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Cordyceps militaris has been widely studied for its various pharmacological activities such as antitumor, anti-inﬂammation, and immune regulation. The binding of an allergen to IgE-sensitized mast cells in nasal mucosa triggers allergic rhinitis..

OncologyImmune support

High relevance

King Oyster · 2021 · Journal Article · Food & function

JNK pathway and heat shock response mediate the survival of C26 colon carcinoma bearing mice fed with the mushroom Pleurotus eryngii var. eryngii without affecting tumor growth or cachexia.

In the last few years, there has been emerging interest in developing treatments against human diseases using natural bioactive content. Here, the powder of the edible mushroom Pleurotus eryngii var.

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2021 · Research Article · Nutrients

Lactic Acid Bacteria Fermented Cordyceps militaris (GRC-SC11) Suppresses IgE Mediated Mast Cell Activation and Type I Hypersensitive Allergic Murine Model.

Cordyceps militaris (C. militaris) has various biomedical applications in traditional oriental medicine for different diseases including inflammatory and immune-dysregulated diseases.

OncologyImmune support

High relevance

Cordyceps · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Low Dose of Fluoride in the Culture Medium of Cordyceps militaris Promotes Its Growth and Enhances Bioactives with Antioxidant and Anticancer Properties.

Cordyceps militaris possesses several compounds with medicinal properties, and is commonly used in traditional Chinese functional food and medicine for a variety of health benefits. Because of its rare occurrence in nature, the market demand for artificial C.

Oncology

High relevance

Cordyceps · 2021 · Research Article · Journal of pharmaceutical analysis

Matrix-assisted laser desorption ionization mass spectrometry based quantitative analysis of cordycepin from Cordyceps militaris.

Cordycepin, which has great immunomodulatory activities such as anticancer, antifungal, antivirus, antileukemia and lipid-lowering ones, is the secondary metabolite of Cordyceps militaris (C. militaris).

OncologyImmune supportRespiratory

High relevance

Cordyceps · 2021 · Research Article · Molecules (Basel, Switzerland)

Molecular Cloning, Expression and Macrophage Activation of an Immunoregulatory Protein from Cordyceps militaris.

Protein components of C. militaris have been reported to possess various biological activities.

OncologyImmune support

High relevance

Turkey Tail · 2021 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, inhibits colorectal cancer stem cell growth.

Colorectal cancer is the second deadly cancer in the world. Trametes versicolor is a traditional Chinese medicinal mushroom with a long history of being used to regulate immunity and prevent cancer..

OncologyImmune supportGut & microbiome

High relevance

King Oyster · 2021 · Journal Article · Carbohydrate polymers

Polysaccharides from Pleurotus eryngii: Selective extraction methodologies and their modulatory effects on THP-1 macrophages.

Polysaccharides from P. eryngii mushroom were selectively extracted using low-cost technologies (water at different conditions of temperature and pressure).

OncologyImmune support

High relevance

Cordyceps · 2021 · Research Article · Foods (Basel, Switzerland)

Polysaccharides Obtained from Cordyceps militaris Alleviate Hyperglycemia by Regulating Gut Microbiota in Mice Fed a High-Fat/Sucrose Diet.

Polysaccharides isolated from fungus Cordyceps militaris display multi-biofunctions, such as immunostimulation, down-regulation of hyperlipidemia, and anti-cancer function. The occurrence of obesity and metabolic syndrome is related to the imbalance of gut microbiota.

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Chaga · 2021 · Journal Article · International journal of medicinal mushrooms

Protective Effects of Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Extract on β-Amyloid-Induced Neurotoxicity in PC12 Cells and Aging Rats: In Vitro and In Vivo Studies.

Modulation of β-amyloid (Aβ)-induced neurotoxicity has emerged as a possible therapeutic approach to ameliorate the onset and progression of Alzheimer's disease. The present study aimed to evaluate the protective effect of Inonotus obliquus extracts (IOEs) on Aβ-induced neurotoxicity in cultured rat pheochromocytoma….

OncologyImmune supportCognition & nerves

High relevance

Shiitake · 2021 · Research Article · Molecules (Basel, Switzerland)

Proteome Analysis and In Vitro Antiviral, Anticancer and Antioxidant Capacities of the Aqueous Extracts of Lentinula edodes and Pleurotus ostreatus Edible Mushrooms.

In this study, we examined aqueous extracts of the edible mushrooms Pleurotus ostreatus (oyster mushroom) and Lentinula edodes (shiitake mushroom). Proteome analysis was conducted using LC-Triple TOF-MS and showed the expression of 753 proteins by Pleurotus ostreatus, and 432 proteins by Lentinula edodes..

OncologyRespiratory

High relevance

Almond Mushroom · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Subcritical Water Extracts from Agaricus blazei Murrill's Mycelium Inhibit the Expression of Immune Checkpoint Molecules and Axl Receptor.

Agaricus blazei Murrill or Himematsutake is an edible and medicinal mushroom. Agaricus blazei Murrill's fruiting body extracts have anticancer properties, although the mechanism is unknown..

OncologyImmune supportRespiratory

High relevance

King Oyster · 2021 · Journal Article · Andrologia

The antioxidant and anti-apoptotic potential of Pleurotus eryngii extract and its chitosan-loaded nanoparticles against doxorubicin-induced testicular toxicity in male rats.

This study was conducted to evaluate the protective role of Pleurotus eryngii extract (PE) and Pleurotus eryngii extract-loaded chitosan nanoparticles (PE-CSNP) against doxorubicin (DOX)-induced testicular toxicity in rats..

Oncology

High relevance

Reishi · 2021 · Journal Article · Tissue & cell

The association between testicular toxicity induced by Li2Co3 and protective effect of Ganoderma lucidum: Alteration of Bax & c-Kit genes expression.

Ganoderma lucidum has received a lot of attention recently due to its medicinal potential activities. The aim of this designed experiment was to evaluate the beneficial effects of Ganoderma lucidum extract against lithium carbonate induced testicular toxicity and related lesions in mice testis..

OncologyImmune support

High relevance

Cordyceps · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

The Feasibility of Utilizing Cultured Cordyceps militaris Residues in Cosmetics: Biological Activity Assessment of Their Crude Extracts.

Solid-based residues (SBRs) left from harvesting the fruiting bodies of cultured Cordyceps mushrooms are a challenge to sustainability. Therefore, in this study, the SBRs from the cultivation of Cordyceps militaris (C..

OncologySkin & hydration

High relevance

Maitake · 2021 · Journal Article · Food & function

The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury via the miR-122-Nrf2/ARE pathways.

Polysaccharides can be used as a potential hepatoprotective agent in the treatment of acute liver injury. However, the underlying mechanism governing how polysaccharides protect against acute liver injury induced by lipopolysaccharide/d-galactosamine (LPS/d-GalN) remains unclear..

OncologyImmune supportLiver supportRespiratory

High relevance

Chaga · 2021 · Research Article · Molecules (Basel, Switzerland)

Total Triterpenoid Extraction from Inonotus Obliquus Using Ionic Liquids and Separation of Potential Lactate Dehydrogenase Inhibitors via Ultrafiltration High-Speed Countercurrent Chromatography.

Extracts of the fungus Inonotus obliquus exhibit cytotoxic properties against different cancers; hence, this fungal species has been extensively studied. This study aimed to extract total triterpenoids from Inonotus obliquus using ionic liquids (ILs) and separate potential lactate dehydrogenase (LDH) inhibitors via….

Oncology

High relevance

Yellow Morel · 2021 · Journal Article · Preparative biochemistry & biotechnology

Utilization of Morchella esculenta-mediated green synthesis golden nanoparticles in biomedicine applications.

This study aimed to synthesize gold nanoparticles (AuNPs) by hot water extract in room conditions using edible Morchella esculenta (ME) and investigate the bioactive properties of the synthesized Morchella esculenta-based gold nanoparticles (ME-AuNPs)..

OncologyEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2021 · Research Article · Molecules (Basel, Switzerland)

Virtual Screening for Biomimetic Anti-Cancer Peptides from Cordyceps militaris Putative Pepsinized Peptidome and Validation on Colon Cancer Cell Line.

Colorectal cancer is one of the leading causes of cancer-related death in Thailand and many other countries. The standard practice for curing this cancer is surgery with an adjuvant chemotherapy treatment.

OncologyCognition & nervesGut & microbiome

High relevance

Reishi · 2022 · Journal Article · Molecular biology reports

Investigation of HER-3 gene expression under the influence of carbohydrate biopolymers extract of shiitake and reishi in MCF-7 cell line.

INTRODUCTION: Edible-medicinal fungi are mainly used in Asian countries to prevent various diseases. These mushrooms are also used to treat lung diseases and cancer.

OncologyImmune supportRespiratory

High relevance

Maitake · 2009 · Systematic Review · Journal of the Society for Integrative Oncology

Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration.

The objective of this study was to evaluate the scientific evidence on maitake, including expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. This review serves as a clinical support tool..

OncologyImmune supportMetabolic health

High relevance

Oyster Mushroom · 2026 · Preprint · journal metadata

Integrated in silico pharmacology of Pleurotus ostreatus derived bioactive compounds targeting EGFR using network pharmacology and molecular simulations

Abstract Cancer remains a most important worldwide health burden, demanding the progress of pioneering and mechanism-driven therapeutic strategies. In this study, we employed an consolidative in silico pharmacology approach combination network pharmacology, molecular docking, ADMET profiling, and molecular dynamics….

OncologyLiver supportRespiratory

High relevance

Mesima · 2025 · Preprint · journal metadata

A combination of the extract from Phellinus linteus with Smilax spp. attenuates colorectal and prostate cancers

The current study investigated the effects of Thai remedy herbal extracts from Phellinus linteus (PL) and a combination of P. linteus with Smilax corbularia and S..

OncologyImmune support

High relevance

Cordyceps · 2025 · Published Erratum · Frontiers in pharmacology

Corrigendum: Protective effects of Cordyceps militaris against hepatocyte apoptosis and liver fibrosis induced by high palmitic acid diet.

[This corrects the article DOI: 10.3389/fphar.2024.1438997.]..

OncologyLiver support

High relevance

Reishi · 2025 · Preprint · journal metadata

Evaluation of Bioactive Compounds, Antioxidant Activity, and Anticancer Potential of Wild Ganoderma lucidum Extracts from High-Altitude Regions of Nepal

Wild Ganoderma lucidum from Nepal’s high-altitude regions was studied to identify key bioactive compounds and assess the influence of solvent type—water, ethanol, methanol, and acetone—on extraction efficiency and biological activity..

Oncology

High relevance

Cordyceps · 2025 · Comparative Study · Applied biochemistry and biotechnology

GC-MS Analysis of Polysaccharides from an Intergeneric Hybrid of Pleurotus florida and Cordyceps militaris: A Comparative Study.

Edible and medicinal mushrooms are valuable sources of polysaccharides, known for their dual roles as immunostimulants and immunosuppressants. This study aimed to enhance polysaccharide content by fusing two mushroom species, P.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Shiitake · 2025 · Preprint · journal metadata

Lentinula edodes Cultured Extract Treated Mesenchymal-Derived Extracellular Vesicle Modulated Breast Cancer Stem Cells and Reprogramming of microRNAs

Background: Breast carcinoma represents the most frequent malignancy in women in Canada. The intrinsic or acquired drug resistance significantly contributes to in-creased risk of recurrence and metastasis.

Oncology

High relevance

Yellow Morel · 2025 · Preprint · journal metadata

Morchella esculenta Intensifies Testosterone Production and Spermatogenesis in Male Mice with High-Fat Diet-Induced Obesity by Enhancing Antioxidant Capacity

Obesity has become a major health concern worldwide and is strongly correlated with various comorbidities including reproductive dysfunction. Therefore, this study aimed to explore the ef-fects of Morchella esculenta (ME) in improving reproductive dysfunction caused by high-fat di-et-induced obesity..

OncologyImmune supportLiver support

High relevance

Reishi · 2025 · Preprint · journal metadata

Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid Metabolism

Abstract Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Shiitake · 2025 · Preprint · journal metadata

Oral Lentinula edodes mycelia extract enhances the antitumor effect of radiotherapy via gut-associated activation of dendritic and cytotoxic T cells

Abstract Oral administration of Lentinula edodes mycelia extract (L.E.M.) has been shown to stimulate systemic T cell–mediated antitumor immunity and inhibit tumor growth in mice, suggesting its potential to modulate host immune responses. However, the route of this systemic antitumor effect remains unclear..

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Reishi · 2025 · Preprint · journal metadata

Overexpression of GlATIC gene enhances adenosine production in Ganoderma lucidum

Adenosine recognized for its immunomodulatory, anti-inflammatory, and anti-cancer properties, has limited clinical and commercial applications due to low production levels in Ganoderma lucidum..

OncologyImmune support

High relevance

Shiitake · 2025 · Preprint · journal metadata

Screening of Lentinula edodes Strains for High Polysaccharide Productions and In Vitro Antioxidant Activities

Lentinan is one of the main metabolites of Lentinula edodes, and exhibits numerous biological activities such as anti-tumor and antioxidant. Despite recent advancements, its commercialization remains constrained by a lengthy cultivation cycle, low yield, and high cost..

OncologyImmune supportMetabolic health

High relevance

Reishi · 2025 · Preprint · journal metadata

Study on the anti-tumor effect of Wall-broken Ganoderma lucidum spore powder on papillary thyroid cancer

Abstract Ganoderma lucidum wall-broken spores (BGLSP), traditionally used in Traditional Chinese Medicine for immunity and chronic diseases, contain bioactive triterpenoids with anti-tumor potential, but their mechanisms against papillary thyroid cancer (PTC) remain unclear..

OncologyImmune supportGut & microbiomeSkin & hydration

High relevance

Reishi · 2025 · Preprint · journal metadata

Synergistic Anti-Tumor and Immunomodulatory Effects of Sporoderm-Removed Ganoderma Lucidum Spore Powder and Anti-PD-L1 Antibody in Lung Cancer Mice

Abstract Background The therapeutic efficacy of PD-1/PD-L1 inhibitors in lung cancer management remains suboptimal. Sporoderm-removed Ganoderma Lucidum Spore Powder (RGLS), an immunostimulant, has been shown to amplify the anti-tumor effects of anti-PD-L1 antibodies (αPD-L1)..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Reishi · 2024 · Preprint · journal metadata

Bioactive compounds and nanoparticles in Ganoderma lucidum: New perspectives on health benefits

The unique medicinal properties of Ganoderma lucidum have led to a growing demand for it as an essential source of dietary supplements in the food sector. The wide array of therapeutic and pharmacological effects of G.

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Snow Fungus · 2024 · Preprint · journal metadata

Overcharged lipid metabolism in mechanisms of antitumor by Tremella Fuciformis Polysaccharide

Tremella Fuciformis polysaccharides (TFP) is a natural macromolecular compound well-known for whitening, lipid and immunity regulation. To evaluate the effect of TFP on melanogenesis, lipid metabolism programmes and immune system of B16 cells in vitro and in vivo, the cell proliferation, cell cycle and apoptosis were….

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Snow Fungus · 2024 · Preprint · journal metadata

Tremella fuciformis polysaccharides alleviate early brain injury in experimental subarachnoid hemorrhage by inhibiting the KDR-mediated P38 MAPK/NF-κB pathway

Abstract Background Subarachnoid hemorrhage is associated with high mortality and morbidity rates. In its early stages, the substantial influx of blood into the subarachnoid space triggers excessive activation of microglial cells, which markedly contributes to early brain injury, a pivotal determinant of poor….

OncologyImmune supportCognition & nerves

High relevance

Cordyceps · 2021 · Journal Article · European journal of medicinal chemistry

Large-scale isolation and antitumor mechanism evaluation of compounds from the traditional Chinese medicine Cordyceps Militaris.

We established a large-scale separation and purification platform to obtain kilogram amounts of natural compounds from the extraction of the fruiting bodies of C. militaris..

Oncology

High relevance

Cordyceps · 2020 · Review · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Advances in biosynthesis of cordycepin from Cordyceps militaris].

Cordycepin as the main active ingredient of Cordyceps militaris, a traditional medicinal fungus in China, has many physiological functions such as anti-cancer, anti-tumor and anti-virus activity. The most potential route for effective cordycepin production has been considered as liquid fermentation of C..

OncologyEnergy & fatigueMetabolic healthRespiratory

High relevance

Almond Mushroom · 2020 · Review · Nutrients

Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies.

Since the 1980s, medicinal effects have been documented in scientific studies with the related Basidiomycota mushrooms Agaricus blazei Murill (AbM), Hericium erinaceus (HE) and Grifola frondosa (GF) from Brazilian and Eastern traditional medicine..

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Cordyceps · 2020 · Review · Journal of ethnopharmacology

Can Cordyceps cicadae be used as an alternative to Cordyceps militaris and Cordyceps sinensis? - A review.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps cicadae (Mig.) Massee is one of the oldest and well-known traditional Chinese medicine (TCM), with its uses recorded as far back as the 5th century A.D. For centuries, C..

OncologyMetabolic health

High relevance

King Oyster · 2020 · Review · International journal of biological macromolecules

Extraction, structure and bioactivities of the polysaccharides from Pleurotus eryngii: A review.

Pleurotus eryngii (also known as king trumpet mushroom or king oyster mushroom) is an edible mushroom cultivated widely in many regions of the world. Polysaccharides from P.

OncologyImmune supportMetabolic health

High relevance

Reishi · 2020 · Review · International journal of biological macromolecules

Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review.

Ganoderma lucidum, commonly known as "Lingzhi" in Chinese, are well-known medicinal mushrooms. Lingzhi has been used in traditional Chinese herbal medicines for more than two thousand years.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Cordyceps · 2019 · Review · International journal of biological macromolecules

Advance in Cordyceps militaris (Linn) Link polysaccharides: Isolation, structure, and bioactivities: A review.

Cordyceps militaris is a unique and precious medical fungus in Chinese Cordyceps, which has been widely used as the traditional medicines or as biocontrol agents against pests in China for centuries..

OncologyImmune supportSkin & hydration

High relevance

Agarikon · 2019 · Review · Mycology

Antimicrobial properties of Fomitopsis officinalis in the light of its bioactive metabolites: a review.

Fomitopsis officinalis, also known as Laricifomes officinalis, is a medicinal polypore used for millennia (Agarikon) to contrast several diseases, particularly the pulmonary ones..

OncologyImmune supportGut & microbiomeRespiratory

High relevance

Lion's Mane · 2019 · Review · Critical reviews in food science and nutrition

Recent developments in Hericium erinaceus polysaccharides: extraction, purification, structural characteristics and biological activities.

Hericium erinaceus (H. erinaceus), an edible mushroom with medicinal value, has a long history of usage in China and other oriental countries.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Maitake · 2019 · Review · Progress in molecular biology and translational science

The biological activities of the antitumor drug Grifola frondosa polysaccharide.

Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps..

OncologyImmune supportMetabolic healthRespiratory

High relevance

Zhu Ling · 2019 · Review · Progress in molecular biology and translational science

The efficacy of Polyporus Umbellatus polysaccharide in treating hepatitis B in China.

Polyporus umbellatus polysaccharide (PUPS) has been identified as the major bioactive component in the mushroom Polyporus umbellatus that has immuno-enhancing, anti-tumor, anti-inflammatory, and hepatoprotective activities..

OncologyImmune supportLiver supportRespiratory

High relevance

Lion's Mane · 2019 · Review · International journal of molecular sciences

Therapeutic Potential of Hericium erinaceus for Depressive Disorder.

Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects..

OncologyImmune supportCognition & nervesMetabolic health