MycoData

This study was carried out to provide a platform for the pre-clinical evaluation of anti-cancer properties of a unique CAM (complementary and alternative medicine) agent, Antrodia camphorata alcohol extract (ACAE), in a mouse model with the advantageous non-invasive in vivo bioluminescence molecular imaging….

OncologyImmune supportRespiratory

Medium relevance

Mesima · 2011 · Research Support, Non U.S. Gov'T · Fish & shellfish immunology

Diet enriched with mushroom Phellinus linteus extract enhances the growth, innate immune response, and disease resistance of kelp grouper, Epinephelus bruneus against vibriosis.

The effect of diet supplemented with Phellinus linteus fed for 30 days was investigated in grouper Epinephelus bruneus challenged with Vibrio anguillarum, Vibrio harveyi, Vibrio alginolyticus, and Vibrio carchariae; infected and treated fish had a significantly higher percent weight gain and feed efficiency..

Immune supportRespiratory

Medium relevance

Mesima · 2011 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Preparation of Black Hoof medicinal mushroom Phellinus linteus (Berk. et M.A. Curt.) Teng (Aphyllophoromycetideae) beta-glucan sulfate and in vitro tumor cell growth inhibitory activity.

Polysaccharide beta-glucans were extracted from the medicinal mushroom Phellinus linteus (Hymenochaetaceae, Aphyllophoromycetideae) and subjected to sulfation. Chemical modification of the beta-glucan was confirmed by structural analysis, and its biological properties were compared with those of native beta-glucan..

OncologyImmune supportRespiratory

Medium relevance

Maitake · 2011 · Comparative Study · Journal of agricultural and food chemistry

Profiling of hepatic gene expression of mice fed with edible japanese mushrooms by DNA microarray analysis: comparison among Pleurotus ostreatus, Grifola frondosa, and Hypsizigus marmoreus.

To compare and estimate the effects of dietary intake of three kinds of mushrooms (Pleurotus ostreatus, Grifola frondosa, and Hypsizigus marmoreus), mice were fed a diet containing 10-14% of each mushroom for 4 weeks. Triacylglycerol in the liver and plasma decreased and plasma cholesterol increased in the P..

Immune supportMetabolic healthLiver supportRespiratory

Medium relevance

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Immunology

Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced T helper type 2 responses in a mouse model of asthma.

Asthma is a chronic disease characterized by airway inflammation caused by the dysregulated production of cytokines secreted by allergen-specific type 2 T helper (Th2) cells. Antrodia camphorata is a commonly used fungus in Asian folk medicine, and A..

OncologyImmune supportRespiratory

Medium relevance

Enoki · 2010 · Research Support, Non U.S. Gov'T · Virology journal

Characterization of a mycovirus associated with the brown discoloration of edible mushroom, Flammulina velutipes.

BACKGROUND: A mycovirus previously identified in brown discolored fruiting bodies of the cultivated mushroom Flammulina velutipes was characterized. We tentatively named the virus the F.

Respiratory

Medium relevance

Niu-Chang-Chih · 2009 · Patent · journal metadata

Novel compounds from antrodia camphorata

Antroquinonol B (X=OH) and Antroquinonol C (X=OMe) are described. They can be isolated from Antrodia camphorata extracts and may inhibit the growth of cancer cells (e.g.

OncologyLiver supportRespiratory

Medium relevance

Maitake · 2008 · Patent · journal metadata

GRIFOLA FRONDOSA-ORIGIN SUBSTANCE HAVING ANTIINFLUENZA VIRUS ACTIVITY AND METHOD OF PRODUCING THE SAME

It has been found out that a fraction having a potent antiinfluenza virus activity via microphage activation or an active substance is distributed in low-molecular weight fractions of a Grifola frondosa extract..

Respiratory

Medium relevance

Maitake · 2008 · Research Support, Non U.S. Gov'T · The American journal of Chinese medicine

Inhibitory Effect of TNF-alpha Produced by Macrophages Stimulated with Grifola frondosa Extract (ME) on the Growth of Influenza A/Aichi/2/68 Virus in MDCK Cells.

We investigated the inhibitory effect of the conditioned medium (CM) from P338D1 (D1) cells, a murine macrophage cell line, stimulated for 10 hours with a fixed dose (100 mug/ml) of the extracts from the fruit bodies of Grifola frondosa (ME) or its ultra filtration-based fractions (MFs), on the growth of influenza….

Immune supportRespiratory

Medium relevance

Niu-Chang-Chih · 2008 · Research Support, Non U.S. Gov'T · International immunopharmacology

Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni.

Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities..

OncologyImmune supportLiver supportRespiratory

Medium relevance

Mesima · 2007 · Research Support, Non U.S. Gov'T · Molecular carcinogenesis

Modulation of lung cancer growth arrest and apoptosis by Phellinus Linteus.

The Phellinus Linteus (PL) mushroom has been shown to possess anti-tumor properties. Through influencing lymphocytes, PL indirectly augments the host's immune system against cancer cells.

OncologyImmune supportRespiratory

Medium relevance

Mesima · 2007 · Research Support, Non U.S. Gov'T · British journal of cancer

Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells.

It is known that polysaccharides extracted from the Phellinus linteus (PL) mushroom possess antitumour activity. We previously have demonstrated that high doses of PL render murine or human lung cancer cells susceptible to apoptosis..

OncologyImmune supportRespiratory

Medium relevance

Niu-Chang-Chih · 2006 · Patent · journal metadata

Antrodia camphorata mycelium fermented extract and application thereof

The invention discloses an Antrodia camphorate mycelium fermentation extract abstracted by ethanol, wherein the Antrodia camphorata bacterial strain Ac001 was preserved in the China General Microbiological Culture Collection Center with a docket number of CGMCC No.1460..

OncologyLiver supportRespiratory

Medium relevance

Maitake · 2006 · Research Support, Non U.S. Gov'T · Antiviral research

Inhibition of hepatitis B virus by D-fraction from Grifola frondosa: synergistic effect of combination with interferon-alpha in HepG2 2.2.15.

In this study, D-fraction extracted from Grifola frondosa (GF-D) and its combination with human interferon alpha-2b (IFN) were investigated for the inhibitory effect on hepatitis B virus (HBV) in HepG2 2.2.15 cells (2.2.15 cells)..

Immune supportLiver supportRespiratory

Medium relevance

Yellow Morel · 2026 · Journal Article · Journal of virological methods

Prevalence and ribavirin-mediated elimination of Morchella importuna endornavirus 1 (MiEV1) in cultivated Morchella species in China.

Fungal viruses compromise the cultivation of Morchella. We surveyed five mycoviruses (Morchella importuna endornavirus 1 [MiEV1], Morchella importuna endornavirus 2 [MiEV2], Morchella importuna endornavirus 3 [MiEV3], Morchella esculenta fusarivirus 1 [MeFV1], and Morchella esculenta fusarivirus 2 [MeFV2]) in 24….

Respiratory

Medium relevance

Cordyceps · 2025 · Research Article · Virology journal

Molecular characterization of four novel mycoviruses in entomopathogenic and nematophagous fungi.

BACKGROUND: Research on fungal viruses has predominantly focused on phytopathogenic fungi, with some studies elucidating their roles in modulating fungal virulence and influencing plant-fungus interactions..

Respiratory

Medium relevance

Reishi · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Immuno-physiological effects of dietary reishi mushroom powder as a source of beta-glucan on Rohu, Labeo rohita challenged with Aeromonas veronii.

Beta-glucans have immense potential to stimulate immune modulation in fish by being injected intramuscularly, supplemented with feed or immersion routes of administration. We studied how supplementing Labeo rohita's diet with reishi mushroom powder containing beta-glucan influenced immunological function..

Immune supportEnergy & fatigueLiver supportRespiratory

Medium relevance

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Structure and immunomodulatory activity of a water-soluble α-glucan from Hirsutella sinensis mycelia.

Hirsutella sinensis, the anamorph of Ophiocordyceps sinensis (syn. Cordyceps sinensis), is a great substitute for precious and rare wild Cordyceps sinensis to effectively treat a variety of lung and kidney diseases..

Immune supportRespiratory

Medium relevance

Almond Mushroom · 2020 · Preprint · journal metadata

CoV-ABM: A stochastic discrete-event agent-based framework to simulate spatiotemporal dynamics of COVID-19

The paper develops a stochastic Agent-Based Model (ABM) mimicking the spread of infectious diseases in geographical domains. The model is designed to simulate the spatiotemporal spread of SARS-CoV2 disease, known as COVID-19..

Respiratory

Medium relevance

Cordyceps · 2020 · Journal Article · Science China. Life sciences

Developmental recording of the ghost-moth larvae after ex situ infection by Ophiocordyceps sinensis.

Metadata-grounded summary: This journal article indexes research on Ophiocordyceps sinensis in Science China. Life sciences in 2020.

Energy & fatigueRespiratory

Medium relevance

Wood Ear · 2020 · Research Article · European journal of integrative medicine

Evaluation of the phytoconstituents of Auricularia auricula-judae mushroom and antimicrobial activity of its protein extract.

INTRODUCTION: The growing resistance to antibiotics and the complexity of defeating multi-drug resistant bacteria have led to an increase in the search for novel and effective antimicrobials from various plants..

Respiratory

Medium relevance

Cordyceps · 2020 · Research Article · Microorganisms

Haplotype Diversity of NADPH-Cytochrome P450 Reductase Gene of Ophiocordyceps sinensis and the Effect on Fungal Infection in Host Insects.

Ophiocordyceps sinensis Berk. is a fungal parasite that parasitizes the larvae of Hepialidae and is used as a traditional Chinese medicine.

Respiratory

Medium relevance

Shiitake · 2020 · Journal Article · Minerva gastroenterologica e dietologica

Possible therapeutic role of a highly standardized mixture of active compounds derived from cultured Lentinula edodes mycelia (AHCC) in patients infected with 2019 novel coronavirus.

The outbreak of SARS-CoV-2 disease (COVID-19) is currently, March 2020, affecting more than 100,000 people worldwide and, according to the WHO (World Health Organization), a pandemic is shortly expected..

Immune supportLiver supportRespiratory

Medium relevance

Cordyceps · 2019 · Journal Article · Proceedings for Annual Meeting of The Japanese Pharmacological Society

Ophiocordyceps sinensis may ameliorate cardiovascular remodeling in pulmonary arterial hypertension via TRPM7 inhibition

Metadata-grounded summary: This journal article indexes research on Ophiocordyceps sinensis in Proceedings for Annual Meeting of The Japanese Pharmacological Society in 2019. MycoData maps the paper to metabolic health, respiratory based on its title, species context, article metadata, and study classification..

Metabolic healthRespiratory

Medium relevance

Cordyceps · 2018 · Research Article · Protein & cell

Investigation on natural resources and species conservation of Ophiocordyceps sinensis, the famous medicinal fungus endemic to the Tibetan Plateau.

Metadata-grounded summary: This research article indexes research on Ophiocordyceps sinensis in Protein & cell in 2018. MycoData maps the paper to energy & fatigue, respiratory based on its title, species context, article metadata, and study classification..

Energy & fatigueRespiratory

Medium relevance

Shiitake · 2017 · Journal Article · Gan to kagaku ryoho. Cancer & chemotherapy

[Survival Benefit by Combined Administration of Cyclophosphamide, Lentinula edodes Mycelia Extract(LEM), and Ganoderma lucidum Mycelia Extract(MAK)in S1018B10 Tumor-Bearing Mice].

Cyclophosphamide(CY)was intraperitoneally administered once a week to C57BL/10mice that had received Rous sarcoma virus(RSV)-induced S1018B10 syngeneic tumor transplantation and in whom tumor diameter exceeded 4.5 mm. Survival was prolonged in a group of mice that also received a mixture of LEM and MAK orally..

OncologyRespiratory

Medium relevance

Mesima · 2017 · Research Article · International journal of molecular sciences

Phellinus linteus Grown on Germinated Brown Rice Increases Cetuximab Sensitivity of KRAS-Mutated Colon Cancer.

Colon cancer is one of the most common types of cancer, and it has recently become a leading cause of death worldwide. Among colon cancers, the v-ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated form is notorious for its non-druggable features..

OncologyGut & microbiomeSkin & hydrationRespiratory

Medium relevance

Maitake · 2017 · Journal Article · Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan

温度依存的に蓄積するGrifola frondosa RNA virus 1（GfRV1）がマイタケ宿主遺伝子群の発現に及ぼす影響

Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan in 2017. MycoData maps the paper to respiratory based on its title, species context, article metadata, and study classification..

Respiratory

Medium relevance

Shiitake · 2020 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Mixed polysaccharides derived from Shiitake mushroom, Poriacocos, Ginger, and Tangerine peel enhanced protective immune responses in mice induced by inactivated influenza vaccine.

Influenza viruses are responsible for severe respiratory tract infections of individuals and may cause pandemics with a high risk of mortality and morbidity. Although vaccination is a primary means for prevention of influenza virus infections, poor vaccine performance or inadequate immune responses limits the efficacy….

Immune supportEnergy & fatigueRespiratory

Medium relevance

Shiitake · 2018 · Journal Article · International journal of medicinal mushrooms

Cross-Flow Ultrafiltration Fractions of a Cold Aqueous Extract of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Exhibit Apoptosis in Tumor Cells.

Lentinus edodes (shiitake) ranks among the most well-known medicinal mushrooms worldwide. Immune-modulating effects of shiitake extracts have been widely demonstrated in animals and humans.

OncologyImmune supportRespiratory

Medium relevance

Cordyceps · 2012 · Review · journal metadata

Cordyceps

Metadata-grounded summary: This review indexes research on Ophiocordyceps sinensis in 2012. MycoData maps the paper to energy & fatigue, respiratory based on its title, species context, article metadata, and study classification..

Energy & fatigueRespiratory

Medium relevance

Almond Mushroom · 2025 · Review · Journal of intensive care medicine

Lumbar Puncture and Brain Herniation in Acute Bacterial Meningitis: An Updated Narrative Review.

The risk of lumbar puncture (LP) to precipitate brain herniation in acute bacterial meningitis (ABM) was reviewed in this journal in 2007. We report the case of an infant with ABM who had acute apnea requiring intubation and tonic posturing (mistaken for seizure), and then had brain herniation within four hours of an….

Cognition & nervesRespiratory

Medium relevance

Cordyceps · 2024 · Case Reports · Cureus

A Case of Allergic Bronchopulmonary Mycosis Caused by Cordyceps farinosa, a Species of Caterpillar Fungi.

A female patient in her thirties presented with persistent cough and sputum, unresponsive to conventional treatments. Chest imaging showed infiltrative opacities and high attenuation mucus.

Immune supportRespiratory

Medium relevance

Almond Mushroom · 2024 · Scoping Review · BMC infectious diseases

Agent based modelling of blood borne viruses: a scoping review.

BACKGROUND: The models that historically have been used to model infectious disease outbreaks are equation-based and statistical models. However, these models do not capture the impact of individual and social factors that affect the spread of common blood-borne viruses (BBVs) such as human immunodeficiency virus….

Immune supportLiver supportRespiratory

Medium relevance

Shiitake · 2024 · Review · European journal of medical research

Lentinan progress in inflammatory diseases and tumor diseases.

Shiitake mushrooms are a fungal food that has been recorded in Chinese medicine to nourish the blood and qi. Lentinan (lLNT) is an active substance extracted from shiitake mushrooms with powerful antioxidant, anti-inflammatory, anti-tumor functions..

OncologyImmune supportRespiratory

Medium relevance

Almond Mushroom · 2023 · Research Article · Procedia computer science

An Intelligent ABM-based Framework for Developing Pandemic-Resilient Urban Spaces in Post-COVID Smart Cities.

As of August 2022, the COVID-19 pandemic has accounted for over six million deaths globally. The urban population has been severely affected by this viral pandemic and the ensuing lockdowns, resulting in increased poverty and inequality, slowed economic growth, and a general decline in quality of life..

Cognition & nervesRespiratory

Medium relevance

Cordyceps · 2023 · Journal Article · Chinese journal of integrative medicine

Protective Mechanism of Cordyceps sinensis Treatment on Acute Kidney Injury-Induced Acute Lung Injury through AMPK/mTOR Signaling Pathway.

OBJECTIVE: To investigate protective effect of Cordyceps sinensis (CS) through autophagy-associated adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling pathway in acute kidney injury (AKI)-induced acute lung injury (ALI)..

OncologyImmune supportRespiratory

Medium relevance

Cordyceps · 2023 · Research Article · Natural products and bioprospecting

Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus.

Three previously undescribed compounds, cordycicadione (1), cordycicadin F (2), and 7-hydroxybassiatin (3), were isolated from the cultures of Cordyceps cicadae JXCH1, an entomopathogenic fungus. Their structures and relative configurations were elucidated primarily by NMR spectroscopic analysis..

OncologyImmune supportRespiratory

Medium relevance

Cordyceps · 2022 · Journal Article · Frontiers in pharmacology

Bailing capsule (Cordyceps sinensis) ameliorates renal triglyceride accumulation through the PPARα pathway in diabetic rats.

Diabetic nephropathy (DN) is a severe diabetic complication of the kidney and is the main cause of end-stage kidney disease worldwide. Cordyceps sinensis (C.

Immune supportMetabolic healthRespiratory

Medium relevance

Cordyceps · 2022 · Journal Article · Journal of ethnopharmacology

Preparation of the sphingolipid fraction from mycelia of Cordyceps sinensis and its immunosuppressive activity.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps sinensis (CS) is an herbal tonic in traditional Chinese medicine and is used to treat a wide range of disorders, including immune, kidney, respiratory, lung and cardiovascular diseases, in China..

OncologyImmune supportRespiratory

Medium relevance

Cordyceps · 2021 · Journal Article · Journal of biochemical and molecular toxicology

Cordyceps acid alleviates lung cancer in nude mice.

The aim of this study is to examine the effect of cordyceps acid (CA) on lung cancer in mice. A lung cancer animal model was established by inoculating lung cancer cells under the armpit of nude mice.

OncologyImmune supportMetabolic healthRespiratory

Medium relevance

Shiitake · 2021 · Journal Article · Bioscience, biotechnology, and biochemistry

Mixed polysaccharides derived from shiitake mushroom, Poriacocos, Ginger, and Tangerine peel prevent the H1N1 virus infections in mice.

The pandemic influenza A (H1N1) virus spread globally and posed one of the most serious global public health challenges. The traditional Chinese medicine is served as a complementary treatment strategy with vaccine immunization..

Immune supportRespiratory

Medium relevance

Cordyceps · 2021 · Journal Article · ACS omega

Novel Fatty Acid in Cordyceps Suppresses Influenza A (H1N1) Virus-Induced Proinflammatory Response Through Regulating Innate Signaling Pathways.

Influenza virus (IV) infections usually cause acute lung injury characterized by exaggerated proinflammatory responses. The paucity of therapeutic strategies that target host immune response to attenuate lung injury poses a substantial challenge in management of IV infections..

Immune supportRespiratory

Medium relevance

Cordyceps · 2021 · Journal Article · Food science & nutrition

Safety assessment of HEA-enriched Cordyceps cicadae mycelia on the central nervous system (CNS), cardiovascular system, and respiratory system in ICR male mice.

Cordyceps cicadae, an entomopathogenic fungus, is a source of traditional Chinese medicine in China. Due to the low yield of wild C.

Respiratory

Medium relevance

Shiitake · 2026 · Research Article · Frontiers in immunology

Evaluation of Imoviral® effects on early immune response in Sparus aurata challenged with Vibrio anguillarum.

BACKGROUND: An acute phase response (APR) was experimentally induced in Sparus aurata (Linnaeus, 1758) by intraperitoneal (IP) injection of Vibrio anguillarum to evaluate the effects of dietary supplementation with the Imoviral® complex (CRISTALFARMA) on fish growth performance and health status, through the analysis….

Immune supportEnergy & fatigueRespiratory

Medium relevance

Reishi · 2026 · Research Article · Chinese medicine

Guominkang formula alleviates airway inflammation in HDM-induced asthma mice by regulating Wnt/β-Catenin pathway.

BACKGROUND: The Guominkang formula (GMK), formulated according to the principle of "treatment based on constitution differentiation," comprises Prunus mume (Siebold) Siebold & Zucc. (Wumei), Saposhnikovia divaricata (Turcz.

Immune supportGut & microbiomeRespiratory

Medium relevance

King Oyster · 2025 · Journal Article · Journal of agricultural and food chemistry

Rational Screening of Four Peroxidases with High Aflatoxin B1 Degradation Efficiency via Integrated Computational Simulations.

Aflatoxin B1 (AFB1) degradation remains a critical challenge due to limitations of conventional methods. This study proposed a computational screening strategy to screen the AFB1-degrading enzymes, and four peroxidases derived from Agrocybe pediades (ApeLip), Klebsiella pneumoniae (KpDyp), Trametopsis cervina….

Respiratory

Medium relevance

Cordyceps · 2024 · Research Article · iScience

Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection.

Cordycepin, a natural derivative of adenosine from Cordyceps militaris, can inhibit the replication of the dengue virus (DENV). Here, we investigated its antiviral and anti-inflammatory effects in DENV infected cells.

Immune supportRespiratory

Medium relevance

Agarikon · 2022 · Review · Environmental chemistry letters

Old growth forests and large old trees as critical organisms connecting ecosystems and human health. A review.

Old forests containing ancient trees are essential ecosystems for life on earth. Mechanisms that happen both deep in the root systems and in the highest canopies ensure the viability of our planet..

Cognition & nervesEnergy & fatigueRespiratory

Medium relevance

Shiitake · 2021 · Randomized Controlled Trial · Nutrients

Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot Trial.

Senior individuals can suffer from immunosenescence and novel strategies to bolster the immune response could contribute to healthy ageing. In this double-blind, randomised, controlled pilot trial, we investigated the ability of non-digestible polysaccharide (NPS) preparations to enhance the immune response in a human….

Immune supportGut & microbiomeRespiratory