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OncologyImmune supportGut & microbiome

Reishi · 2025 · Journal Article · Current pharmaceutical biotechnology

Ganoderma lucidum: A Medicinal Mushroom with Prebiotic and Anticancer Potential in Gastrointestinal Cancers.

INTRODUCTION: Ganoderma lucidum is considered a medicinal mushroom, as it primarily improves gut health by modulating the gut microbiota. As an abundant source of bioactive metabolites, antioxidants, and industrial enzymes, mushrooms make significant contributions to functional foods, nutrition, and pharmaceuticals..

OncologyImmune supportMetabolic healthGut & microbiome

Maitake · 2025 · Research Article · Foods (Basel, Switzerland)

Grifola frondosa Polysaccharides Alleviated Cyclophosphamide-Induced Intestinal Injury Based on Microbiota, Metabolite and Immune Axis Modulation.

Grifola frondosa polysaccharides (GFP), which possess antitumor properties, can counteract intestinal injury induced by cyclophosphamide (CTX). The objective of this research was to evaluate the efficacy of GFP in protecting the intestinal barrier of mice and investigate the mechanisms behind this effect..

OncologyImmune supportGut & microbiome

Lion's Mane · 2025 · Journal Article · Animal Nutrition

Hericium erinaceus polysaccharides improve eggshell quality by improving uterine health and modulating uterine microbiota in aged hens

Hericium erinaceus polysaccharide (HEP) is widely regarded as a potential food additive because of its rich nutritional value. This study aimed to explore the effect of HEP on the eggshell quality of aged laying hens and to reveal the mechanisms with particular emphasis on the alterations of uterine microbiota and….

OncologyImmune supportGut & microbiome

Lion's Mane · 2025 · Research Article · Animal nutrition (Zhongguo xu mu shou yi xue hui)

Hericium erinaceus polysaccharides improve eggshell quality by improving uterine health and modulating uterine microbiota in aged hens.

Metabolic healthGut & microbiomeLiver support

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

Hericium erinaceus Protein Alleviates High-Fat Diet-Induced Hepatic Lipid Accumulation and Oxidative Stress In Vivo.

Dietary interventions with food-derived natural products have emerged as a promising strategy to alleviate obesity. This study aims to investigate the anti-obesity effect of Hericium erinaceus protein (HEP) and its underlying mechanism..

Immune supportGut & microbiomeLiver support

Reishi · 2025 · Journal Article · International journal of biological macromolecules

High molecular weight polysaccharides from Ganoderma lucidum attenuates inflammatory responses, gut microbiota, and liver metabolomic in lipopolysaccharide-induced liver injury mice.

High molecular weight polysaccharides (GLPH, ≥300 kDa) are the major compounds of Ganoderma lucidum with improving liver function. However, the effect of GLPH on improving acute liver injury (ALI) wasn't revealed..

Lion's Mane · 2025 · Research Article · Biology

Hypoglycemic Effect of Pleurotus citrinopileatus and Hericium erinaceus Buccal Tablets on Diabetic Mice.

Diabetes mellitus poses a global health challenge, necessitating natural adjuvants with minimal side effects. The aims of this study were to optimize the concentrations of chromium (Cr), zinc (Zn), and germanium (Ge) in the liquid fermentation media of Pleurotus citrinopileatus and Hericium erinaceus and to evaluate….

Oyster Mushroom · 2025 · Preprint · journal metadata

Identification and Domestication of a Wild Edible Oyster Mushroom Growing on Loblolly Pine ( Pinus taeda ) in Mississippi

The oyster mushroom is among the most extensively cultivated edible mushrooms worldwide. These mushrooms typically thrive on decaying broadleaf deciduous trees but are rarely found on conifers.

Shiitake · 2025 · Journal Article · Journal of the science of food and agriculture

Identification of a novel calcium-binding peptide from Lentinula edodes and structure, stability and absorption evaluation of its calcium chelate.

BACKGROUND: Peptide-Ca chelates are promising calcium supplements. Lentinula edodes (LE) is rich in amino acids with calcium-binding ability, and so it is hypothesized that it can be used to develop peptide-Ca chelates..

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and Palmitoylethanolamide.

Oxidative stress, driven by impaired antioxidant defence systems, is a major contributor to cognitive decline and neurodegenerative processes in brain ageing. This study investigates the neuroprotective effects of a natural compound mixture-composed of Hericium erinaceus, Palmitoylethanolamide, Bilberry extract, and….

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Influence and underlying mechanism of soluble dietary fiber derived from Ganoderma Lucidum-fermented sweet potato residue on the physicochemical-digestive characteristics of wheat starch.

Chronic overconsumption of starchy foods has been associated with health risks including cardiovascular diseases and diabetes. Soluble dietary fiber (SDF) presents a promising solution for modifying starch-based food products..

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Insights into the Mycosphere Fungal Community and Its Association with Nucleoside Accumulation in Ophiocordyceps sinensis.

Soil microbiomes are critical environmental factors influencing the occurrence and quality formation of Ophiocordyceps sinensis, a valuable medicinal fungus endemic to the Qinghai-Tibet Plateau..

OncologyImmune supportGut & microbiomeSkin & hydration

Chaga · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Integrating Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Inonotus obliquus Polysaccharide in the Treatment of Rheumatoid Arthritis.

Background/Objectives: Rheumatoid arthritis (RA) is a chronic, systemic, and progressive autoimmune-inflammatory disease primarily affecting small joints. Inonotus obliquus polysaccharide (IOP) is the main component of the parasitic fungus obliquus, which has anti-tumor, anti-inflammatory, and antioxidant effects..

OncologyImmune supportMetabolic healthGut & microbiome

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Investigation of the fingerprint-activity relationship of Tremella fuciformis polysaccharides and its mitigating effect on radiation-induced intestinal injury.

The aim of this study was to conduct a comprehensive analysis of the relationship between the fingerprint of Tremella fuciformis polysaccharides (TFPs) sourced from China and their bioactivities, with an emphasis on identifying the most bioactive TFP variety that significantly mitigated radiation-induced intestinal….

OncologyEnergy & fatigueGut & microbiomeLiver support

Lion's Mane · 2025 · Research Article · Frontiers in fungal biology

LED light spectra influence the stimulation of mycelial growth and anticancer activity in Hericium erinaceus mycelium.

INTRODUCTION: Hericium erinaceus is a medicinal mushroom known for producing diverse bioactive metabolites with therapeutic potential. However, cultivation strategies aimed at enhancing both fungal yield and metabolite bioactivity, particularly through light-mediated physiological modulation, remain insufficiently….

Shiitake · 2025 · Research Article · Scientific reports

Lentinula edodes cultured extract intake alleviates long-term immune deregulation induced by early-life gut microbiota dysbiosis.

The establishment of gut microbiota during early life is crucial for immune system development and its disturbance within this critical period exerts enduring adverse effects on health. Perinatal antibiotic exposure perturbs early-life microbiota and leads to long-term immune dysregulation..

OncologyEnergy & fatigueGut & microbiomeRespiratory

Maitake · 2025 · Research Article · Food science & nutrition

Mesenchymal Stem Cell-Conditioned Media-Derived Exosomes Loaded With Grifola frondosa Extract Inhibit Lung Cancer via NF-κB and MAPK Pathway Modulation.

The increasing prevalence of drug resistance diminishes the efficacy of chemotherapy and other therapeutic modalities for individuals diagnosed with lung cancer. Therefore, it is imperative to develop novel treatment approaches..

Immune supportGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Food & function

Modification of Ganoderma lucidum spore shells into probiotic carriers: selective loading and colonic delivery of Lacticaseibacillus rhamnosus and effective therapy of inflammatory bowel disease.

Inflammatory bowel disease (IBD) is a chronic inflammation with a high incidence rate. Many probiotics, including Lacticaseibacillus rhamnosus (L.

Immune supportEnergy & fatigueGut & microbiome

Mesima · 2025 · Research Article · Frontiers in microbiology

Modulating effects of Phellinus linteus polysaccharides on antioxidant capacity, immune function, intestinal function and microbiota in lipopolysaccharide-challenged broilers.

Phellinus linteus polysaccharides (PLP) have been shown to have beneficial effects on gut function and gut microbiota in animals. The intention of this study was to examine the effects of PLP on growth performance, immune function, intestinal barrier function and intestinal microbial community in broilers under….

Yellow Morel · 2025 · Journal Article · Chinese journal of integrative medicine

Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation.

OBJECTIVE: To explore the potential apoptotic mechanisms of 3 Morchella extracts (Morchella conica, Morchella esculenta and Morchella delicosa) on breast and colon cancer cell lines using apoptotic biomarkers..

OncologyGut & microbiome

Cordyceps · 2025 · Research Article · BMC biology

Ophiocordyceps sinensis-induced changes in Thitarodes xiaojinensis: from intestinal barrier destruction, microbiome dysbiosis to immune responses at the molecular level.

BACKGROUND: The entomopathogenic fungus (EPF) Ophiocordyceps sinensis has a long-term coexistence with its host insect, Thitarodes xiaojinensis, making it a unique model for host-pathogen interactions..

Turkey Tail · 2025 · Research Article · Mycobiology

Optimization of Lactic Fermented Beverages: Integrating Trametes Versicolor Mycelium and Pleurotus ostreatus Extract for Enhanced Functional Properties.

This investigation involved the addition of Trametes versicolor mycelium to Pleurotus ostreatus extract, which was subsequently fermented using Lactobacillus plantarum to improve the quality of the fermented beverage..

Snow Fungus · 2025 · Journal Article · Food chemistry

Phased characterization of soy protein gel modified by lactobacillus plantarum JYLP-326 in cooperation with acidic tremella fuciformis fruiting body polysaccharide: Focus on structural network, interaction and gel properties.

Soybean protein isolate (SPI) and acidic tremella fuciformis fruiting body polysaccharide (AP) were used to prepare phased products "sterilized soft gel (SPI-AP)" and "fermented strong gel (FSPI-AP)" to study the structural network, interaction and gel characteristics..

Immune supportEnergy & fatigueGut & microbiome

Mesima · 2025 · Journal Article · International journal of medicinal mushrooms

Phellinus linteus (Agaricomycetes) Polysaccharides Ameliorate Inflammatory Injury in H2O2-Induced Caco-2 Cells and DSS-Induced Ulcerative Colitis Mice.

Phellinus linteus (Agaricomycetes) is a valuable medicinal mushroom traditionally used as a food supplement and medicinal ingredient. Polysaccharides of Ph.

Immune supportGut & microbiomeSkin & hydration

Zhu Ling · 2025 · Journal Article · International journal of biological macromolecules

Polyporus Umbellatus polysaccharide ameliorates rheumatoid arthritis via inhibiting inflammation and regulating gut microbiota.

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that can cause cartilage and bone damage as well as a disability. Polyporus Umbellatus polysaccharide (PUP) as a β-glucan exhibit remarkable anti-inflammatory activity..

Cordyceps · 2025 · Journal Article · Journal of functional foods

Polysaccharide from natural Ophiocordyceps sinensis alleviated dextran sulfate sodium-induced colitis through modulating sIgA formation and gut microbiota

Polysaccharide from natural Ophiocordyceps sinensis (NCSP-50) significantly modulated the gut microbiota composition and elevated the levels of sIgA in dextran sodium sulfate (DSS)-induced colitis mice. However, the in-depth mechanism remains unknown..

Oyster Mushroom · 2025 · Research Article · Scientific reports

Prebiotic properties and antioxidant effect of crude extracts and polysaccharides from Agaricus bisporus and Pleurotus ostreatus mushrooms.

Modifying the gut microbiome, also known as bacteriotherapy, is a key strategy that uses probiotics, prebiotics, or synbiotics to reduce inflammation and fight infection and colonization by pathogenic bacteria..

Maitake · 2025 · Journal Article · Chemistry & biodiversity

Preparation and Characterization of Polysaccharides From Grifola frondosa and Their Human Intestinal Flora-modulating Effect.

A novel and efficient hydrogen peroxide/ascorbic acid-assisted extraction method for the preparation of Grifola frondosa polysaccharide (GFP) was developed, and two GFP fractions (GFP-H and GFP-L) with different molecular weights (Mws) were obtained by separation with ultrafiltration..

Metabolic healthGut & microbiomeLiver support

Yellow Morel · 2025 · Journal Article · Food & function

Preparation of Morchella esculenta protein and its preventive effect on nonalcoholic fatty liver disease in mice.

Morchella esculenta is a valuable edible fungus with multidimensional bioactivities; however, research on M. esculenta protein and its beneficial effects on nonalcoholic fatty liver disease (NAFLD) have been limited.

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Preparation, Structural Characterization, and In Vitro Modulation of the Gut Microbiota Activity of a Novel α-Glucan in Hericium erinaceus.

Hericium erinaceus (H. erinaceus) is a kind of medicinal and edible fungus that contains polysaccharide as the most studied effective component at present.

Maitake · 2025 · Journal Article · Biotechnology and applied biochemistry

Protective Effect and Gut Microbiota Modulation of Grifola frondosa Antioxidant Peptides in Sodium Dextran Sulfate-Induced Ulcerative Colitis Mice.

Grifola frondosa antioxidant peptides (GFAP) were prepared through trypsin enzymolysis and characterized. This study conducted a comprehensive assessment of clinical symptoms, colon pathological injuries, levels of inflammatory factors, expression of inflammation-related proteins, and alterations in gut microbiota….

Immune supportCognition & nervesGut & microbiomeLiver support

Lion's Mane · 2025 · Journal Article · International Journal of Biological Macromolecules

Recent insights into Hericium erinaceus polysaccharides: Gastrointestinal, gut microbiota, microbial metabolites, overall health and structure-function correlation

Hericium erinaceus polysaccharides (HEPs) have attracted significant interest due to their potential to support gastrointestinal health and modulate gut microbiota..

Cognition & nervesGut & microbiome

Lion's Mane · 2025 · Journal Article · Analytical methods: advancing methods and applications

Recognition of the impact of Hericium erinaceus mycelium extract on ethanol-damaged gastric epithelial cells using atomic force microscopy.

Atomic force microscopy (AFM) is used to measure live cells. Changes in the biomechanical properties of a single cell under Hericium erinaceus mycelium extract (Heme) treatment play a critical role in drug efficacy evaluation and drug development, but they remain underexplored..

Energy & fatigueGut & microbiome

Reishi · 2025 · Journal Article · Heliyon

Removal of cyanobacterial harmful algal blooms (HABs) from contaminated local park lake using Ganoderma lucidum mycelial pellets

Eutrophication and hypereutrophication in lakes foster harmful blue-green algal blooms, which pose a significant threat to the ecological health of freshwater reservoirs..

Energy & fatigueGut & microbiome

Reishi · 2025 · Research Article · Heliyon

Removal of cyanobacterial harmful algal blooms (HABs) from contaminated local park lake using Ganoderma lucidum mycelial pellets.

Eutrophication and hypereutrophication in lakes foster harmful blue-green algal blooms, which pose a significant threat to the ecological health of freshwater reservoirs..

Immune supportEnergy & fatigueGut & microbiomeRespiratory

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Restoring Mitochondrial Function and Remodeling Gut Microbiota by Low-Molecular-Weight β-Glucan of Hericium erinaceus in Alcohol-Induced Gastrointestinal Injury.

Excessive alcohol consumption poses significant risks for gastrointestinal injury; β-glucans from Hericium erinaceus are known for gastroprotective properties; however, the efficacy of its high-molecular-weight β-glucan is often limited by poor solubility and bioavailability, leaving its protective mechanisms against….

Turkey Tail · 2025 · Journal Article · Phytochemistry

Reverse chemical ecology to study the defense of the plant host Sextonia rubra and the chemical mediators of its endophyte Fusarium falciforme against phytopathogen Trametes versicolor

Sextonia rubra is a tropical tree endemic to the Guiana Shield and the Brazilian Amazon. Despite its renowned wood durability, it remains susceptible to degradation by white-rot fungi such as Trametes versicolor..

Turkey Tail · 2025 · Journal Article · Phytochemistry

Reverse chemical ecology to study the defense of the plant host Sextonia rubra and the chemical mediators of its endophyte Fusarium falciforme against phytopathogen Trametes versicolor.

Chaga · 2025 · Research Article · Journal of microbiology and biotechnology

Revitalization of the Endophytic Fungus Acremonium sp. MEP2000 and Its Impact on the Growth and Accumulation of Bioactive Compounds in Inonotus obliquus.

Inonotus obliquus is a large, medicinal and edible fungus known for its extremely slow growth. It has garnered significant attention due to its high socioeconomic and pharmaceutical value.

Reishi · 2025 · Journal Article · Environmental geochemistry and health

Risk assessment of potentially toxic elements exposure through ganoderma lucidum consumption in the population of Longquan, China.

As a major production area of Ganoderma lucidum, Longquan City has a population with habitual consumption of this medicinal mushroom. This study employed a relative source contribution (RSC) model, coupled with Monte Carlo simulation, aimed to quantify the probabilistic health risk associated with potentially toxic….

Energy & fatigueGut & microbiome

Enoki · 2025 · Journal Article · Food Bioscience

Screening of mixed lactic acid bacteria starter and exploring the sources of flavor substances in co-fermentation of Flammulina velutipes with different vegetables

To augment the flavor components of Flammulina velutipes pickles (FVP) and enhance its acceptability, F. velutipes were co-fermented with various raw materials (cabbages, cowpeas, radishes, millet peppers, gingers, Sichuan peppercorns) using lactic acid bacteria (LAB)..

OncologyImmune supportEnergy & fatigueGut & microbiome

Maitake · 2025 · Journal Article · International Journal of Biological Macromolecules

Selenium release during the simulated gastrointestinal digestion and antioxidant activity of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates

In the study, Grifola frondosa polysaccharides (GFPs) and gallic acid (GA) were utilized to synthesize selenium nanoparticles (GFPs-GA-SeNPs) through a redox reaction involving sodium selenite and ascorbic acid..

OncologyImmune supportEnergy & fatigueGut & microbiome

Maitake · 2025 · Journal Article · International journal of biological macromolecules

Selenium release during the simulated gastrointestinal digestion and antioxidant activity of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates.

Immune supportMetabolic healthGut & microbiome

Snow Fungus · 2025 · Journal Article · Journal of agricultural and food chemistry

Simulated Digestion and Metabolic Outcomes of Tremella fuciformis Polysaccharides and Their Effects on the Gut Microbiota.

Tremella fuciformis polysaccharides (TFP) were evaluated for their gastrointestinal stability and microbiota-modulating effects using in vitro digestion and fecal fermentation..

Immune supportMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Simulated gut microbiota fermentation of polysaccharide extracts from Ganoderma lucidum and Ganoderma neo-japonicum.

This study compared the chemical composition and effects on the gut microbiota of hot-water extracts from two Ganoderma species: Ganoderma lucidum (GL), a well-studied medicinal mushroom, and Ganoderma neo-japonicum (GN), a lesser-known counterpart..

Reishi · 2025 · Journal Article · Journal of microbiology (Seoul, Korea)

Simultaneous gene editing of both nuclei in a dikaryotic strain of Ganoderma lucidum using Cas9-gRNA ribonucleoprotein.

The presence of multiple nuclei in a common cytoplasm poses a significant challenge to genetic modification in mushrooms. Here, we demonstrate successful gene editing in both nuclei of a dikaryotic strain of Ganoderma lucidum using the Cas9-gRNA ribonucleoprotein complex (RNP)..

Immune supportGut & microbiomeLiver supportSkin & hydration

Snow Fungus · 2025 · Journal Article · Langmuir: the ACS journal of surfaces and colloids

Soy Protein Isolate/Tremella Fuciformis Polysaccharide Complex-Stabilized High Internal Phase Pickering Emulsions: Andrographolide Delivery, Digestive Behavior, and 3D Printability.

The development of advanced bioactive delivery systems is critical for enhancing nutraceutical stability, controlled release, and functional food design. This study presented the fabrication of high internal phase Pickering emulsions (HIPPEs) stabilized by soy protein isolate (SPI) and Tremella fuciformis….

Reishi · 2025 · Journal Article · Food chemistry

Spatiotemporal digestion and intestinal microbial fermentation properties of Ganoderma lucidum based on in vitro digestive system.

Ganoderma lucidum (GL) is a renowned medicinal fungus. In this study, the structure of GL was characterized using ion chromatography and nuclear magnetic resonance spectroscopy..

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Sporoderm-broken of Ganoderma lucidum spore polysaccharides alleviate dextran sulfate sodium-induced colon inflammation in mice by regulating Th17/Treg homeostasis and restore gut microbiota balance

Sporoderm-Broken Ganoderma lucidum spore polysaccharides (BGLSPs) have demonstrated therapeutic potential in inflammatory bowel disease (IBD), however, their mechanisms of action in colitis remain unclear..