MycoData

OncologyImmune supportSkin & hydration

Almond Mushroom · 2026 · Preprint · journal metadata

Informing agent-based models with spatial data using convolutional autoencoders

Spatial computational models such as agent-based models (ABMs) offer powerful in silico tools to study tumor dynamics, yet imaging data are still rarely used to inform these models directly..

Immune supportMetabolic healthGut & microbiome

Reishi · 2026 · Review · The American journal of Chinese medicine

Medicinal and Edible Plants for the Management of Inflammatory Bowel Disease: Synergistic Modulation of the Microbiota-Metabolite-Immune Axis.

Inflammatory bowel disease (IBD) is a chronic condition driven by the intertwined interplay of gut dysbiosis, immune perturbation, and metabolic imbalance. Current single-target therapies often fail to durably restore homeostasis in this complex ecosystem, and have thereby increased interest in diet-based holistic….

Immune supportSkin & hydration

Reishi · 2026 · Review · International journal of medicinal mushrooms

Mushrooms and Their Bioactive Ingredients as Natural Resources for Development of Innovative Skin Care Formulations and Products.

Glowing skin is the aspiration of individuals especially women for enhancing the beauty and charm. Modern lifestyle attaches significant importance to skin care.

OncologyImmune supportMetabolic healthLiver support

Reishi · 2026 · Review · Cancer pathogenesis and therapy

Mushrooms as potent autophagy modulators in cancer therapy: Current evidence and therapeutic prospects.

Mushrooms, recognized for their culinary and medicinal applications, are emerging as promising autophagy modulators in cancer therapy. Autophagy is cellular degradation triggered by organelle damage, protein aggregation, metabolic disturbances, or nutrient scarcity..

OncologyImmune supportCognition & nerves

Lion's Mane · 2026 · Review · Molecules (Basel, Switzerland)

Recent Advances in Erinacine A: Preparation, Biological Activities, and Biosynthetic Pathway.

Erinacine A, a cyathane diterpenoid derived from the medicinal and edible fungus Hericium erinaceus, is increasingly recognized for its potent neurotrophic and neuroprotective properties..

Immune supportCognition & nerves

Reishi · 2026 · Review · Nutrients

The Potential of Plant-Derived Foods to Treat Glaucoma: A Review.

Glaucoma, characterized by progressive retinal ganglion cell degeneration and optic nerve damage, is the leading cause of irreversible blindness worldwide. Multiple risk factors influence the pathogenesis and progression of glaucoma..

Chaga · 2026 · Review · Veterinary sciences

Toxoplasma gondii as a Direct Cause of Reproductive Dysfunction: Dual Threats to Male and Female Fertility.

Toxoplasma gondii, an obligate intracellular protozoan infecting approximately one-third of the global population, poses a significant yet underappreciated threat to reproductive health in both sexes..

Reishi · 2025 · Review · Nutrients

Critical Review on the Anti-Tumor Activity of Bioactive Compounds from Edible and Medicinal Mushrooms over the Last Five Years.

In recent years, the incidence rate of cancer has been on the rise all over the world, and the age of cancer patients has shown a younger trend, which seriously endangers patients' health..

Almond Mushroom · 2025 · Preprint · journal metadata

Data-driven simulations elucidate how lymphocyte motility behaviors drive cell-cell interactions within germinal centers

ABSTRACT Lymphocytes rely on cell motility to surveil immune microenvironments and engage in contact-mediated interactions with other cells as part of the adaptive immune response..

Immune support

Immune supportMetabolic healthGut & microbiome

Reishi · 2025 · Review · Poultry science

Harnessing mushrooms for poultry nutrition: Boosting health, immunity, and productivity.

Edible mushrooms, the fruiting bodies of fungi, are emerging as promising functional feed additives in poultry nutrition, offering a sustainable alternative to synthetic growth promoters..

OncologyImmune supportSkin & hydration

Turkey Tail · 2025 · Review · Foods (Basel, Switzerland)

Himalayan Mushrooms as a Natural Source of Ergosterol and Vitamin D2: A Review of Nutraceutical and Functional Food Perspectives.

Mushroom diversity is essential for maintaining ecological balance and provides valuable bioactive compounds for human use. Beyond their nutritional value, mushrooms contribute to functional foods and have applications in nutraceuticals, pharmaceuticals, and biotechnology..

Immune supportMetabolic healthLiver supportSkin & hydration

Reishi · 2025 · Review · Frontiers in cell and developmental biology

Hydrogels incorporating active compounds from traditional Chinese medicine for diabetic wound healing: mechanistic pathways and bioengineering progress.

Diabetic wounds, especially foot ulcers, pose significant clinical challenges due to persistent inflammation, oxidative stress, impaired angiogenesis, and a high risk of infection. Advanced therapeutic strategies are needed to actively modulate the wound microenvironment..

Immune supportCognition & nervesEnergy & fatigue

Maitake · 2025 · Review · Journal of fungi (Basel, Switzerland)

Immunoregulation in Fungal Infections: A Review and Update on the Critical Role of Myeloid-Derived Suppressor Cells.

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immune cells that play a central role in regulating host immune responses during fungal infections..

Immune supportEnergy & fatigueGut & microbiome

Reishi · 2025 · Review · Poultry science

Molecular approaches for enhancing fermented bamboo-derived feed additives: A sustainable nutritional innovation for poultry.

The function of fermented and non fermented bamboo-derived feed additives in poultry nutrition is critically assessed in this review, with emphasis on the effects on growth performance, immunity, intestinal health, egg and meat quality..

Reishi · 2025 · Review · Drug design, development and therapy

Molecular Pharmacological Interventions for Endometrial Cancer: A Comprehensive Review.

Endometrial cancer, a common malignancy of the female reproductive system, has a rising incidence and complex clinical management due to its diverse molecular subtypes..

OncologyImmune supportMetabolic healthGut & microbiome

Lion's Mane · 2025 · Review · Foods (Basel, Switzerland)

Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products.

Mushrooms are known to be a nutritional powerhouse, offering diverse bioactive compounds that promote and enhance health. Mushrooms provide a distinguishable taste and aroma and are an essential source of vitamin D2, vitamin B complex, hydroxybenzoic acids (HBAs) and hydroxycinnamic acids (HCAs), terpenes, sterols,….

Immune supportSkin & hydration

Reishi · 2025 · Review · Archives of dermatological research

Mushrooms in modern cosmetics: unlocking anti-aging, antioxidant, and therapeutic potential.

Mushrooms have gained significant attention in the cosmetics industry due to their rich bioactive compounds with numerous skin benefits. This review explores the potential of various mushroom species as ingredients in cosmeceuticals, focusing on their anti-aging, anti-wrinkle, skin whitening, moisturizing,….

OncologyImmune supportRespiratory

Almond Mushroom · 2025 · Preprint · bioRxiv: the preprint server for biology

Partially-functional exhausted CD8+ T cells can contribute to short-term viral suppression: a computational prediction for children with perinatal HIV.

We and others have reported evidence of T cell exhaustion in children with perinatal HIV with increased expression of inhibitory receptors PD-1, CD160, and TIM-3, but there is limited data on the virologic functional consequences of this immune exhaustion..

Reishi · 2025 · Review · Frontiers in pharmacology

Plant polysaccharides influence tumor development based on epigenetics: a review.

Plant polysaccharides have emerged as pivotal epigenetic modulators in oncology, offering multi-target therapeutic potential to address toxicity and drug resistance limitations of conventional therapies..

Lion's Mane · 2025 · Review · Journal of fungi (Basel, Switzerland)

Potential Medicinal Fungi from Freshwater Environments as Resources of Bioactive Compounds.

Owing to their nutritional, culinary, and nutraceutical, mushrooms are worldwide consumed and appreciated. Moreover, many of these mushrooms are also known as medicinal mushrooms since they possess several pharmacological properties attributable to a huge number of bioactive compounds derived from their sporophores..

Reishi · 2025 · Review · Food research international (Ottawa, Ont.)

Radioprotective effect of edible and medicinal mushrooms against ionizing radiation: Components, potential mechanisms, and applications.

Ionizing radiation can cause severe damage to the body. The use of natural products as radioprotective agents has gained increasing popularity and attention in recent years..

Reishi · 2025 · Review · Carbohydrate polymers

Refined regulation of polysaccharide biosynthesis in edible and medicinal fungi: From pathways to production.

Polysaccharides derived from edible and medicinal fungi (EMF) exhibit various biological activities, rendering them useful in the pharmaceutical, nutraceutical, and food industries..

Enoki · 2025 · Review · Current issues in molecular biology

Research Progress on Nutritional Components, Functional Active Components, and Pharmacological Properties of Floccularia luteovirens.

Edible and medicinal fungi are a general term for large fungi with both edible and medicinal values. As a unique wild edible and medicinal fungus in the Qinghai-Tibet Plateau, the 'Four Medical Classics' of the Tang Dynasty has recorded Floccularia luteovirens effects of external application and internal….

Almond Mushroom · 2025 · Preprint · bioRxiv: the preprint server for biology

Rethinking the seven-day treatment-free interval in T-cell engager therapy using agent-based modeling.

BACKGROUND: The CD3/CD19 bispecific T cell engager (TCE) blinatumomab has shown efficacy in relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL), but response rates are often limited by T cell exhaustion..

OncologyImmune supportEnergy & fatigueMetabolic health

Almond Mushroom · 2025 · Preprint · journal metadata

Spatiotemporal Simulation of Radiotherapy Impact on Stage III Sigmoid Colon Cancer Using a Metabolically Coupled Agent-Based Model

Colorectal cancer (CRC), particularly sigmoid colon adenocarcinoma, presents complex therapeutic challenges at advanced stages. While fractionated radiotherapy combined with chemotherapy and immune involvement is clinically effective, its outcomes vary due to tumor heterogeneity, hypoxia, and treatment-induced….

Shiitake · 2025 · Preprint · journal metadata

Statistical optimization of fermentation conditions for metabolites production by Lentinus edodes and investigation of anticancer activity

Abstract The investigation was carried out to increase polysaccharide yield utilizing statistical strategies, starting with submerge and shifting to solid-state fermentation, with the main aim of promoting the anticancer properties of Lentinus edodes (shiitake) fruit and exploring the rheological properties of….

Reishi · 2025 · Review · Current cardiology reviews

Use of Herbal Drugs in Cardiovascular Disease- A Review.

Thirty percent of deaths worldwide are caused by cardiovascular disorders (CVDs). As per the WHO data, the number of fatalities due to CVDs is 17.9 million years, and it is projected to cause 22.2 million deaths by 2030.

Almond Mushroom · 2024 · Preprint · journal metadata

Agent-Based Modeling of Virtual Tumors Reveals the Critical Influence of Microenvironmental Complexity on Immunotherapy Efficacy

Since the introduction of the first immune checkpoint inhibitor (ICI), immunotherapy has changed the landscape of molecular therapeutics for cancers. However, ICIs do not work equally well on all cancers and for all patients..

Shiitake · 2024 · Review · Current opinion in biotechnology

Anti-inflammatory and immunomodulatory properties of polysaccharides in mushrooms.

Mushrooms are distinguished as important food-containing polysaccharides possessing potent anti-inflammatory and immunomodulating properties. These compounds belong mostly to polysaccharides that are mostly β-D-glucans..

Immune supportRespiratory

Almond Mushroom · 2024 · Preprint · journal metadata

Estimates of SARS-CoV-2 infections and population immunity after the COVID-19 pandemic in Austria: Analysis of national wastewater data

ABSTRACT Background Post-pandemic surveillance data on COVID-19 infections may help inform future public health policies regarding SARS-CoV-2 testing, vaccinations or other COVID-19 measures..

OncologyImmune supportCognition & nerves

Reishi · 2024 · Review · International journal of medicinal mushrooms

Ganoderic Acid A: A Potential Natural Neuroprotective Agent for Neurological Disorders: A Review.

Ganoderic acid A (GAA) is one of the major triterpenoids in Ganoderma lucidum (GL). Accumulating evidence has indicated that GAA demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders..

OncologyImmune supportEnergy & fatigueMetabolic health

Mesima · 2024 · Review · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Initial report on the multiple biological and pharmacological properties of hispolon: Exploring stochastic mechanisms.

The development of natural substances derived from nature poses a significant challenge as technologies for the extraction and characterization of active principles advance. Hispolon has received a lot of attention in recent years, ascribable to its wide range of biological activities..

Immune supportLiver support

Reishi · 2024 · Review · Physiology international

Innovative prophylactic and therapeutic approaches in liver cirrhosis.

Liver cirrhosis is the consequence of chronicisation and of the evolution of untreated liver diseases. The complexity of the disease and the complications it can cause have been and are still intensively researched, aiming to discover new therapies or improve existing ones for the effective management of liver….

Almond Mushroom · 2024 · Preprint · journal metadata

Integrating mechanism-based T cell phenotypes into a model of tumor-immune cell interactions

ABSTRACT Interactions between cancer cells and immune cells in the tumor microenvironment influence tumor growth and can contribute to the response to cancer immunotherapies. It is difficult to gain mechanistic insights into the effects of cell-cell interactions in tumors using a purely experimental approach..

OncologyImmune supportCognition & nervesLiver support

Cordyceps · 2024 · Review · Current issues in molecular biology

Medicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Potential as Adjuvant in Clinical Settings?

Breast cancer (BC) is the most commonly diagnosed tumor, remaining one of the leading causes of morbidity and mortality in females worldwide, with the highest rates in Western countries..

Almond Mushroom · 2024 · Preprint · journal metadata

On the equivalence between agent-based and continuum models for cell population modeling. Application to glioblastoma evolution in microfluidic devices

A bstract Mathematical models are invaluable tools for understanding the mechanisms and interactions that control the behavior of complex systems. Modeling a problem as cancer evolution includes many coupled phenomena being therefore impossible to obtain sufficient experimental results to fully evaluate all possible….

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2024 · Review · Antioxidants (Basel, Switzerland)

Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review.

Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder that gives rise to motor incoordination and progressive functional disabilities. Although pharmacological interventions have revealed promising prospects in the management of SCA3, adverse effects may become unbearable..

Oyster Mushroom · 2024 · Preprint · journal metadata

Pleurotus sajor-caju (Fr.) Singer β-1,3- Glucanoligosaccharide (Ps-GOS) suppresses RANKLInduced Osteoclast Differentiation and Function in Pre-Osteoclastic RAW 264.7 Cells by Inhibiting the RANK/NFκB/cFOS/NFATc1 Signalling Pathway

Edible grey oyster mushroom, Pleurotus sajor-caju, β (1,3), (1,6) glucan possesses a wide range of biological activities, including anti-inflammation, anti- microorganisms, and antioxidant. However, its biological activity is limited by their low water solubility resulting from the high molecular weight..

OncologyImmune supportLiver support

Reishi · 2024 · Review · Chinese journal of natural medicines

Polysaccharides from Chinese herbal medicine: a review on the hepatoprotective and molecular mechanism.

Polysaccharides, predominantly extracted from traditional Chinese medicinal herbs such as Lycium barbarum, Angelica sinensis, Astragalus membranaceus, Dendrobium officinale, Ganoderma lucidum, and Poria cocos, represent principal bioactive constituents extensively utilized in Chinese medicine..

Reishi · 2024 · Review · International journal of biological macromolecules

Polysaccharides targeting autophagy to alleviate metabolic syndrome.

Metabolic syndrome is a prevalent non-communicable disease characterized by central obesity, insulin resistance, hypertension, hyperglycemia, and hyperlipidemia. Epidemiological statistics indicate that one-third of the world's population is affected by metabolic syndrome..

OncologyImmune supportGut & microbiomeLiver support

Reishi · 2024 · Review · Chinese medicine

Potential of natural products and gut microbiome in tumor immunotherapy.

Immunotherapy is a novel treatment approach for malignant tumors, which has opened a new journey of anti-tumor therapy. Although some patients will show a positive response to immunotherapy, unfortunately, most patients and cancer types do not achieve an ideal response to immunotherapy..

Reishi · 2024 · Review · Antioxidants (Basel, Switzerland)

Potentials of Natural Antioxidants in Reducing Inflammation and Oxidative Stress in Chronic Kidney Disease.

Chronic kidney disease (CKD) presents a substantial global public health challenge, with high morbidity and mortality. CKD patients often experience dyslipidaemia and poor glycaemic control, further exacerbating inflammation and oxidative stress in the kidney..

Almond Mushroom · 2024 · Preprint · journal metadata

Spatially Fractionated GRID radiation potentiates immune-mediated tumor control

Abstract Background Tumor-immune interactions shape a developing tumor and its tumor immune microenvironment (TIME) resulting in either well-infiltrated, immunologically inflamed ‘hot’ tumor beds, or ‘cold’ immune deserts with low levels of infiltration..

Cordyceps · 2024 · Review · Frontiers in pharmacology

Structural and pharmacological insights into cordycepin for neoplasms and metabolic disorders.

Cytotoxic adenosine analogues were among the earliest chemotherapeutic agents utilised in cancer treatment. Cordycepin, a natural derivative of adenosine discovered in the fungus Ophiocordyceps sinensis, directly inhibits tumours not only by impeding biosynthesis, inducing apoptosis or autophagy, regulating the cell….

Reishi · 2024 · Review · Phytomedicine: international journal of phytotherapy and phytopharmacology

Targeting CD8+ T cells with natural products for tumor therapy: Revealing insights into the mechanisms.

BACKGROUND: Despite significant advances in cancer immunotherapy over the past decades, such as T cell-engaging chimeric antigen receptor (CAR)-T cell therapy and immune checkpoint blockade (ICB), therapeutic failure resulting from various factors remains prevalent..

Immune supportSkin & hydration

Shiitake · 2019 · Case Reports · Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete

[Reflectance confocal microscopy in Shiitake dermatitis].

Shiitake dermatitis usually occurs 1-2 days after consumption of incompletely cooked or raw shiitake mushrooms and is characterized by linear, pruritic, erythematous papulovesicular rashes. It is caused by lentinan, a polysaccharide component of the cell walls of shiitake mushrooms..

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2019 · Review · International journal of medicinal mushrooms

Medicinal, Nutritional, and Cosmetic Values of Macrofungi Distributed in Mazandaran Province of Northern Iran (Review).

A total of 82 species and 2 variations of medicinal and edible macrofungi (Basidiomycota and Ascomy-cota) have been collected and identified in Mazandaran Province of Northern Iran..

Immune supportGut & microbiome

Shiitake · 2019 · Randomized Controlled Trial · Nutrients

Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longum, AHCC® and Azithromycin in Healthy Individuals.

The probiotic Bifidus BB536 (BB536), which contains Bifidobacterium longum, has been shown to have enhanced probiotic effects when given together with a standardized extract of cultured Lentinula edodes mycelia (AHCC®, Amino Up Co. Ltd., Sapporo, Japan)..