MycoData

BACKGROUND: The gut microbiota (GM) is recognized as a significant contributor to the immune system. In the present study, the effects of Hericium erinaceus polysaccharides (HEP) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were investigated to elucidate the attenuate of immunosuppression by….

Immune supportMetabolic healthGut & microbiome

High relevance

Lion's Mane · 2023 · Journal Article · Journal of the science of food and agriculture

Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide‐treated mice

BACKGROUND: The gut microbiota (GM) is recognized as a significant contributor to the immune system. In the present study, the effects of Hericium erinaceus polysaccharides (HEP) on immunoregulation and GM in cyclophosphamide (CTX)‐treated mice were investigated to elucidate the attenuate of immunosuppression by….

Immune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2023 · Journal Article · Applied microbiology and biotechnology

Multifactorial interaction of selenium, iron, xylose, and glycine on cordycepin metabolism in Cordyceps militaris.

Cordycepin, a nucleoside analog, is the main antioxidative and antimicrobial substance in Cordyceps militaris. To improve the metabolism of cordycepin, carbon sources, nitrogen sources, trace elements, and precursors were studied by single factor, Plackett-Burman, and central composite designs in C..

Metabolic health

High relevance

Mesima · 2023 · Journal Article · Fitoterapia

Phellinus linteus mycelia extract in COVID-19 prevention and identification of its key metabolic compounds profiling using UPLC-QTOF-MS/MS spectrometry.

For centuries, food, herbal medicines, and natural products have been valuable resources for discovering novel antiviral drugs, uncovering new structure-activity relationships, and developing effective strategies to prevent/treat viral infections..

Energy & fatigueMetabolic healthRespiratory

High relevance

King Oyster · 2023 · Research Article · Foods (Basel, Switzerland)

Pleurotus eryngii Chips-Chemical Characterization and Nutritional Value of an Innovative Healthy Snack.

Nowadays, as the pandemic has reshaped snacking behaviors, and consumers have become more health-conscious, the need for the incorporation of "healthy snacking" in our diets has emerged..

Immune supportMetabolic healthSkin & hydration

High relevance

Cordyceps · 2023 · Journal Article · Biomedical chromatography: BMC

Poly-pathways metabolomics for high-yielding cordycepin of Cordyceps militaris.

Cordycepin is an important quality control marker in Cordyceps militaris. This study aimed to explain the metabolic mechanisms for high-yielding cordycepin of C.

Immune supportMetabolic healthSkin & hydration

High relevance

Snow Fungus · 2023 · Research Article · Ultrasonics sonochemistry

Preparation of low molecular weight polysaccharides from Tremella fuciformis by ultrasonic-assisted H2O2-Vc method: Structural characteristics, in vivo antioxidant activity and stress resistance.

Different methods were used to degrade Tremella fuciformis polysaccharides (TFP) and prepare low molecular weight polysaccharides of Tremella fuciformis (TFLP) to improve their bioavailability..

Immune supportMetabolic health

High relevance

Cordyceps · 2023 · Research Article · Pharmaceuticals (Basel, Switzerland)

Process Optimization for the Bioinspired Synthesis of Gold Nanoparticles Using Cordyceps militaris, Its Characterization, and Assessment of Enhanced Therapeutic Efficacy.

The promising therapeutic implications of nanoparticles have spurred their development for biomedical applications. An eco-friendly methodology synthesizes gold nanoparticles using Cordyceps militaris, an edible mushroom (Cord-Au-NPs), using a quality-by-design approach (central composite design)..

Metabolic health

High relevance

Chaga · 2023 · Research Article · Nutrition research and practice

Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system.

BACKGROUND/OBJECTIVES: Inonotus obliquus has been used as antidiabetic herb around the world, especially in the Russian and Scandinavian countries. Diabetes is widely believed to be a key factor in Alzheimer's disease (AD), which is widely considered to be type III diabetes.

Immune supportCognition & nervesMetabolic health

High relevance

Reishi · 2023 · Research Article · Foods (Basel, Switzerland)

Regulatory Effects of Ganoderma lucidum, Grifola frondosa, and American ginseng Extract Formulation on Gut Microbiota and Fecal Metabolomics in Mice.

The bioactivities of Ganoderma lucidum, Grifola frondosa, and American ginseng have been extensively studied and documented. However, the effects of their complexes on the structural properties of intestinal microbiota and fecal metabolism remain unclear..

Immune supportMetabolic healthGut & microbiome

High relevance

Chaga · 2023 · Research Article · International journal of molecular sciences

Renoprotective Impacts of Inonotus obliquus Ethanol-Ethyl Acetate Extract on Combined Streptozotocin and Unilateral Nephrectomy-Induced Diabetic Nephropathy in Mice.

Diabetes nephropathy (DN) is one of the most common causes of end stage renal disease (ESRD) globally. Medication options to stop or slow the progression of chronic renal disease (CKD) are limited, and patients with DN remain at a high risk of developing renal failure..

Immune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2023 · Research Article · Food chemistry: X

Structural characterization of polysaccharides after fermentation from Ganoderma lucidum and its antioxidant activity in HepG2 cells induced by H2O2.

In this study, Lactiplantibacillus plantarum ATCC14917 was used to ferment Ganoderma lucidum spore powder. Two polysaccharides were purified from unfermented (GLP) and fermented (FGLP) Ganoderma lucidum spore powder.

Immune supportMetabolic health

High relevance

Maitake · 2023 · Research Article · Frontiers in nutrition

Structural properties and anti-inflammatory activity of purified polysaccharides from Hen-of-the-woods mushrooms (Grifola frondosa).

Grifola frondosa is an edible medicinal mushroom that has been proven to have a variety of health benefits. The main active ingredients of this mushroom are polysaccharides.

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2023 · Journal Article · Food & function

The chemical profiling and assessment of antioxidative, antidiabetic and antineurodegenerative potential of Kombucha fermented Camellia sinensis, Coffea arabica and Ganoderma lucidum extracts.

The scientific interest in the medicinal properties of Kombucha beverages, a carbonated drink with live microorganisms, has increased recently. Hence, the aim of this study was to determine the chemical profile and to examine the antioxidant, antidiabetic and antineurodegenerative potential of unfermented and also….

Cognition & nervesMetabolic health

High relevance

Reishi · 2023 · Research Article · Frontiers in pharmacology

The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens.

Ganoderma lucidum (GL), commonly known as "Lingzhi", is a well-known medicinal mushroom with antioxidant and anti-cancer activity. This study examined the effects of a commercial GL product (GLSF) containing the spore and fruiting body in a 30:8 ratio on tobacco smoke carcinogen-induced lung toxicity and….

OncologyImmune supportMetabolic healthRespiratory

High relevance

Cordyceps · 2023 · Research Article · Frontiers in nutrition

Transcriptome and metabolome profiling unveils the mechanisms of naphthalene acetic acid in promoting cordycepin synthesis in Cordyceps militaris.

Cordycepin, an important active substance in Cordyceps militaris, possesses antiviral and other beneficial activities. In addition, it has been reported to effectively promote the comprehensive treatment of COVID-19 and thus has become a research hotspot..

Metabolic healthRespiratory

High relevance

Cordyceps · 2022 · Journal Article · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Mechanism of Cordyceps militaris against non-small cell lung cancer: based on serum metabolomics].

This study investigated the potential mechanism of Cordyceps militaris(CM) against non-small cell lung cancer(NSCLC) based on serum untargeted metabolomics. Specifically, Balb/c nude mice were used to generate the human lung cancer A549 xenograft mouse model..

OncologyMetabolic healthRespiratory

High relevance

King Oyster · 2022 · Research Article · Antioxidants (Basel, Switzerland)

A Randomized Controlled Trial on Pleurotus eryngii Mushrooms with Antioxidant Compounds and Vitamin D2 in Managing Metabolic Disorders.

This study examined the effects of a Pleurotus eryngii mushroom snack on metabolically unhealthy patients. After harvest, mushrooms were baked and subjected to UV-B irradiation to enhance vitamin D2 content.

Immune supportMetabolic health

High relevance

Oyster Mushroom · 2022 · Journal Article · Food research international (Ottawa, Ont.)

Activation of mycelial defense mechanisms in the oyster mushroom Pleurotus ostreatus induced by Tyrophagus putrescentiae.

Fungal chemicals are vital in processes recognizing damage- and microbe-associated molecules (DAMPs/MAMPs) that trigger defense responses in fungi. Pleurotus ostreatus is a widely cultivated edible fungus that is prone to attack from fungivorous insects and mites.

Energy & fatigueMetabolic healthSkin & hydration

High relevance

Reishi · 2022 · Research Article · iScience

Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.

Ganoderma lucidum is a traditional Chinese medicine with a variety of active compounds and possesses adequate lipid-lowering and anti-atherosclerotic effects. However, its main active components and potential mechanisms still remain unclear..

Metabolic healthLiver support

High relevance

Lion's Mane · 2022 · Journal Article · Biological & pharmaceutical bulletin

Ameliorating Effect of the Edible Mushroom Hericium erinaceus on Depressive-Like Behavior in Ovariectomized Rats

Estrogen deficiency during menopause causes a variety of neurological symptoms, including depression. The edible Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers..

OncologyCognition & nervesMetabolic health

High relevance

Maitake · 2022 · Journal Article · Industrial crops and products

Aqueous two-phase simultaneous extraction and purification of a polysaccharide from Grifola frondosa: Process optimization, structural characteristics and antioxidant activity

Traditional method for Grifola frondosa polysaccharide (CGFP) separation is water extraction or other method assistance, ethanol precipitation and further purification via column chromatography..

Immune supportMetabolic health

High relevance

Niu-Chang-Chih · 2022 · Research Article · Frontiers in pharmacology

Clinical Benefits of Golden-Antrodia Camphorata Containing Antroquinonol in Liver Protection and Liver Fat Reduction After Alcoholic Hepatitis.

Objective: It has been reported that antroquinonol extracted from Golden-Antrodia camphorate exerts protective effects on liver function both in vitro and in vivo. However, the protective effects of Golden-Antrodia camphorata on liver function have not been fully investigated in human clinical studies..

Metabolic healthLiver support

High relevance

Cordyceps · 2022 · Research Article · Mycobiology

Cordycepin from Medicinal Fungi Cordyceps militaris Mitigates Inflammaging-Associated Testicular Damage via Regulating NF-κB/MAPKs Signaling in Naturally Aged Rats.

Inflammaging in male reproductive organs covers a wide variety of problems, including sexual dysfunction and infertility. In this study, the beneficial effects of cordycepin (COR), isolated from potential medicinal fungi Cordyceps militaris, in aging-associated testicular inflammation and serum biochemical changes in….

Immune supportMetabolic healthLiver support

High relevance

Cordyceps · 2022 · Research Article · Life (Basel, Switzerland)

Cordyceps militaris Inhibited Angiotensin-Converting Enzyme through Molecular Interaction between Cordycepin and ACE C-Domain.

One of the most important therapeutic modalities for the management of hypertension is the inhibition of the angiotensin-converting enzyme (ACE). Cordyceps militaris has received substantial attention because to its therapeutic potential and biological value..

Metabolic health

High relevance

Wood Ear · 2022 · Research Article · Foods (Basel, Switzerland)

Dietary Supplementation of Auricularia auricula-judae Polysaccharides Alleviate Nutritional Obesity in Mice via Regulating Inflammatory Response and Lipid Metabolism.

The incidence of lipid metabolism disorder and obesity that is caused by high-calorie diets is increasing year by year, which has become an urgent global health problem..

Immune supportEnergy & fatigueMetabolic healthLiver support

High relevance

Oyster Mushroom · 2022 · Research Article · Frontiers in microbiology

Dynamic succession of microbial compost communities and functions during Pleurotus ostreatus mushroom cropping on a short composting substrate.

Cultivating oyster mushrooms (Pleurotus ostreatus), a typical primary decomposer of lignocellulose, on a short composting substrate is a novel procedure which possesses energy conserves, reduced the chance of infection by competitive species, shorter production duration and achieved high production efficiency..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Cordyceps · 2022 · Journal Article · Preparative biochemistry & biotechnology

Effect of Cordyceps militaris on formation of short-chain fatty acids as postbiotic metabolites.

The aim of the current study was to determine the growth-promoting-effect of Cordyceps militaris, known as a medicinal mushroom, on Lactobacillus casei and Lactobacillus acidophilus. To evaluate the best growth-promoting activity of the test substrates including glucose, inulin, and at different concentrations of C..

Metabolic healthGut & microbiome

High relevance

Almond Mushroom · 2022 · Journal Article · Electronic Journal of Biotechnology

Effects of Agaricus blazei acidic polysaccharide on the aging of mice through keap1-Nrf2/ARE and MAPKs signal pathway

In view of the increasing human life and the aging of the population, the search for safe anti-aging drugs has become a hot topic. Agaricus blazei Murrill is a rare edible fungus, with a variety of biological activities..

Immune supportMetabolic healthSkin & hydration

High relevance

Maitake · 2022 · Journal Article · Food & function

Effects of alkaloid-rich extracts obtained from Grifola frondosa on gut microbiota and glucose homeostasis in rats.

Grifola frondosa (GF), also known as maitake (a type of mushroom), has been widely used as a food item and it exhibits various health-beneficial hypoglycemic activities..

Metabolic healthGut & microbiome

High relevance

Cordyceps · 2022 · Research Article · Microbial cell factories

Enhancement of ergothioneine production by discovering and regulating its metabolic pathway in Cordyceps militaris.

BACKGROUND: Cordyceps militaris is a traditional medicinal fungus contains a variety of functional ingredients and has been developed as an important mushroom food recently. Ergothioneine, one of the antioxidative compounds in C..

Metabolic health

High relevance

Cordyceps · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

Enhancing Genome-Scale Model by Integrative Exometabolome and Transcriptome: Unveiling Carbon Assimilation towards Sphingolipid Biosynthetic Capability of Cordyceps militaris.

Cordyceps militaris is an industrially important fungus, which is often used in Asia as traditional medicine. There has been a published genome-scale metabolic model (GSMM) of C..

Metabolic health

High relevance

Cordyceps · 2022 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Enhancing the prebiotic and antioxidant effects of exopolysaccharides derived from Cordyceps militaris by enzyme-digestion

Cordyceps militaris is an edible and potentially medicinal mushroom. It contains various biologically active compounds, including exopolysaccharides.

Immune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

Establishment of an Efficient Polyethylene Glycol (PEG)-Mediated Transformation System in Pleurotus eryngii var. ferulae Using Comprehensive Optimization and Multiple Endogenous Promoters.

Pleurotus eryngii var. ferulae, a fungus of the genus Pleurotus, efficiently degrades lignin, especially during co-cultivation with other fungi.

Metabolic health

High relevance

Shiitake · 2022 · Research Article · Animals: an open access journal from MDPI

Evaluation of Shiitake Mushroom (Lentinula edodes) Supplementation on the Blood Parameters of Young Thoroughbred Racehorses.

The aim of this study was to evaluate the effect of shiitake mushroom (Lentinula edodes) supplementation on the hematology and biochemical blood parameters of young Thoroughbred racehorses. The study was conducted with 20 horses divided into two groups: the supplemented and the control group..

Metabolic health

High relevance

Shiitake · 2022 · Journal Article · Letters in applied microbiology

Evaluation of the biological activities of β-glucan isolated from Lentinula edodes.

Lentinula edodes (shiitake) is an edible mushroom that contains many constituents and β-glucan is considered a major polysaccharide. This study, therefore, aimed to characterize β-glucan and evaluate its activities.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Lion's Mane · 2022 · Research Article · International journal of exercise science

Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition.

Hericium erinaceus (HE), also known as Lion's Mane mushroom, has been found to enhance cognition and metabolic flexibility in various animal models. To date however, only four studies exist in humans and none have evaluated the effects of HE on markers of metabolic flexibility or cognitive performance..

Cognition & nervesEnergy & fatigueMetabolic healthRespiratory

High relevance

Cordyceps · 2022 · Journal Article · Journal of agricultural and food chemistry

Functional Characterization and Structural Basis of the β-1,3-Glucan Synthase CMGLS from Mushroom Cordyceps militaris.

β-1,3-Glucan synthases play key roles in glucan synthesis, cell wall assembly, and growth of fungi. However, their multi-transmembrane domains (over 14 TMHs) and large molecular masses (over 100 kDa) significantly hamper understanding of their catalytic characteristics and mechanisms..

Metabolic health

High relevance

Reishi · 2022 · Research Article · Antioxidants (Basel, Switzerland)

Ganoderma lucidum Modulates Glucose, Lipid Peroxidation and Hepatic Metabolism in Streptozotocin-Induced Diabetic Pregnant Rats.

The consumption of functional foods, such as mushrooms, apparently influences Gestational Diabetes Mellitus (GDM), and brings benefits to maternal-fetal health. Ganoderma lucidum contains a variety of bioactive compounds, such as polysaccharides, proteins and polyphenols that are able to control blood glucose and be….

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2022 · Journal Article · Food & function

Ganoderma lucidum polysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters.

Hyperuricemia (HUA) affects human health and is involved in the pathogenesis of common chronic diseases. Previous studies showed that Ganoderma lucidum extract lowered HUA in animals.

Immune supportMetabolic healthLiver support

High relevance

Maitake · 2022 · Journal Article · Applied biochemistry and biotechnology

Grifola frondosa Polysaccharide Ameliorates Early Diabetic Nephropathy by Suppressing the TLR4/NF-κB Pathway.

Grifola frondosa is a medicinal macro-fungus with a wide range of biological activities. Polysaccharides from Grifola frondosa (PGF) play a positive role in regulating blood glucose and alleviating kidney injury.

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2022 · Journal Article · Food research international (Ottawa, Ont.)

Homologous overexpression of genes in Cordyceps militaris improves the production of polysaccharides

The maximum yield of EPS produced by mutant CM-pgm-H was 4.63 ± 0.23 g/L, whereas the yield of wild-type strain was 3.43 ± 0.26 g/L. In addition, the data obtained in the present study indicated that the yield of EPS produced by the engineered strain treated with the co-overexpression of phosphoglucomutase and….

Immune supportMetabolic health

High relevance

Reishi · 2022 · Journal Article · Cellular and molecular biology (Noisy-le-Grand, France)

Immunomodulatory effect of Ganoderma lucidum polysaccharide extract on peritoneal macrophage function of BALB/c mice.

Ganoderma lucidum has been suggested as a natural immunomodulator. It is not yet clear exactly which combination of this extract is responsible for its immunomodulatory effects..

Immune supportMetabolic health

High relevance

Reishi · 2022 · Journal Article · International journal of medicinal mushrooms

Immunomodulatory Effects of Extract of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Basidiocarps Cultivated on Alternative Substrate.

Ganoderma lucidum is a medicinal mushroom exhibiting numerous health benefits primarily based on strong immunostimulatory effects. The study aimed to investigate if there were differences in effects of extracts of commercially (GC) and alternatively (wheat straw) (GA) cultivated G..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2022 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris.

BACKGROUND: Chronic kidney disease (CKD) is a critical public health issue with a huge financial burden for both patients and society worldwide. Unfortunately, there are currently no efficacious therapies to prevent or delay the progression of end-stage renal disease (ESRD)..

OncologyImmune supportMetabolic healthLiver support

High relevance

Chaga · 2022 · Research Article · Evidence-based complementary and alternative medicine: eCAM

In Vitro Immunomodulatory Effects of Inonotus obliquus Extracts on Resting M0 Macrophages and LPS-Induced M1 Macrophages.

BACKGROUND: Inonotus obliquus (Chaga) is a parasitic fungus that is distributed mainly in northeast China. Our literature research showed chaga polysaccharides have bilateral effects on tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels when they exert antitumor and antidiabetic activities..

OncologyImmune supportMetabolic health

High relevance

Shiitake · 2022 · Journal Article · International journal of medicinal mushrooms

In Vivo Evaluation and Nutritional Quality of By-Products Subjected to Solid-State Fermentation Using Shiitake Culinary-Medicinal Mushroom, Lentinula edodes (Agaricomycetes).

This study evaluates the nutritional quality and in vivo biological activity of a peach palm by-product food ingredient processed via solid-state fermentation by shiitake culinary-medicinal mushroom, Lentinula edodes..

Metabolic healthGut & microbiomeLiver support

High relevance

Cordyceps · 2022 · Journal Article · International journal of biological macromolecules

Isolation and immune activity of a new acidic Cordyceps militaris exopolysaccharide.

A new type of acidic exopolysaccharide (AESP-II) was extracted and separated from the fermentation broth of Cordyceps militaris (C. militaris), which was further purified to elucidate its structural characteristics and immunological activity..

Immune supportMetabolic health

High relevance

King Oyster · 2022 · Research Article · Molecules (Basel, Switzerland)

Isolation, Structural Characterization, and Hypoglycemic Activities In Vitro of Polysaccharides from Pleurotus eryngii.

Pleurotus eryngii (PE) is an edible mushroom with high nutritional value. Pleurotus eryngii polysaccharides (PEPs) are one of the main active ingredients and manifest a great variety of biological activities..

Immune supportMetabolic health

High relevance

Cordyceps · 2022 · Journal Article · Ceska a Slovenska farmacie: casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti

Medicinal mushrooms Ophiocordyceps sinensis and Cordyceps militaris.

The main component of Ophiocordyceps sinensis and Cordyceps militaris extracts are polysaccharides. These are natural biopolymers that represent a large class of biologically active components.

OncologyImmune supportMetabolic health