MycoData

The aim of this study was to explore the therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats. Rats were fed high-fat fodder to establish a rat fatty liver model, and were then fed different concentrations of Pleurotus eryngii cellulose for six weeks..

Metabolic healthLiver support

High relevance

King Oyster · 2015 · Journal Article · Journal of food biochemistry

Antitumor and Immunomodulatory Activity of Pleurotus eryngii Extract

Pleurotus eryngii (P. eryngii), also known as the king oyster mushroom, contains many bioactive substances, including polysaccharides, lipids, peptides, sterols and triterpenoids.

OncologyImmune supportLiver supportRespiratory

High relevance

Chaga · 2015 · Journal Article · International journal of medicinal mushrooms

Hepatoprotective Activity of Water Extracts from Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes) Against Tert-Butyl Hydroperoxide-Induced Oxidative Liver Injury in Primary Cultured Rat Hepatocytes.

We examined the hepatoprotective activity of Inonotus obliquus water extract (IO-W) against tert-butyl hydroperoxide (t-BHP)-induced oxidative liver injury in the primary cultured rat hepatocyte..

Liver support

High relevance

King Oyster · 2014 · Journal Article · Journal of the science of food and agriculture

Antiproliferative and immunostimulatory activity of a protein from Pleurotus eryngii

BACKGROUND: Currently, the use of mushrooms as functional foods, nutraceuticals or phytopharmaceuticals source has risen. In contrast, the possible cellular cytotoxicity and immunostimulatory activity of Pleurotus eryngii (DC.

OncologyImmune supportLiver supportRespiratory

High relevance

Oyster Mushroom · 2014 · Research Article · BMC complementary and alternative medicine

Pleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress in acetaminophen-induced hepato-renal injury.

BACKGROUND: Acetaminophen (APAP)-induced toxicity is a predominant cause of acute hepatic and renal failure. In both humans and rodents toxicity begins with a reactive metabolite that binds to proteins.

Energy & fatigueLiver support

High relevance

King Oyster · 2014 · Journal Article · International journal of medicinal mushrooms

The effects of the king oyster mushroom Pleurotus eryngii (higher Basidiomycetes) on glycemic control in alloxan-induced diabetic mice.

The purpose of this study is to investigate the effects of Pleurotus eryngii on glycemic metabolism. Alloxan-induced hyperglycemic mice were used to study the effects of P..

Metabolic healthLiver support

High relevance

Maitake · 2013 · Journal Article · Food and agricultural immunology

Antioxidant and immunomodulatory effects of a α-glucan from fruit body of maitake (Grifola frondosa)

The antioxidant and immunomodulatory effect of an α-glucan (designated here as MT-α-glucan) from fruit body of Maitake mushroom (Grifola frondosa) on D-galactose (D-gal)-induced senescent mice model was evaluated..

Immune supportCognition & nervesMetabolic healthLiver support

High relevance

Almond Mushroom · 2013 · Journal Article · Clinical journal of gastroenterology

Drug-induced liver injury associated with Agaricus blazei Murill which is very similar to autoimmune hepatitis.

Agaricus blazei Murill (ABM) is one of the most popular complementary alternative medicines (CAM). We experienced a case of a 60-year-old woman with severe hepatitis associated with extract of ABM and extract of Ganoderma lucidum, and a case of a 75-year-old man with drug-induced liver injury (DILI) associated with….

OncologyImmune supportLiver supportRespiratory

High relevance

Maitake · 2013 · Journal Article · Journal of oleo science

Effect of Dietary Maitake (Grifola frondosa) Mushrooms on Plasma Cholesterol and Hepatic Gene Expression in Cholesterol-Fed Mice

To investigate the effects of dietary Grifola frondosa on cholesterol, normal mice were fed a diet containing 1% cholesterol (HC group) or 1% cholesterol and 10% freeze-dried G..

Immune supportMetabolic healthLiver support

High relevance

Almond Mushroom · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM

The Medicinal Values of Culinary-Medicinal Royal Sun Mushroom (Agaricus blazei Murrill).

Agaricus blazei Murrill (ABM), a mushroom native to Brazil, is a basidiomycete brown fungus, which is popularly known as "Cogumelo do Sol" in Brazil or "Himematsutake" in Japan, and there has been a prominent increase in the use of ABM for therapeutic and medicinal purposes..

OncologyMetabolic healthLiver support

High relevance

Almond Mushroom · 2012 · Research Article · Saudi journal of biological sciences

Agaricus blazei Murill as an efficient hepatoprotective and antioxidant agent against CCl4-induced liver injury in rats.

Agaricus blazei Murill is one of the very popular edible medicinal mushrooms. The present study investigated the protective effect of this biologically active mushroom on the tissue peroxidative damage and abnormal antioxidant levels in carbon tetrachloride induced hepatotoxicity in male albino rats..

Liver support

High relevance

Shiitake · 2012 · Journal Article · Biological & pharmaceutical bulletin

Direct Cytotoxicity of Lentinula edodes Mycelia Extract on Human Hepatocellular Carcinoma Cell Line

Lentinula edodes mycelia (L.E.M.) is a dried powder extracted from shiitake mushrooms (Lentinula edodes). We previously demonstrated that it has immunomodulatory effects.

OncologyImmune supportLiver supportSkin & hydration

High relevance

Almond Mushroom · 2011 · Journal Article · International journal of oncology

Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NFκB-mediated increase of intracellular doxorubicin accumulation.

It has been demonstrated that the Agaricus blazei Murill (ABM) mushroom, which primarily consists of polysaccharides, possesses anti-tumor activities. However, the mechanisms by which ABM inhibits human hepatocellular carcinoma growth remain unknown..

OncologyImmune supportLiver support

High relevance

King Oyster · 2011 · Research Article · Saudi journal of biological sciences

Dietary effect of Pleurotus eryngii on biochemical function and histology in hypercholesterolemic rats.

This work was conducted to investigate diet supplement of king oyster mushroom fruiting bodies on biochemical and histological changes in hypercholesterolemic rats. Six-week old female Sprague-Dawley albino rats were divided into three groups of 10 rats each..

Metabolic healthLiver support

High relevance

Almond Mushroom · 2011 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission.

Although many cancer patients use complementary and alternative medicine, including Agaricus blazei Murill (ABM), safety is not yet well understood. Cancer survivors took 1.8, 3.6, or 5.4 g ABM granulated powder (Kyowa Wellness Co., Ltd., Tokyo, Japan) per day orally for 6 months..

OncologyImmune supportGut & microbiomeLiver support

High relevance

Chaga · 2010 · Journal Article · Journal of food biochemistry

Glycosidase inhibitory activity and antioxidant properties of a polysaccharide from the mushroom inonotus obliquus

A water-soluble polysaccharide from Inonotus obliquus (IOPS) was isolated from the mushroom Inonotus obliquus (Fr.) Pilat. The chemical compositions, molecular weight and inhibitory activities on glycosidase and antioxidant properties of IOPS were investigated..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Maitake · 2007 · Journal Article · The Journal of pharmacy and pharmacology

Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice.

We have evaluated the anti-diabetic effect of a alpha-glucan (MT-alpha-glucan) from the fruit body of maitake mushrooms (Grifola frondosa) on KK-Ay mice (a kind of genetical type 2 diabetes animal model)..

Metabolic healthLiver support

High relevance

Niu-Chang-Chih · 2007 · Journal Article · Journal of ethnopharmacology

Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats.

The hepatoprotective effects of the mycelia of Antrodia camphorata and Armillariella tabescens were evaluated in vivo using acute ethanol-intoxicated rats as an experimental model..

Liver support

High relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Journal of biomedical materials research. Part B, Applied biomaterials

Agaricus blazei Murill extract-loaded in alginate/poly(vinyl alcohol) films prepared by Ca2+ cross-linking for wound healing applications.

This work aimed the development and evaluation of the wound healing activity of films based on sodium alginate, polyvinyl alcohol (PVA) and Ca2+ loaded with Agaricus blazei Murill hydroalcoholic extract (AbE). Firstly, AbE was prepared using a previously standardized methodology..

Liver supportSkin & hydration

High relevance

Reishi · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Amelioration of CCl4-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in long evans rats.

Liver disease is a serious health problem affecting people worldwide at an alarming rate. The present study aimed to investigate the protective effects of Ganoderma lucidum against CCl4-induced liver toxicity in rats..

Immune supportMetabolic healthLiver supportSkin & hydration

High relevance

Reishi · 2023 · Research Support, Non U.S. Gov'T · Journal of materials chemistry. B

Improving nanochemoimmunotherapy efficacy by boosting "eat-me" signaling and downregulating "don't-eat-me" signaling with Ganoderma lucidum polysaccharide-based drug delivery.

To address the challenges posed by low immunogenicity and immune checkpoints during cancer treatment, we propose an alternative strategy that combines immunogenic cell death (ICD) effects with CD47/SIRPα blockade to reactivate phagocytosis of tumor cells by macrophages with polysaccharide-based drug delivery..

OncologyImmune supportLiver support

High relevance

Niu-Chang-Chih · 2023 · Research Support, Non U.S. Gov'T · Aging

Triterpene acid from Antrodia camphorata alleviates inflammation in acute liver injury.

This study aimed to investigate the role and mechanism of Anctin A, the Antrodia camphorata terpene component, in resisting liver injury. Network pharmacology analysis revealed that MAPK3 was the major action target of Antcin A..

Immune supportLiver support

High relevance

Maitake · 2022 · Research Support, Non U.S. Gov'T · Frontiers in endocrinology

Grifola frondosa may play an anti-obesity role by affecting intestinal microbiota to increase the production of short-chain fatty acids.

BACKGROUND: Grifola frondosa (G. frondosa) is a fungus with good economic exploitation prospects of food and medicine homologation.

Energy & fatigueGut & microbiomeLiver support

High relevance

Mesima · 2022 · Research Support, Non U.S. Gov'T · Aging

Phellinus linteus polysaccharides mediates acetaminophen-induced hepatotoxicity via activating AMPK/Nrf2 signaling pathways.

Overdose of acetaminophen (APAP) is currently one of the main causes of hepatoxicity and acute liver injury, which is often linked to oxidative stress. Phellinus linteus polysaccharides (Phps) have shown many hepatoprotective effects, however, the mechanism of Phps on APAP-induced acute liver injury has not been….

Immune supportEnergy & fatigueLiver support

High relevance

Lion's Mane · 2022 · Research Support, Non U.S. Gov'T · Biomacromolecules

Smart pH-Sensitive Hydrogel Based on the Pineapple Peel-Oxidized Hydroxyethyl Cellulose and the Hericium erinaceus Residue Carboxymethyl Chitosan for Use in Drug Delivery.

Pineapple and hericium erinaceus (HE) produce a lot of residues in the process of food processing. These processed residues are good potential derivative precursors..

Energy & fatigueGut & microbiomeLiver support

High relevance

Maitake · 2022 · Research Support, Non U.S. Gov'T · Frontiers in immunology

The anti-obesity effects of a water-soluble glucan from Grifola frondosa via the modulation of chronic inflammation.

Polysaccharides from Grifola frondosa (G. frondosa) have anti-obesity and anti-inflammatory activities.

Immune supportMetabolic healthLiver support

High relevance

Reishi · 2025 · Preprint · journal metadata

Integrated analysis of NAFLD mitigation mechanism by Ganoderma lucidum insoluble dietary fiber based on transcriptomics, metabolomics and gut microbiota

Abstract The study established a mouse model of NAFLD induced by a 12-week high-fat diet (HFD). Utilizing hepatic transcriptomics, 16S rDNA sequencing, and metabolomics, the study examined the mechanisms by which GIDF exerts hepatic protection and modulates lipid metabolism in NAFLD through the gut-liver axis.The….

Metabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2021 · Research Support, Non U.S. Gov'T · Experimental eye research

PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage.

Oxidative stress-related ocular surface epithelial damage can be initiated by ambient oxygen, UV radiation, and chemical burns. The oxidative damage to cornea can lead to inflammation and even vision loss..

Immune supportEnergy & fatigueLiver supportSkin & hydration

High relevance

Wood Ear · 2026 · Research Article · Medicine

AMBP gene activation promotes cholangiocarcinoma progression through the WNT/β-catenin signaling pathway: Regulatory effect of polysaccharides from Auricularia auricula-judae.

Cholangiocarcinoma (CCA), an aggressive hepatobiliary malignancy with poor prognosis, involves abnormal molecular regulatory networks. This study explores α-1-microglobulin/bikunin precursor's (AMBP's) role in CCA, its pro-carcinogenic mechanisms via the wingless/integrated (WNT) pathway, and Huaier polysaccharide's….

OncologyImmune supportLiver support

High relevance

Reishi · 2026 · Journal Article · Applied biochemistry and biotechnology

Transcriptomic and Metabolomic Profiling of Heat Stress Responses and Ganoderic Acid Biosynthesis in Ganoderma lucidum.

Ganoderma lucidum (G. lucidum) produces ganoderic acids (GAs), which are pharmacologically important triterpenoids with hepatoprotective, anti-inflammatory, and immunomodulatory properties..

Immune supportMetabolic healthLiver support

High relevance

Reishi · 2025 · Journal Article · Mushroom Science and Biotechnology

Analysis of functional components in preserving Ganoderma lucidum fruiting bodies

Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Mushroom Science and Biotechnology in 2025. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..

OncologyImmune supportMetabolic healthLiver support

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

DCs-targeted full-cell nanovaccine based on chitosan oligosaccharide self-assembled with ganoderma lucidum polysaccharide for enhancing tumor immunotherapy.

Tumor vaccines, designed to deliver immunogenic antigens and initiate tumor-specific immune responses, hold significant promise for cancer prevention and therapy. However, their efficacy remains limited by the inherently low immunogenicity of tumor antigens and inefficient antigen presentation..

OncologyImmune supportLiver supportRespiratory

High relevance

Reishi · 2025 · Research Article · NPJ science of food

Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.

The study established a mouse model of NAFLD induced by a 12-week high-fat diet (HFD). Utilizing hepatic transcriptomics, 16S rDNA sequencing, and metabolomics, the study examined the mechanisms by which GIDF exerts hepatic protection and modulates lipid metabolism in NAFLD through the gut-liver axis.The results….

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Shiitake · 2020 · Journal Article · Applied microbiology and biotechnology

Anti-intoxication and protective effects of a recombinant serine protease inhibitor from Lentinula edodes against acute alcohol-induced liver injury in mice.

Serine protease inhibitors (serpins) are involved in inflammation, coagulation, fibrinolysis, tumor suppression, molecular chaperone, chromatin densification, and hormone transport. However, their anti-intoxication activity has not been determined..

OncologyImmune supportLiver support

High relevance

Niu-Chang-Chih · 2020 · Journal Article · Journal of ethnopharmacology

Antrodin A from mycelium of Antrodia camphorata alleviates acute alcoholic liver injury and modulates intestinal flora dysbiosis in mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata (A. camphorata) is a rare functional fungus in Taiwan and contains a variety of biologically active ingredients.

Immune supportGut & microbiomeLiver support

High relevance

Turkey Tail · 2020 · Journal Article · Current microbiology

Extracellular and Intracellular Polysaccharide Extracts of Trametes versicolor Improve Lipid Profiles Via Serum Regulation of Lipid-Regulating Enzymes in Hyperlipidemic Mice.

Trametes versicolor extracts have been shown to have health-promoting benefits in hypercholesterolemia, obesity, hepatic steatosis, and cardiovascular disease. However, hypolipidemic or the anti-hyperlipidemic effects of polysaccharide extracts of T.

Immune supportMetabolic healthLiver support

High relevance

Cordyceps · 2020 · Journal Article · International journal of medicinal mushrooms

Fruiting Bodies of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes) Alleviate Diabetes-Associated Oxidative Stress.

Hyperglycemia-induced complications, the major causes of death in diabetes, are closely related to the elevated oxidative stress. Our previous study indicated that fruiting bodies of Ophiocordyceps sinensis attenuated polydipsia and hyperglycemia in diabetic rats..

Metabolic healthLiver support

High relevance

Mesima · 2020 · Journal Article · International journal of biological macromolecules

Hepatoprotective effect of Phellinus linteus mycelia polysaccharide (PL-N1) against acetaminophen-induced liver injury in mouse.

Edible and medicinal fungi are one of the major sources for extraction and identification of polysaccharides, which are important biological response modifiers with notable antitumor, hepatoprotective effect and other pharmacological activities..

OncologyImmune supportLiver support

High relevance

Maitake · 2020 · Journal Article · International journal of biological macromolecules

Hypoglycemic and hypolipidemic activities of Grifola frondosa polysaccharides and their relationships with the modulation of intestinal microflora in diabetic mice induced by high-fat diet and streptozotocin.

This study aimed to investigate the hypoglycemic and hypolipidemic activities of polysaccharides from Grifola frondosa (GFP) in diabetic mice induced by high-fat diet (HFD) and streptozotocin (STZ)..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Maitake · 2020 · Journal Article · International journal of biological macromolecules

Hypoglycemic and hypolipidemic mechanism of organic chromium derived from chelation of Grifola frondosa polysaccharide-chromium (III) and its modulation of intestinal microflora in high fat-diet and STZ-induced diabetic mice.

Polysaccharide from Grifola frondosa is an excellent metal-ion chelating agent owing to its distinctive structure and outstanding functional activities. Our previous research has successfully synthesized novel organic chromium derived from the chelation ofG.

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Niu-Chang-Chih · 2020 · Research Article · Nutrients

Protective Effect of Spore Powder of Antrodia camphorata ATCC 200183 on CCl4-Induced Liver Fibrosis in Mice.

Liver fibrosis is a pathological process with intrahepatic diffused deposition of the excess extracellular matrix, which leads to various chronic liver diseases. Drugs with high efficacy and low toxicity for liver fibrosis are still unavailable..

OncologyImmune supportEnergy & fatigueLiver support

High relevance

Lion's Mane · 2019 · Research Article · Molecules (Basel, Switzerland)

Absolute Bioavailability, Tissue Distribution, and Excretion of Erinacine S in Hericium erinaceus Mycelia.

Erinacine S, so far known to have been produced only in Hericium erinaceus mycelia, has just recently been discovered and is able to reduce amyloid plaque growth and improve neurogenesis in aged brain of rats..

Cognition & nervesMetabolic healthGut & microbiomeLiver support

High relevance

Niu-Chang-Chih · 2019 · Research Article · International journal of molecular sciences

Antidiabetic and Antihyperlipidemic Effects of Sulphurenic Acid, a Triterpenoid Compound from Antrodia camphorata, in Streptozotocin-Induced Diabetic Mice.

The present study was designed to evaluate the protective effect of sulphurenic acid (SA), a pure compound from Antrodia camphorata, on diabetes and hyperlipidemia in an animal model study and to clarify the underlying molecular mechanism..

Energy & fatigueMetabolic healthLiver support

High relevance

Enoki · 2019 · Research Article · Food technology and biotechnology

Development of a Transgenic Flammulina velutipes Oral Vaccine for Hepatitis B.

Orally administered fungal vaccines show promise for the prevention of infectious diseases. Edible mushrooms are deemed appropriate hosts to produce oral vaccines due to their low production cost and low risk of gene contamination..

Immune supportLiver supportRespiratory

High relevance

Maitake · 2019 · Journal Article · Food & function

Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats.

The purpose of this study was to assess the potential effects of polysaccharides from edible mushroom Grifola frondosa (GFP) on lipid metabolic disorders and gut microbiota dysbiosis, and elucidate their possible regulatory mechanisms on lipid and cholesterol metabolism in high-fat diet (HFD)-exacerbated….

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Yellow Morel · 2019 · Research Article · Oxidative medicine and cellular longevity

Hepatoprotective Effects of Morchella esculenta against Alcohol-Induced Acute Liver Injury in the C57BL/6 Mouse Related to Nrf-2 and NF-κB Signaling.

This study investigated the hepatoprotective effects of Morchella esculenta fruit body (ME) and the underlying mechanisms in mice with alcohol-induced acute liver injury. Systematic analysis revealed that ME contained 21 types of fatty acid, 17 types of amino acid, and 12 types of mineral..

Immune supportEnergy & fatigueMetabolic healthLiver support

High relevance

Niu-Chang-Chih · 2019 · Journal Article · Chinese journal of natural medicines

Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice.

Antrodia camphorata, a well-known and highly valued edible medicinal mushroom with intriguing activities like liver protection, has been traditionally used for the treatment of alcoholic liver disease. A.

Metabolic healthLiver support

High relevance

Niu-Chang-Chih · 2019 · Research Article · RSC advances

Structural characterization and anti-inflammatory effect in hepatocytes of a galactoglucan from Antrodia camphorata mycelium.

The galactoglucan ACP2 was isolated from cultured Antrodia camphorata mycelium through anion-exchange column chromatography and Sephadex G-100 chromatography and shown to exhibit hepatoprotective function in L02 cells..

Immune supportMetabolic healthLiver support

High relevance

Niu-Chang-Chih · 2019 · Research Article · Molecules (Basel, Switzerland)

The Effects of Ergosta-7,9(11),22-trien-3β-ol from Antrodia camphorata on the Biochemical Profile and Exercise Performance of Mice.

Antrodia camphorata (AC) is a rare and unique mushroom that is difficult to cultivate. Previous studies have demonstrated the bioactivity of the compound Ergosta-7,9(11),22-trien-3β-ol (EK100) from AC in submerged culture..

OncologyEnergy & fatigueMetabolic healthLiver support

High relevance

Chaga · 2019 · Journal Article · International journal of biological macromolecules

The polysaccharide from Inonotus obliquus protects mice from Toxoplasma gondii-induced liver injury.

The study aimed to explore the protective effects and mechanism of Inonotus obliquus polysaccharide (IOP) on liver injury caused by Toxoplasma gondii (T. gondii) infection in mice..

OncologyImmune supportEnergy & fatigueLiver support