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Chaga · 2018 · Research Article · International journal of molecular sciences

Actions of Inonotus obliquus against Hyperuricemia through XOD and Bioactives Screened by Molecular Modeling.

Inonotus obliquus is an edible mushroom and also a remedy against various diseases, especially metabolic syndrome. In this paper we report the actions of an ethanol extract of I.

Niu-Chang-Chih · 2018 · Research Article · RSC advances

Antidiabetic and hypolipidemic activities of eburicoic acid, a triterpenoid compound from Antrodia camphorata, by regulation of Akt phosphorylation, gluconeogenesis, and PPARα in streptozotocin-induced diabetic mice.

The study is designed to examine the potential effects and underlying mechanisms of eburicoic acid (TRR), a compound from Antrodia camphorata, in streptozotocin (STZ)-induced diabetic mice..

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Shiitake · 2018 · Journal Article · International journal of biological macromolecules

Antioxidant and anti-inflammation of enzymatic-hydrolysis residue polysaccharides by Lentinula edodes.

The present work investigated the antioxidative, anti-inflammatory and organ protective effects of residue polysaccharide (RPS) and its enzymatic-RPS (ERPS) of Lentinula edodes against the LPS-induced sepsis in mice..

Niu-Chang-Chih · 2018 · Research Article · Frontiers in pharmacology

Antrodia camphorata Mycelia Exert Anti-liver Cancer Effects and Inhibit STAT3 Signaling in vitro and in vivo.

Hepatocellular carcinoma (HCC), the major form of primary liver cancer, is a common cause of cancer-related death worldwide. Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in HCC and has been proposed as a chemotherapeutic target for HCC..

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Chaga · 2018 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Effects of polysaccharides from Inonotus obliquus and its chromium (III) complex on advanced glycation end-products formation, α-amylase, α-glucosidase activity and H2O2-induced oxidative damage in hepatic L02 cells.

In the present study, the antioxidant activity, anti-glycation activity, α-amylase, α-glucosidase inhibitory activity of polysaccharides from Inonotus obliquus (UIOPS) and its chromium (III) complex (UIOPC) were investigated..

Mesima · 2018 · Research Article · Molecules (Basel, Switzerland)

Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus.

In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D⁻N (4⁻14), from the P..

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Mesima · 2018 · Journal Article · Carbohydrate polymers

Polysaccharides extracted from Phellinus linteus ameliorate high-fat high-fructose diet induced insulin resistance in mice.

Phellinus linteus polysaccharide (PLP) has hypoglycemic effects, but mechanisms remain unclear. Male C57BL/6 J mice were either fed a normal diet (CON) or a high-fat high-fructose diet (HFD) for 16 weeks, and starting from week 12, HFD-fed animals in PLP group were orally given PLP..

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Enoki · 2018 · Journal Article · Carbohydrate polymers

Structural characteristics and bioactive properties of a novel polysaccharide from Flammulina velutipes.

A new water-soluble polysaccharide (FVP1) was extracted from Flammulina velutipes by traditional method "water extraction and alcohol precipitation" and purified by column chromatography. Physicochemical characterization showed that FVP1 was a homogeneous polysaccharide with a relative molecular weight of 54.78 kDa..

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Niu-Chang-Chih · 2018 · Journal Article · Journal of dermatological science

The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata.

BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disease with an associated barrier dysfunction and Staphylococcus aureus infection. The mainstay steroid and calcineurin inhibitor therapy shows some adverse effects..

Chaga · 2017 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway.

Polysaccharides are the main components of mushroom Inonotus obliquus (I. obliquus) with antihyperglycemic activities.

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Maitake · 2017 · Journal Article · International journal of medicinal mushrooms

Anti-Inflammation and Lipogenic Inhibition of Taiwanofungus salmonea Mycelium and Grifola frondosa Fruiting Body.

A long-term inflammatory response can cause the development of nonalcoholic steatohepatitis (NASH), which is mainly caused by abnormal metabolism of lipids in the liver..

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Enoki · 2017 · Journal Article · Carbohydrate polymers

Antimicrobial and antioxidant activities of Flammulina velutipes polysaccharides and polysaccharide-iron(III) complex [corrected].

FVP is polysacchrides obtained from Flammulina velutipes. A polysacchride named FVP2 was isolated from FVP by DEAE cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography.

Almond Mushroom · 2017 · Journal Article · Veterinary research communications

Control of Haemonchus contortus in sheep using basidiocarps of Agaricus blazei Murril.

OBJECTIVE: This study evaluated the effects in vitro and in vivo of Agaricus blazei against Haemonchus contortus in sheep. METHODS: The in vitro efficacy of aqueous extract on egg hatching inhibition (EHI) was investigated and after 72 h incubation with varying concentrations the effects on, blastomeres, embryonated….

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Niu-Chang-Chih · 2017 · Research Article · International journal of molecular sciences

Eburicoic Acid, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects in Palmitate-Treated C2C12 Myotubes and in High-Fat Diet-Fed Mice.

This study was designed to investigate the antidiabetic and antihyperlipidemic effects and mechanisms of eburicoic acid (TRR); one component of Antrodia camphorata in vitro and in an animal model for 14 weeks..

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Niu-Chang-Chih · 2017 · Journal Article · Journal of ethnopharmacology

Hepatoprotective activities of Antrodia camphorata and its triterpenoid compounds against CCl4-induced liver injury in mice.

ETHNOPHARMACOLOGY RELEVANCE: Antrodia camphorata (AC) is a rare and precious fungus indigenous to Taiwan used as a traditional medicine for the treatment of liver injury. Triterpenoids are the major bioactive constituents of A.

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Yellow Morel · 2017 · Journal Article · International journal of biological macromolecules

Purification, antitumor and immunomodulatory activity of polysaccharides from soybean residue fermented with Morchella esculenta.

Crude polysaccharides (MPS) from soybean residue fermented with Morchella esculenta were extracted and purified by DEAE Sephadex A-50 chromatography and Sephadex G-100 size-exclusion chromatography in sequence. Three main fractions MP-1, MP-3 and MP-4 were obtained during the purification steps..

Maitake · 2017 · Journal Article · Apoptosis: an international journal on programmed cell death

The induction of apoptosis and autophagy in human hepatoma SMMC-7721 cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa.

Polysaccharides extracted from the mushroom Grifola frondosa (GFP) are a potential anticancer agent. The objective of this study was to investigate the effect of GFP and vitamin C (VC) alone and in combination on the viability of human hepatocarcinoma SMMC-7721 and HepG2 cells..

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Mesima · 2017 · Journal Article · International journal of medicinal mushrooms

Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) and IL-23 Induced by Polysaccharide of the Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes).

Matrix metalloproteinase-9 (MMP-9) has diverse roles associated with cell growth, migration, invasion, and angiogenesis. Tissue inhibitor of metalloproteinase-1 (TIMP-1) is known to inhibit MMP-9 by complexing with it at a 1:1 ratio..

Zhu Ling · 2016 · Journal Article · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Molecular cloning and characterization of two kind of heat-shock protein gene from Polyporus umbellatus].

With RT-PCR approaches, the full-length cDNA of two heat shock protein genes were cloned from total RNA of the Polyporus umbellatus sclerotium. The full open reading frame cDNA sequence of the Hsp90 was 2 091 bp, encoding 696 amino acid residues with a predicted molecular mass of 78.9 kDa..

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Niu-Chang-Chih · 2016 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Antcin K, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects via Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in Muscles.

The purpose of this study was to screen firstly the potential effects of antcin K (AnK), the main constituent of the fruiting body of Antrodia camphorata, in vitro and further evaluate the activities and mechanisms in high-fat-diet- (HFD-) induced mice..

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Niu-Chang-Chih · 2016 · Journal Article · Antiviral therapy

Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia.

BACKGROUND: Antrodia camphorata, a traditional Chinese medicine, is widely used in the treatment of liver diseases and cancers. Anti-inflammatory properties have also been described.

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Niu-Chang-Chih · 2016 · Research Article · Molecules (Basel, Switzerland)

Antiinflammatory and Antiphotodamaging Effects of Ergostatrien-3β-ol, Isolated from Antrodia camphorata, on Hairless Mouse Skin.

Ergostatrien-3β-ol (EK100), isolated from the submerged whole broth of Antrodia camphorata, has antidiabetic, hyperlipidemic, and hepatoprotective activities. However, the antiphotodamage activity of EK100 has still not been revealed..

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Niu-Chang-Chih · 2016 · Research Article · Frontiers in pharmacology

Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells.

Antrodia camphorata is a Taiwanese-specific fungus which has been used clinically to treat hypertension, immune- and liver-related diseases and cancer; however, it has never been studied in type 2 diabetes mellitus (T2DM). Hyperglycemia in T2DM causes endoplasmic reticulum (ER) stress, leading to β-cell dysfunction..

Maitake · 2016 · Research Article · Experimental biology and medicine (Maywood, N.J.)

Cold-water extracts of Grifola frondosa and its purified active fraction inhibit hepatocellular carcinoma in vitro and in vivo.

Mushrooms are used in traditional Chinese medicine to treat a variety of diseases. Grifola frondosa (GF) is an edible mushroom indigenous to many Asian countries with a large fruiting body characterized by overlapping caps..

OncologyLiver support

Niu-Chang-Chih · 2016 · Research Article · International journal of molecular sciences

Dehydroeburicoic Acid from Antrodia camphorata Prevents the Diabetic and Dyslipidemic State via Modulation of Glucose Transporter 4, Peroxisome Proliferator-Activated Receptor α Expression and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice.

This study investigated the potential effects of dehydroeburicoic acid (TT), a triterpenoid compound from Antrodia camphorata, in vitro and examined the effects and mechanisms of TT on glucose and lipid homeostasis in high-fat-diet (HFD)-fed mice..

Metabolic healthGut & microbiomeLiver support

Lion's Mane · 2016 · Journal Article · Journal of ethnopharmacology

Haematological, biochemical and histopathological aspects of Hericium erinaceus ingestion in a rodent model: A sub-chronic toxicological assessment.

ETHNOPHARMACOLOGICAL RELEVANCE: Hericium erinaceus is a culinary-medicinal mushroom and has a long history of usage in traditional Chinese medicine as a tonic for stomach disorders, ulcers and gastrointestinal ailments..

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Niu-Chang-Chih · 2016 · Journal Article · Hepatology research: the official journal of the Japan Society of Hepatology

Identification of antrodin B from Antrodia camphorata as a new anti-hepatofibrotic compound using a rapid cell screening method and biological evaluation.

AIM: Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) resulting from chronic liver diseases. Efficient and well-tolerated drugs for its treatment are urgently needed..

Lion's Mane · 2016 · Journal Article · Current microbiology

Protective Effects of Extracellular and Intracellular Polysaccharides on Hepatotoxicity by Hericium erinaceus SG-02.

The protective effects of extracellular and intracellular polysaccharides from Hericium erinaceus SG-02 on the CCl4-induced hepatic injury of mice were investigated in this work..

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Mesima · 2016 · Journal Article · International journal of biological macromolecules

Structure and antioxidative property of a polysaccharide from an ammonium oxalate extract of Phellinus linteus.

In this paper, the novel polysaccharide PL-A11 was purified from an ammonium oxalate extract of Phellinus linteus mycelia. Its physicochemical properties, structural characteristics, and antioxidant activities were investigated..

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Maitake · 2016 · Research Article · Frontiers in microbiology

The Mechanisms Underlying the Hypolipidaemic Effects of Grifola frondosa in the Liver of Rats.

The present study investigated the hypolipidaemic effects of Grifola frondosa and its regulation mechanism involved in lipid metabolism in liver of rats fed a high-cholesterol diet. The body weights and serum lipid levels of control rats, of hyperlipidaemic rats, and of hyperlipidaemic rats treated with oral G..

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Niu-Chang-Chih · 2012 · Review · International journal of medicinal mushrooms

Review of biological and pharmacological activities of the endemic Taiwanese bitter medicinal mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (higher Basidiomycetes).

Antrodia camphorata is an extremely rare fungus native to the forested regions of Taiwan. It is also a traditional Chinese medicine, and Taiwanese aborigines applied it for treating liver diseases and protecting from food and drug intoxication.

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Niu-Chang-Chih · 2009 · Review · Journal of ethnopharmacology

Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases.

Niuchangchih (Antrodia camphorata (M. Zang & C.H.

King Oyster · 2004 · Research Article · Journal of Huaiyin Teachers College(Natural Science Edition)

The analysis of the fatty acid compositions in the fruitbody and the mixture barley and mycelium of pleurotus eryngii

Tumor growth and survival time were followed in rats transplanted with Morris hepatoma 5123 and previously injected with a crude homogenate of the same tumor by the intradermic or intralymphatic route. Female rats treated by the intralymphatic route showed a longer survival time and impaired tumor growth..

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Maitake · 2003 · Journal Article · Journal of medicinal food

Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients.

Maitake D-Fraction, extracted from maitake mushroom, has been reported to exert its antitumor effect in tumor-bearing mice by enhancing the immune system through activation of macrophages, T cells, and natural killer (NK) cells..

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Maitake · 2001 · Journal Article · Experimental biology and medicine (Maywood, N.J.)

Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats.

The effects of mushroom fibers on serum cholesterol and hepatic low-density lipoprotein (LDL) receptor mRNA in rats were investigated. Rats were fed a cholesterol-free diet with 50 g/kg cellulose powder (CP), 50 g/kg maitake (Grifola frondosa) fiber (MAF), 50 g/kg shiitake (Lentinus edodes) fiber (SF), or 50 g/kg….

Maitake · 2001 · Journal Article · Journal of experimental & clinical cancer research: CR

Nitric oxide-mediated antitumor activity induced by the extract from Grifola frondosa (Maitake mushroom) in a macrophage cell line, RAW264.7.

We have investigated D-fraction (MDF) extracted from Grifola frondosa (Maitake mushroom) on the inducible nitric oxide synthase (iNOS)-mediated nitric oxide (NO) production in RAW264.7 (RAW) cells, a murine monocyte/macrophage cell line, with special reference to antitumor activity of MDF against human….

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Maitake · 2000 · Journal Article · Japanese journal of pharmacology

Effects of maitake (Grifola frondosa) polysaccharide on collagen-induced arthritis in mice.

We recently reported the anti-hepatitis effect of a polysaccharide, designated as the D-fraction, extracted from maitake. Its effect includes immuno-regulating activities.

Gut & microbiomeLiver support

Lion's Mane · 1998 · Journal Article · Shanxi shi da xue bao. Zi ran ke xue ban = Journal of Shaanxi Normal University

Determination and evaluation of main nutritive componeurts in Hericium erinaceus from wild

A substance that stimulates growth of colonies of mononuclear granulocytic cells derived from the bone marrow of mice was produced by incubating fetal liver cells (conditioned medium). This substance appears to have the same properties described elsewhere as colony-stimulating factor (CSF)..

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Maitake · 1997 · Journal Article · Biological & pharmaceutical bulletin

Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I.

Experimental rat models (5-week-old Sprague-Dawley rats) with hyperlipemia were prepared by feeding high-cholesterol feed containing sodium cholate and casein as a protein source. Dried maitake (Grifola frondosa) powder was mixed with the basic high-cholesterol feed and the serum lipids were periodically measured..

Reishi · 2026 · Research Article · Food science & nutrition

A Triterpenoid-Enriched GLE70 Fraction From Ganoderma lingzhi Ameliorates Alcoholic Liver Disease via Multi-Target Regulation.

Alcoholic liver disease (ALD) arises from chronic alcohol consumption and progresses toward severe hepatic injury. Ganoderma lingzhi (G.

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Ganoderma lingzhi Triterpenoids Ameliorate CCl4-Induced Acute Liver Injury in Mice.

The liver is a critical organ in drug metabolism and detoxification. Ganoderma lingzhi triterpenoids, a major class of bioactive compounds in G.

Cordyceps · 2025 · Journal Article · Journal of medicinal food

Wild Cordyceps Polysaccharides Alleviate Atherosclerosis by Attenuating Macrophage Cholesterol Accumulation Through the PPARγ-LXRα-ABCA1/ABCG1 Pathway.

Cordyceps has been clinically used to treat atherosclerosis (AS) since the 1980s. However, the active components responsible for its effects and the underlying mechanisms remain poorly understood.

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Cordyceps · 2025 · Research Article · Frontiers in pharmacology

Wild Cordyceps sinensis exhibits far lower arsenic accumulation and hepatorenal toxicity in mice compared to equivalent dose of inorganic arsenic.

INTRODUCTION: Wild Cordyceps sinensis (C. sinensis) is a Chinese medicinal material known for its renal and pulmonary benefits.

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Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

Cordyceps polysaccharide improves polycystic ovary syndrome by inhibiting gut-derived LPS/TLR4 pathway to attenuates insulin resistance.

Polycystic ovary syndrome (PCOS) is an endocrine disorder marked by aberrant glucose metabolism and reproductive dysfunction. It is characterized by polycystic ovaries, ovulatory dysfunction, and hyperandrogenemia..

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Chaga · 2024 · Research Article · Polymers

Lignin-Based Hydrogels for the Delivery of Bioactive Chaga Mushroom Extract.

Lignin-poly(ethylene)glycol diglycidyl ether hydrogels were synthesized from lignin fractions readily extracted during the hot-water treatment of angiosperms: hardwoods, sugar maple and energy-crop willow, monocotyledons, grasses, miscanthus and agriculture residues, and wheat straw..

Cordyceps · 2022 · Review · Frontiers in pharmacology

Potential Therapeutic Strategies for Renal Fibrosis: Cordyceps and Related Products.

At present, there is no effective drug for the treatment of renal fibrosis; in particular, a safe and effective treatment for renal fibrosis should be established..

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Mesima · 2020 · Research Article · International journal of molecular sciences

The Biofunctional Effects of Mesima as a Radiosensitizer for Hepatocellular Carcinoma.

The tropical basidiomycete fungus Phellinus linteus (Mesima) exhibits anti-tumor, anti-angiogenic, and immunomodulatory properties in various cancers including prostate, colon, and lung cancer along with melanoma by, for example, inducing apoptosis or cell cycle arrest..

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Chaga · 2018 · Journal Article · Nanoscale

Synthesis of porous Pd nanoparticles by therapeutic chaga extract for highly efficient tri-modal cancer treatment.

Porous palladium nanoparticles were designed and synthesized to maximize the pharmacological activity of the chaga mushroom (Inonotus obliquus) extract, which has anticancer and antibacterial activities..