MycoData

Almond Mushroom · 2026 · Research Article · Bulletin of mathematical biology

Modelling Immune Dynamics in Locally Advanced MSI-H/dMMR Colorectal Cancer with Neoadjuvant Pembrolizumab Treatment: From Differential Equations to an Agent-Based Framework.

Colorectal cancer (CRC) is the third most common malignancy worldwide, and accounts for approximately 10% of all cancers and an estimated 850,000 deaths annually..

OncologyImmune support

Immune supportGut & microbiomeLiver support

Shiitake · 2026 · Journal Article · Food Research International

Self-assembled Lentinus edodes ergosterol-amyloid fiber hydrogel for zebrafish enteritis mitigation: Role of intestinal flora regulation and metabolomic remodeling

Inflammatory bowel disease (IBD) necessitates the development of effective and safe therapeutic strategies derived from food sources. Ergosterol from Lentinus edodes (Shiitake) exhibits anti-colitic properties but is limited by its poor bioavailability..

Immune supportGut & microbiomeLiver support

Shiitake · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Self-assembled Lentinus edodes ergosterol-amyloid fiber hydrogel for zebrafish enteritis mitigation: Role of intestinal flora regulation and metabolomic remodeling.

Immune supportEnergy & fatigueMetabolic healthLiver support

Cordyceps · 2026 · Journal Article · The Journal of pharmacy and pharmacology

The CGA combination enhances bile acids alternative biosynthesis pathway and alleviates MASH induced by methionine-choline-deficient diet.

OBJECTIVE: CGA combination consisting of Cordyceps sinensis polysaccharide, gypenosides, and amygdalin, is derived from Fuzheng Huayu capsule (a traditional Chinese medicine approved for liver fibrosis) via previous Uniform Design Experimentation..

Chaga · 2026 · Journal Article · International immunopharmacology

The mast cell-stabilizing effects of inotodiol and lanosterol result from ubiquitin-mediated degradation of HMG-CoA reductase.

Inotodiol, a C22-hydroxy lanosterol uniquely found in chaga mushroom, possesses potent anti-anaphylactic and mast cell-stabilizing activities; however, its underlying mechanism remains poorly understood..

King Oyster · 2025 · Journal Article · Pharmacological reports: PR

Antiplatelet potencies of polysaccharides extracted from eight cultivated edible Pleurotus mushroom species.

BACKGROUND: Cardiovascular diseases remain a leading global health challenge, necessitating effective antiplatelet therapies to mitigate thrombotic risks. Conventional antiplatelet agents, such as acetylsalicylic acid (ASA) and purinergic receptor type Y, subtype 12 (P2Y12) inhibitors, are effective but present….

Immune supportMetabolic health

Nameko · 2025 · Journal Article · Carbohydrate research

Autoclave extraction applied to residual mushroom biomass: An efficient method for high-yield polysaccharide recovery.

Mushroom-derived polysaccharides, particularly β-D-glucans, are valued for their biological activities and broad biotechnological applications. Although several conventional extraction methods have been established (cold-water, hot-water, and alkaline), the biomass that remains after exhaustive treatments is often….

Oyster Mushroom · 2025 · Research Article · Foods (Basel, Switzerland)

Centesimal Composition, Bioactive Compounds, Antioxidant and α-Glucosidase Inhibitory Activities of Commercial Edible Oyster Mushrooms at Different Maturity Stages in Northern Thailand.

Oyster mushrooms (Pleurotus spp.) are widely cultivated due to their high nutritional value and bioactive compounds with health-promoting properties. However, the fruiting body developmental stage significantly influences the centesimal composition and bioactive compound levels..

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2025 · Journal Article · International immunopharmacology

Cordycepin alleviates renal ischemia-reperfusion injury by suppressing the p38/JNK signaling pathway.

Renal ischemia-reperfusion injury (IRI) makes a significant contribution to delayed graft function (DGF) and reduced allograft survival time post-transplantation, thereby complicating the prognosis of renal transplant recipients..

Cordyceps · 2025 · Journal Article · British journal of pharmacology

Cordycepin ameliorates autoimmunity by promoting STING degradation via autophagy pathway.

BACKGROUND AND PURPOSE: Stimulator of interferon response cGAMP interactor 1 (STING), a central hub protein of cyclic GMP-AMP synthase (cGAS)-STING signalling pathway, has a crucial role in regulating type I interferons (IFNs) production and response..

Immune supportCognition & nervesRespiratory

Chaga · 2025 · Research Article · Frontiers in digital health

Dissecting the difference between positive and negative brain health sentiment using X data.

INTRODUCTION: Human behavior is significantly influenced by emotions, with negative sentiments such as fear and anxiety driving various coping mechanisms, including cognitive behavioral therapy (CBT), dietary changes, and medication use..

OncologyImmune supportRespiratory

Cordyceps · 2025 · Journal Article · Immunological investigations

Hirsutella sinensis Fungus Promotes CD8+ T Cell-Mediated Anti-Tumor Immunity by Affecting Tumor-Associated Macrophages-Derived CCRL2.

INTRODUCTION: Hirsutella sinensis fungus (HSF)is an artificial substitute for Cordyceps sinensis and has shown promising therapeutic effects in various diseases including cancer. Previous studies have demonstrated that HSF can affect macrophage polarization and activate systemic immune response..

Immune supportRespiratory

Almond Mushroom · 2025 · Research Article · Scientific reports

HIV case management using agent-based modeling approach subject to antiretroviral therapy and lifestyle treatment plan.

This study presents a spatially explicit stochastic agent-based model (ABM) to simulate the complex non-linear interactions between T-cells, HIV virions, and therapeutic agents..

Immune supportMetabolic healthGut & microbiome

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Human fecal fermentation of high/low-molecular weight exopolysaccharides from a medicinal fungus Cs-HK1 and anti-inflammatory protection on gut barrier function.

The exopolysaccharides (EPS) produced by the Cordyceps sinensis Cs-HK1 fungus have shown multiple bioactivities and potential health benefits in previous studies. This study was to assess the prebiotic properties and the protective effects on gut barrier of EPS and human fecal fermentation products..

Immune supportCognition & nervesEnergy & fatigue

Cordyceps · 2025 · Research Article · Scientific reports

In vitro and in silico neuroprotective evaluation of new biotransformation metabolites of (-)-α-bisabolol.

Biotransformation of (-)-α-bisabolol (1) was investigated by screening twenty-two fungal strains in an effort to produce new more polar and potentially bioactive metabolites. Three fungi were selected for scale-up biotransformation: Cordyceps sinensis, Alternaria alternata and Aspergillus flavus..

OncologyImmune supportRespiratory

Chaga · 2025 · Research Article · Allergy, asthma & immunology research

Inotodiol Attenuates Mucosal Inflammation in a Mouse Model of Eosinophilic Chronic Rhinosinusitis.

PURPOSE: Inotodiol (22-hydroxy lanosterol), a unique component of chaga mushrooms, is believed to be a medicinal component with reported antitumor, antiviral, and anti-inflammatory properties..

Immune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2025 · Research Article · Frontiers in integrative neuroscience

Kiperin Mind Focus supplement mitigates chronic stress-induced neuroinflammation and molecular dysregulation and improves stress-related affective and exploratory behaviors in rats.

BACKGROUND: Chronic stress is known to impair emotional regulation and adaptive behavioral responses through neuroinflammatory activation, oxidative imbalance, and dysregulation of neuroplasticity-related genes..

Immune supportRespiratory

Shiitake · 2025 · Research Article · Toxics

Lentinan Alleviated PM2.5 Exposure-Induced Epithelial-Mesenchymal Transition in Pulmonary Epithelial Cells by Inhibiting the GARP/TGF-β/Smad Pathway.

PM2.5 (fine particulate matter) is an air pollutant widely present in urban and industrial areas, which has emerged as a significant threat to human health. Specifically, long-term exposure to PM2.5 could lead to various lung diseases, including pulmonary fibrosis and Chronic Obstructive Pulmonary Disease (COPD)..

Immune supportEnergy & fatigue

Almond Mushroom · 2025 · Journal Article · Bone

OMIBONE: Omics-driven computer model of bone regeneration for personalized treatment.

Treatment of bone fractures are standardized according to the AO classification, which mainly refers to the mechanical stabilization required in a given situation but neglect individual differences due to patient's healing potential or accompanying diseases..

OncologyImmune supportMetabolic health

Almond Mushroom · 2025 · Journal Article · Biotechnology and applied biochemistry

Preliminary Assessment of Cytotoxic Effects of Murraya koenigii Toluene Extracts on PA1 Cells via LC-MS, In Vitro, and In Silico Approaches.

Murraya koenigii (MK) is a medicinal plant known for its diverse phytochemical constituents and therapeutic properties. This study presents the first comprehensive analysis of MK leaf and stem whole extracts obtained using toluene, a non-polar solvent that enabled selective extraction of lipophilic phytochemicals..

Immune supportEnergy & fatigue

Cordyceps · 2025 · Journal Article · Natural product research

Structurally diverse oxygen-containing aromatic compounds with anti-inflammatory activity from Aspergillus sp. LY-1-2.

Three isocoumarins, ascoisocoumarin A (1), embeurekol (2), and sclerotinin A (3), and five biosynthetically related derivatives, ascospinols A-C (4, 6, and 7), and talaflavuols C and B (5 and 8), together with twelve polyketides or terpenes (9-20) were isolated from the fungus Aspergillus sp..

Immune supportMetabolic healthLiver supportSkin & hydration

Reishi · 2025 · Journal Article · Current issues in molecular biology

Sublingual Dripping Pill Formulation of Ganoderma amboinense Fruiting Body Extract Attenuates CCl4-Induced Liver Fibrosis via Multi-Pathway Regulation.

Liver fibrosis remains difficult to treat, in part because many hepatoprotective triterpenoids suffer from poor oral bioavailability and lack of optimized delivery formats..

OncologyImmune supportEnergy & fatigue

Cordyceps · 2025 · Research Article · Scientific reports

The impact of Nrf2/HO-1, PD-L1/Bax/Bcl-2 and TNF-α/Il-6 signaling pathways in the ameliorative role of cordycepin against acrylamide-induced cardiac toxicity in rats.

Acrylamide (ACR) is a hazardous and possibly carcinogenic chemical compound that humans are constantly exposed to in their daily life. ACR passively affect many organ systems, including the cardiovascular system..

Immune supportMetabolic healthGut & microbiome

Cordyceps · 2025 · Research Article · Frontiers in immunology

Therapeutic effects of Isaria felina on postmenopausal osteoporosis: modulation of gut microbiota, metabolites, and immune responses.

BACKGROUND: The intricate relationship between human health and gut microecology has emerged as a central theme in contemporary medical research. Postmenopausal osteoporosis, primarily driven by estrogen deficiency, remains a major health concern..

Nameko · 2024 · Journal Article · Carbohydrate polymers

(1 → 3),(1 → 6) and (1 → 3)-β-D-glucan physico-chemical features drive their fermentation profile by the human gut microbiota

Mushroom polysaccharides consist of a unique set of polymers that arrive intact in the human large intestine becoming available for fermentation by resident gut bacteria with potential benefits to the host..

Nameko · 2024 · Journal Article · Carbohydrate polymers

(1 → 3),(1 → 6) and (1 → 3)-β-D-glucan physico-chemical features drive their fermentation profile by the human gut microbiota.

Immune supportCognition & nerves

Almond Mushroom · 2024 · Research Article · Antibodies (Basel, Switzerland)

50 Years of Antibody Numbering Schemes: A Statistical and Structural Evaluation Reveals Key Differences and Limitations.

BACKGROUND: The complementarity-determining region (CDR) of antibodies represents the most diverse region both in terms of sequence and structural characteristics, playing the most critical role in antibody recognition and binding for immune responses..

Cordyceps · 2024 · Journal Article · Journal of agricultural and food chemistry

A Hirsutella sinensis Alcohol Extract Exerts Bidirectional Immunoregulatory Effects by Regulating Macrophage Polarization.

For background, Hirsutella sinensis, the only anamorphic fungus considered an effective substitute for Cordyceps sinensis, possesses immunoregulatory properties. However, the specific mechanism underlying the immunoregulatory function of Hirsutella sinensis remains unclear..

Almond Mushroom · 2024 · Research Article · Computational and structural biotechnology journal

Advancing PFAS risk assessment: Integrative approaches using agent-based modelling and physiologically-based kinetic for environmental and health safety.

Per- and polyfluoroalkyl substances (PFAS), ubiquitous in a myriad of consumer and industrial products, and depending on the doses of exposure represent a hazard to both environmental and public health, owing to their persistent, mobile, and bio accumulative properties..

OncologyImmune supportEnergy & fatigueLiver support

Almond Mushroom · 2024 · Research Article · eLife

Agent-based model demonstrates the impact of nonlinear, complex interactions between cytokinces on muscle regeneration.

Muscle regeneration is a complex process due to dynamic and multiscale biochemical and cellular interactions, making it difficult to identify microenvironmental conditions that are beneficial to muscle recovery from injury using experimental approaches alone..

OncologyImmune supportSkin & hydration

Almond Mushroom · 2024 · Journal Article · Computer methods and programs in biomedicine

An agent-based method to estimate 3D cell migration trajectories from 2D measurements: Quantifying and comparing T vs CAR-T 3D cell migration.

BACKGROUND AND OBJECTIVE: Immune cell migration is one of the key features that enable immune cells to find invading pathogens, control tissue damage, and eliminate primary developing tumors. Chimeric antigen receptor (CAR) T-cell therapy is a novel strategy in the battle against various cancers..

Cordyceps · 2024 · Journal Article · Carbohydrate polymers

Anti-bacterial effects, and metabolites derived from bifidobacterial fermentation of an exopolysaccharide of Cs-HK1 medicinal fungus

This study was to investigate the antibacterial effects and metabolites derived from bifidobacterial fermentation of an exopolysaccharide EPS-LM produced by a medicinal fungus Cordyceps sinensis, Cs-HK1..

Cordyceps · 2024 · Journal Article · Carbohydrate polymers

Anti-bacterial effects, and metabolites derived from bifidobacterial fermentation of an exopolysaccharide of Cs-HK1 medicinal fungus.

Immune supportLiver supportRespiratory

Shiitake · 2024 · Research Article · Poultry science

Application of lentinan in suppression of Marek's disease virus infection.

Marek's disease virus (MDV) is an extremely widespread avian immunosuppressive virus. In recent years, many reports have shown that there are still cases of MDV infection and immunosuppression after immunization with the vaccine..

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2024 · Journal Article · Journal of ethnopharmacology

Bioinformatics analyses of infiltrating immune cell participation on pancreatic ductal adenocarcinoma progression and in vivo experiment of the therapeutic effect of Shuangshen granules.

ETHNOPHARMACOLOGICAL RELEVANCE: Shuangshen granules (SSG), a nationally patented Chinese medicinal formula, including Panax quinquefolium L., Panax notoginseng (Burkill) F. H..

Immune supportEnergy & fatigue

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Characterization of a polysaccharide from Amauroderma rugosum and its proangiogenic activities in vitro and in vivo.

Amauroderma rugosum (AR), also known as "Blood Lingzhi" in Chinese, is a basidiomycete belonging to the Ganodermataceae family. Four polysaccharide fractions were systematically isolated and purified from AR..

Immune supportEnergy & fatigueGut & microbiome

Reishi · 2024 · Journal Article · International journal of pharmaceutics: X

Colon targeting in rats, dogs and IBD patients with species-independent film coatings.

Polysaccharides were identified, which allow for colon targeting in human Inflammatory Bowel Disease (IBD) patients, as well as in rats and dogs (which are frequently used as animals in preclinical studies)..

Immune supportMetabolic healthGut & microbiomeLiver support

Enoki · 2024 · Journal Article · Journal of the science of food and agriculture

Complex insoluble dietary fiber alleviates obesity and liver steatosis, and modulates the gut microbiota in C57BL/6J mice fed a high-fat diet.

BACKGROUND: Obesity has been demonstrated as a risk factor that seriously affects health. Insoluble dietary fiber (IDF), as a major component of dietary fiber, has positive effects on obesity, inflammation and diabetes..

Immune supportMetabolic healthGut & microbiomeLiver support

Enoki · 2024 · Journal Article · Journal of the science of food and agriculture

Complex insoluble dietary fiber alleviates obesity and liver steatosis, and modulates the gut microbiota in C57BL/6J mice fed a high‐fat diet

OncologyImmune supportGut & microbiome

Cordyceps · 2024 · Journal Article · Cancer genomics & proteomics

Cordycepin Activates Autophagy to Suppress FGF9-induced TM3 Mouse Leydig Progenitor Cell Proliferation.

BACKGROUND/AIM: Fibroblast growth factor 9 (FGF9) is a member of the human FGF family known for its pivotal roles in various biological processes, such as cell proliferation, tissue repair, and male sex determination including testis formation..

Cordyceps · 2024 · Research Article · Heliyon

Cordycepin enhances anti-tumor immunity in breast cancer by enhanceing ALB expression.

OBJECTIVE: The treatment of breast cancer still faces great challenges, and it is necessary to continuously explore effective drugs and targets to promote immune precision medicine. This study aims to investigate the immune-related regulatory mechanism of cordycepin in breast cancer..

OncologyImmune support

OncologyImmune supportGut & microbiome

Cordyceps · 2024 · Journal Article · European journal of pharmacology

Cordycepin enhances the Anticancer efficacy of PD-L1 blockade by modulating the tumor microenvironment of colon cancer.

BACKGROUND: PD-L1 blockade has been found to be effective in treating multiple malignancies. Combined therapy is proposed to provide better therapeutic effects.

OncologyImmune supportRespiratory

Maitake · 2024 · Journal Article · Molecules (Basel, Switzerland)

Effects of a β-Glucan-Rich Blend of Medicinal Mushrooms and Botanicals on Innate Immune Cell Activation and Function Are Enhanced by a Very Low Dose of Bovine Colostrum Peptides.

Nutraceutical immune support offers potential for designing blends with complementary mechanisms of action for robust support of innate immune alertness. We documented enhanced immune activation when bovine colostrum peptides (BC-Pep) were added to an immune blend (IB) containing β-glucans from yeast, shiitake,….

Immune supportMetabolic healthLiver support

Cordyceps · 2024 · Journal Article · Veterinary parasitology

Efficacy of cordycepin against Neospora caninum infection in vitro and in vivo.

Neospora caninum (N. caninum) is an obligate intracellular Apicomplexa parasite that causes abortions in dairy cows and incurs substantial to significant economic losses in the global dairy farming industry..

OncologyImmune supportSkin & hydration

Reishi · 2024 · Journal Article · International journal of molecular sciences

Exploring Senolytic and Senomorphic Properties of Medicinal Plants for Anti-Aging Therapies.

Senolytic and senomorphic therapies have gained more and more attention in the last decade. This kind of therapy is based on the killing of cellular senescent cells without harming the "normal" cells.

Nameko · 2024 · Research Article · International journal of molecular sciences

Exploring the Potential of Fungal Biomass for Bisphenol A Removal in Aquatic Environments.

Bisphenol A is a plastic component, which shows endocrine activity that is detrimental to humans and aquatic ecosystems. The elimination of BPA from the environment is one of the solutions for BPA contaminant management..

OncologyImmune supportMetabolic healthLiver support

Reishi · 2024 · Journal Article · Scientific reports

Ganoderma tsuage promotes pain sensitivity in aging mice.

Advances in modern medicine have extended human life expectancy, leading to a world with a gradually aging society. Aging refers to a natural decline in the physiological functions of a species over time, such as reduced pain sensitivity and reaction speed..

OncologyImmune supportMetabolic healthLiver support

Cordyceps · 2024 · Journal Article · Journal of the Chinese Medical Association: JCMA

Hirsutella sinensis intensifies testicular function and spermatogenesis in male mice with high-fat diet-induced obesity.

BACKGROUND: Hirsutella sinensis (HS) is a mycelium isolated from the fruiting body of the medicinal mushroom Cordyceps sinensis. This study explored whether HS treatment affects reproductive dysfunction in a high-fat diet (HFD)-induced mouse model and regulates various mechanisms, focusing on oxidative stress,….

Cordyceps · 2024 · Journal Article · Mycoscience

Identification of the oosporein biosynthesis gene cluster in an entomopathogenic fungus Blackwellomyces cardinalis

Blackwellomyces cardinalis (≡ Cordyceps cardinalis) is an entomopathogenic fungus that hosts lepidopteran insect larvae. Oosporein, produced by Bl.