MycoData

OncologyImmune supportCognition & nervesLiver support

Mesima · 2016 · Research Support, Non U.S. Gov'T · Scientific reports

A proteomic analysis of mushroom polysaccharide-treated HepG2 cells.

The anti-tumor properties of fungal polysaccharides have gained significant recognition in Asia and tropical America. In this study, the differential expression of proteins in normal HepG2 cells and those treated with polysaccharides that had been isolated from Phellinus linteus (PL), Ganoderma lucidum (GL) and….

Wood Ear · 2016 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Changes in shape and size of the stiff branched β-glucan in dimethlysulfoxide/water solutions.

The conformation transition of the short branched β-glucan AF1 isolated from Auricularia auricula-judae in DMSO/water solutions was investigated with viscometry and static/dynamic light scattering (SLS/DLS)..

Shiitake · 2015 · Journal Article · Journal of microbiological methods

A high throughput colorimetric assay of β-1,3-D-glucans by Congo red dye.

Mushroom strains contain complex nutritional biomolecules with a wide spectrum of therapeutic and prophylactic properties. Among these compounds, β-d-glucans play an important role in immuno-modulating and anti-tumor activities..

OncologyImmune supportRespiratory

Niu-Chang-Chih · 2015 · Research Article · BioMed research international

Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.

The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum..

Turkey Tail · 2015 · Journal Article · International journal of medicinal mushrooms

Significant Correlation between TLR2 Agonist Activity and TNF-α Induction in J774.A1 Macrophage Cells by Different Medicinal Mushroom Products.

In the US market, there is a variety of mushroom preparations available, even within the same species of mushroom. Nonetheless, little is known about whether species or the various extraction methods affect biological activity and potency of the immune modulatory activity of mushroom extracts..

Turkey Tail · 2015 · Journal Article · Journal of natural medicines

The TLR2 agonist in polysaccharide-K is a structurally distinct lipid which acts synergistically with the protein-bound β-glucan.

Protein-bound polysaccharide-K (Krestin; PSK) is a hot-water extract of Trametes versicolor with immune stimulatory activity. It has been used for the past 30 years and has demonstrated anti-tumor efficacy in multiple types of cancer..

Immune supportMetabolic health

Yellow Morel · 2014 · Journal Article · Bioprocess and biosystems engineering

Patterns of major metabolites biosynthesis by different mushroom fungi grown on glucose-based submerged cultures.

The biosynthetic potential of four basidiomycetes (Agrocybe aegerita, Flammulina velutipes, Ganoderma applanatum and Pleurotus pulmonarius) and one ascomycete (Morchella esculenta) was examined in regard to biomass, intracellular (endopolysaccharides and lipids) and extracellular (exopolysaccharides) compounds'….

Turkey Tail · 2014 · Journal Article · Innate immunity

Protein-bound polysaccharide-K induces IL-1β via TLR2 and NLRP3 inflammasome activation.

Inflammasome activation has been shown to regulate both innate and adaptive immune responses. It is important to investigate whether immune-enhancing natural products can also activate inflammasome..

Turkey Tail · 2014 · Journal Article · BMC genomics

The genome of the Tiger Milk mushroom, Lignosus rhinocerotis, provides insights into the genetic basis of its medicinal properties.

BACKGROUND: The sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden or Tiger milk mushroom (Polyporales, Basidiomycota) is a valuable folk medicine for indigenous peoples in Southeast Asia..

Turkey Tail · 2014 · Journal Article · Chemosphere

Use of stable isotope probing to assess the fate of emerging contaminants degraded by white-rot fungus.

The widespread of emerging contaminants in the environment and their potential impact on humans is a matter of concern. White-rot fungi are cosmopolitan organisms able to remove a wide range of pharmaceuticals and personal care products (PPCP) through cometabolism (i.e..

OncologyImmune supportMetabolic health

Turkey Tail · 2013 · Journal Article · International journal of medicinal mushrooms

Polysaccharide production by submerged and solid-state cultures from several medicinal higher Basidiomycetes.

Polysaccharides produced by microorganisms represent an industrially unexploited market. An important number of polysaccharides have been isolated from fungi, especially mushrooms, with many interesting biological functions, such as antitumor, hypoglycemic, and immunostimulating activities..

Turkey Tail · 2013 · Journal Article · Immunobiology

Protein-bound polysaccharide activates dendritic cells and enhances OVA-specific T cell response as vaccine adjuvant.

Protein-bound polysaccharide-K (PSK) is a hot water extract from Trametes versicolor mushroom. It has been used traditionally in Asian countries for its immune stimulating and anti-cancer effects.

Turkey Tail · 2012 · Journal Article · International journal of medicinal mushrooms

Assessment of anti-inflammatory, lipid peroxidation and acute toxicity of extracts obtained from wild higher basidiomycetes mushrooms collected from Akure (southwest Nigeria).

Ethanolic extracts of three wild medicinal mushrooms, namely Lenzites betulina (LET), Trametes versicolor (TET), and Coriolopsis polyzona (CET), collected from Akure, southwest Nigeria, were assessed for their lipid peroxidation, anti-inflammatory, and acute toxicity effects..

Turkey Tail · 2012 · Journal Article · International journal of oncology

Polysaccharide-K augments docetaxel-induced tumor suppression and antitumor immune response in an immunocompetent murine model of human prostate cancer.

Advanced castration-resistant prostate cancer has high mortality rates and limited treatment options. Novel therapies are needed to better contend with this disease.

Immune supportEnergy & fatigueSkin & hydration

Turkey Tail · 2011 · Journal Article · PLoS pathogens

A permeable cuticle is associated with the release of reactive oxygen species and induction of innate immunity.

Wounded leaves of Arabidopsis thaliana show transient immunity to Botrytis cinerea, the causal agent of grey mould. Using a fluorescent probe, histological staining and a luminol assay, we now show that reactive oxygen species (ROS), including H(2)O(2) and O(2) (-), are produced within minutes after wounding..

OncologyImmune supportGut & microbiome

Maitake · 2011 · Journal Article · Food chemistry

Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents.

We evaluated the effects of seven mushroom extracts (Grifola frondosa, Pholiota nameko, Panellus serotinus, Hypsizygus marmoreus, Pleurotus cornucopiae, Armillaria mellea, and Flammulina velutipes) on cytotoxic activity and cytokine production of lamina propria leukocytes (LPLs) isolated from rat small (S) and large….

Turkey Tail · 2011 · Journal Article · Journal of biotechnology

Oxidation of galactomannan by laccase plus TEMPO yields an elastic gel.

Chemical modifications of galactomannans are applied to improve and/or modify their solubility, rheological and functional properties, but have limited specificity and are often difficult to control..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Mesima · 2011 · Research Article · Laboratory animal research

Single- and repeated-dose toxicities of aloe fermentation products in rats.

In this study, aloe fermentation products were derived from mycelia from 3 mushrooms: Ganoderma lucidum (AG), Hericium erinaceum (AH), and Phellinus linteus (AP). Levels of aloin A and B increased with fermentation time.

Turkey Tail · 2011 · Journal Article · Clinical cancer research: an official journal of the American Association for Cancer Research

TLR2 agonist PSK activates human NK cells and enhances the antitumor effect of HER2-targeted monoclonal antibody therapy.

PURPOSE: The therapeutic effect of trastuzumab monoclonal antibody (mAb) therapy has been shown to be partially dependent on functional natural killer (NK) cells. Novel agents that enhance NK cell function could potentially improve the antitumor effect of trastuzumab..

Maitake · 2010 · Journal Article · Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology

Anti-fungal Cell Wall β-glucan Antibody in Animal Sera

beta-Glucan is a major component of the cell walls and pathogen-associated microbial patterns of fungi. We previously reported the presence of an antibody which reacts to beta-glucan, anti-beta-glucan (BG) antibody, in human sera..

OncologyImmune supportCognition & nervesGut & microbiome

Mesima · 2010 · Journal Article · Molecular nutrition & food research

Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure?

Mushrooms are known for their immune-modulating and anti-tumour properties. The polysaccharide fraction, mainly beta-glucans, is responsible for the immune-modulating effects.

Turkey Tail · 2010 · Journal Article · Nutrition journal

Immunomodulatory dietary polysaccharides: a systematic review of the literature.

BACKGROUND: A large body of literature suggests that certain polysaccharides affect immune system function. Much of this literature, however, consists of in vitro studies or studies in which polysaccharides were injected.

Turkey Tail · 2010 · Journal Article · Chemosphere

White-rot fungus-mediated degradation of the analgesic ketoprofen and identification of intermediates by HPLC-DAD-MS and NMR.

Ketoprofen is a nonsteroidal anti-inflammatory drug that has been detected in the environment in the range of ng L(-1)-microg L(-1) due to its low degradability in some wastewater treatment plants..

Maitake · 2009 · Research Article · Clinical and molecular allergy: CMA

An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy.

BACKGROUND: Agaricus blazei Murill (AbM) is an edible Brazilian mushroom that has been used in traditional medicine for a range of diseases. It has been shown to have anti-infection and anti-tumor properties in the mouse, which are due to induction of Th1 responses..

OncologyImmune supportGut & microbiomeRespiratory

Lion's Mane · 2009 · Journal Article · Journal of acupuncture and meridian studies

Antimetastatic and immunomodulating effect of water extracts from various mushrooms.

This experiment was conducted to evaluate inhibitory effects against lung metastasis and promotion of splenocytes by water extracts from various mushrooms including Armillaria mellea, Grifola frondosa, Garnoderma frondosa, Codyceps militaris, Hericium erinaceus, Coriolus versicolor, Agaricus Blazei with Lycium….

Maitake · 2008 · Journal Article · International immunopharmacology

Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells.

Immunomodulation by fungal compounds can be determined by the capacity of the compounds to influence the cytokine production by human peripheral blood mononuclear cells (hPBMC). These activities include mitogenicity, stimulation and activation of immune effector cells..

Lion's Mane · 2007 · Journal Article · Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]

[Preparation and biological properties of basidiomycete aqueous extracts and their mycelial compositions].

The basidiomycetes Ganoderma lucidum, Hericium erinaceus, Lentinus edodes and Trametes versicolor were used for preparation of aqueous extracts. A polysaccharide preparation (VPG) was isolated from the G.

Immune supportMetabolic health

Maitake · 2007 · Journal Article · Asia Pacific journal of clinical nutrition

The immune effects of edible fungus polysaccharides compounds in mice.

Most of the current researches on immune function of fungus polysaccharides were based on individual component. Only a few studies were involved in the mixture of proprietary compounds from different species of edible fungi..

King Oyster · 2004 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

beta-Glucan synthase induction in mushrooms grown on olive mill wastewaters.

beta-1-3-Glucan synthase activity and its induction by olive mill wastewaters (OMW) was studied in ten fungal strains (Auricularia auricula-judae, Lentinula edodes, Pleurotus eryngii, Stropharia aeruginosa, Agrocybe aegerita, P. pulmonarius, Armillaria mellea, P.

King Oyster · 2002 · Research Support, Non U.S. Gov'T · Microbiology (Reading, England)

Molecular cloning of a laccase isozyme gene from Pleurotus sajor-caju and expression in the heterologous Pichia pastoris host.

The Psc lac4 gene from Pleurotus sajor-caju has been cloned and expressed in the heterologous host Pichia pastoris, under the control of the AOX1 methanol inducible promoter. The native Ple.

King Oyster · 2000 · Comparative Study · Journal of agricultural and food chemistry

Solid-state (13)C CP MAS NMR spectroscopy of mushrooms gives directly the ratio between proteins and polysaccharides.

The solid-state (13)C CP MAS NMR technique has the potential of monitoring the chemical composition in the solid state of an intact food sample. This property has been utilized to study mushrooms of different species (Pleurotus ostreatus, Pleurotus eryngii, Pleurotus pulmunarius, and Lentinula edodes), already….

OncologyImmune supportCognition & nervesGut & microbiome

Agarikon · 2013 · Comparative Study · International journal of medicinal mushrooms

Cytotoxicity of blended versus single medicinal mushroom extracts on human cancer cell lines: contribution of polyphenol and polysaccharide content.

The use of mushrooms contributes to human nutrition by providing low lipid content of lipids and high dietary fiber content, as well as significant content of other biologically active compounds such as polysaccharides, minerals, vitamins, and polyphenolic antioxidants..

OncologyImmune supportGut & microbiome

Chaga · 2010 · Dissertation · journal metadata

The effect of oxidative stress in lymphocytes from patients with inflammatory bowel disease and various cancer states compared with healthy control individuals

Metadata-grounded summary: This dissertation indexes research on Inonotus obliquus in 2010. MycoData maps the paper to oncology, immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Maitake · 2008 · Research Support, Non U.S. Gov'T · Vaccine

Evaluation of widely consumed botanicals as immunological adjuvants.

BACKGROUND: Many widely used botanical medicines are claimed to be immune enhancers. Clear evidence of augmentation of immune responses in vivo is lacking in most cases.

Immune supportSkin & hydration

Wood Ear · 2008 · Patent · journal metadata

METHOD OF USING COSMETIC AND COSMETIC

It is intended to provide a method of using a cosmetic which provides an excellent immediate effect and is capable of significantly confirming an effect such as improvement of wrinkles, lift-up effect, improvement of clearness, hair growth or antiinflammation; and a cosmetic which can be prepared as an oil-based….

Maitake · 2006 · Patent · journal metadata

Immune system activating formula composed of selected long chain polysaccharides from natural sources

A combination of two, specialized, high molecular weight-long chain fractions isolated from Aloe Vera and Maitake TD to stimulate immune system activity comprise long chain-high molecular weight polysaccharides which activate the body's natural immune response, triggering an increase in the production of macrophages,….

Chaga · 2005 · Patent · journal metadata

COMPOSITION COMPRISING THE EXTRACT OF CHAGA MUSHROOM HAVING ANTI-INFLAMMATORY ACTIVITY

Metadata-grounded summary: This patent indexes research on Inonotus obliquus in 2005. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Maitake · 2005 · Patent · journal metadata

PHYSIOLOGICALLY ACTIVE SUBSTANCE FROM NAMEKO AND/OR MAITAKE MUSHROOMS AND PRODUCING METHOD AND AGENCY

Metadata-grounded summary: This patent indexes research on Grifola frondosa in 2005. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Nameko · 2004 · Patent · journal metadata

DRIED NAMEKO MUSHROOM AND BEVERAGE OF THE SAME

Metadata-grounded summary: This patent indexes research on Pholiota microspora in 2004. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Nameko · 2004 · Patent · journal metadata

METHOD FOR CULTURING LARGE-SIZED NAMEKO MUSHROOM

OncologyImmune supportGut & microbiomeRespiratory

Maitake · 2000 · Review · Alternative medicine review: a journal of clinical therapeutic

The use of mushroom glucans and proteoglycans in cancer treatment.

Immunoceuticals can be considered as substances having immunotherapeutic efficacy when taken orally. More than 50 mushroom species have yielded potential immunoceuticals that exhibit anticancer activity in vitro or in animal models and of these, six have been investigated in human cancers..

OncologyImmune supportMetabolic health

Maitake · 1996 · Review · Nutrition reviews

Functional properties of edible mushrooms.

Edible mushrooms such as shiitake may have important salutary effects on health or even in treating disease. A mushroom characteristically contains many different bioactive compounds with diverse biological activity, and the content and bioactivity of these compounds depend on how the mushroom is prepared and….

Nameko · 1982 · Case Reports · Nihon Kyobu Shikkan Gakkai zasshi

[A case of hypersensitivity pneumonitis due to inhalation of spores of Pholiota nameko].

Metadata-grounded summary: This case reports indexes research on Pholiota microspora in Nihon Kyobu Shikkan Gakkai zasshi in 1982. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Enoki · 2005 · Journal Article · Journal of agricultural and food chemistry

The antiproliferative and differentiating effects of human leukemic U937 cells are mediated by cytokines from activated mononuclear cells by dietary mushrooms.

Proliferation of human leukemic U937 cells was remarkably inhibited by conditioned medium (CM) of human peripheral blood mononuclear cells (MNC-CM) stimulated with cold-water extracts (CWE) (10-800 microg/mL of medium) of dietary mushrooms, Hypsizigus mamoreus (HM), Agrocybe aegerita (AA), Flammulina velutipes (FV),….

Enoki · 2004 · Research Article · Zhong cao yao = Chinese traditional and herbal drugs

Conformation of flammulin by FTIR and Raman spectra

Metadata-grounded summary: This research article indexes research on Flammulina velutipes in Zhong cao yao = Chinese traditional and herbal drugs in 2004. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Zhu Ling · 2004 · Journal Article · Andrologia

Effects of several Chinese herbal aqueous extracts on human sperm motility in vitro.

The effects of six kinds of aqueous extracts of Chinese herbal medicine (Astragalus membranaceus, Acanthopanacis senticosi, Panax genseng and Ophiopogon japonicus, P..

Enoki · 2004 · Research Article · Hua zhong nong ye da xue xue bao = Journal Huazhong (Central China) Agricultural University

Inhibitions of lysine analogue on mycelial growth of six edible fungi

Metadata-grounded summary: This research article indexes research on Flammulina velutipes in Hua zhong nong ye da xue xue bao = Journal Huazhong (Central China) Agricultural University in 2004. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Enoki · 2003 · Research Article · Shandong Da Xue xue bao. Yi xue ban

Preparation of rabbit antibody probe and qualitative analysis specific for flammulin

Metadata-grounded summary: This research article indexes research on Flammulina velutipes in Shandong Da Xue xue bao. Yi xue ban in 2003.

Enoki · 2003 · Research Article · Jun wu xi tong = Mycosystema

purification and molecular weight determination of flammulin

Metadata-grounded summary: This research article indexes research on Flammulina velutipes in Jun wu xi tong = Mycosystema in 2003. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..