MycoData

Ophiocordyceps sinensis (Berk.) is an entomopathogenic fungus that can infect the larva of the ghost moth, Hepialus xiaojinensis, causing mummification after more than one year. This prolonged infection provides a valuable model for studying the immunological interplay between an insect host and a pathogenic fungus..

Immune supportCognition & nerves

High relevance

Snow Fungus · 2022 · Research Article · Frontiers in microbiology

Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota.

Obesity is a metabolic disease associated with gut microbiota and low-grade chronic inflammation. Tremella fuciformis is a medicinal and edible fungus; polysaccharide (TP) is the main active component, which has a variety of biological activities, such as hypoglycemic and hypolipidemic..

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2022 · Research Article · Frontiers in pharmacology

Tremella fuciformis polysaccharides alleviate induced atopic dermatitis in mice by regulating immune response and gut microbiota.

Atopic dermatitis (AD), characterized by severe pruritus, immune imbalance, and skin barrier dysfunction, has a high incidence worldwide. Recent evidence has shown that the modulation of gut microbiota is crucial for alleviating clinical symptoms of AD..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Chaga · 2022 · Journal Article · Phytochemistry

Triterpenoids as bivalent and dual inhibitors of acetylcholinesterase/butyrylcholinesterase from the fruiting bodies of Inonotus obliquus.

Inonotus obliquus, an edible and medicinal mushroom parasitic on birches, has been used in human diet and for traditional therapies in the high latitude regions of Europe and Asia for a long time..

Cognition & nerves

High relevance

Reishi · 2022 · Journal Article · Fitoterapia

Triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH.

Seventeen triterpenoids including four new lanostane triterpenoids (1-3 and 5) were isolated from the fruiting bodies of Ganoderma lucidum by various chromatographic techniques. Their chemical structures were determined by extensive spectroscopic data, including 1D-NMR, 2D-NMR, and HRESIMS..

OncologyImmune supportCognition & nerves

High relevance

Maitake · 2021 · Research Article · Pharmaceutics

Anti-Inflammatory and Immunomodulatory Effects of the Grifola frondosa Natural Compound o-Orsellinaldehyde on LPS-Challenged Murine Primary Glial Cells. Roles of NF-κβ and MAPK.

In response to foreign or endogenous stimuli, both microglia and astrocytes adopt an activated phenotype that promotes the release of pro-inflammatory mediators. This inflammatory mechanism, known as neuroinflammation, is essential in the defense against foreign invasion and in normal tissue repair; nevertheless, when….

Immune supportCognition & nerves

High relevance

Turkey Tail · 2021 · Research Article · Saudi journal of biological sciences

Deciphering the CNS anti-depressant, antioxidant and cytotoxic profiling of methanol and aqueous extracts of Trametes versicolor and molecular interactions of its phenolic compounds.

The present study sought to evaluate the central nervous system (CNS) depressant, antioxidant, and cytotoxicity activity of methanol and aqueous extract of Trametes versicolor (METV and AETV)..

OncologyCognition & nervesEnergy & fatigue

High relevance

Enoki · 2021 · Journal Article · Nanotechnology

Edible mushroom (Flammulina velutipes) as biosource for silver nanoparticles: from synthesis to diverse biomedical and environmental applications.

The current study reports advanced, ecofriendly and biosynthesized silver NPs for diverse biomedical and environmental applications using Flammulina velutipes as biosource. In the study, a simple aqueous extract of F.

OncologyCognition & nervesMetabolic health

High relevance

Lion's Mane · 2021 · Research Article · Molecules (Basel, Switzerland)

Effect of Water and Ethanol Extracts from Hericium erinaceus Solid-State Fermented Wheat Product on the Protection and Repair of Brain Cells in Zebrafish Embryos.

Extracts from Hericium erinaceus can cause neural cells to produce nerve growth factor (NGF) and protect against neuron death. The objective of this study was to evaluate the effects of ethanol and hot water extracts from H..

Cognition & nerves

High relevance

Lion's Mane · 2021 · Research Article · Nutrients

Erinacine A-Enriched Hericium erinaceus Mycelium Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice.

There have been many reports on the neuroprotective effects of Hericium erinaceus mycelium, in which the most well-known active compounds found are diterpenoids, such as erinacine A..

Cognition & nerves

High relevance

Lion's Mane · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment.

Hericium erinaceus (H. erinaceus) is a rare and appreciated fungal species belonging to the division Basidiomycota used for centuries in traditional Chinese medicine for its medicinal value..

Cognition & nerves

High relevance

Yellow Morel · 2021 · Research Article · Molecules (Basel, Switzerland)

Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta.

Mushroom polysaccharides are active medicinal compounds that possess immune-modulatory and anticancer properties. Currently, the mushroom polysaccharides krestin, lentinan, and polysaccharopeptides are used as anticancer drugs..

OncologyImmune supportCognition & nerves

High relevance

Lion's Mane · 2021 · Research Article · Chinese medicine

Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression.

BACKGROUND: Depression is a severe neuropsychiatric disorder that affects more than 264 million people worldwide. The efficacy of conventional antidepressants are barely adequate and many have side effects..

Immune supportCognition & nerves

High relevance

Oyster Mushroom · 2021 · Journal Article · Journal of dietary supplements

Pleurotus ostreatus and Lentinus subnudus supplemented diets restore altered acetylcholinesterase and butyrylcholinesterase activities and improve antioxidant status in transgenic Drosophila melanogaster model.

Pleurotus ostreatus (P. ostreatus) and Lentinus subnudus (L.

Cognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2021 · Research Article · Molecules (Basel, Switzerland)

Preclinical Bioavailability, Tissue Distribution, and Protein Binding Studies of Erinacine A, a Bioactive Compound from Hericium erinaceus Mycelia Using Validated LC-MS/MS Method.

Erinacine A, derived from the mycelia of Hericium erinaceus, has attracted much attention due to its neuroprotective properties. However, very few studies have been conducted on the bioavailability, tissue distribution, and protein binding of erinacine A..

Cognition & nerves

High relevance

Niu-Chang-Chih · 2021 · Journal Article · Phytotherapy research: PTR

Protective effects of Antrodia camphorata extract against hypoxic cell injury and ischemic stroke brain damage.

Ischemic stroke is the most prevalent stroke condition in the world resulted in either a transient ischemic attack or long-lasting neurological problems due to the interrupted or reduced blood flow to the brain..

Cognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2021 · Journal Article · International journal of biological macromolecules

Structural characterization of polysaccharide purified from Hericium erinaceus fermented mycelium and its pharmacological basis for application in Alzheimer's disease: Oxidative stress related calcium homeostasis.

The purified polysaccharides from Hericium erinaceus fermented mycelium entitled with PHEB was analyzed and it was mainly composed of six glycosidic bonds. It has been confirmed to show the relieving activity against Alzheimer's Disease (AD)- just as behaviors of B6C3-Tg (APPswePSEN1d E9)/Nju double transgenic….

Immune supportCognition & nerves

High relevance

Lion's Mane · 2024 · Research Support, Non U.S. Gov'T · Amyotrophic lateral sclerosis & frontotemporal degeneration

ALSUntangled #73: Lion's Mane.

Lion's Mane (Hericium erinaceus) has historically been used as traditional medicine in Asia and Europe for its potential benefits in fighting infection and cancer..

OncologyImmune supportCognition & nerves

High relevance

Lion's Mane · 2020 · Review · Antioxidants (Basel, Switzerland)

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea.

Recent studies focused on the pharmacology and feasibility of herbal compounds as a potential strategy to target a variety of human diseases ranging from metabolic to brain disorders..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

Mesima · 2019 · Review · Molecules (Basel, Switzerland)

A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus.

Phellinus linteus is a popular medicinal mushroom that is widely used in China, Korea, Japan, and other Asian countries. P.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Niu-Chang-Chih · 2019 · Review · Applied microbiology and biotechnology

Diversity of potentially exploitable pharmacological activities of the highly prized edible medicinal fungus Antrodia camphorata.

Antrodia camphorata, also known as A. cinnamomea, is a precious medicinal basidiomycete fungus endemic to Taiwan.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Snow Fungus · 2019 · Review · International journal of biological macromolecules

Structure, bioactivities and applications of the polysaccharides from Tremella fuciformis mushroom: A review.

Tremella fuciformis is an important edible mushroom that has been widely cultivated and used as food and medicinal ingredient in traditional Chinese medicine. In the past decades, many researchers have reported that T..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Lion's Mane · 2018 · Review · Behavioural neurology

Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines.

Hericium erinaceus, an ideal culinary-medicinal mushroom, has become a well-established candidate in promoting positive brain and nerve health-related activities by inducing the nerve growth factor from its bioactive ingredient..

Cognition & nerves

High relevance

Cordyceps · 2026 · Review · Journal of inflammation research

Anti-Inflammatory Mechanisms and Translational Relevance of Cordyceps sinensis and Its Bioactive Constituents.

Cordyceps sinensis, an important medicinal fungus in traditional Chinese medicine, has gained increasing attention for its diverse pharmacological activities, particularly its anti-inflammatory properties..

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Review · Zeitschrift fur Naturforschung. C, Journal of biosciences

Ethnopharmacology and current conservational status of Cordyceps sinensis.

Cordyceps sinensis, known as the caterpillar fungus, constitutes an invaluable and irreplaceable part of traditional Chinese medicine (TCM) and is now gaining widespread global recognition and dedicated attention owing to both highly promising characteristics as well as grave dangers that are suggestive of an….

Cognition & nerves

High relevance

Cordyceps · 2025 · Review · Current pharmaceutical design

Immunopharmacological Insights into Cordyceps spp.: Harnessing Therapeutic Potential for Sepsis.

Cordyceps spp. (CS), a well-known medicinal mushroom that belongs to Tibetan medicine and is predominantly found in the high altitudes in the Himalayas.

Immune supportCognition & nervesLiver supportRespiratory

High relevance

Shiitake · 2025 · Preprint · journal metadata

Machine Vision and Deep Learning for Robotic Harvesting of Shiitake Mushrooms

Automation and computer vision are increasingly vital in modern agriculture, yet mushroom harvesting remains largely manual due to complex morphology and occluded growing environments..

Cognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2025 · Review · International journal of molecular sciences

Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease.

Alzheimer's disease (AD) is considered one of the main pathologies of our time, whose incidence and prevalence are suggested to be strongly underestimated. AD presents as a complex neurodegenerative condition characterized by marked neuroinflammation and a significant decline in the cognitive and mnemonic functions of….

OncologyImmune supportCognition & nerves

High relevance

Cordyceps · 2024 · Review · Journal of ethnopharmacology

Cordyceps: Alleviating ischemic cardiovascular and cerebrovascular injury - A comprehensive review.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps has a long medicinal history as a nourishing herb in traditional Chinese medicine (TCM). Ischemic cardio-cerebrovascular diseases (CCVDs), including cerebral ischemic/reperfusion injury (CI/RI) and myocardial ischemic/reperfusion injury (MI/RI), are major contributors to….

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

King Oyster · 2020 · Comparative Study · International journal of medicinal mushrooms

Comparative Neuroprotective, Anti-Inflammatory and Neurite Outgrowth Activities of Extracts of King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes).

Pleurotus eryngii (king oyster mushroom) is a renowned culinary mushroom with various medicinal properties that may be beneficial for health maintenance and disease prevention. However, its effect on the nervous system remains elusive.

Immune supportCognition & nerves

High relevance

Cordyceps · 2020 · Abstract · Current developments in nutrition

The Antidepressive and Anxiolytic Effects of Formula Consisted of Poria cocos and Cordyceps militaris Waster Medium Extract in Unpredictable Chronic Mild Stress Animal Model

Abstract Objectives According to the WHO report, depression will be the first of the global burden of diseases in 2030. There is more than fifty % of people suffered from depression and anxiety..

Immune supportCognition & nervesMetabolic health

High relevance

Reishi · 2019 · Research Support, Non U.S. Gov'T · Progress in molecular biology and translational science

Ganoderma lucidum polysaccharide used for treating physical frailty in China.

Ganoderma lucidum is an edible medicinal mushroom known as "Lingzhi" in China and "Reishi or Manetake" in Japan. It is a highly prized vitality-enhancing herb for >2000 years.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2019 · Research Support, Non U.S. Gov'T · The Journal of biological chemistry

Structural basis for the specific cleavage of core-fucosylated N-glycans by endo-β-N-acetylglucosaminidase from the fungus Cordyceps militaris.

N-Linked glycans play important roles in various cellular and immunological events. Endo-β-N-acetylglucosaminidase (ENGase) can release or transglycosylate N-glycans and is a promising tool for the chemoenzymatic synthesis of glycoproteins with homogeneously modified glycans..

Immune supportCognition & nerves

High relevance

Maitake · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

A polysaccharide-peptide with mercury clearance activity from dried fruiting bodies of maitake mushroom Grifola frondosa.

Mercury is considered to be "a global pollutant" and raises concern worldwide. Once mercury enters the body, it will be distributed all over the body but will accumulate in the brain, kidney and liver.

Immune supportCognition & nervesLiver support

High relevance

Lion's Mane · 2017 · Research Support, Non U.S. Gov'T · Scientific reports

Genomic and transcriptomic analyses reveal differential regulation of diverse terpenoid and polyketides secondary metabolites in Hericium erinaceus.

The lion's mane mushroom Hericium erinaceus is a famous traditional medicinal fungus credited with anti-dementia activity and a producer of cyathane diterpenoid natural products (erinacines) useful against nervous system diseases..

Cognition & nerves

High relevance

Maitake · 2017 · Comparative Study · Molecular nutrition & food research

Oral administration of Grifola frondosa polysaccharides improves memory impairment in aged rats via antioxidant action.

SCOPE: Grifola frondosa is an edible/medicinal mushroom with great nutritional value and bioactivity. The present study was performed to evaluate the beneficial effect of polysaccharides isolated from Grifola frondosa on memory impairment in aged rats..

Immune supportCognition & nerves

High relevance

Cordyceps · 2016 · Research Support, Non U.S. Gov'T · Gene

De novo transcriptome analysis of Thitarodes jiachaensis before and after infection by the caterpillar fungus, Ophiocordyceps sinensis.

Thitarodes jiachaensis is a host species of the pathogenic caterpillar fungus Ophiocordyceps sinensis, which is a fungus with broad medical effects and great economic value. Curated genomic information on Thitarodes is still limited, and the interaction between host Thitarodes larvae and O..

Cognition & nerves

High relevance

Almond Mushroom · 2015 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Aqueous Extract of Agaricus blazei Murrill Prevents Age-Related Changes in the Myenteric Plexus of the Jejunum in Rats.

This study evaluated the effects of the supplementation with aqueous extract of Agaricus blazei Murrill (ABM) on biometric and blood parameters and quantitative morphology of the myenteric plexus and jejunal wall in aging Wistar rats..

Cognition & nervesMetabolic healthGut & microbiome

High relevance

Mesima · 2015 · Journal Article · Food & function

Structural characterization and immunomodulatory effects of polysaccharides from Phellinus linteus and Phellinus igniarius on the IL-6/IL-10 cytokine balance of the mouse macrophage cell lines (RAW 264.7).

Phellinus linteus and igniarius (L.) Quel. have been used in traditional Asian medicine for over two centuries against a variety of diseases.

Immune supportCognition & nervesMetabolic health

High relevance

Chaga · 2014 · Journal Article · International journal of medicinal mushrooms

Inhibitory effects of a polysaccharide extract from the Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), on the proliferation of human neurogliocytoma cells.

This study aimed to investigate the inhibitory roles of a polysaccharide extract from Inonotus obliquus on U251 human neurogliocytoma cells cultured in vitro. After administering the polysaccharide extract from I..

OncologyImmune supportCognition & nerves

High relevance

Maitake · 2013 · Journal Article · Food and agricultural immunology

Antioxidant and immunomodulatory effects of a α-glucan from fruit body of maitake (Grifola frondosa)

The antioxidant and immunomodulatory effect of an α-glucan (designated here as MT-α-glucan) from fruit body of Maitake mushroom (Grifola frondosa) on D-galactose (D-gal)-induced senescent mice model was evaluated..

Immune supportCognition & nervesMetabolic healthLiver support

High relevance

Chaga · 2011 · Journal Article · International journal of medicinal mushrooms

Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): in vitro studies.

The medicinal mushroom Chaga, Inonotus obliquus (Pers.:Fr.) Pilát (Hymenochaetaceae), has been used in folk medicine in Russia, Poland, and most of the Baltic countries, as a cleansing and disinfecting measure, and as decoctions for stomach diseases, intestinal worms, liver and heart ailments, and cancer treatment..

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Lion's Mane · 2023 · Research Support, Non U.S. Gov'T · Journal of food and drug analysis

Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation.

Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion..

Cognition & nerves

High relevance

Oyster Mushroom · 2023 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Preparation, structural characterization and neuroprotective effects to against H2O2-induced oxidative damage in PC12 cells of polysaccharides from Pleurotus ostreatus.

Pleurotus ostreatus is one of the most common edible and medicinal fungi in life, and its polysaccharide has been a hot research topic in recent years. In this paper, a new intracellular polysaccharide component named P.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Niu-Chang-Chih · 2022 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Solid-state-cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6-hydroxydopamine-induced toxicity in PC12 cells.

Antrodia camphorata (A. camphorata) is an edible fungus containing various bioactive compounds generally used for health benefits.

OncologyCognition & nerves

High relevance

Enoki · 2021 · Research Support, Non U.S. Gov'T · ACS biomaterials science & engineering

Natural Flammulina velutipes-Based Nerve Guidance Conduit as a Potential Biomaterial for Peripheral Nerve Regeneration: In Vitro and In Vivo Studies.

The treatment and repair of serious peripheral nerve injuries remain challenging in the clinical practice, while the application of multifunctional nerve guidance conduits (NGCs) based on naturally derived polymers has attracted much attention in recent years because of their excellent physicochemical properties and….

Cognition & nerves

High relevance

Shiitake · 2021 · Research Support, Non U.S. Gov'T · Journal of translational medicine

β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis.

BACKGROUND: Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes (L.

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Almond Mushroom · 2025 · Preprint · journal metadata

Agaricus blazei extract FA-2b-β inhibits microglial pyroptosis by regulating the activation of the NF-κB signaling pathway mediated by Aβ 1-42 through the NLRP3 pathway

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Intracellular neurofibrillary tangles (NFTs) and neuroinflammatory plaques formed by amyloid-β (Aβ) are the main pathological features of AD..

OncologyImmune supportCognition & nerves

High relevance

Shiitake · 2023 · Research Support, Non U.S. Gov'T · Proceedings of the National Academy of Sciences of the United States of America

A global phylogenomic analysis of the shiitake genus Lentinula.

Lentinula is a broadly distributed group of fungi that contains the cultivated shiitake mushroom, L. edodes.

Cognition & nerves