoderma lucidum polysaccharide peptides in proteinuric nephropathy.

Excessive proteinuria leads to renal dysfunction and damage. Ganoderma lucidum polysaccharide peptide (GL-PP) and Ganoderma lucidum polysaccharide peptide 2 (GL-PP2) are biologically active compounds extracted from Ganoderma lucidum..

Chaga · 2023 · Research Article · BMC genomics

Integrated omic profiling of the medicinal mushroom Inonotus obliquus under submerged conditions.

BACKGROUND: The Inonotus obliquus mushroom, a wondrous fungus boasting edible and medicinal qualities, has been widely used as a folk medicine and shown to have many potential pharmacological secondary metabolites..

King Oyster · 2023 · Journal Article · Carbohydrate polymers

Investigation of the structural and immunomodulatory properties of alkali-soluble β-glucans from Pleurotus eryngii fruiting bodies.

Fungal β-glucans have received a lot of interest due to their proinflammatory activity towards cells of the innate immune system. Although commonly described as (1➔3)-β-glucans with varying degree of (1➔6)-branching, the fungal β-glucans constitute a diverse polysaccharide class..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Shiitake · 2023 · Journal Article · Trends in food science & technology

Lentinan, β-glucan from Shiitake (Lentinula edodes): A review on structure, conformational transition, and gastro-intestinal interaction contributing towards its anti-diabetic potential

Lentinan (LNT), a β-glucan in Shiitake mushroom (Lentinula edodes) has attracted attention for its potent biofunctionalities and immune-boosting properties. Despite comprehensive research into its chemical structure and conformation transitions, the exact mechanism of digestion and absorption remains a subject of….

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2023 · Journal Article · Food & function

Mapping the metabolic characteristics of probiotic-fermented Ganoderma lucidum and its protective mechanism against Cd-induced nephrotoxicity.

An animal model of Cd-induced kidney damage was designed to investigate the nephroprotective potential of the probiotic-fermented Ganoderma lucidum (FGL) via metabonomic analysis. The results showed that FGL enhanced sugar and amino acid metabolism..