MycoData

Polycyclic aromatic hydrocarbons (PAHs) are environmentally recalcitrant contaminants formed from naturally or incomplete combustion of organic materials and some of them are difficult to degrade due to their hydrophobicity and persistency..

Metabolic health

High relevance

Cordyceps · 2022 · Research Article · Microbial biotechnology

Multiplex gene precise editing and large DNA fragment deletion by the CRISPR-Cas9-TRAMA system in edible mushroom Cordyceps militaris.

The medicinal mushroom Cordyceps militaris contains abundant valuable bioactive ingredients that have attracted a great deal of attention in the pharmaceutical and cosmetic industries. However, the development of this valuable mushroom faces the obstacle of lacking powerful genomic engineering tools..

Metabolic healthSkin & hydration

High relevance

Cordyceps · 2022 · Journal Article · Cellular and molecular biology (Noisy-le-Grand, France)

Oral administration of human FGF21 expressed by mycelium of Cordyceps militaris improves blood glucose and lipid in type II diabetes mellitus.

The purpose of this study was to express human FGF21 (hFGF21) using Cordyceps militaris (C. militaris) as a bioreactor and to observe its hypoglycemic and lipid-lowering effects on type II diabetes.

OncologyImmune supportMetabolic healthLiver support

High relevance

Cordyceps · 2022 · Research Article · Microbial cell factories

Overlapping promoter library designed for rational heterogenous expression in Cordyceps militaris.

BACKGROUND: Cordyceps militaris, a kind of edible and medicinal fungus widely accepted in East Asia, has attracted much attention as a potential cell factory for producing adenosine analogs. Despite the rapid development in gene editing techniques and genome modeling, the diversity of DNA elements in C..

Metabolic health

High relevance

Shiitake · 2022 · Research Article · Frontiers in microbiology

Oxidative Stress and Autophagy Are Important Processes in Post Ripeness and Brown Film Formation in Mycelium of Lentinula edodes.

Lentinula edodes (Berk.) Pegler, the shiitake mushroom, is one of the most important mushrooms in the global mushroom industry. Although mycelium post ripeness and brown film (BF) formation are crucial for fruiting body initiation, the underlying molecular mechanisms of BF formation are largely unknown..

Metabolic health

High relevance

Shiitake · 2022 · Journal Article · International journal of medicinal mushrooms

Peach Palm By-Product Bioconversion by Shiitake Culinary-Medicinal Mushroom Lentinula edodes (Agaricomycetes) for Food Products Application in Brazil.

This study aims to analyze the peach palm by-product (shells) bioconversion by culinary-medicinal mushroom Lentinula edodes to obtain a food ingredient for dietary supplementation containing high contents of dietary fiber, protein, and β-glucans. The β-glucans production by L..

Metabolic health

High relevance

Reishi · 2022 · Research Article · Metabolites

Pharmacokinetic, Metabolomic, and Stability Assessment of Ganoderic Acid H Based Triterpenoid Enriched Fraction of Ganoderma lucidum P. Karst.

Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major phytoconstituents.

Cognition & nervesEnergy & fatigueMetabolic health

High relevance

Lion's Mane · 2022 · Research Article · Nutrients

Polysaccharides from Hericium erinaceus Fruiting Bodies: Structural Characterization, Immunomodulatory Activity and Mechanism.

Five fractions from crude Hericium erinaceus polysaccharides (HEPs), including HEP-1, HEP-2, HEP-3, HEP-4 and HEP-5, were obtained through column chromatography with a DEAE Cellulose-52 column and Sephadex G-100 column. The contents of total carbohydrates and uronic acid in HEPs were 53.36% and 32.56%, respectively..

OncologyImmune supportMetabolic health

High relevance

Niu-Chang-Chih · 2022 · Research Article · EFSA journal. European Food Safety Authority

Safety of freeze-dried mycelia of Antrodia camphorata as a novel food pursuant to regulation (EU) 2015/2283.

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on freeze-dried mycelia of Antrodia camphorata as a novel food (NF) pursuant to Regulation (EU) 2015/2283..

Metabolic healthLiver support

High relevance

Reishi · 2022 · Research Article · Food & nutrition research

Sporoderm-broken spore powder of Ganoderma lucidum ameliorate obesity and inflammation process in high-fat diet-induced obese mice.

OBJECTIVE: This study examined the anti-obesity and anti-inflammatory effects of sporoderm-broken spore powder of Ganoderma lucidum (SSPL) against obese mice fed with a high-fat diet..

OncologyImmune supportMetabolic healthLiver support

High relevance

Reishi · 2022 · Journal Article · International journal of medicinal mushrooms

Structure Characterization and Anti-Inflammatory Activity of Polysaccharides from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) by Microwave-Assisted Freeze-Thaw Extraction.

A water-soluble polysaccharide (GLP-2) was isolated and purified from Ganoderma lucidum by the microwave-assisted freeze-thaw method. Microwave-assisted rapid thawing treatment can greatly improve the extraction yield of polysaccharides..

Immune supportMetabolic health

High relevance

Reishi · 2022 · Journal Article · Carbohydrate polymers

Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation

Ganoderma lucidum has been shown to have anti-obesity effects. However, polysaccharide extracted from the sporoderm-broken spores of Ganoderma lucidum (BSGLP) against obesity and its underlying mechanisms have never been reported..

Immune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2022 · Research Article · BMC complementary medicine and therapies

System-level investigation of anti-obesity effects and the potential pathways of Cordyceps militaris in ovariectomized rats.

BACKGROUND: Cordyceps species have been used as tonics to enhance energy, stamina, and libido in traditional Asian medicine for more than 1600 years, indicating their potential for improving reproductive hormone disorders and energy metabolic diseases..

OncologyEnergy & fatigueMetabolic healthLiver support

High relevance

Cordyceps · 2022 · Journal Article · International journal of medicinal mushrooms

Transcriptome Sequencing to Identify Candidate Genes for Mycelium Period Metabolism of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes), Exposed to Light Treatment.

The Chinese caterpillar mushroom, Ophiocordyceps sinensis, is rare in traditional Chinese herbal medicine. It was reported that the development of ascospores in sexual stage of Chinese Cordyceps requires certain UV irradiation, but whether light has effect on the asexual stage of O.

Immune supportMetabolic healthGut & microbiome

High relevance

Chaga · 2022 · Journal Article · Journal of food biochemistry

Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation in hyperuricemic mice: Possible inhibitory effects on xanthine oxidase activity

The purpose of this study was to explore the hypouricemic effect in hyperuricemia mice of triterpenoid acids from Inonotus obliquus (TAIO), and decipher of the underlying xanthine oxidase inhibitory mechanism. Measurement of xanthine oxidase (XO) inhibitory activity was assayed..

Immune supportEnergy & fatigueMetabolic healthLiver support

High relevance

Cordyceps · 2021 · Research Article · Veterinary world

A study of the aphrodisiac properties of Cordyceps militaris in streptozotocin-induced diabetic male rats.

BACKGROUND AND AIM: Cordyceps militaris (CM) is a fungus that has been used to enhance aphrodisiac activity in men, but to date, no studies have focused on its antidiabetic properties. This study aimed to investigate the effects of CM on reproductive performance of streptozotocin (STZ)-induced diabetic male rats..

Energy & fatigueMetabolic health

High relevance

Shiitake · 2021 · Research Article · Journal of food science and technology

Angiotensin-I converting enzyme inhibitory peptide derived from the shiitake mushroom (Lentinula edodes).

ABSTRACT: Angiotensin-I converting enzyme (ACE) inhibitors are widely used to control hypertension. In this study, protein hydrolysates from shiitake mushroom were hydrolyzed to prepare ACE-inhibitory peptides..

Metabolic health

High relevance

Cordyceps · 2021 · Research Article · Foods (Basel, Switzerland)

Anti-Hyperlipidemia and Gut Microbiota Community Regulation Effects of Selenium-Rich Cordyceps militaris Polysaccharides on the High-Fat Diet-Fed Mice Model.

Supplementation of polysaccharides is a promising gut microbiota-targeted therapeutic method for obesity and metabolic diseases. Biological activities of Cordyceps militaris polysaccharides have been well reported, but the effect of selenium (Se)-rich C..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2021 · Research Article · Asian Pacific journal of cancer prevention: APJCP

Antiangiogenic and Proapoptotic Activities of Atorvastatin and Ganoderma lucidum in Tumor Mouse Model via VEGF and Caspase-3 Pathways.

BACKGROUND: The statin drug Atorvastatin (AT) used for cholesterol reduction and Ganoderma lucidum (Gl) mushroom extract exhibited satisfactory antitumor activities towards various types of cancer..

OncologyImmune supportMetabolic health

High relevance

Reishi · 2021 · Journal Article · International journal of food science & technology

Comparative evaluation of physicochemical properties of Lingzhi (Ganoderma lucidum) as affected by drying conditions and extraction methods

Lingzhi (Ganoderma lucidum) is a high‐potential mushroom which is used as a dietary supplement or a source of nutrients and antioxidant agents. The aims were to investigate the effect of drying conditions (hot air and vacuum dry) and to compare the extraction methods of microwave‐assisted extraction (MAE) and pulsed….

Immune supportMetabolic health

High relevance

Cordyceps · 2021 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Comparison of effects on colitis-associated tumorigenesis and gut microbiota in mice between Ophiocordyceps sinensis and Cordyceps militaris.

BACKGROUND: Gut microbiota plays an indispensable role in the treatment of inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). As traditional medicinal fungi, previous studies have shown that Ophiocordyceps sinensis could better maintain intestinal health via promoting the growth of probiotics in….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Chaga · 2021 · Journal Article · Journal of ethnopharmacology

Effect of Inonotus obliquus (Fr.) Pilat extract on the regulation of glycolipid metabolism via PI3K/Akt and AMPK/ACC pathways in mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus (Fr.) Pilat is a mushroom belonging to the family Hymenochaetaceae. It is popularly called the Chaga mushroom in Russian folk medicine and has been used as a traditional medicine to treat diabetes mellitus in Eastern European and Asian countries..

Metabolic healthLiver support

High relevance

Cordyceps · 2021 · Journal Article · Enzyme and microbial technology

Enhancement of carotenoid production and its regulation in edible mushroom Cordyceps militaris by abiotic stresses.

Cordyceps militaris carotenoids are widely used as food additives, animal feed supplements, and so on. However, the biosynthetic pathway of carotenoids in C.

Energy & fatigueMetabolic health

High relevance

Lion's Mane · 2021 · Journal Article · International journal of medicinal mushrooms

Evaluation of In Vitro Antioxidant and Antihyperglycemic Activities of Extracts from the Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes).

To obtain activated fractions, the ethanol extract (EE) of Hericium erinaceus was fractionated to get petroleum ether fraction (PEF), chloroform fraction (CF), ethyl acetate fraction (EAF) and n-butanol fraction (NF)..

Metabolic health

High relevance

Maitake · 2021 · Research Article · Nutrients

Grifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves Health Span in C. elegans through the DAF-16/FOXO and SKN-1/NRF2 Signalling Pathways.

In recent years, food ingredients rich in bioactive compounds have emerged as candidates to prevent excess adiposity and other metabolic complications characteristic of obesity, such as low-grade inflammation and oxidative status..

Immune supportMetabolic health

High relevance

Cordyceps · 2021 · Journal Article · Journal of ethnopharmacology

Immunostimulatory effects of the intracellular polysaccharides isolated from liquid culture of Ophiocordyceps sinensis (Ascomycetes) on RAW264.7 cells via the MAPK and PI3K/Akt signaling pathways.

ETHNOPHARMACOLOGICAL RELEVANCE: Chinese Cordyceps (DongChong XiaCao), a parasitic complex of a fungus Ophiocordyceps sinensis and a caterpillar, is a traditional Chinese medicine. Polysaccharides extracted from O.

Immune supportMetabolic health

High relevance

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Integrated bioinformatics analysis of the anti-atherosclerotic mechanisms of the polysaccharide CM1 from Cordyceps militaris.

Cordyceps militaris is a well-known traditional Chinese medicine. Studies have demonstrated that the polysaccharides of C.

OncologyImmune supportMetabolic health

High relevance

King Oyster · 2021 · Journal Article · Food & function

JNK pathway and heat shock response mediate the survival of C26 colon carcinoma bearing mice fed with the mushroom Pleurotus eryngii var. eryngii without affecting tumor growth or cachexia.

In the last few years, there has been emerging interest in developing treatments against human diseases using natural bioactive content. Here, the powder of the edible mushroom Pleurotus eryngii var.

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Shiitake · 2021 · Research Article · Biomolecules

Metabolic Profiles, Bioactive Compounds, and Antioxidant Capacity in Lentinula edodes Cultivated on Log versus Sawdust Substrates.

Lentinula edodes (shiitake) is a popular nutritious edible mushroom with a desirable aroma and flavor. Traditional cultivation of L.

Energy & fatigueMetabolic health

High relevance

Cordyceps · 2021 · Research Article · Lipids in health and disease

Polysaccharide CM1 from Cordyceps militaris hinders adipocyte differentiation and alleviates hyperlipidemia in LDLR(+/-) hamsters.

BACKGROUND: Cordyceps militaris is cultured widely as an edible mushroom and accumulating evidence in mice have demonstrated that the polysaccharides of Cordyceps species have lipid-lowering effects..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Yellow Morel · 2021 · Journal Article · Food & function

Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.

The pharmaceutical application of fungal polysaccharides has been extensively studied based on their multiple biological activities. However, the effect of Morchella esculenta polysaccharides on the development of atherosclerosis remains unknown..

Immune supportMetabolic healthLiver support

High relevance

Cordyceps · 2021 · Research Article · Foods (Basel, Switzerland)

Polysaccharides Obtained from Cordyceps militaris Alleviate Hyperglycemia by Regulating Gut Microbiota in Mice Fed a High-Fat/Sucrose Diet.

Polysaccharides isolated from fungus Cordyceps militaris display multi-biofunctions, such as immunostimulation, down-regulation of hyperlipidemia, and anti-cancer function. The occurrence of obesity and metabolic syndrome is related to the imbalance of gut microbiota.

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2021 · Journal Article · International journal of medicinal mushrooms

Production and Nutritional Composition of King Oyster Culinary-Medicinal Mushroom Pleurotus eryngii (Agaricomycetes) Biomass from Brazil.

The present study aimed to evaluate the nutritional composition and production of mycelial biomass of Pleurotus eryngii in different culture media, formulated with infusion of purple-skinned sweet potato, glucose concentrations, and the presence or absence of yeast extract..

Metabolic health

High relevance

Chaga · 2021 · Research Article · Frontiers in pharmacology

Renal Protective Effects of Inonotus obliquus on High-Fat Diet/Streptozotocin-Induced Diabetic Kidney Disease Rats: Biochemical, Color Doppler Ultrasound and Histopathological Evidence.

Diabetic kidney disease (DKD) is the current leading cause of end-stage renal disease. Inonotus obliquus (chaga), a medicinal fungus, has been used in treatment of diabetes..

Metabolic health

High relevance

Lion's Mane · 2021 · Journal Article · International journal of medicinal mushrooms

Screening and Comparison of Anti-Intestinal Inflammatory Activities of Three Polysaccharides from the Mycelium of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Agaricomycetes).

Three major polysaccharides (wHEP-1, wHEP-2, and wHEP-3) were isolated from the mycelium of Hericium erinaceus. This study assessed their chemical and physical properties, molecular weight, monosaccharide compositions, and anti-ulcerative colitis ability to protect Caco-2 cells from lipopolysaccharide (LPS)-induced….

Immune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2021 · Research Article · Insects

Stage- and Rearing-Dependent Metabolomics Profiling of Ophiocordyceps sinensis and Its Pipeline Products.

Cordyceps, a parasitic complex of the fungus Ophiocordyceps sinensis (Berk.) (Hypocreales: Ophiocordycipitaceae) and the ghost moth Thitarodes (Lepidoptera: Hepialidae), is a historical ethnopharmacological commodity in China..

Metabolic health

High relevance

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Structure analysis and antioxidant activity of polysaccharide-iron (III) from Cordyceps militaris mycelia.

Iron-enriched Cordyceps militaris was obtained by adding FeSO4 solution to the mycelia for biotransformation. The polysaccharide-iron (III) was extracted by water extraction and alcohol precipitation.

Immune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Structure and hypoglycemic activity of a novel exopolysaccharide of Cordyceps militaris.

A novel neutral exopolysaccharide (EPS-III) was isolated from culture broth of Cordyceps militaris (C. militaris).

Immune supportMetabolic health

High relevance

Yellow Morel · 2021 · Journal Article · Food & function

The chemical structure and immunomodulatory activity of an exopolysaccharide produced by Morchella esculenta under submerged fermentation.

The extracellular polysaccharide of Morchella esculenta cultivated under submerged fermentation was extracted. A single polysaccharide was purified through DEAE-Cellulose 52 and Sephadex G 100, and named as MEP 2a.

Immune supportMetabolic health

High relevance

Chaga · 2021 · Research Article · Food science & nutrition

The difference of regulatory effect of two Inonotus obliquus extracts on high-fat diet mice in relation to the fatty acid elongation function of gut microbiota.

Obesity is a disease that causes metabolic disorders in the human body and is closely related to intestinal microbes. This experiment compares the therapeutic effects of two Inonotus obliquus extracts on high-fat diet (HFD) mice and explores the effects and mechanisms of intestinal flora and its metabolites..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Maitake · 2009 · Systematic Review · Journal of the Society for Integrative Oncology

Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration.

The objective of this study was to evaluate the scientific evidence on maitake, including expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. This review serves as a clinical support tool..

OncologyImmune supportMetabolic health

High relevance

Oyster Mushroom · 2026 · Preprint · journal metadata

Antifungal and Bioactive Potential of Pleurotus ostreatus Cultivated on Agro-Waste Substrates with Molecular Identification and Functional Characterization

The increasing prevalence of antifungal resistance among clinically relevant pathogens such as Candida albicans and Aspergillus fumigatus necessitates the exploration of novel bioactive compounds from sustainable sources..

Metabolic health

High relevance

Cordyceps · 2025 · Comparative Study · Applied biochemistry and biotechnology

GC-MS Analysis of Polysaccharides from an Intergeneric Hybrid of Pleurotus florida and Cordyceps militaris: A Comparative Study.

Edible and medicinal mushrooms are valuable sources of polysaccharides, known for their dual roles as immunostimulants and immunosuppressants. This study aimed to enhance polysaccharide content by fusing two mushroom species, P.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Reishi · 2025 · Preprint · journal metadata

Identification of a Ganoderma lucidum Endogenous Reference Gene and Its Validation for Quantitative Analysis of Spore Powders and Fruiting Bodies from Different Land Sources

Background: Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) are believed to be one of the major bioactive components to promote health benefits.

Immune supportMetabolic health

High relevance

Lion's Mane · 2025 · Preprint · journal metadata

Metabolic Profiling and Substrate Utilization of Hericium erinaceus (Lion’s Mane) Mycelia Isolate Using Biolog Phenotype Microarray

Abstract Hericium erinaceus, has long been recognized in traditional Chinese medicine for its extensive health benefits. H.

Cognition & nervesMetabolic health

High relevance

Reishi · 2025 · Preprint · journal metadata

Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid Metabolism

Abstract Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Oyster Mushroom · 2025 · Preprint · journal metadata

Pleurotus ostreatus modulates the intestinal glucose absorption by the Na(+)/glucose cotransporter 1 (SGLT1) in C57BL/6 mice

Abstract The use of medicinal mushrooms for the treatment of glycemic metabolism disorders has been extensively tested as a therapeutic alternative. The aim of this study was to analyze the effect of Pleurotus ostreatus extract on intestinal glucose absorption mediated by Na(+)-glucose cotransporter 1 (SGLT1) in….

Metabolic healthGut & microbiome

High relevance

Shiitake · 2025 · Preprint · journal metadata

Screening of Lentinula edodes Strains for High Polysaccharide Productions and In Vitro Antioxidant Activities

Lentinan is one of the main metabolites of Lentinula edodes, and exhibits numerous biological activities such as anti-tumor and antioxidant. Despite recent advancements, its commercialization remains constrained by a lengthy cultivation cycle, low yield, and high cost..

OncologyImmune supportMetabolic health

High relevance

Shiitake · 2025 · Preprint · journal metadata

The alterations of the synthetic pathway and metabolic flux of auxin indole-3-acetic acid (IAA) govern thermotolerance in Lentinula edodes mycelia subjected to heat stress

ABSTRACT Heat stress poses a significant constraint on the annual production of Lentinula edodes(L. edodes), a challenge that has been intensified by global warming.

Energy & fatigueMetabolic healthLiver support

High relevance

Maitake · 2024 · Preprint · journal metadata

Grifola frondosa polysaccharide Ameliorates Inflammation and Insulin Resistance by Regulating Macrophage Polarization of liver in Type 2 diabetes mellitus Rats

Type 2 diabetes mellitus (T2DM) is a common metabolic disease characterized by a lack of insulin secretion, insulin resistance (IR), and hyperglycemia. Given its high prevalence and multifarious complications, diabetes is globally ranked as the third leading cause of mortality..

Immune supportMetabolic healthLiver support