MycoData

The optimal conditions for melanin extraction from Auricularia auricula-judae (Hei 29) fruiting bodies was determined on the basis of the extract yield of melanin, calculated by using a single-factor experiment and response surface methodology. Its antioxidant activities were also studied in vitro..

Skin & hydration

High relevance

Cordyceps · 2018 · Research Article · International journal of molecular sciences

Pediococcus pentosaceus-Fermented Cordyceps militaris Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis.

Cordyceps militaris is a medicinal mushroom used to treat immune-related diseases in East Asia. We investigated the anti-inflammatory effect of the extract of C.

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Niu-Chang-Chih · 2017 · Research Article · PloS one

Antimelanogenic, Antioxidant and Antiproliferative Effects of Antrodia camphorata Fruiting Bodies on B16-F0 Melanoma Cells.

Antrodia camphorata is a fungus that is endemic to Taiwan, and its fruiting body has been used as a folk medicine for the prevention or treatment of diverse diseases..

OncologySkin & hydration

High relevance

King Oyster · 2017 · Journal Article · International journal of biological macromolecules

Antioxidant, antitumor and immunostimulatory activities of the polypeptide from Pleurotus eryngii mycelium.

The objective of this study was to investigate the antioxidant, antitumor and immunological activities of the polypeptide from Pleurotus eryngii mycelium (PEMP). The ability of the polypeptide to stimulate Ana-1 macrophages to englobe neutral red, secrete NO, H2O2, TNF-α, and IL-6, increase TLR2 and TLR4 expression….

OncologyImmune supportSkin & hydrationRespiratory

High relevance

Turkey Tail · 2017 · Research Article · Materials (Basel, Switzerland)

Biological Degradation of Chinese Fir with Trametes Versicolor (L.) Lloyd.

Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.) has been an important afforestation species in northeast China. It has obvious defects of buckling and cracking easily, which are caused by its chemical components..

Gut & microbiomeSkin & hydration

High relevance

Cordyceps · 2017 · Research Article · Mycology

Determination and comparative analysis of 13 nucleosides and nucleobases in natural fruiting body of Ophiocordyceps sinensis and its substitutes.

Nucleosides and nucleobases are one of the most important indicators of quality control. A sensitive and reliable high performance liquid chromatography-ultraviolet method was applied to analyse 13 nucleosides and nucleobases simultaneously in 15 batches of nine Ophiocordyceps species and its allies in China..

Energy & fatigueSkin & hydration

High relevance

Cordyceps · 2017 · Research Article · Marine drugs

Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions.

Deep ocean water (DOW) has been shown to enhance the functional components of fungi, resulting in increased health benefits. Therefore, using DOW for culturing fungi can enhance the cordycepin and adenosine of Cordyceps militaris (CM) and its protective effects on the liver..

Immune supportEnergy & fatigueLiver supportSkin & hydration

High relevance

Cordyceps · 2017 · Research Article · Food technology and biotechnology

The Quality Improvement of Solid-State Fermentation with Cordyceps militaris by UVB Irradiation.

Cordyceps militaris, a medicinal and edible mushroom, was used to ferment buckwheat and embryo rice by solid-state fermentation (SSF). Our aim was to investigate the effect of ultraviolet B (UVB) light irradiation on the content of vitamin D2 and biologically effective components, and antioxidant properties of….

Immune supportSkin & hydration

High relevance

Snow Fungus · 2017 · Research Article · Molecular medicine reports

Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1.

Tremella fuciformis polysaccharide (TFPS), which is the extract of Tremella fuciformis Berk, has previously been demonstrated to exhibit potent anti‑oxidative, anti‑inflammatory and anti‑aging effects. However, the mechanisms underlying these protective and therapeutic effects remain to be elucidated..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2016 · Research Article · PloS one

Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice.

Diabetic nephropathy is derived from long-term effects of high blood glucose on kidney function in type 2 diabetic patients. Several antidiabetic drugs and herbal medications have failed to prevent episodes of DN..

Immune supportMetabolic healthSkin & hydration

High relevance

Enoki · 2016 · Journal Article · International journal of medicinal mushrooms

Structural Characterization and Immunological Activities of a Novel Water-Soluble Polysaccharide from the Fruiting Bodies of Culinary-Medicinal Winter Mushroom, Flammulina velutipes (Agaricomycetes).

A water-soluble polysaccharide, designated FVPA2, was isolated from the fruiting bodies of Flammulina velutipes using DEAE Sepharose Fast Flow and gel-permeation chromatography..

Immune supportEnergy & fatigueSkin & hydration

High relevance

Chaga · 2010 · Review · Applied microbiology and biotechnology

Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production.

Inonotus obliquus (Fr.) Pilat is a white rot fungus belonging to the family Hymenochaetaceae in the Basidiomycota. In nature, this fungus rarely forms a fruiting body but usually an irregular shape of sclerotial conk called 'Chaga'.

OncologyImmune supportSkin & hydrationRespiratory

High relevance

Shiitake · 2026 · Evaluation Study · Food chemistry

Intense pulsed light-assisted water extraction of polysaccharides from Lentinula edodes: In vitro structural characterization and verification of antioxidant activities.

Polysaccharides from Lentinula edodes (L. edodes) exhibit antioxidant and immunomodulatory activities, but conventional extraction is limited by low efficiency and potential loss of bioactivity..

Immune supportGut & microbiomeSkin & hydration

High relevance

Chaga · 2025 · Research Support, Non U.S. Gov'T · Bioengineered

Photoregulation of the biosynthetic activity of fungus Inonotus obliquus using colloidal solutions of biogenic metal nanoparticles and low-intensity laser radiation.

This article presents new data on the integrated use of colloidal solutions of nanoparticles and low-intensity laser radiation on the biosynthetic activity of the medicinal mushroom Inonotus obliquus in vitro..

Immune supportSkin & hydration

High relevance

Niu-Chang-Chih · 2024 · Research Support, Non U.S. Gov'T · Cell communication and signaling: CCS

The in vitro and in vivo depigmentation activity of coenzyme Q0, a major quinone derivative from Antrodia camphorata, through autophagy induction in human melanocytes and keratinocytes.

BACKGROUND: Coenzyme Q0 (CoQ0), a novel quinone derivative of Antrodia camphorata, has been utilized as a therapeutic agent (including antioxidant, anti-inflammatory, antiangiogenic, antiatherosclerotic, and anticancer agents); however, its depigmenting efficiency has yet to be studied..

OncologyImmune supportSkin & hydration

High relevance

Turkey Tail · 2024 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Trametes versicolor laccase-derived silver nanoparticles: Green synthesis, structural characterization and multifunctional biological properties.

Isolated enzymes serve as advantageous platforms for the fabrication of nanomaterials. The objective of this study was to fabricate silver nanoparticles (AgNPs) incorporated with Trametes versicolor laccase and evaluate their diverse biological properties..

Energy & fatigueSkin & hydration

High relevance

Shiitake · 2023 · Research Article · Microorganisms

A Comparative Analysis of Biodegradation and Bioconversion of Lentinula edodes and Other Exotic Mushrooms.

Mushrooms are capable of bioconverting organic residues into food. Understanding the relationship between high-quality yields and substrate biomass from these residues is critical for mushroom farms when choosing new strains..

Skin & hydration

High relevance

Reishi · 2023 · Research Article · Foods (Basel, Switzerland)

A Novel Strain Breeding of Ganoderma lucidum UV119 (Agaricomycetes) with High Spores Yield and Strong Resistant Ability to Other Microbes' Invasions.

The spore powder of Ganoderma lucidum (G. lucidum) has been proven to have a variety of pharmacological activities, and it has become a new resource for the development of health products and pharmaceuticals..

Skin & hydration

High relevance

Almond Mushroom · 2023 · Journal Article · International journal of biological macromolecules

Agaricus blazei Murill polysaccharides/alginate/poly(vinyl alcohol) blend as dressings for wound healing.

Macromolecules with antioxidant properties such as polysaccharides from Agaricus blazei Murill mushroom (PAbs) are an excellent option for manufacturing wound dressings..

Immune supportSkin & hydration

High relevance

Reishi · 2023 · Journal Article · International journal of biological macromolecules

An antioxidative, green and safe nanofibers-based film containing pullulan, sodium hyaluronate and Ganoderma lucidum fermentation for enhanced skincare.

Dry masks made of natural active ingredients that are packaged in sustainable paper and free of irritating additives (e.g. preservatives, stabilizers) are a trend in the concept of healthy skincare, which possess the advantages of portability, safety and environmental friendliness..

OncologyGut & microbiomeSkin & hydration

High relevance

Turkey Tail · 2023 · Research Article · Journal of veterinary research

Antioxidant and antimicrobial properties of an extract rich in proteins obtained from Trametes versicolor.

INTRODUCTION: Bioactive proteins and peptides generated from fruit, vegetables, meat or fish have great potential as functional food or substitutes for antibiotics. In recent years it has also been demonstrated that the fungus kingdom could be a source of these compounds..

Skin & hydrationRespiratory

High relevance

Cordyceps · 2023 · Research Article · International journal of molecular sciences

Characterization and Biological Activities of Melanin from the Medicinal Fungi Ophiocordyceps sinensis.

Melanin is a complex natural pigment that is widely present in fungi. The mushroom Ophiocordyceps sinensis has a variety of pharmacological effects.

Energy & fatigueSkin & hydration

High relevance

Reishi · 2023 · Research Article · Life (Basel, Switzerland)

Chemical Characterization and Evaluation of Antimicrobial Properties of the Wild Medicinal Mushroom Ganoderma lucidum Growing in Northern Moroccan Forests.

Ganoderma lucidum is an extensively famous medicinal mushroom distributed worldwide. Despite being widely grown in Moroccan forests, there are no studies on its nutritional, nutraceutical and pharmaceutical values..

Skin & hydration

High relevance

Lion's Mane · 2023 · Research Article · Biology

Cognitive Healthy Aging in Mice: Boosting Memory by an Ergothioneine-Rich Hericium erinaceus Primordium Extract.

Brain aging is a crucial risk factor for several neurodegenerative disorders and dementia. The most affected cognitive function is memory, worsening early during aging..

Immune supportCognition & nervesSkin & hydration

High relevance

Chaga · 2023 · Research Article · Molecules (Basel, Switzerland)

Comparison of Bioactive Secondary Metabolites and Cytotoxicity of Extracts from Inonotus obliquus Isolates from Different Host Species.

Inonotus obliquus, a wood-decaying mushroom, has been used as a health-promoting supplement and nutraceutical for centuries. It is a source of bioactive compounds accumulated in both the conks (pseudosclerotia/sclerotia) and the biomass obtained in vitro..

OncologyLiver supportSkin & hydration

High relevance

Shiitake · 2023 · Research Article · Foods (Basel, Switzerland)

Disentangling the Tissue-Specific Variations of Volatile Flavor Profiles of the Lentinula edodes Fruiting Body.

For Lentinula edodes, its characteristic flavor is the key determinant for consumer preferences. However, the tissue-specific volatile flavor variations of the fruiting body have been overlooked..

Cognition & nervesSkin & hydration

High relevance

Reishi · 2023 · Journal Article · Food & function

Edible and medicinal mushrooms (Pleurotus ostreatus, Ustilago maydis, Ganoderma lucidum) reduce endoplasmic reticulum stress and inflammation in adipose tissue of obese Wistar rats fed with a high fat plus saccharose diet.

Obesity is an increasing global public health problem. A strategy to treat obesity is the use of functional foods.

Immune supportMetabolic healthGut & microbiomeSkin & hydration

High relevance

Enoki · 2023 · Research Article · Antioxidants (Basel, Switzerland)

Effects of UV Stress in Promoting Antioxidant Activities in Fungal Species Тrametes versicolor (L.) Lloyd and Flammulina velutipes (Curtis) Singer.

Trametes versicolor and Flammulina velutipes, after submerged cultivation, with intermittent exposure to ultraviolet light (UV), were studied for Total Phenolic content (TP) and Total Proteins (TPR) contents and antioxidant properties against free radicals..

Skin & hydration

High relevance

Enoki · 2023 · Journal Article · Food chemistry

Flammulina velutipes polysaccharide improves the water-holding capacity in the dorsal muscle of freeze-thawed cultured large yellow croaker (Larimichthys crocea).

To investigate the effect of Flammulina velutipes polysaccharide (FVP) on the water-holding capacity (WHC) in the dorsal muscle of freeze-thawed large yellow croaker, fresh fish were treated with FVP, commercial cryoprotectant (CC), and distilled water before freezing..

Immune supportEnergy & fatigueSkin & hydration

High relevance

Enoki · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

FvbHLH1 Regulates the Accumulation of Phenolic Compounds in the Yellow Cap of Flammulina velutipes.

Flammulina velutipes is a renowned edible and medicinal fungus. Commercially cultivated F.

Skin & hydration

High relevance

Reishi · 2023 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.

BACKGROUND: Ganoderma lucidum polysaccharide (GLP) has many biological properties, however, the anti-fibrosis effect of GLP is unknown at present. PURPOSE: This study aimed to examine the anti-fibrogenic effect of GLP and its underlying molecular mechanisms in vivo and in vitro..

OncologyImmune supportLiver supportSkin & hydration

High relevance

Reishi · 2023 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.

BACKGROUND: Not many drugs with fewer side effects are available for the treatment of rheumatoid arthritis (RA). Ganoderma lucidum polysaccharide peptide (GLPP) has good immunomodulatory effects, but whether it is effective in managing RA is not clear..

OncologyImmune supportLiver supportSkin & hydration

High relevance

Reishi · 2023 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Inhibitory effects of Ganoderma lucidum spore oil on rheumatoid arthritis in a collagen-induced arthritis mouse model.

Holistic healthcare practitioners have now started to focus on specific traditional medicinal mushrooms to treat rheumatoid arthritis (RA). Ganoderma lucidum (GL) is one of the oldest mushrooms that have been used in ancient Chinese medicine to treat inflammatory ailments, including autoimmune diseases such as RA..

OncologyImmune supportSkin & hydration

High relevance

Reishi · 2023 · Journal Article · Phytochemistry

Isolation and characterization of dihydropyran-ring containing meroterpenoids from Ganoderma lucidum and their inhibitory activity against renal fibrosis-related protein expression.

The Ganoderma lucidum mushroom, which has been used as a traditional medicine in China for more than 2000 years, is a source of many interesting natural product. In this study, the five undescribed minor meroterpenoids baoslingzhines F-J (1-5), containing a dihydropyran moiety, were isolated as racemic mixtures from….

Skin & hydration

High relevance

Snow Fungus · 2023 · Research Article · International journal of oncology

Overcharged lipid metabolism in mechanisms of antitumor by Tremella fuciformis‑derived polysaccharide.

Tremella fuciformis‑derived polysaccharide (TFP) is a natural macromolecular compound that is well known for whitening skin, as well as for its ability to regulate lipids and immunity. However, its mechanism of action is not clear..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Snow Fungus · 2023 · Journal Article · Food Hydrocolloids

Phase behavior and complex coacervation of whey protein isolate-Tremella fuciformis polysaccharide solution

Different methods were used to monitor transformations and protein-polysaccharide complexes formation resulting from the interaction of whey protein isolate (WPI) and Tremella fuciformis polysaccharide (TPS) over the pH range of 2.0–7.0..

Immune supportEnergy & fatigueSkin & hydration

High relevance

Oyster Mushroom · 2023 · Journal Article · International journal of biological macromolecules

Physicochemical properties and protective effects on UVA-induced photoaging in Hs68 cells of Pleurotus ostreatus polysaccharides by fractional precipitation.

The development of natural ingredients protecting skin from UVA-induced photoaging is widely expected. The present study investigated the physicochemical properties, antioxidant, moisturizing, collagenase and elastase inhibitory activities, and protective effect on UVA-induced photoaging in Hs68 cells of Pleurotus….

Immune supportSkin & hydration

High relevance

Reishi · 2023 · Journal Article · International journal of biological macromolecules

Significance of culture period on the physiochemistry and anti-cancer potentials of polysaccharides from mycelia of Ganoderma lucidum.

Ganoderma lucidum polysaccharides (GPS) have many functions. Polysaccharides are abundant in G.

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Snow Fungus · 2023 · Journal Article · Photochemical & photobiological sciences: Official journal of the European Photochemistry Association and the European Society for Photobiology

Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2.

INTRODUCTION: Skin is exposed to a wide range of environmental risk factors including ultraviolet (UV) and all kinds of pollutants. Excessive UV exposure contributes to many disorders, such as photoaging, skin inflammation, and carcinogenesis..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Snow Fungus · 2022 · Journal Article · Antonie van Leeuwenhoek

Alternative oxidase is involved in oxidative stress resistance and melanin synthesis in Annulohypoxylon stygium, a companion fungus of Tremella fuciformis.

Annulohypoxylon stygium, a companion fungus of Tremella fuciformis, provides nutrition for growth and development of T. fuciformis.

Skin & hydration

High relevance

Lion's Mane · 2022 · Research Article · Nutrients

Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts.

Nutrition has relevant consequences for human health and increasing pieces of evidence indicate that medicinal mushrooms have several beneficial effects. One of the main issues in Western countries is represented by the challenges of aging and age-related diseases, such as neurodegenerative disorders..

Cognition & nervesSkin & hydration

High relevance

Niu-Chang-Chih · 2022 · Research Article · Frontiers in molecular biosciences

Antrodia camphorata-Derived Antrodin C Inhibits Liver Fibrosis by Blocking TGF-Beta and PDGF Signaling Pathways.

Hepatic stellate cells (HSCs) play an essential role in the development of liver fibrosis. Antrodia camphorata (A.

Energy & fatigueLiver supportSkin & hydration

High relevance

Lion's Mane · 2022 · Journal Article · International journal of medicinal mushrooms

Aqueous Extracts of Pleurotus ostreatus and Hericium erinaceus Protect against Ultraviolet A-Induced Damage in Human Dermal Fibroblasts.

Pleurotus ostreatus (PO) and Hericium erinaceus (HE) have been traditionally used to treat various diseases, owing to their antioxidant, antimicrobial, neuroprotective, and antitumor effects. However, few studies have been reported on their antiaging effects..

OncologyImmune supportCognition & nervesSkin & hydration

High relevance

Enoki · 2022 · Research Article · Frontiers in bioengineering and biotechnology

Biocompatible and antibacterial Flammulina velutipes-based natural hybrid cryogel to treat noncompressible hemorrhages and skin defects.

Hemorrhage, infection, and frequent replacement of dressings bring great clinical challenges to wound healing. In this work, Flammulina velutipes extract (FV) and hydroxyethyl cellulose (HEC) were chemically cross-linked and freeze-dried to obtain novel HFV cryogels (named HFVn, with n = 10, 40, or 70 corresponding to….

Immune supportCognition & nervesLiver supportSkin & hydration

High relevance

Snow Fungus · 2022 · Research Article · Frontiers in nutrition

Chemical profile and antioxidant activity of bidirectional metabolites from Tremella fuciformis and Acanthopanax trifoliatus as assessed using response surface methodology.

This study aimed to establish a bidirectional fermentation system using Tremella fuciformis and Acanthopanax trifoliatus to promote the transformation and utilization of the synthesized antioxidant metabolites from fermentation supernatant..

Immune supportEnergy & fatigueSkin & hydration

High relevance

Oyster Mushroom · 2022 · Journal Article · Journal of food composition and analysis

Effect of the ultrasound-assisted extraction parameters on the determination of ergosterol and vitamin D2 in Agaricus bisporus, A. bisporus Portobello, and Pleurotus ostreatus mushrooms

Ergosterol is an important secondary metabolite precursor of vitamin D₂ in mushrooms and is responsible for various health-promoting effects. The increasing interest in searching and analyzing foods rich in provitamin and vitamin D requires the optimization of a fast and effective extraction method..

Skin & hydration

High relevance

Snow Fungus · 2022 · Journal Article · Food chemistry

Effects of combined drying methods on physicochemical and rheological properties of instant Tremella fuciformis soup.

The textural, rheological and flavor reconstitution behaviors of rehydrated instant Tremella fuciformis soup, treated by combined freeze drying + vacuum drying (FD-VD), freeze drying + far-infrared drying (FD-FIRD) and freeze drying + hot air drying (FD-HAD), were evaluated and compared with fresh soup..

Immune supportSkin & hydration

High relevance

Mesima · 2022 · Research Article · Journal of nanobiotechnology

Exosome-like nanovesicles derived from Phellinus linteus inhibit Mical2 expression through cross-kingdom regulation and inhibit ultraviolet-induced skin aging.

BACKGROUND: Phellinus linteus (PL), which is a typical medicinal fungus, has been shown to have antitumor and anti-inflammatory activities. However, studies on the effect of anti-photoaging are limited..

OncologyImmune supportSkin & hydration

High relevance

Reishi · 2022 · Journal Article · Scientific reports

Ganoderma lucidum aqueous extract inducing PHGPx to inhibite membrane lipid hydroperoxides and regulate oxidative stress based on single-cell animal transcriptome.

In this study, the single-cell eukaryotic model organism Tetrahymena thermophila was used as an experimental material to reveal the anti-aging mechanism of Ganoderma lucidum aqueous extract. After treatment with the G.

Energy & fatigueMetabolic healthSkin & hydration

High relevance

Reishi · 2022 · Journal Article · Acta biochimica Polonica

Ganoderma lucidum polysaccharide inhibits the proliferation of leukemic cells through apoptosis.

OBJECTIVE: To investigate the cytotoxic effect of polysaccharides derived from Ganoderma lucidum on T lymphocyte leukemia cells. METHODS: Water-soluble polysaccharides were extracted from the fruit bodies of G.

OncologyImmune supportSkin & hydration