MycoData

Immune supportMetabolic health

Maitake · 2010 · Research Support, Non U.S. Gov'T · International journal of medical sciences

Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats.

OBJECTIVE: We assessed the ability of two commercially-available fractions labeled SX and D derived from the edible maitake mushroom to overcome many age-associated metabolic perturbations such as progressive, age-related elevation of blood pressure, over activity of the renin-angiotensin system (RAS), decreased….

Nameko · 2010 · Patent · journal metadata

Preparation method of pholiota nameko polysaccharide extract

The invention discloses a preparation method of a pholiota nameko polysaccharide extract and provides the preparation method which has the advantages of scale production, simple process and low cost..

Maitake · 2009 · Patent · journal metadata

LOW-MOLECULAR-WEIGHT SUBSTANCE DERIVED FROM MAITAKE MUSHROOM AND HAVING IMMUNOSTIMULATING ACTIVITY AND ANTI-TUMOR ACTIVITY

Disclosed is a substance derived from a Maitake mushroom, which has a lower molecular weight compared with those of conventional saccharide-protein complexes and a different structure from those of the conventional saccharide-protein complexes, and also has a high immunostimulating activity and a high anti-tumor….

Immune supportGut & microbiome

Chaga · 2007 · Research Support, Non U.S. Gov'T · BioFactors (Oxford, England)

Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease.

Inflammatory Bowel Disease (IBD) is partly caused by oxidative stress from free radicals and reduced antioxidant levels. Using hydrogen peroxide to induce oxidative stress in vitro in peripheral lymphocytes we investigated the induction of DNA damage supplemented with ethanolic extract of Chaga mushroom as a….

Immune supportRespiratory

Enoki · 2006 · Case Reports · Internal medicine (Tokyo, Japan)

Hypersensitivity Pneumonitis Induced by Spores of Penicillium citrinum in a Worker Cultivating Enoki Mushroom

A 47-year-old Japanese woman was admitted to our hospital with a 2-week history of dry cough and shortness of breath. She had been engaged in Enoki mushroom production for 22 years.

Immune supportEnergy & fatigueRespiratory

Almond Mushroom · 2026 · Im · Infection

Cerebrospinal fluid lipocalin-2 and bactericidal/permeability-increasing protein in acute bacterial versus viral meningitis: a prospective study.

PURPOSE: Distinguishing acute bacterial meningitis (ABM) from acute viral meningitis (AVM) remains challenging in clinically ambiguous scenarios, particularly during early disease stages or following partial antibiotic treatment..

OncologyImmune supportEnergy & fatigue

Almond Mushroom · 2025 · Research Support, Non U.S. Gov'T · Acta biomaterialia

Dual-targeting Aggregation-induced emission polymer micelles mediate immunogenic sonodynamic therapy for Tumor cell growth inhibition and macrophage reprogramming.

Sonodynamic therapy (SDT) is a promising cancer treatment known for its deep tumor penetration and high efficacy. However, developing highly efficient sonosensitizers remains a significant challenge..

Immune supportRespiratory

Almond Mushroom · 2025 · Research Support, Non U.S. Gov'T · Viruses

Perpetuation of Avian Influenza from Molt to Fall Migration in Wild Swan Geese (Anser cygnoides): An Agent-Based Modeling Approach.

Wild waterfowl are considered to be the reservoir of avian influenza, but their distinct annual life cycle stages and their contribution to disease dynamics are not well understood..

Almond Mushroom · 2024 · Research Support, Non U.S. Gov'T · Physiology & behavior

Acupressure bladder meridian alleviates anxiety disorder in rats by regulating MAPK and BDNF signal pathway.

The aim of this study was to investigate the effects of acupressure bladder meridian (ABM) on anxiety in rats. Chronic stress was induced rats to establish rat anxiety model.

Almond Mushroom · 2024 · Research Support, Non U.S. Gov'T · Technology in cancer research & treatment

Dose-Volume Parameters of Spared Magnetic Resonance Imaging-Defined Active Bone Marrow Predict Hematologic Toxicity in Pelvic Malignancies Patients Undergoing Radiotherapy: A Cohort Study.

Background: The objective of this investigation is to evaluate the superiority of dose-volume parameters relying on magnetic resonance imaging (MRI)-defined active bone marrow (ABM) over those based on total bone marrow (TBM) contoured via CT in the prediction of hematologic toxicity (HT) occurrence among patients….

Immune supportEnergy & fatigueMetabolic healthLiver support

Almond Mushroom · 2024 · Research Support, Non U.S. Gov'T · Stem cell research & therapy

Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood.

BACKGROUND: Hematopoietic stem progenitor cells (HSPCs) undergo phenotypical and functional changes during their emergence and development. Although the molecular programs governing the development of human hematopoietic stem cells (HSCs) have been investigated broadly, the relationships between dynamic metabolic….

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Tolypocladium sinense Mycelium Polysaccharide Alleviates Obesity, Lipid Metabolism Disorder, and Inflammation Caused by High Fat Diet via Improving Intestinal Barrier and Modulating Gut Microbiota.

SCOPE: Tolypocladium sinense is a fungus isolated from Cordyceps. Cordyceps has some medicinal value and is also a daily health care product.

Immune supportCognition & nervesMetabolic healthLiver support

Almond Mushroom · 2023 · Journal Article · Fish & shellfish immunology

Abamectin induced brain and liver toxicity in carp: The healing potential of silybin and potential molecular mechanisms.

Abamectin (ABM) abuse contaminated aquatic environment and posed a potential threat to fish health as well as public safety. Silybin (SIL), a flavonoid, has been widely used as a novel feed additive to promote fish health..

Almond Mushroom · 2023 · Research Article · Frontiers in bioengineering and biotechnology

An agent-based model of cardiac allograft vasculopathy: toward a better understanding of chronic rejection dynamics.

Cardiac allograft vasculopathy (CAV) is a coronary artery disease affecting 50% of heart transplant (HTx) recipients, and it is the major cause of graft loss. CAV is driven by the interplay of immunological and non-immunological factors, setting off a cascade of events promoting endothelial damage and vascular….

OncologyImmune supportGut & microbiome

Maitake · 2023 · Research Article · Pharmaceuticals (Basel, Switzerland)

Influences of Yogurt with Functional Ingredients from Various Sources That Help Treat Leaky Gut on Intestinal Barrier Dysfunction in Caco-2 Cells.

The impact of yogurts made with starter culture bacteria (L. bulgaricus and S.

Oyster Mushroom · 2023 · Journal Article · Biotechnology and applied biochemistry

Nutritional qualities and antioxidant activity of Pleurotus floridanus grown on composted peach sawdust substrate with different composting time.

Recently, composting cultivation method is widely used in oyster mushroom production. In this study, we focused on the effects of composting processes on nutritional qualities and antioxidant activity of Pleurotus floridanus mushroom fruiting bodies..

OncologyImmune supportEnergy & fatigueSkin & hydration

Reishi · 2023 · Journal Article · The Gulf journal of oncology

Oral Intake of Combined Natural Immunostimulants Suppresses the 7,12-DMBA/ Croton Oil Induced Two-step Skin Carcinogenesis in Swiss Albino Mice.

BACKGROUND: The immune system is critical in fighting cancer, so is it possible that the natural stimulation of this system can slow down or stop the evolution of cancer?.

Immune supportGut & microbiome

Cordyceps · 2023 · Research Article · Molecules (Basel, Switzerland)

Polysaccharides from Paecilomyces hepiali Prevent Acute Colitis in Association with Modulating Gut Microbiota and Treg/Th17 Immune Balance in Mice.

Cordyceps exopolysaccharide (CEP) has shown emerging potential in adjustment of gut microbiota and immune cell function. In this study, a water-soluble CEP with a molecular weight of 58.14 kDa was extracted from the fermentation broth of Paecilomyces hepiali, an endophytic fungus of Cordyceps sinensis..

OncologyImmune supportCognition & nervesMetabolic health

Almond Mushroom · 2023 · Research Article · Environmental science and pollution research international

The potential effect of Moringa oleifera ethanolic leaf extract against oxidative stress, immune response disruption induced by abamectin exposure in Oreochromis niloticus.

Abamectin (ABM), a naturally fermented product of Streptomyces avermitilis, is applied to pest control in livestock and agriculture fields. The aim of the current study is to evaluate the protective effects of Moringa oleifera leaf ethanolic extract (MOE) on biochemical changes including oxidative stress indices,….

OncologyImmune supportRespiratory

Almond Mushroom · 2022 · Journal Article · Iranian journal of allergy, asthma, and immunology

Agent-based Modeling of Tumor and Immune System Interactions in Combinational Therapy with Low-dose 5-fluorouracil and Dendritic Cell Vaccine in Melanoma B16F10.

This study is designed to present an agent-based model (ABM) to simulate the interactions between tumor cells and the immune system in the melanoma model. The Myeloid-derived Suppressor Cells (MDSCs) and dendritic cells (DCs) are considered in this model as immunosuppressive and antigen-presenting agents respectively..

Immune supportEnergy & fatigueMetabolic healthLiver support

Almond Mushroom · 2022 · Research Article · Frontiers in pharmacology

Ameliorating effect of the biological Zinc nanoparticles in abamectin induced hepato-renal injury in a rat model: Implication of oxidative stress, biochemical markers and COX-2 signaling pathways.

Extensive use of abamectin (ABM) as an anthelmintic in veterinary systems adversely affects the health and welfare of animals and humans. Zinc nanoparticles (ZnNPs) have therapeutic benefits and ameliorate the effect of environmental pollutants..

OncologyImmune supportRespiratory

Almond Mushroom · 2022 · Research Article · International journal of molecular sciences

An Agent-Based Model of Radiation-Induced Lung Fibrosis.

Early- and late-phase radiation-induced lung injuries, namely pneumonitis and lung fibrosis (RILF), severely constrain the maximum dose and irradiated volume in thoracic radiotherapy..

Immune supportCognition & nervesRespiratory

Almond Mushroom · 2022 · Journal Article · Inflammation research: official journal of the European Histamine Research Society... [et al.]

Deciphering the TLR transcriptome and downstream signaling pathway in cerebrospinal fluid in pediatric meningitis.

OBJECTIVE/DESIGN: Pediatric meningitis is characterized by a colossal inflammatory response to the pathogen in the central nervous system (CNS). This unabated inflammatory response persists even after the removal of the pathogen by antibiotics/steroids causing collateral damage to CNS tissue..

Immune supportCognition & nervesLiver supportRespiratory

Almond Mushroom · 2022 · Research Article · Advanced healthcare materials

Designer Extracellular Vesicles Modulate Pro-Neuronal Cell Responses and Improve Intracranial Retention.

Gene/oligonucleotide therapies have emerged as a promising strategy for the treatment of different neurological conditions. However, current methodologies for the delivery of neurogenic/neurotrophic cargo to brain and nerve tissue are fraught with caveats, including reliance on viral vectors, potential toxicity, and….

OncologyImmune supportCognition & nervesLiver support

Reishi · 2022 · Journal Article · PloS one

Ganoderma tsugae prevents cognitive impairment and attenuates oxidative damage in d-galactose-induced aging in the rat brain.

Lingzhi has long been regarded as having life-prolonging effects. Research in recent years has also reported that Lingzhi possesses anti-tumor, anti-inflammatory, immunomodulatory, hepatoprotective, and anti-lipogenic effects..

Immune supportSkin & hydration

Reishi · 2022 · Journal Article · Journal of fungi (Basel, Switzerland)

GlPP2C1 Silencing Increases the Content of Ganodermalingzhi Polysaccharide (GL-PS) and Enhances Slt2 Phosphorylation.

Polysaccharides have attracted much attention in the food industry due to their diverse biological activities. To date, research on the mechanism of polysaccharide synthesis has mainly focused on the role of crucial enzymes in the polysaccharide synthesis pathway, but other genes that regulate polysaccharide synthesis….

Almond Mushroom · 2022 · Journal Article · Environmental toxicology

Investigation of the effects of hesperidin administration on abamectin-induced testicular toxicity in rats through oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, autophagy, and JAK2/STAT3 pathways.

In this study, the potential effects of hesperidin (HES) on chronic toxicity caused by abamectin (ABM) in the testicular tissue were investigated through oxidative stress, inflammation, endoplasmic reticulum stress (ERS), apoptosis, and autophagy pathways. Male Sprague Dawley rats were used in the study..

OncologyImmune supportCognition & nervesRespiratory

Almond Mushroom · 2021 · Journal Article · Cancers

An Agent-Based Model of Combination Oncolytic Viral Therapy and Anti-PD-1 Immunotherapy Reveals the Importance of Spatial Location When Treating Glioblastoma.

Oncolytic viral therapies and immunotherapies are of growing clinical interest due to their selectivity for tumor cells over healthy cells and their immunostimulatory properties..

OncologyImmune supportEnergy & fatigue

Cordyceps · 2021 · Journal Article · The American journal of Chinese medicine

Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway.

A well-known medicinal mushroom in the field of traditional Chinese medicine, Cordyceps sinensis, is a rare natural-occurring entomopathogenic fungus, and it typically grows at high altitudes on the plateau of the Himalayan..

Almond Mushroom · 2021 · Journal Article · Molecular pharmaceutics

Evaluation of Copper-64-Labeled αvβ6-Targeting Peptides: Addition of an Albumin Binding Moiety to Improve Pharmacokinetics.

The incorporation of non-covalent albumin binding moieties (ABMs) into radiotracers results in increased circulation time, leading to a higher uptake in the target tissues such as the tumor, and, in some cases, reduced kidney retention..

Cordyceps · 2021 · Journal Article · Biological & pharmaceutical bulletin

Identification of Ophiocordyceps gracilioides by Its Anti-tumor Effects through Targeting the NFκB-STAT3-IL-6 Inflammatory Pathway

Although more than 400 species of Cordyceps s.l. have been identified, most have not been well explored regarding their potential for medicinal use.

Immune supportGut & microbiome

Cordyceps · 2021 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Nutraceutical intervention protects against bacterial and chemical-induced gastrotoxicity in a non-mammalian model, Galleria mellonella.

Preparations of the fungus Cordyceps sinensis and bovine colostrum are considered nutraceuticals due to their anti-inflammatory, repair and gut alimentation properties in mammalian models..

OncologyImmune supportRespiratory

Almond Mushroom · 2021 · Journal Article · International journal of radiation oncology, biology, physics

Outcomes of Patients Living With HIV and Anal Cancer Treated With Definitive Intensity-Modulated Radiation Therapy and 5-Fluorouracil- or Capecitabine-Based Chemotherapy.

Purpose/objective(s) To assess outcomes after definitive chemo-irradiation in HIV patients with anal cancer, and evaluate hemato-immunologic (HI) toxicity by dynamics of CD4+ cell counts and lymphocytes and their association with the dose received by active bone marrow (ABM)..

Almond Mushroom · 2021 · Journal Article · Biomaterials science

Structural influence of antibody recruiting glycodendrimers (ARGs) on antitumoral cytotoxicity.

The recruitment of endogenous antibodies against cancer cells has become a reliable antitumoral immunotherapeutic alternative over the last decade. The covalent attachment of antibody and tumor binding modules (ABM and TBM) within a single, well-defined synthetic molecule was indeed demonstrated to promote the….

Immune supportEnergy & fatigueMetabolic healthLiver support

Almond Mushroom · 2021 · Journal Article · Aquaculture

The stress of abamectin toxicity reduced water quality, growth performance, immunity and antioxidant capacity of Oreochromis niloticus fish: Modulatory role of Simmondsia chinensis extract as a dietary supplement

The present study was conducted to investigate the toxic effect of abamectin (ABM) and to evaluate the modulatory role of heat treated jojoba leaves extract (JLE) as feed additive in Oreochromis niloticus (O. niloticus) fish..

Almond Mushroom · 2021 · Journal Article · Frontiers in physiology

The Use of Artificial Neural Networks to Forecast the Behavior of Agent-Based Models of Pathophysiology: An Example Utilizing an Agent-Based Model of Sepsis.

Introduction: Disease states are being characterized at finer and finer levels of resolution via biomarker or gene expression profiles, while at the same time. Machine learning (ML) is increasingly used to analyze and potentially classify or predict the behavior of biological systems based on such characterization..

Almond Mushroom · 2021 · Research Article · Frontiers in physiology

Utilizing the Heterogeneity of Clinical Data for Model Refinement and Rule Discovery Through the Application of Genetic Algorithms to Calibrate a High-Dimensional Agent-Based Model of Systemic Inflammation.

Introduction: Accounting for biological heterogeneity represents one of the greatest challenges in biomedical research. Dynamic computational and mathematical models can be used to enhance the study and understanding of biological systems, but traditional methods for calibration and validation commonly do not account….

Cordyceps · 2020 · Video Audio Media · Journal of visualized experiments: JoVE

Gene Mining and Sequence Analysis of Purine Nucleosidase Based on RNA-Seq.

Caterpillar fungus (Ophiocordyceps sinensis) is one of the most valued fungal Traditional Chinese medicine (TCM), and it contains plenty of active ingredients such as adenosine. Adenosine is considered as a biologically effective ingredient that has a variety of anti-tumor and immunomodulatory activities..

Immune supportEnergy & fatigue

King Oyster · 2014 · Journal Article · Applied biochemistry and biotechnology

Construction of a laccase chimerical gene: recombinant protein characterization and gene expression via yeast surface display.

The ERY4 laccase gene from Pleurotus eryngii was expressed in Saccharomyces cerevisiae and the recombinant laccase resulted to be not biologically active. This gene was thus modified to obtain chimerical enzymes derived from the substitution of N-, C- and both N- and C-terminal regions with the corresponding regions….

OncologyImmune supportCognition & nervesMetabolic health

Almond Mushroom · 2011 · Research Article · Journal of clinical biochemistry and nutrition

Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats

Ipomoea batatas, Agaricus blazei and Smallanthus sonchifolius are known to favorably influence diabetes mellitus. To clarify their antidiabetic efficacy and hypoglycemic mechanisms, we treated streptozotocin-induced diabetic rats with daily oral feeding of powdered Ipomoea batatas (5 g kg(-1) d(-1)), Agaricus blazei….

Immune supportEnergy & fatigueMetabolic healthLiver support

Cordyceps · 2022 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.

Fatigue, a most commonly sub-health condition, may cause people more susceptible to many diseases. Cordycepin, a principal active ingredient from Cordyceps militaris, exerts various pharmacological activities including anti-diabetes, anti-inflammatory, immunomodulatory and antioxidant effects..

Cordyceps · 2022 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Cordycerebroside A inhibits ICAM-1-dependent M1 monocyte adhesion to osteoarthritis synovial fibroblasts.

Osteoarthritis (OA) is represented by the accumulation and adhesion of M1 macrophages into synovium tissues in the joint microenvironment and subsequent inflammatory response..

Cordyceps · 2022 · Research Support, Non U.S. Gov'T · Developmental and comparative immunology

Immulectin-2 from the ghost moth, Thitarodes xiaojinensis (Lepidoptera: Hepialidae), modulates cellular and humoral responses against fungal infection.

C type-lectins constitute a large family of pattern recognition receptors, playing important roles in insect immune defenses. Thitarodes xiaojinensis larvae showed distinct immune features after Ophiocordyceps sinensis, Cordyceps militaris, or Beauveria bassiana infection..

Immune supportEnergy & fatigue

King Oyster · 2022 · Research Support, Non U.S. Gov'T · Frontiers in immunology

Immune regulatory functions of biologically active proteins from edible fungi.

Proteins from edible mushrooms have a variety of biological activities. Here, thirteen precious edible mushrooms such as Ophiocordyceps sinensis, Ganoderma lucidum, and Morchella esculenta and nine common edible mushrooms such as Flammulina velutipes, Pleurotus ostreatus, and Pleurotus eryngii, etc., from which their….

Immune supportCognition & nervesEnergy & fatigue

Cordyceps · 2021 · Research Support, Non U.S. Gov'T · Neurotoxicology

Anti-inflammatory and neuroprotective effects of natural cordycepin in rotenone-induced PD models through inhibiting Drp1-mediated mitochondrial fission.

Accumulating evidences suggest that inflammation-mediated neurons dysfunction participates in the initial and development of Parkinson's disease (PD), whereas mitochondria have been recently recognized as crucial regulators in NLRP3 inflammasome activation..

Immune supportMetabolic healthLiver support

Cordyceps · 2021 · Research Support, Non U.S. Gov'T · Hepatology (Baltimore, Md.)

Cordycepin Ameliorates Nonalcoholic Steatohepatitis by Activation of the AMP-Activated Protein Kinase Signaling Pathway.

BACKGROUND AND AIMS: Nonalcoholic fatty liver disease, especially nonalcoholic steatohepatitis (NASH), has become a major cause of liver transplantation and liver-associated death..

Immune supportMetabolic health

Chaga · 2005 · Patent · journal metadata

COMPOSITION OF THE EXTRACTS OF INONOTUS OBLIQUUS FOR LOWERING BLOOD SUGAR LEVEL AND IMPROVING ANTI-INFLAMMATORY ACTIVITY AND ITS PREPARATION METHOD

Metadata-grounded summary: This patent indexes research on Inonotus obliquus in 2005. MycoData maps the paper to immune support, metabolic health based on its title, species context, article metadata, and study classification..

Maitake · 2005 · Patent · journal metadata

EXTRACT FROM GRIFOLA FRONDOSA (A KIND OF MUSHROOM) AND GLYCOPROTEIN AND METHOD FOR PRODUCING THE SAME

Metadata-grounded summary: This patent indexes research on Grifola frondosa in 2005. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Maitake · 2005 · Patent · journal metadata

GENE ENCODING LECTIN DERIVED FROM GRIFOLA FRONDOSA